Palladium-Catalyzed Suzuki-Miyaura Cross-Coupling Reactions of Enantiomerically Enriched Potassium β-Trifluoroboratoamides with Various Aryl- and Hetaryl Chlorides.
Summary of "Palladium-Catalyzed Suzuki-Miyaura Cross-Coupling Reactions of Enantiomerically Enriched Potassium β-Trifluoroboratoamides with Various Aryl- and Hetaryl Chlorides."
Enantiomerically enriched potassium β-trifluoroboratoamides were synthesized as air-stable solids in greater than 95:5 dr using pseudoephedrine as the chiral auxiliary. With these chiral nucleophiles, Suzuki-Miyaura cross-coupling reactions were carried out with various aryl- and hetaryl chlorides in good to excellent yields. Moreover, the diastereoselectivities were preserved throughout the Suzuki-Miyaura cross-coupling reactions.
Affiliation
Roy and Diana A. Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323.
Journal Details
This article was published in the following journal.
Name: Organic letters
ISSN: 1523-7052
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20831191
- DOI: http://dx.doi.org/10.1021/ol101865e
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