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Leptin promotes lupus T-cell autoimmunity.

08:00 EDT 12th September 2013 | BioPortfolio

Summary of "Leptin promotes lupus T-cell autoimmunity."

In systemic lupus erythematosus (SLE), the impairment in apoptosis can facilitate the initiation and maintenance of autoimmune responses to self antigens. Here we show that the adipocytokine leptin, which is abnormally elevated in SLE, promotes the survival and proliferation of autoreactive T-cells in mice with an autoreactive T-cell repertoire, including (NZB x NZW)F1 lupus-prone mice. This ability of leptin to promote lupus T-cell autoimmunity suggests the possibility of a therapeutic targeting of leptin in SLE.

Affiliation

Department of Medicine, University of California at Los Angeles, CA, USA.

Journal Details

This article was published in the following journal.

Name: Clinical immunology (Orlando, Fla.)
ISSN: 1521-7035
Pages: 530-533

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