The association of common variable immune deficiency with idiopathic inflammatory myopathies.
Summary of "The association of common variable immune deficiency with idiopathic inflammatory myopathies."
No Summary Available
Affiliation
Department of Rheumatology, Institute of Internal Medicine, University of Debrecen Medical and Health Science Center, 22, Móricz Zs. street, Debrecen, H-4032, Hungary.
Journal Details
This article was published in the following journal.
Name: Joint, bone, spine : revue du rhumatisme
ISSN: 1778-7254
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20851031
- DOI: http://dx.doi.org/10.1016/j.jbspin.2010.07.004
Medical and Biotech [MESH] Definitions
Common Variable Immunodeficiency
Heterogeneous group of immunodeficiency syndromes characterized by hypogammaglobulinemia of most isotypes, variable B-cell defects, and the presence of recurrent bacterial infections.
Immune Reconstitution Inflammatory Syndrome
Exuberant inflammatory response towards previously undiagnosed or incubating opportunistic pathogens. It is frequently seen in AIDS patients following HAART.
Cathepsin Z
A ubiquitously-expressed cysteine peptidase that exhibits carboxypeptidase activity. It is highly expressed in a variety of immune cell types and may play a role in inflammatory processes and immune responses.
Protein Deficiency
A nutritional condition produced by a deficiency of proteins in the diet, characterized by adaptive enzyme changes in the liver, increase in amino acid synthetases, and diminution of urea formation, thus conserving nitrogen and reducing its loss in the urine. Growth, immune response, repair, and production of enzymes and hormones are all impaired in severe protein deficiency. Protein deficiency may also arise in the face of adequate protein intake if the protein is of poor quality (i.e., the content of one or more amino acids is inadequate and thus becomes the limiting factor in protein utilization). (From Merck Manual, 16th ed; Harrison's Principles of Internal Medicine, 12th ed, p406)
Guillain-barre Syndrome
An acute inflammatory autoimmune neuritis caused by T cell- mediated cellular immune response directed towards peripheral myelin. Demyelination occurs in peripheral nerves and nerve roots. The process is often preceded by a viral or bacterial infection, surgery, immunization, lymphoma, or exposure to toxins. Common clinical manifestations include progressive weakness, loss of sensation, and loss of deep tendon reflexes. Weakness of respiratory muscles and autonomic dysfunction may occur. (From Adams et al., Principles of Neurology, 6th ed, pp1312-1314)
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