Advertisement

Topics

A Rare Unilateral Case of Ocular Mucous Membrane Pemphigoid.

06:00 EDT 18th September 2010 | BioPortfolio

Summary of "A Rare Unilateral Case of Ocular Mucous Membrane Pemphigoid."


PURPOSE:
: Ocular mucous membrane pemphigoid (MMP) is known to be rapidly progressive in younger patients and affects both eyes. We are aware of only one other reported case of unilateral ocular MMP. The case presented in this study is unique in that it demonstrates genuinely unilateral ocular MMP in a younger patient.
METHODS:
: We report a case of a 50-year-old man who presented with a 3-month history of left eye redness, irritation, and mild discharge. He also suffered from mouth ulcers, skin lesions, and recurrent nose bleeds secondary to nasal mucosal lesions.
RESULTS:
: Examination revealed unilateral lid granulomas and cicatricial conjunctivitis in his left eye. There were no abnormal findings in his right eye. Biopsy of the lesions showed nonspecific inflammation with positive immunofluorescence for immunoglobulin G and C3 on epithelial basement membranes of conjunctiva, buccal mucosa, and skin, which were consistent with MMP. He was treated with immunosuppression and had no disease progression at 12-month follow-up.
CONCLUSIONS:
: This represents a rare case of unilateral nonprogressive ocular MMP in a younger patient. Histological analysis and immunofluorescence testing excluded a neoplastic process and confirmed the diagnosis. This case demonstrates that the presentation of unilateral eyelid pyogenic granulomas should include ocular MMP in the differential diagnosis once a neoplastic process has been excluded.

Affiliation

From the *The Save Sight Institute, The University of Sydney and The Sydney Eye Hospital, Sydney, Australia; †Department of Anatomical Pathology, Prince of Wales Hospital, Sydney, Australia; ‡Department of Ophthalmology, Auckland University, Auckland,

Journal Details

This article was published in the following journal.

Name: Cornea
ISSN: 1536-4798
Pages:

Links

DeepDyve research library

PubMed Articles [17237 Associated PubMed Articles listed on BioPortfolio]

Assessment and Management of Laryngeal Mucous Membrane Pemphigoid: Our Experience in Six Patients and a Proposed Severity Scale.

Mucous membrane pemphigoid (MMP) comprises a heterogenous spectrum of rare subepithelial blistering disorders affecting characteristic tissues throughout the body(1) . The prevalence is approximately ...

A rare Case of Unilateral Isolated Naso-Ocular Cleft Treated by a Rotation-Advancement Technique.

The isolated naso-ocular cleft is rare. In this article, the authors report an extremely rare case of unilateral isolated naso-ocular cleft. And a new rotation-advancement technique was used in repair...

Rituximab for the Treatment of Isolated Refractory Desquamative Gingivitis Due to Mucous Membrane Pemphigoid.

Unilateral Eye Findings: A Rare Herald of Acute Leukemia.

Unilateral choroidal infiltration as the initial manifestation of leukemic relapse in adults is rare, particularly after an extended period of remission. This report describes this unique ophthalmic p...

Metronidazole-Induced Bullous Pemphigoid: A Case Report.

Bullous pemphigoid is an autoimmune cutaneous blistering disorder, the exact pathogenesis of which is still not fully elucidated. Drug-induced bullous pemphigoid eruptions are rare but have been repor...

Clinical Trials [2500 Associated Clinical Trials listed on BioPortfolio]

Clinical Trial Evaluating Rituximab in Ocular Cicatricial Pemphigoid

Cicatricial pemphigoid is an autoimmune blistering disease which affects the skin, mucous membranes, and, in a small subset of patients, the eye. Progressive ocular disease can lead to ir...

Genetic Susceptibility and Influence of the Microbiome in Bullous Pemphigoid

Autoimmune bullous dermatoses include pemphigus, bullous pemphigoid, pemphigoid gestationis, linear IgA dermatosis, mucous membrane, lichen pemphigoid, anti-p200 pemphigoid, epidermolysis ...

Efficacy and Safety of Omalizumab in Bullous Pemphigoid

The primary objective is to test the safety and efficacy of Xolair in the treatment of the autoimmune blistering disease, bullous pemphigoid (BP). This is a pilot, open label case-control...

Optimizing the Ocular Surface Prior to Cataract Surgery

Prospective study to evaluate the efficacy of using self-retained cryopreserved amniotic membrane after debridement in treating Epithelial Base Membrane Dystrophy (EBMD) to optimize the oc...

Clinical Trial of NPB-01 in Patients With Bullous Pemphigoid Unresponsive to Corticosteroids.

Patients diagnosed with bullous pemphigoid were confirmed based on the investigators national diagnostic criteria. Patients who meet all inclusion criteria and conflict the exclusion crite...

Medical and Biotech [MESH] Definitions

A chronic blistering disease with predilection for mucous membranes and less frequently the skin, and with a tendency to scarring. It is sometimes called ocular pemphigoid because of conjunctival mucous membrane involvement.

An itching, autoimmune, bullous SKIN disease that occurs during the last two trimesters of PREGNANCY and PUERPERIUM. It also affects non-pregnant females with tissue of PLACENTA origin, such as CHORIOCARCINOMA; or HYDATIDIFORM MOLE. It exhibits antigenic and clinical similarity to bullous pemphigoid (PEMPHIGOID, BULLOUS). This disease does not involve herpes viruses (old name, herpes gestationis).

A variant of bullous erythema multiforme. It ranges from mild skin and mucous membrane lesions to a severe, sometimes fatal systemic disorder. Ocular symptoms include ulcerative conjunctivitis, keratitis, iritis, uveitis, and sometimes blindness. The cause of the disease is unknown.

The mucous membrane lining the RESPIRATORY TRACT, including the NASAL CAVITY; the LARYNX; the TRACHEA; and the BRONCHI tree. The respiratory mucosa consists of various types of epithelial cells ranging from ciliated columnar to simple squamous, mucous GOBLET CELLS, and glands containing both mucous and serous cells.

The dioptric adjustment of the EYE (to attain maximal sharpness of retinal imagery for an object of regard) referring to the ability, to the mechanism, or to the process. Ocular accommodation is the effecting of refractive changes by changes in the shape of the CRYSTALLINE LENS. Loosely, it refers to ocular adjustments for VISION, OCULAR at various distances. (Cline et al., Dictionary of Visual Science, 4th ed)

Quick Search
Advertisement
 


DeepDyve research library

Relevant Topic

Dermatology
Acne Dermatology Eczema Psoriasis Wound Care Dermatology is the medical specialty concerned with the diagnosis and treatment of skin disorders (Oxford Medical Dictionary). As well as studying how the skin works, dermatology covers...


Searches Linking to this Article