New emerging technologies and the intradermal route: the novel way to immunize against influenza.
Summary of "New emerging technologies and the intradermal route: the novel way to immunize against influenza."
Influenza-related illness is an enormous health burden in all age groups. Immunization remains the best method of prevention, yet despite the availability of a safe and effective vaccine, many individuals go unvaccinated each season. Intradermal (ID) vaccination represents an alternative approach to standard intramuscular (IM) vaccination and takes advantage of the immunologically active dermis capable of producing a robust immune response. Enhanced immunogenicity with ID vaccination compared with standard IM vaccination has been observed in several groups with a history of poor vaccine response rates, such as older adults and haemodialysis patients. In addition, these methods of delivery may increase acceptability in children and persons with needle phobias, thus addressing some of the present barriers to influenza immunization.
Affiliation
Rochester General Hospital, NY 14621, USA. ann.falsey@rochestergeneral.org
Journal Details
This article was published in the following journal.
Name: Vaccine
ISSN: 1873-2518
Pages: D24-32
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20713257
- DOI: http://dx.doi.org/10.1016/j.vaccine.2010.08.026
Medical and Biotech [MESH] Definitions
Ureterostomy
Surgical formation of an opening in the ureter for external drainage of the urine; cutaneous route utilizes a ureteral orifice emerging through the skin.
Influenza B Virus
Species of the genus INFLUENZAVIRUS B that cause HUMAN INFLUENZA and other diseases primarily in humans. Antigenic variation is less extensive than in type A viruses (INFLUENZA A VIRUS) and consequently there is no basis for distinct subtypes or variants. Epidemics are less likely than with INFLUENZA A VIRUS and there have been no pandemics. Previously only found in humans, Influenza B virus has been isolated from seals which may constitute the animal reservoir from which humans are exposed.
Nevus, Intradermal
A nevus in which nests of melanocytes are found in the dermis, but not at the epidermal-dermal junction. Benign pigmented nevi in adults are most commonly intradermal. (Stedman, 25th ed)
Hemagglutinin Glycoproteins, Influenza Virus
Membrane glycoproteins from influenza viruses which are involved in hemagglutination, virus attachment, and envelope fusion. Fourteen distinct subtypes of HA glycoproteins and nine of NA glycoproteins have been identified from INFLUENZA A VIRUS; no subtypes have been identified for Influenza B or Influenza C viruses.
Influenza In Birds
Infection of domestic and wild fowl and other BIRDS with INFLUENZA A VIRUS. Avian influenza usually does not sicken birds, but can be highly pathogenic and fatal in domestic POULTRY.
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