Inter-catheter reproducibility of near-infrared spectroscopy for the in-vivo detection of coronary lipid core coronary plaques.
Summary of "Inter-catheter reproducibility of near-infrared spectroscopy for the in-vivo detection of coronary lipid core coronary plaques."
: To evaluate the inter-catheter reproducibility of catheter-based intracoronary near-infrared spectroscopy (NIRS) for the detection of lipid core coronary plaques (LCPs).
: The inter-catheter in-vivo reproducibility of coronary NIRS findings has not been evaluated in vivo.
: NIRS assessment using an automated pullback catheter was performed in triplicate in 10 patients using 2 different NIRS catheters to evaluate the reproducibility of the Lipid Core Burden Index (LCBI).
: Mean age was 62+/-7 years and all patients were men with high prevalence of hypertension (90%), hyperlipidemia (90%), diabetes (50%) and current smoking (50%). The mean LCBI measured by the 1st and 2nd catheter was 64+/-55 and 69+/-47, respectively (intra-class correlation coefficient 0.97, 95% CI 0.90-0.99, and Spearman's rho 0.95, P<0.001 for both). The mean LCBI measured again with the 2nd catheter was 71+/-63 (intra-class correlation coefficient 0.96, 95% CI 0.84-0.99, and Spearman's rho 0.95, P<0.001 for both). The mean number of LCPs detected by the 1st and 2nd catheter was 1.9+/-1.2 and 2.0+/-1.5, respectively, (intra-class correlation coefficient 0.75, P=0.005, and Spearman's rho 0.74, P=0.01). The mean number of LCPs at reimaging with the 2nd catheter was 2.0+/-1.76, (intra-class correlation coefficient 0.96, and Spearman's rho 0.98, P<0.001 for both).
: NIRS measurements of LCP with 2 different catheters have high reproducibility. The findings support the use of NIRS to assess the status of LCP in patients over time, and to assess LCP changes in response to novel treatments. (c) 2010 Wiley-Liss, Inc.
VA North Texas Healthcare System and University of Texas Southwestern Medical Center, Dallas, Texas.
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Medical and Biotech [MESH] Definitions
Reproducibility Of Results
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
Electron Spin Resonance Spectroscopy
A technique applicable to the wide variety of substances which exhibit paramagnetism because of the magnetic moments of unpaired electrons. The spectra are useful for detection and identification, for determination of electron structure, for study of interactions between molecules, and for measurement of nuclear spins and moments. (From McGraw-Hill Encyclopedia of Science and Technology, 7th edition) Electron nuclear double resonance (ENDOR) spectroscopy is a variant of the technique which can give enhanced resolution. Electron spin resonance analysis can now be used in vivo, including imaging applications such as MAGNETIC RESONANCE IMAGING.
A noninvasive technique that uses the differential absorption properties of hemoglobin and myoglobin to evaluate tissue oxygenation and indirectly can measure regional hemodynamics and blood flow. Near-infrared light (NIR) can propagate through tissues and at particular wavelengths is differentially absorbed by oxygenated vs. deoxygenated forms of hemoglobin and myoglobin. Illumination of intact tissue with NIR allows qualitative assessment of changes in the tissue concentration of these molecules. The analysis is also used to determine body composition.
Spectroscopy, Fourier Transform Infrared
A spectroscopic technique in which a range of wavelengths is presented simultaneously with an interferometer and the spectrum is mathematically derived from the pattern thus obtained.
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