Advertisement
Advertise here Publish your press releases here Sponsor BioPortfolio
Follow us on Twitter Sign up for daily news and research emails Contributors wanted

Leptin promotes lupus T-cell autoimmunity.

14:31 EDT 17th April 2014 | BioPortfolio

Summary of "Leptin promotes lupus T-cell autoimmunity."

In systemic lupus erythematosus (SLE), the impairment in apoptosis can facilitate the initiation and maintenance of autoimmune responses to self antigens. Here we show that the adipocytokine leptin, which is abnormally elevated in SLE, promotes the survival and proliferation of autoreactive T-cells in mice with an autoreactive T-cell repertoire, including (NZB x NZW)F1 lupus-prone mice. This ability of leptin to promote lupus T-cell autoimmunity suggests the possibility of a therapeutic targeting of leptin in SLE.

Affiliation

Department of Medicine, University of California at Los Angeles, CA, USA.

Journal Details

This article was published in the following journal.

Name: Clinical immunology (Orlando, Fla.)
ISSN: 1521-7035
Pages: 530-533

Links

PubMed Articles [13078 Associated PubMed Articles listed on BioPortfolio]

Deficient Leptin Signaling Ameliorates Systemic Lupus Erythematosus Lesions in MRL/Mp-Faslpr Mice.

Leptin is secreted by adipocytes, the placenta, and the stomach. It not only controls appetite through leptin receptors in the hypothalamus, it also regulates immunity. In the current study, we produc...

A8.16 T helper lymphocytes and monocytes as biosensors of type I interferon responses in viral infection and autoimmunity.

Immune responses in viral infections and autoimmunity are characterised by type I interferon (IFN) gene signatures detectable in peripheral blood mononuclear cells (PBMC). We have identified cell-spec...

Immunopathology of lupus nephritis.

When patients with systemic lupus erythematosus (SLE) present with urinary abnormalities, a renal biopsy is usually needed to rule out or confirm lupus nephritis. Renal biopsy is also needed to define...

A8.13 Changes in the relationship between BAFF, BAFF-R and B cell phenotype following rituximab in patients with systemic lupus erythematosus.

In vitro, BAFF (B-lymphocyte activating factor) differentially promotes the survival of B-cells and plasmablasts through receptors for the key B-cell cytokine BAFF. Following rituximab (RTX) therapy i...

Subclinical Atherosclerosis in Systemic Lupus Erythematosus and Antiphospholipid Syndrome: Focus on β2GPI-Specific T Cell Response.

Systemic Lupus Erythematosus (SLE) and antiphospholipid syndrome (APS) are associated with a high prevalence of atherosclerosis. β2 glycoprotein I (β2GPI) represents a link between autoimmunity and...

Clinical Trials [3247 Associated Clinical Trials listed on BioPortfolio]

Estrogen and Gender Biased Autoimmunity

This study involves research to investigate how estrogen affects women of childbearing age and its correlation to Systemic Lupus Erythematosus. The findings from this study might help dete...

Autoimmunity in Sisters of Lupus Patients

This study enrolled over 400 unaffected sisters of young women diagnosed with SLE. These unaffected sisters are being followed with an annual health questionnaire (CSQ) and blood sample.

Effect of Mesenchymal Stem Cell Transplantation for Lupus Nephritis

Mesenchymal Stem Cell (MSC) has been shown to have immunosuppressive and repairing properties. Manifestations of systemic lupus eryhematosus(SLE) may in most patients be ameliorated with m...

Effects of Leptin Replacement in Children

We will assess the endocrine and immune effects of leptin replacement in leptin-deficient children, from a consanguineous Turkish family. We hypothesize that leptin replacement will have...

Leptin and Endothelial Function

The purpose of this trial was to determine if injections of leptin would improve vascular function in normal-weight, healthy volunteers.

Medical and Biotech [MESH] Definitions

Cell surface receptors for obesity factor (LEPTIN), a hormone secreted by the WHITE ADIPOCYTES. Upon leptin-receptor interaction, the signal is mediated through the JAK2/STAT3 pathway to regulate food intake, energy balance and fat storage.

Process whereby the immune system reacts against the body's own tissues. Autoimmunity may produce or be caused by AUTOIMMUNE DISEASES.

A 16-kDa peptide hormone secreted from WHITE ADIPOCYTES. Leptin serves as a feedback signal from fat cells to the CENTRAL NERVOUS SYSTEM in regulation of food intake, energy balance, and fat storage.

A form of lupus erythematosus in which the skin may be the only organ involved or in which skin involvement precedes the spread into other body systems. It has been classified into three forms - acute (= LUPUS ERYTHEMATOSUS, SYSTEMIC with skin lesions), subacute, and chronic (= LUPUS ERYTHEMATOSUS, DISCOID).

Glomerulonephritis associated with autoimmune disease SYSTEMIC LUPUS ERYTHEMATOSUS. Lupus nephritis is histologically classified into 6 classes: class I - normal glomeruli, class II - pure mesangial alterations, class III - focal segmental glomerulonephritis, class IV - diffuse glomerulonephritis, class V - diffuse membranous glomerulonephritis, and class VI - advanced sclerosing glomerulonephritis (The World Health Organization classification 1982).

Search BioPortfolio:
Advertisement
Advertisement

Searches Linking to this Article