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Life span extension by resveratrol, rapamycin, and metformin: The promise of dietary restriction mimetics for an healthy aging.

06:00 EDT 18th September 2010 | BioPortfolio

Summary of "Life span extension by resveratrol, rapamycin, and metformin: The promise of dietary restriction mimetics for an healthy aging."

Life expectancy at the turn of the 20th century was 46 years on average worldwide and it is around 65 years today. The correlative increase in age-associated diseases incidence has a profound public health impact and is an important matter of concern for our societies. Aging is a complex, heterogeneous, and multifactorial phenomenon, which is the consequence of multiple interactions between genes and environment. In this review, we survey animals models that have been of great help for both investigating mechanism of aging and identifying molecules, which slow down the onset of age-related diseases. Resveratrol (RSV) is one of those. We will report evidences supporting RSV as a molecule that acts by mimicking the beneficial effects of dietary restriction, and may share common downstream targets with rapamycin and metformin. Although those molecules do not reveal all the secrets of the fountain of youth, they may help us maintaining the quality of life in the old age. © 2010 International Union of Biochemistry and Molecular Biology, Inc.

Affiliation

UMR5201, CNRS Université Lyon1, Laboratoire de Génétique Signalisation et Cancer, Centre Léon Bérard, 28 rue Laënnec, Lyon, France.

Journal Details

This article was published in the following journal.

Name: BioFactors (Oxford, England)
ISSN: 1872-8081
Pages:

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PubMed Articles [11838 Associated PubMed Articles listed on BioPortfolio]

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Medical and Biotech [MESH] Definitions

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Calcium compounds used as food supplements or in food to supply the body with calcium. Dietary calcium is needed during growth for bone development and for maintenance of skeletal integrity later in life to prevent osteoporosis.

Component of the NATIONAL INSTITUTES OF HEALTH. It conducts and supports clinical and basic research to establish a scientific basis for the care of individuals across the life span, from the management of patients during illness and recovery to the reduction of risks for disease and disability; the promotion of healthy lifestyles; the promotion of quality of life in those with chronic illness; and the care for individuals at the end of life. It was established in 1986.

A family of the order DIPTERA. These flies are generally found around decaying vegetation and fruit. Several species, because of their short life span, giant salivary gland chromosomes, and ease of culturing, have been used extensively in studies of heredity.

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