The inverse association of serum HBV DNA level with HDL and adiponectin in chronic hepatitis B infection.
Summary of "The inverse association of serum HBV DNA level with HDL and adiponectin in chronic hepatitis B infection."
The natural history of hepatitis B virus (HBV) is complex and influenced by the level of viral replication and host factors. The hepatoprotective role of high density lipoproteins (HDL) and adiponectin as host factors on HBV persistence is less well understood.
To investigate correlation between HBV DNA level with clinical parameters in patients with chronic hepatitis B, 92 male subjects with HBV infection without any risk factors for diabetes were enrolled in this study. Age and BMI of the study population were matched and HBV DNA, ALT, tumor necrosis factor alpha (TNF-alpha), adiponectin and lipid levels was measured.
Serum HBV DNA correlated inversely with serum HDL level (r= 0.23; P=0.014). The median of log copies/ml for HBV DNA (3.67) was considered as cut off point. Patients with HBV DNA level higher than cut off point had lower adiponectin (8.7+/-5.3 vs 10.7+/-4.9 mug/ml p=0.05). Also, adiponectin had a negative correlation with TNF-alpha (r= 0.21, P=0.04) and positive correlations with HDL (r= 0.18, P=0.043).Multivariate regression models show that serum HDL level is an independed factor to predict serum HBV DNA.
Our findings showed that higher HBV DNA levels are associated with lower HDL and adiponectin but induced TNF-alpha values.
This article was published in the following journal.
Name: Virology journal
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20840785
- DOI: http://dx.doi.org/10.1186/1743-422X-7-228
Medical and Biotech [MESH] Definitions
Cell surface receptors for ADIPONECTIN, an antidiabetic hormone secreted by ADIPOCYTES. Adiponectin receptors are membrane proteins with multiple cytoplasmic and extracellular regions. They are about 43 kDa and encoded by at least two genes with different affinities for globular and full-length adiponectin.
Hepatitis C, Chronic
INFLAMMATION of the LIVER in humans that is caused by HEPATITIS C VIRUS lasting six months or more. Chronic hepatitis C can lead to LIVER CIRRHOSIS.
A chronic self-perpetuating hepatocellular INFLAMMATION of unknown cause, usually with HYPERGAMMAGLOBULINEMIA and serum AUTOANTIBODIES.
A 30-kDa COMPLEMENT C1Q-related protein, the most abundant gene product secreted by FAT CELLS of the white ADIPOSE TISSUE. Adiponectin modulates several physiological processes, such as metabolism of GLUCOSE and FATTY ACIDS, and immune responses. Decreased plasma adiponectin levels are associated with INSULIN RESISTANCE; TYPE 2 DIABETES MELLITUS; OBESITY; and ATHEROSCLEROSIS.
INFLAMMATION of the LIVER with ongoing hepatocellular injury for 6 months or more, characterized by NECROSIS of HEPATOCYTES and inflammatory cell (LEUKOCYTES) infiltration. Chronic hepatitis can be caused by viruses, medications, autoimmune diseases, and other unknown factors.
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