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Likelihood ratio-based quality control for nuchal translucency measurements at 11-14 weeks of gestation.

06:00 EDT 4th September 2010 | BioPortfolio

Summary of "Likelihood ratio-based quality control for nuchal translucency measurements at 11-14 weeks of gestation."


OBJECTIVE:
To develop a quantitative quality control process of nuchal translucency (NT) at 11 to 14 weeks of gestation based on the mixture model (1), based on the analysis of the corresponding distribution of the likelihood ratio (LHR).
METHODS:
Based on the published mixture-model for NT measurement at first trimester (1), we simulated the expected distribution of NT and corresponding LHR. This approach was then tested for the quality control of 15 048 NT measurements performed by four FMF trained operators. The new quality control approach based on LHR was compared to existing processes based on NT plots, median of MoMs and analysis of the 95(th) percentile
RESULTS:
Each operator contributed for 2176 to 4730 examinations. The median, 5(th) and 95(th) percentile of NT values ranged from 1.4 to 1.6mm, 1.0mm and 2.2 to 2.6 mm respectively. Median of NT MoM ranged from 0.83 to 0.95 MoM. Analysis of the distribution of NT measurements confirmed departure from the assumption of the Delta-NT and MoM NT models. Analysis of LHR distributions demonstrated a significant difference between observed and expected distributions for all operators (p<10(-4)).
CONCLUSION:
LHR-based quality control process is feasible at 11-14 weeks. Because it is less sensitive to measurements' bias around the critical area of the 95(th) percentile, its use should be encouraged Copyright (c) 2010 ISUOG. Published by John Wiley & Sons, Ltd.

Affiliation

Obstetrics and maternal-fetal medicine, GHU Necker-Enfants Malades, AP-HP, Université Paris Descartes, France.

Journal Details

This article was published in the following journal.

Name: Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gyneco
ISSN: 1469-0705
Pages:

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