From the Cover: Gene limiting cadmium accumulation in rice.
Summary of "From the Cover: Gene limiting cadmium accumulation in rice."
Intake of toxic cadmium (Cd) from rice caused Itai-itai disease in the past and it is still a threat for human health. Therefore, control of the accumulation of Cd from soil is an important food-safety issue, but the molecular mechanism for the control is unknown. Herein, we report a gene (OsHMA3) responsible for low Cd accumulation in rice that was isolated from a mapping population derived from a cross between a high and low Cd-accumulating cultivar. The gene encodes a transporter belonging to the P(1B)-type ATPase family, but shares low similarity with other members. Heterologous expression in yeast showed that the transporter from the low-Cd cultivar is functional, but the transporter from the high-Cd cultivar had lost its function, probably because of the single amino acid mutation. The transporter is mainly expressed in the tonoplast of root cells at a similar level in both the low and high Cd-accumulating cultivars. Overexpression of the functional gene from the low Cd-accumulating cultivar selectively decreased accumulation of Cd, but not other micronutrients in the grain. Our results indicated that OsHMA3 from the low Cd-accumulating cultivar limits translocation of Cd from the roots to the above-ground tissues by selectively sequestrating Cd into the root vacuoles.
Affiliation
Institute of Plant Science and Resources, Okayama University, Kurashiki 710-0046, Japan.
Journal Details
This article was published in the following journal.
Name: Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Pages: 16500-5
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20823253
- DOI: http://dx.doi.org/10.1073/pnas.1005396107
Medical and Biotech [MESH] Definitions
Cadmium Radioisotopes
Unstable isotopes of cadmium that decay or disintegrate emitting radiation. Cd atoms with atomic weights 103-105, 107, 109, 115, and 117-119 are radioactive cadmium isotopes.
Pyricularia Grisea
The anamorphic form of the fungus MAGNAPORTHE GRISEA and the most important pathogen of rice worldwide. It causes rice blast which prevents maturation of the rice grains.
Cadmium Compounds
Inorganic compounds that contain cadmium as an integral part of the molecule.
Cadmium Poisoning
Poisoning occurring after exposure to cadmium compounds or fumes. It may cause gastrointestinal syndromes, anemia, or pneumonitis.
Cadmium
An element with atomic symbol Cd, atomic number 48, and atomic weight 114. It is a metal and ingestion will lead to CADMIUM POISONING.
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