Scanning Droplet Cell for Chemoselective Patterning through Local Electroactivation of Protected Quinone Monolayers.
Summary of "Scanning Droplet Cell for Chemoselective Patterning through Local Electroactivation of Protected Quinone Monolayers."
A reagentless strategy for template-free patterning of uniformly inert surfaces is suggested. A layer of p-hydroquinone (HQ) protected by the tert-butyldimethylsilyl (TBDMS) group is electrografted onto glassy carbon electrodes. Chemoselective activation is performed through electrochemically controlled cleavage of the TBDMS group, which yields the redox-active surface-confined quinone moieties. The latter are shown to undergo electrochemically induced Michael addition, which serves for subsequent functionalization of the electrode surface. Patterning of the TBDMS-quinone-modified surface is accomplished by using selective localized cleavage of the protecting group. State-of-the-art direct-mode scanning electrochemical microscopy (SECM) patterning fails to yield the anticipated interfacial reaction; however, the electrochemical scanning droplet cell (SDC) is capable of conducting the localized chemoselective reaction. In a small area, dictated by the dimensions of the droplet, electrochemically induced cleavage of the protecting group can be performed locally to give rise to arrays of active quinone spots. Upon deprotection, the redox signals, attributed to the hydroquinone/benzoquinone couple, provide the first direct evidence for chemoselective electrochemical patterning of sensitive functionalities. Subsequent SECM studies of the resulting modified areas demonstrate spatial control of the proposed patterning technique.
This article was published in the following journal.
Name: Chemphyschem : a European journal of chemical physics and physical chemistry
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/24353197
- DOI: http://dx.doi.org/10.1002/cphc.201300937
We report on a versatile technique for microfluidic droplet manipulation that proves effective at every step: from droplet generation to propulsion to sorting, rearrangement or break-up. Non-wetting d...
We present a technique to pattern the charge density of a large-area epitaxial graphene sheet locally without using metallic gates. Instead, local intercalation of the graphene-substrate interface can...
The simple and quick patterning of functional proteins on engineered surfaces affords an opportunity to fabricate protein microarrays in lab-on-chip systems. We report on the programmable patterning o...
Myelinated axons are patterned into discrete and often-repeating domains responsible for the efficient and rapid transmission of electrical signals. These domains include nodes of Ranvier and axon ini...
Droplet microfluidics may soon change the paradigm of performing chemical analyses and related instrumentation. It can improve not only the analysis scale, possibility for sensitivity improvement, and...
To examine the relationships of obesity and fat patterning with morbidity and mortality in Black Americans.
The goal of this clinical research study is to learn if PET/CT scanning can be used to detect mantle cell lymphoma in the colon. Researchers want to learn if PET/CT scanning can produce g...
The primary objective is to compare the diagnostic performance of 18F- Fluoride PET/CT scanning to that of conventional bone scanning for detecting cancer that has spread to the bone (bone...
To study the natural history of the accumulation of intra-abdominal fat as women progress through the menopause.
The purpose of this study is to monitor and follow non-pacemaker dependent patients with implanted permanent pacemakers, who undergo medically required MRI scans. Patients with pacemakers...
Medical and Biotech [MESH] Definitions
Scanning microscopy in which a very sharp probe is employed in close proximity to a surface, exploiting a particular surface-related property. When this property is local topography, the method is atomic force microscopy (MICROSCOPY, ATOMIC FORCE), and when it is local conductivity, the method is scanning tunneling microscopy (MICROSCOPY, SCANNING TUNNELING).
The processes occurring in early development that direct morphogenesis. They specify the body plan ensuring that cells will proceed to differentiate, grow, and diversify in size and shape at the correct relative positions. Included are axial patterning, segmentation, compartment specification, limb position, organ boundary patterning, blood vessel patterning, etc.
A scanning microscope-based, cytofluorimetry technique for making fluorescence measurements and topographic analysis on individual cells. Lasers are used to excite fluorochromes in labeled cellular specimens. Fluorescence is detected in multiple discrete wavelengths and the locational data is processed to quantitatively assess APOPTOSIS; PLOIDIES; cell proliferation; GENE EXPRESSION; PROTEIN TRANSPORT; and other cellular processes.
A type of TRANSMISSION ELECTRON MICROSCOPY in which the object is examined directly by an extremely narrow electron beam scanning the specimen point-by-point and using the reactions of the electrons that are transmitted through the specimen to create the image. It should not be confused with SCANNING ELECTRON MICROSCOPY.
A family of immunoglobulin-related cell adhesion molecules that are involved in NERVOUS SYSTEM patterning.