Behcet's disease and heart transplantation: A word of caution.

18:28 EDT 2nd August 2015 | BioPortfolio

Summary of "Behcet's disease and heart transplantation: A word of caution."

Behcet's disease is a rare autoimmune disease characterized by oral and genital ulcers, and by multisystem disease, including arthritis, neurologic complications and vasculitis. Large-vessel and coronary artery aneurysms are often an indication for surgery, but the return of aneurysms, thrombosis, and the tendency to exhibit an exaggerated inflammatory response at puncture sites (pathergy) complicate surgical recovery. As such, cardiac transplantation, which requires atrial and large-vessel anastomoses, has not been reported in patients with Behcet's disease. We report the first orthotopic heart transplant with >1-year survival in a patient with Behcet's disease despite major complications. The investigators remain pessimistic about cardiac transplantation in patients with Behcet's disease until advances in preventing recurrent vascular pathology ensue.

Affiliation

Department of Pediatrics (Cardiology), Lucile Salter Packard Children's Hospital, Stanford University Medical Center, Stanford, California.

Journal Details

This article was published in the following journal.

Name: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
ISSN: 1557-3117
Pages:

Links

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