Likelihood ratio-based quality control for nuchal translucency measurements at 11-14 weeks of gestation.

06:00 EDT 4th September 2010 | BioPortfolio

Summary of "Likelihood ratio-based quality control for nuchal translucency measurements at 11-14 weeks of gestation."

To develop a quantitative quality control process of nuchal translucency (NT) at 11 to 14 weeks of gestation based on the mixture model (1), based on the analysis of the corresponding distribution of the likelihood ratio (LHR).
Based on the published mixture-model for NT measurement at first trimester (1), we simulated the expected distribution of NT and corresponding LHR. This approach was then tested for the quality control of 15 048 NT measurements performed by four FMF trained operators. The new quality control approach based on LHR was compared to existing processes based on NT plots, median of MoMs and analysis of the 95(th) percentile
Each operator contributed for 2176 to 4730 examinations. The median, 5(th) and 95(th) percentile of NT values ranged from 1.4 to 1.6mm, 1.0mm and 2.2 to 2.6 mm respectively. Median of NT MoM ranged from 0.83 to 0.95 MoM. Analysis of the distribution of NT measurements confirmed departure from the assumption of the Delta-NT and MoM NT models. Analysis of LHR distributions demonstrated a significant difference between observed and expected distributions for all operators (p<10(-4)).
LHR-based quality control process is feasible at 11-14 weeks. Because it is less sensitive to measurements' bias around the critical area of the 95(th) percentile, its use should be encouraged Copyright (c) 2010 ISUOG. Published by John Wiley & Sons, Ltd.


Obstetrics and maternal-fetal medicine, GHU Necker-Enfants Malades, AP-HP, Université Paris Descartes, France.

Journal Details

This article was published in the following journal.

Name: Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gyneco
ISSN: 1469-0705


PubMed Articles [37056 Associated PubMed Articles listed on BioPortfolio]

Comparative Analysis of Two- Versus Three-Dimensional Sonography for Nuchal Translucency Measurement.

Objective The aim of this article is to test the hypothesis that three-dimensional (3D) sonography is correlated to the two-dimensional (2D) sonography for nuchal translucency (NT) measurement durin...

Doubtful association between progesterone therapy and fetal nuchal translucency.

Increased Nuchal Translucency and Early Growth Retardation Related to Confined Placental Mosaicism of Trisomy 16 in a Dichorionic Twin.

Confined placental mosaicism (CPM) of trisomy 16 is related to intrauterine growth restriction; however, its association with increased nuchal translucency (NT) has not been sufficiently studied. We r...

The effect of powder A2/powder A3 mixing ratio on color and translucency parameters of dental porcelain.

The purpose of this study is to mix dental ceramic powder in varying ratios and evaluate the effect of the mixing ratio on color and translucency.

Permutation-based variance component test in generalized linear mixed model with application to multilocus genetic association study.

In many medical studies the likelihood ratio test (LRT) has been widely applied to examine whether the random effects variance component is zero within the mixed effects models framework; whereas litt...

Clinical Trials [6061 Associated Clinical Trials listed on BioPortfolio]

A Theory-based Sleep Intervention in Improving Sleep Quality in Adolescents

Sleep education has been used as a method of primary and secondary prevention of sleep problems in all age groups. An especially vulnerable age group are adolescents who frequently have po...

Comparison of Bystander Fatigue and CPR Quality When Using Two Different CPR Ratios.

STUDY OBJECTIVES The overall goal of this study is to compare bystander fatigue and CPR quality after 5 minutes of the new 30:2 versus the old 15:2 chest compression to ventilation Interna...

Severing Nuchal Cord at the Time of Delivery.

Umbilical cord often becomes encircled around portions of the fetus, usually the neck. The incidence ranges from 1 loop in 21% to 3 loops in 0.2%. In this study we wish to assessed the pra...

Non-invasive Optical Detection of Iron Deficiency

This study aims to evaluate a prototype device detecting zinc protoporphyrin-IX fluorescence non-invasively from the intact oral mucosa. Zinc protoporphyrin-IX is an established indicator ...

The Effect of Frequent Self Measurements of Blood Pressure on the Control of Hypertension

Despite knowledge regarding the importance of controlling patients' blood pressure (BP) only 30% of treated patients achieve BP goals. Our objective was to determine the effect of frequent...

Medical and Biotech [MESH] Definitions

A prenatal ultrasonic measurement of the thickness or translucent area below the SKIN in the back of the fetal NECK, or nape of the neck, during the first 11-14 weeks of gestation (PREGNANCY TRIMESTER, FIRST). Abnormal thickness or nuchal translucent measurements resulting from fluid collection, is associated with increased risks of CHROMOSOME ABNORMALITIES. (Nicolaides et al., 1992)

The ratio of two odds. The exposure-odds ratio for case control data is the ratio of the odds in favor of exposure among cases to the odds in favor of exposure among noncases. The disease-odds ratio for a cohort or cross section is the ratio of the odds in favor of disease among the exposed to the odds in favor of disease among the unexposed. The prevalence-odds ratio refers to an odds ratio derived cross-sectionally from studies of prevalent cases.

A system for verifying and maintaining a desired level of quality in a product or process by careful planning, use of proper equipment, continued inspection, and corrective action as required. (Random House Unabridged Dictionary, 2d ed)

The levels of excellence which characterize the health service or health care provided based on accepted standards of quality.

The weight of the FETUS in utero. It is usually estimated by various formulas based on measurements made during PRENATAL ULTRASONOGRAPHY.


Relevant Topic

A diagnostic test is any kind of medical test performed to aid in the diagnosis or detection of disease. For example: to diagnose diseases to measure the progress or recovery from disease to confirm that a person is free from disease Clin...

Searches Linking to this Article