Immunoadjuvant Efficacy of N-Carboxymethyl Chitosan for Vaccination via Dendritic Cell Activation.
Summary of "Immunoadjuvant Efficacy of N-Carboxymethyl Chitosan for Vaccination via Dendritic Cell Activation."
Abstract To induce humoral- and cell-mediated immune responses in protein-based vaccinations, immunoadjuvants are needed. In this study, we investigated the immunoadjuvant effect of N-carboxymethyl chitosan (N-CMCh) on the vaccination system through dendritic cell activation. The results showed that N-CMCh nanoparticle enhanced the secretion of cytokines (interleukin [IL]-6, IL-12p70, and tumor necrosis factor-α) and antigen uptake in bone marrow-derived dendritic cells. This activated antigen-specific Th1 cell responses, including IL-2 and interferon-gamma production and proliferation. In addition, N-CMCh delayed the dissemination of ovalbumin (OVA) from an injection site in female C57BL/6 mice. As a result, in the subcutaneous vaccination, OVA-N-CMCh nanoparticles enhanced both humoral and cell-mediated vaccine responses.
1 Department of Biology, Sunchon National University , Suncheon, Korea.
This article was published in the following journal.
Name: Journal of medicinal food
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/24325456
- DOI: http://dx.doi.org/10.1089/jmf.2013.2921
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Medical and Biotech [MESH] Definitions
Recirculating, dendritic, antigen-presenting cells containing characteristic racket-shaped granules (Birbeck granules). They are found principally in the stratum spinosum of the EPIDERMIS and are rich in Class II MAJOR HISTOCOMPATIBILITY COMPLEX molecules. Langerhans cells were the first dendritic cell to be described and have been a model of study for other dendritic cells (DCs), especially other migrating DCs such as dermal DCs and INTERSTITIAL DENDRITIC CELLS.
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