Likelihood ratio-based quality control for nuchal translucency measurements at 11-14 weeks of gestation.

06:00 EDT 4th September 2010 | BioPortfolio

Summary of "Likelihood ratio-based quality control for nuchal translucency measurements at 11-14 weeks of gestation."

To develop a quantitative quality control process of nuchal translucency (NT) at 11 to 14 weeks of gestation based on the mixture model (1), based on the analysis of the corresponding distribution of the likelihood ratio (LHR).
Based on the published mixture-model for NT measurement at first trimester (1), we simulated the expected distribution of NT and corresponding LHR. This approach was then tested for the quality control of 15 048 NT measurements performed by four FMF trained operators. The new quality control approach based on LHR was compared to existing processes based on NT plots, median of MoMs and analysis of the 95(th) percentile
Each operator contributed for 2176 to 4730 examinations. The median, 5(th) and 95(th) percentile of NT values ranged from 1.4 to 1.6mm, 1.0mm and 2.2 to 2.6 mm respectively. Median of NT MoM ranged from 0.83 to 0.95 MoM. Analysis of the distribution of NT measurements confirmed departure from the assumption of the Delta-NT and MoM NT models. Analysis of LHR distributions demonstrated a significant difference between observed and expected distributions for all operators (p<10(-4)).
LHR-based quality control process is feasible at 11-14 weeks. Because it is less sensitive to measurements' bias around the critical area of the 95(th) percentile, its use should be encouraged Copyright (c) 2010 ISUOG. Published by John Wiley & Sons, Ltd.


Obstetrics and maternal-fetal medicine, GHU Necker-Enfants Malades, AP-HP, Université Paris Descartes, France.

Journal Details

This article was published in the following journal.

Name: Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gyneco
ISSN: 1469-0705


DeepDyve research library

PubMed Articles [38979 Associated PubMed Articles listed on BioPortfolio]

The added value of detailed early anomaly scan in fetuses with increased nuchal translucency.

To assess the utility of a detailed early fetal anatomy scan prior to karyotyping in the management of pregnancies with an increased nuchal translucency (NT).

Does progesterone therapy increase nuchal translucency in women with threatened miscarriage?

The effect of exogenous progesterone on fetal nuchal translucency (NT) has been proposed recently. In this study, we aimed to compare the thickness of NT of patients receiving and not receiving proges...

Cardiac defects, nuchal edema and abnormal lymphatic development are not associated with morphological changes in the ductus venosus.

In human fetuses with cardiac defects and increased nuchal translucency, abnormal ductus venosus flow velocity waveforms are observed. It is unknown whether abnormal ductus venosus flow velocity wavef...

Are First Trimester Nuchal Septations Independent Risk Factors for Chromosomal Anomalies?

There is conflicting information regarding the role of nuchal septations during first-trimester genetic screening. This study was designed to determine whether nuchal septations are risk factors for c...

Human skull translucency: post mortem studies.

Measurements of optical translucency of human skulls were carried out. An incandescent light source and a CCD camera were used to measure the distribution of light transmitted through the skull in 10 ...

Clinical Trials [8741 Associated Clinical Trials listed on BioPortfolio]

Prediction of Preeclampsia and Other Pregnancy Complications Following Combined Iterative Screening

Preterm birth (PTB), preeclampsia (PE), fetal growth restriction (FGR) and intra-uterine fetal death (IUFD) constitutes the main causes of perinatal morbidity and mortality and are called ...

Application of GeneXpert on Bronchoscopic Samples in the Clinical Management of Patients Suspicious of TB

This is a case control observational study using Bronchial-alveolar lavage (BAL) as specimen for GeneXpert, a real time polymerase chain reaction (PCR) test for detection of tuberculosis (...

A Theory-based Sleep Intervention in Improving Sleep Quality in Adolescents

Sleep education has been used as a method of primary and secondary prevention of sleep problems in all age groups. An especially vulnerable age group are adolescents who frequently have po...

Application of GeneXpert on Bronchoscopic Samples for Patients Suspicious of TB

This is an observational study using Bronchial-alveolar lavage (BAL) as specimen for GeneXpert, a real time polymerase chain reaction (PCR) test for detection of tuberculosis (TB). Patient...

Comparison of Bystander Fatigue and CPR Quality When Using Two Different CPR Ratios.

STUDY OBJECTIVES The overall goal of this study is to compare bystander fatigue and CPR quality after 5 minutes of the new 30:2 versus the old 15:2 chest compression to ventilation Interna...

Medical and Biotech [MESH] Definitions

A prenatal ultrasonic measurement of the thickness or translucent area below the SKIN in the back of the fetal NECK, or nape of the neck, during the first 11-14 weeks of gestation (PREGNANCY TRIMESTER, FIRST). Abnormal thickness or nuchal translucent measurements resulting from fluid collection, is associated with increased risks of CHROMOSOME ABNORMALITIES. (Nicolaides et al., 1992)

The ratio of two odds. The exposure-odds ratio for case control data is the ratio of the odds in favor of exposure among cases to the odds in favor of exposure among noncases. The disease-odds ratio for a cohort or cross section is the ratio of the odds in favor of disease among the exposed to the odds in favor of disease among the unexposed. The prevalence-odds ratio refers to an odds ratio derived cross-sectionally from studies of prevalent cases.

A system for verifying and maintaining a desired level of quality in a product or process by careful planning, use of proper equipment, continued inspection, and corrective action as required. (Random House Unabridged Dictionary, 2d ed)

The levels of excellence which characterize the health service or health care provided based on accepted standards of quality.

The weight of the FETUS in utero. It is usually estimated by various formulas based on measurements made during PRENATAL ULTRASONOGRAPHY.

Quick Search

DeepDyve research library

Relevant Topic

A diagnostic test is any kind of medical test performed to aid in the diagnosis or detection of disease. For example: to diagnose diseases to measure the progress or recovery from disease to confirm that a person is free from disease Clin...

Searches Linking to this Article