Likelihood ratio-based quality control for nuchal translucency measurements at 11-14 weeks of gestation.

06:00 EDT 4th September 2010 | BioPortfolio

Summary of "Likelihood ratio-based quality control for nuchal translucency measurements at 11-14 weeks of gestation."

To develop a quantitative quality control process of nuchal translucency (NT) at 11 to 14 weeks of gestation based on the mixture model (1), based on the analysis of the corresponding distribution of the likelihood ratio (LHR).
Based on the published mixture-model for NT measurement at first trimester (1), we simulated the expected distribution of NT and corresponding LHR. This approach was then tested for the quality control of 15 048 NT measurements performed by four FMF trained operators. The new quality control approach based on LHR was compared to existing processes based on NT plots, median of MoMs and analysis of the 95(th) percentile
Each operator contributed for 2176 to 4730 examinations. The median, 5(th) and 95(th) percentile of NT values ranged from 1.4 to 1.6mm, 1.0mm and 2.2 to 2.6 mm respectively. Median of NT MoM ranged from 0.83 to 0.95 MoM. Analysis of the distribution of NT measurements confirmed departure from the assumption of the Delta-NT and MoM NT models. Analysis of LHR distributions demonstrated a significant difference between observed and expected distributions for all operators (p<10(-4)).
LHR-based quality control process is feasible at 11-14 weeks. Because it is less sensitive to measurements' bias around the critical area of the 95(th) percentile, its use should be encouraged Copyright (c) 2010 ISUOG. Published by John Wiley & Sons, Ltd.


Obstetrics and maternal-fetal medicine, GHU Necker-Enfants Malades, AP-HP, Université Paris Descartes, France.

Journal Details

This article was published in the following journal.

Name: Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gyneco
ISSN: 1469-0705


DeepDyve research library

PubMed Articles [37980 Associated PubMed Articles listed on BioPortfolio]

Does progesterone therapy increase nuchal translucency in women with threatened miscarriage?

The effect of exogenous progesterone on fetal nuchal translucency (NT) has been proposed recently. In this study, we aimed to compare the thickness of NT of patients receiving and not receiving proges...

Comparative Analysis of Two- Versus Three-Dimensional Sonography for Nuchal Translucency Measurement.

Objective The aim of this article is to test the hypothesis that three-dimensional (3D) sonography is correlated to the two-dimensional (2D) sonography for nuchal translucency (NT) measurement durin...

Prenatal diagnosis of fetuses with increased nuchal translucency using an approach based on quantitative fluorescent polymerase chain reaction and genomic microarray.

To assess the clinical value of prenatal diagnosis of fetuses with increased nuchal translucency (NT) using an approach based on quantitative fluorescent polymerase chain reaction (QF-PCR) and chromos...

Pre- and Postnatal Diagnosis of 10p14 Deletion and 22q11.2 Deletion Syndrome and Significance of Non-Cardiac Markers.

Congenital heart defect (CHD) is the most common form of birth defects. There is a high association between increased nuchal translucency and CHD in fetuses, and CHD in the antenatal period has a high...

The effect of powder A2/powder A3 mixing ratio on color and translucency parameters of dental porcelain.

The purpose of this study is to mix dental ceramic powder in varying ratios and evaluate the effect of the mixing ratio on color and translucency.

Clinical Trials [7217 Associated Clinical Trials listed on BioPortfolio]

Application of GeneXpert on Bronchoscopic Samples in the Clinical Management of Patients Suspicious of TB

This is a case control observational study using Bronchial-alveolar lavage (BAL) as specimen for GeneXpert, a real time polymerase chain reaction (PCR) test for detection of tuberculosis (...

A Theory-based Sleep Intervention in Improving Sleep Quality in Adolescents

Sleep education has been used as a method of primary and secondary prevention of sleep problems in all age groups. An especially vulnerable age group are adolescents who frequently have po...

Comparison of Bystander Fatigue and CPR Quality When Using Two Different CPR Ratios.

STUDY OBJECTIVES The overall goal of this study is to compare bystander fatigue and CPR quality after 5 minutes of the new 30:2 versus the old 15:2 chest compression to ventilation Interna...

EEG Theta-Beta Ratio Neurofeedback-training

This study will investigate the effects of an EEG theta/beta ratio Neurofeedback training using a case series multiple baseline design. Twelve participants will be assigned to one of three...

Non-invasive Optical Detection of Iron Deficiency

This study aims to evaluate a prototype device detecting zinc protoporphyrin-IX fluorescence non-invasively from the intact oral mucosa. Zinc protoporphyrin-IX is an established indicator ...

Medical and Biotech [MESH] Definitions

A prenatal ultrasonic measurement of the thickness or translucent area below the SKIN in the back of the fetal NECK, or nape of the neck, during the first 11-14 weeks of gestation (PREGNANCY TRIMESTER, FIRST). Abnormal thickness or nuchal translucent measurements resulting from fluid collection, is associated with increased risks of CHROMOSOME ABNORMALITIES. (Nicolaides et al., 1992)

The ratio of two odds. The exposure-odds ratio for case control data is the ratio of the odds in favor of exposure among cases to the odds in favor of exposure among noncases. The disease-odds ratio for a cohort or cross section is the ratio of the odds in favor of disease among the exposed to the odds in favor of disease among the unexposed. The prevalence-odds ratio refers to an odds ratio derived cross-sectionally from studies of prevalent cases.

A system for verifying and maintaining a desired level of quality in a product or process by careful planning, use of proper equipment, continued inspection, and corrective action as required. (Random House Unabridged Dictionary, 2d ed)

The levels of excellence which characterize the health service or health care provided based on accepted standards of quality.

The weight of the FETUS in utero. It is usually estimated by various formulas based on measurements made during PRENATAL ULTRASONOGRAPHY.

Quick Search

DeepDyve research library

Relevant Topic

A diagnostic test is any kind of medical test performed to aid in the diagnosis or detection of disease. For example: to diagnose diseases to measure the progress or recovery from disease to confirm that a person is free from disease Clin...

Searches Linking to this Article