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Celiac crisis in a patient with chronic lymphocytic leukemia and hypogammaglobulinemia.

Summary of "Celiac crisis in a patient with chronic lymphocytic leukemia and hypogammaglobulinemia."

Celiac crisis is an acute, fulminant form of celiac disease manifesting with severe diarrhea, metabolic and electrolyte abnormalities, and weight loss. It is mostly seen in children, and there are very few reports in adults. We present a 67-year-old patient with chronic lymphocytic leukemia (CLL) who presented with weight loss of 40pounds, severe diarrhea, hypoalbuminemia and hypokalemia. The patient was immunosuppressed with hypogammaglobulinemia, which is common in CLL. Thus, the patient had negative serological studies for celiac disease. An endoscopic evaluation and HLA typing supported the diagnosis of celiac disease. Although the differential diagnosis was broad, exclusion of other etiologies for diarrhea, prompt diagnosis of celiac disease and initiation of gluten-free diet resolved the crisis. This is the first such report of a patient presenting with celiac crisis on a background of hypogammaglobulinemia.

Affiliation

Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, 72205 Arkansas, USA.

Journal Details

This article was published in the following journal.

Name: Gastroenterologie clinique et biologique
ISSN: 2210-7401
Pages:

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Celiac Disease
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