Development of Novel Nanoparticles Shelled with Heparin for Berberine Delivery to Treat Helicobacter pylori.
Summary of "Development of Novel Nanoparticles Shelled with Heparin for Berberine Delivery to Treat Helicobacter pylori."
Various approaches have been proposed for overcoming unpleasant side effects associated with antibiotics treatment for Helicobacter pylori. The limited effectiveness of such approaches has forced researchers to consider alternative strategies for eliminating H. pylori infection. The plant alkyloid berberine is known to significantly reduce proliferation of H. pylori. To localize berberine to the H. pylori infection site, this study developed a novel nanoparticle berberine carrier shelled with heparin. Analysis of a simulated gastrointestinal medium indicated that the proposed in vitro drug carrier system effectively controls the release of berberine, which interacts specifically with the intercellular space at the site of H. pylori infection. Furthermore, the prepared nanoparticles significantly increased the suppressive effect of berberine on H. pylori growth while efficiently reducing cytotoxic effects in H. pylori-infected cells.
Affiliation
Department of Traditional Chinese Medicine, Taichung Veterans General Hospital, Taichung, Taiwan, ROC.
Journal Details
This article was published in the following journal.
Name: Acta biomaterialia
ISSN: 1878-7568
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20813208
- DOI: http://dx.doi.org/10.1016/j.actbio.2010.08.028
Medical and Biotech [MESH] Definitions
Nanoparticles
Nanometer-sized particles that are nanoscale in three dimensions. They include nanocrystaline materials; NANOCAPSULES; METAL NANOPARTICLES; DENDRIMERS, and QUANTUM DOTS. The uses of nanoparticles include DRUG DELIVERY SYSTEMS and cancer targeting and imaging.
Magnetite Nanoparticles
Synthesized magnetic particles under 100 nanometers possessing many biomedical applications including DRUG DELIVERY SYSTEMS and CONTRAST AGENTS. The particles are usually coated with a variety of polymeric compounds.
Nanodiamonds
Diamond nanoparticles that exhibit unique biological, thermal, mechanical, and optoelectronic properties. They have important NANOMEDICINE applications including DRUG DELIVERY SYSTEMS; DIAGNOSTIC IMAGING; protein separation; and BIOSENSING TECHNIQUES.
Berberine Alkaloids
A group of related plant alkaloids that contain the BERBERINE heterocyclic ring structure.
Metal Nanoparticles
Nanoparticles produced from metals whose uses include biosensors, optics, and catalysts. In biomedical applications the particles frequently involve the noble metals, especially gold and silver.
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