Helicobacter pylori dupA and gastric acid secretion are negatively associated with gastric cancer development.
Summary of "Helicobacter pylori dupA and gastric acid secretion are negatively associated with gastric cancer development."
Few report described the cancer prevalence of peptic ulcer patients with long-term follow up study. We conducted a long-term retrospective cohort study of Japanese peptic ulcer patients and evaluated risk factors for the occurrence of gastric cancer (GCa). A total of 136 patients diagnosed peptic ulcers from 1975 to 1983 were enrolled. These 136 cases [102 males; 69 gastric ulcer (GU) and 67 duodenal ulcer (DU) ones at the time of enrollment; mean follow-up period of 14.4 years (range 1-30 years)] after matching with a tumor registry database in Hiroshima prefecture were surveyed for GCa. We investigated a Helicobactor pylori (H. pylori) duodenal ulcer promoter gene A (dupA) using paraffin-embedded gastric biopsy specimens in 56 cases. Gastric acid secretion, basal acid output (BAO) in 40 cases and maximal acid output (MAO) in 68 cases, had been measured at first diagnosis of peptic ulcers.GCa was detected in 24 (17 with GU, 7 with DU) during the follow-up. The prevalence of GCa was significantly higher in GU than in DU patients (Log-rank test, p<0.05). DupA-positive H. pylori was detected not only in DU (9/20) but also in GU patients (9/36). Gastric acid output was significantly larger in quantity of patients with dupA-positive H. pylori than those with dupA-negative (p<0.05). The occurrence of GCa was significantly lower in patients with dupA-positive H. pylori and high BAO level (Log-rank test, p<0.05). DU, higher acid output and dupA positive were negatively associated with GCa.
1 Department of Medicine and Molecular Science, Hiroshima University;
This article was published in the following journal.
Name: Journal of medical microbiology
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20829397
- DOI: http://dx.doi.org/10.1099/jmm.0.021816-0
Medical and Biotech [MESH] Definitions
A spiral bacterium active as a human gastric pathogen. It is a gram-negative, urease-positive, curved or slightly spiral organism initially isolated in 1982 from patients with lesions of gastritis or peptic ulcers in Western Australia. Helicobacter pylori was originally classified in the genus CAMPYLOBACTER, but RNA sequencing, cellular fatty acid profiles, growth patterns, and other taxonomic characteristics indicate that the micro-organism should be included in the genus HELICOBACTER. It has been officially transferred to Helicobacter gen. nov. (see Int J Syst Bacteriol 1989 Oct;39(4):297-405).
Infections with organisms of the genus HELICOBACTER, particularly, in humans, HELICOBACTER PYLORI. The clinical manifestations are focused in the stomach, usually the gastric mucosa and antrum, and the upper duodenum. This infection plays a major role in the pathogenesis of type B gastritis and peptic ulcer disease.
A species of gram-negative, spiral-shaped bacteria found in the gastric mucosa that is associated with chronic antral gastritis. This bacterium was first discovered in samples removed at endoscopy from patients investigated for HELICOBACTER PYLORI colonization.
Ulceration of the GASTRIC MUCOSA due to contact with GASTRIC JUICE. It is often associated with HELICOBACTER PYLORI infection or consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).
Ulcer that occurs in the regions of the GASTROINTESTINAL TRACT which come into contact with GASTRIC JUICE containing PEPSIN and GASTRIC ACID. It occurs when there are defects in the MUCOSA barrier. The common forms of peptic ulcers are associated with HELICOBACTER PYLORI and the consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).
BACKGROUND: Infection with Helicobacter pylori possessing a newly described virulence factor--duodenal ulcer-promoting gene A (dupA)--has been associated with duodenal ulceration and increased gastric...
ABSTRACT: BACKGROUND: This study investigated if the H. pylori dupA genotype and certain host single nucleotide polymorphisms (SNPs) of matrix metalloproteinases (MMPs) and their inhibitors (TIMPs), i...
BACKGROUND: Helicobacter pylori is pathogenic bacterium that is associated with several gastric diseases in humans. Disease is characterized by severe inflammatory responses is the stomach that are in...
BACKGROUND AND AIM: The relationship between gastroesophageal reflux disease (GERD) and Helicobacter pylori is controversial. We evaluated endoscopic, 24-h gastric and esophageal acid profile among pa...
BACKGROUND: The association of Helicobacter pylori infection with aspirin-induced gastropathy is controversial. H. pylori infection exerts diverse effects on gastric acid secretion. In this study, the...
Helicobacter pylori (HP) is the major risk factors of gastritis, gastric ulcers, duodenal ulcers, mucosa associated lymphoid tissue lymphoma and gastric cancer. Helicobacter pylori are fou...
Helicobacter pylori (H. pylori) is associated with gastric cancer in epidemiological studies.Gastric atrophy and intestinal metaplasia caused by H. pylori are considered as precancerous le...
Recently, the preventive effect of Helicobacter pylori (Hp) eradication treatment on the incidence of gastric cancer has been reported. By Hp eradication treatment being performed for Hp-i...
Helicobacter pylori is a bacteria that infects the lining of the stomach and is associated with ulcers. Helicobacter pylori may also increase the long-term risk of developing certain forms...
Gastric cancer is the fourth most common type of cancer and the second leading cause of cancer-related death in the world. In China, more than 390,000 new patients are diagnosed with gastr...