Gene Therapy for Erectile Dysfunction: What Is the Future?
Summary of "Gene Therapy for Erectile Dysfunction: What Is the Future?"
Gene transfer for the treatment of erectile dysfunction has completed phase 1 safety testing and has shown the necessary safety to proceed to the next level of clinical trial. This review focuses on the background of the components of that have led to US Food and Drug Administration acceptance of human gene transfer trials for nonlethal disease.
Affiliation
Department of Urology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, New York, NY, 10461, USA, arnold.melman@einstein.yu.edu.
Journal Details
This article was published in the following journal.
Name: Current urology reports
ISSN: 1534-6285
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20838943
- DOI: http://dx.doi.org/10.1007/s11934-010-0145-1
Medical and Biotech [MESH] Definitions
Erectile Dysfunction
The inability in the male to have a PENILE ERECTION due to psychological or organ dysfunction.
Impotence, Vasculogenic
Inability to achieve and maintain an erection (ERECTILE DYSFUNCTION) due to defects in the arterial blood flow to the PENIS, defect in venous occlusive function allowing blood drainage (leakage) from the erectile tissue (corpus cavernosum penis), or both.
Penile Implantation
Surgical insertion of cylindric hydraulic devices for the treatment of organic ERECTILE DYSFUNCTION.
Gene Therapy
The introduction of new genes into cells for the purpose of treating disease by restoring or adding gene expression. Techniques include insertion of retroviral vectors, transfection, homologous recombination, and injection of new genes into the nuclei of single cell embryos. The entire gene therapy process may consist of multiple steps. The new genes may be introduced into proliferating cells in vivo (e.g., bone marrow) or in vitro (e.g., fibroblast cultures) and the modified cells transferred to the site where the gene expression is required. Gene therapy may be particularly useful for treating enzyme deficiency diseases, hemoglobinopathies, and leukemias and may also prove useful in restoring drug sensitivity, particularly for leukemia.
Yohimbine
A plant alkaloid with alpha-2-adrenergic blocking activity. Yohimbine has been used as a mydriatic and in the treatment of ERECTILE DYSFUNCTION. It is also alleged to be an aphrodisiac.
PubMed Articles
Gene therapy as future treatment of erectile dysfunction.
Importance of the field: Erectile dysfunction (ED) is a major men's health problem. Although the high success rate of treating ED by phosphodiesterase 5 (PDE5) inhibitors has been reported, there are...
Erectile dysfunction may affect 30% to 50% of men aged 40 to 70 years, with age, smoking, and obesity being the main risk factors, although 20% of cases have psychological causes. METHODS AND OUTCOMES...
Vascular endothelial growth factor (VEGF) is a cytokine involved in angiogenesis and is closely related to the nitric oxide-cyclic guanosine monophosphate pathway, a target for sildenafil. We investig...
Lifestyle/Dietary recommendations for erectile dysfunction and female sexual dysfunction.
Sexual problems are diffuse in both genders. Although epidemiologic evidence seems to support a role for lifestyle factors in erectile dysfunction, limited data are available suggesting the treatment...
Prevention and management of erectile dysfunction after laproscopic radical prostatectomy.
Radical prostatectomy remains the standard treatment for men with clinically localized prostate cancer. Erectile dysfunction (ED) is a common complication for patients who underwent radial prostaectom...
Clinical Trials
Extracorporeal Shock Wave Therapy for the Treatment of Erectile Dysfunction
Low intensity shockwaves have been proven in animal studies to induce local growth of new blood vessels from existing ones. The hypothesis of this study is that shockwave therapy could im...
This study was conducted to evaluate in adult men with erectile dysfunction (often called impotence), the effect of vardenafil HCl on the quality of their erections. Many men experience oc...
Evaluating of the Efficacy and Safety of Vardenafil in Subjects With Erectile Dysfunction
Erectile dysfunction (ED) is defined as the inability to achieve or maintain an erection sufficient for satisfactory sexual performance. An ideal treatment option should be effective and r...
Phase II Trial of SK3530 in Erectile Dysfunction
This study was designed to evaluate the efficacy and safety of the SK3530 tablet and to find the optimal dose and dosage schedule after oral administration to patients with erectile dysfun...
A multicenter open label study to assess the efficacy of sildenafil rapid dose titration to 100 mg in men with erectile dysfunction, based on the Erectile Function (EF) domain score of t...
