Mechanism of delayed puberty in rats whose mothers consumed Hibiscus sabdariffa during lactation.
Summary of "Mechanism of delayed puberty in rats whose mothers consumed Hibiscus sabdariffa during lactation."
Context: Extract of the calyx of Hibiscus sabdariffa Linn. (HS) (Malvaceae) has been reported to decrease fluid and food intake in lactating rats through a mechanism not yet fully understood. It has also been reported that rat pups undernourished during lactation have delayed puberty onset, suggesting a link between nutrition and onset of puberty. There is paucity of data addressing the effect of maternal consumption of HS during lactation on the onset of puberty in the female offspring. Objective: The present study was designed to investigate whether consumption of HS during lactation will affect the onset of puberty and to examine the possible mechanism underlying this. Materials and methods: Lactating Sprague-Dawley rats were randomly grouped into three on postnatal day one. One group had tap water (control); another had 0.6 g aqueous HS extract/100 mL, while the third had 1.8 g aqueous HS extract/100 mL as their drinking solution throughout lactation. Maternal fluid consumption, food consumption, weight gain, plasma Na(+) and corticosterone concentrations were determined. Offspring weights were recorded at 0, 21, 28, 35, and 42 days. Ages at onset of puberty and body weights were also recorded. Results: A decreased maternal fluid and food intake and an increased maternal plasma Na(+) and corticosterone concentration were observed in HS dams. The HS treated female offspring showed delayed onset of puberty. Discussion and Conclusion: The accelerated growth and delayed puberty in the HS offspring may be through increased corticosterone and decreased leptin delivery through breast milk.
Affiliation
Department of Physiology, College of Medicine, University of Nigeria, Enugu Campus, Enugu State, Nigeria.
Journal Details
This article was published in the following journal.
Name: Pharmaceutical biology
ISSN: 1744-5116
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20839905
- DOI: http://dx.doi.org/10.3109/13880200903567120
Medical and Biotech [MESH] Definitions
Puberty, Delayed
The lack of development of SEXUAL MATURATION in boys and girls at a chronological age that is 2.5 standard deviations above the mean age at onset of PUBERTY in a population. Delayed puberty can be classified by defects in the hypothalamic LHRH pulse generator, the PITUITARY GLAND, or the GONADS. These patients will undergo spontaneous but delayed puberty whereas patients with SEXUAL INFANTILISM will not.
Fluoxymesterone
An anabolic steroid that has been used in the treatment of male HYPOGONADISM, delayed puberty in males, and in the treatment of breast neoplasms in women.
Polyvinylpyridine N-oxide
Inhibits the cytotoxic action of quartz and is reported to have delayed the development of experimental silicosis in rats.
Rats, Long-evans
An outbred strain of rats developed in 1915 by crossing several Wistar Institute white females with a wild gray male. Inbred strains have been derived from this original outbred strain, including Long-Evans cinnamon rats (RATS, INBRED LEC) and Otsuka-Long-Evans-Tokushima Fatty rats (RATS, INBRED OLETF), which are models for Wilson's disease and non-insulin dependent diabetes mellitus, respectively.
Rats, Hairless
Mutant strains of rats that produce little or no hair. Several different homozygous recessive mutations can cause hairlessness in rats including rnu/rnu (Rowett nude), fz/fz (fuzzy), shn/shn (shorn), and nznu/nznu (New Zealand nude). Note that while NUDE RATS are often hairless, they are most characteristically athymic.
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