Discovering drug-drug interactions: a text-mining and reasoning approach based on properties of drug metabolism.
Summary of "Discovering drug-drug interactions: a text-mining and reasoning approach based on properties of drug metabolism."
MOTIVATION:
Identifying drug-drug interactions (DDIs) is a critical process in drug administration and drug development. Clinical support tools often provide comprehensive lists of DDIs, but they usually lack the supporting scientific evidences and different tools can return inconsistent results. In this article, we propose a novel approach that integrates text mining and automated reasoning to derive DDIs. Through the extraction of various facts of drug metabolism, not only the DDIs that are explicitly mentioned in text can be extracted but also the potential interactions that can be inferred by reasoning.
RESULTS:
Our approach was able to find several potential DDIs that are not present in DrugBank. We manually evaluated these interactions based on their supporting evidences, and our analysis revealed that 81.3% of these interactions are determined to be correct. This suggests that our approach can uncover potential DDIs with scientific evidences explaining the mechanism of the interactions.
Affiliation
Disease and Translational Informatics, Hoffmann-La Roche, Nutley, NJ 07110, USA. luis.tari@roche.com
Journal Details
This article was published in the following journal.
Name: Bioinformatics (Oxford, England)
ISSN: 1367-4811
Pages: i547-53
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20823320
- DOI: http://dx.doi.org/10.1093/bioinformatics/btq382
Medical and Biotech [MESH] Definitions
Drug Interactions
The action of a drug that may affect the activity, metabolism, or toxicity of another drug.
Pharmacological Phenomena
The properties and processes of drug metabolism and drug interactions.
Drug Carriers
Forms to which substances are incorporated to improve the delivery and the effectiveness of drugs. Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. Carriers are also used in designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. Liposomes, albumin microspheres, soluble synthetic polymers, DNA complexes, protein-drug conjugates, and carrier erythrocytes among others have been employed as biodegradable drug carriers.
Drug Resistance
Diminished or failed response of an organism, disease or tissue to the intended effectiveness of a chemical or drug. It should be differentiated from DRUG TOLERANCE which is the progressive diminution of the susceptibility of a human or animal to the effects of a drug, as a result of continued administration.
United States Office Of National Drug Control Policy
A component of the Executive Office of the President established by the Anti-Drug Abuse Act of 1988. The Office establishes policies, priorities, and objectives for national DRUG AND NARCOTIC CONTROL. The goals of the program are to reduce illicit drug use, manufacturing, and trafficking, drug-related crime and violence, and drug-related health consequences.
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