Anemia of Chronic Disease and Chronic Periodontitis: Does Periodontal Therapy Have Effect on Anemic Status.

06:00 EDT 17th September 2010 | BioPortfolio

Summary of "Anemia of Chronic Disease and Chronic Periodontitis: Does Periodontal Therapy Have Effect on Anemic Status."

Background: As the periodontal tissues mount an immune inflammatory response to bacteria and their products, systemic challenge with these agents also induces a major vascular response. Certain inflammatory cytokines produced during periodontal inflammation, can depress erythropoietin production leading to the development of anemia. The aim of the study was to investigate whether chronic periodontitis patients have anemic status and subsequently analyzed the effect of Non surgical periodontal therapy on anemic status over 6 month period. Methods: A total of 187 chronic periodontitis patients participated into the study. After red blood analysis, 60 patients with Hemoglobin concentration below reference range entered into second part of the study where patients were treated with non surgical periodontal therapy. Clinical parameters and red blood cell analysis were repeated at 3 month and 6 month. Results: As for the first part of our study, 33.6% patients showed hemoglobin concentration below the normal reference range. As a second part of this study, all the red blood cell parameters and clinical parameters showed statistically improvement over 6 month period. Conclusions: Present study strengthens the hypothesis that chronic periodontitis may lead to anemia and provides evidence that non surgical periodontal therapy can improve anemic status of chronic periodontitis patients, with greater improvement in females compared to males.


Journal Details

This article was published in the following journal.

Name: Journal of periodontology
ISSN: 1943-3670


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Medical and Biotech [MESH] Definitions

Chronic inflammation and loss of PERIODONTIUM that is associated with the amount of DENTAL PLAQUE or DENTAL CALCULUS present. Chronic periodontitis occurs mostly in adults and was called adult periodontitis, but this disease can appear in young people.

Inflammation and loss of connective tissues supporting or surrounding the teeth. This may involve any part of the PERIODONTIUM. Periodontitis is currently classified by disease progression (CHRONIC PERIODONTITIS; AGGRESSIVE PERIODONTITIS) instead of age of onset. (From 1999 International Workshop for a Classification of Periodontal Diseases and Conditions, American Academy of Periodontology)

Loss or destruction of periodontal tissue caused by periodontitis or other destructive periodontal diseases or by injury during instrumentation. Attachment refers to the periodontal ligament which attaches to the alveolar bone. It has been hypothesized that treatment of the underlying periodontal disease and the seeding of periodontal ligament cells enable the creating of new attachment.

A severe sometimes chronic anemia, usually macrocytic in type, that does not respond to ordinary antianemic therapy.

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