Association between cystatin C and inflammation in patients with essential hypertension.
Summary of "Association between cystatin C and inflammation in patients with essential hypertension."
BACKGROUND:
Serum cystatin C is not only a marker of renal function but also acts as an independent risk factor for cardiovascular damage, heart failure, and death. It is known that the initiation and progression of these cardiovascular events contributes to renal dysfunction and chronic inflammation. In this study, we investigated the relationship between cystatin C and proinflammatory cytokines.
METHODS:
Eighty-eight patients with essential hypertension participated in the study, which involved measuring proinflammatory cytokines, tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and C reactive protein (CRP).
RESULTS:
Positive correlations were detected between cystatin C and estimated glomerular filtration rate (eGFR) (r = -0.503, p < 0.001), systolic blood pressure (r = -0.246, p = 0.034), and pulse pressure (r = -0.295, p = 0.010). In contrast, serum creatinine correlated only with eGFR (r = -0.755, p < 0.001) and eGFR correlated only with age (r = -0.339, p = 0.001) and not with the other clinical parameters, whereas cystatin C also correlated with log natural (ln) IL-6 (r = -0.247, p = 0.033) and ln TNF-alpha (r = -0.405, p < 0.001) but not with CRP (r = -0.188, p = 0.108). In contrast, plasma creatinine and eGFR did not correlate with any of these proinflammatory cytokines. Stepwise regression analysis showed that ln TNF-alpha, eGFR and pulse pressure were independent determinants of serum cystatin C concentration.
CONCLUSION:
This study showed that cystatin C is a marker of inflammation as well as renal function.
Affiliation
Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine, Toon, Ehime, 791-0295, Japan, okura@m.ehime-u.ac.jp.
Journal Details
This article was published in the following journal.
Name: Clinical and experimental nephrology
ISSN: 1437-7799
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20809110
- DOI: http://dx.doi.org/10.1007/s10157-010-0334-8
Medical and Biotech [MESH] Definitions
Cystatin C
An extracellular cystatin subtype that is abundantly expressed in bodily fluids. It may play a role in the inhibition of interstitial CYSTEINE PROTEASES.
Cystatin M
A cystatin subtype that has a diverse tissue distribution, target specificity, and functions as an endogenous inhibitor of lysosomal cysteine proteases.
Cystatin B
An intracellular cystatin subtype that is found in a broad variety of cell types. It is a cytosolic enzyme inhibitor that protects the cell against the proteolytic action of lysosomal enzymes such as CATHEPSINS.
Ketanserin
A selective serotonin receptor antagonist with weak adrenergic receptor blocking properties. The drug is effective in lowering blood pressure in essential hypertension. It also inhibits platelet aggregation. It is well tolerated and is particularly effective in older patients.
Cystatin A
A cytastin subtype found at high levels in the SKIN and in BLOOD CELLS. Cystatin A incorporates into the cornified cell envelope of stratified squamous epithelial cells and may play a role in bacteriostatic properties of skin.
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