Efficacy and Safety of Sodium Phosphate for Colon Cleansing in Type 2 Diabetes Mellitus.
Summary of "Efficacy and Safety of Sodium Phosphate for Colon Cleansing in Type 2 Diabetes Mellitus."
OBJECTIVES:
: The need for colonoscopy is common among diabetic patients. However, there are no standards per se for bowel preparation in patients with type 2 diabetes. In this study, we evaluated the efficacy, safety, and tolerability of sodium phosphate (NaP), and the quality of bowel cleansing in relation to glycemic control and late complications.
METHODS:
: A total of 50 consecutive type 2 diabetic patients and 50 non-diabetic patients underwent bowel preparation by NaP. Fasting blood glucose, sodium (Na), potassium (K), calcium (Ca), phosphorus (P), magnesium, and creatinine levels were measured on the procedure day. Patients were given a tolerability questionnaire regarding symptoms.
RESULTS:
: With regard to bowel preparation quality, optimal bowel cleansing was achieved in 35 (70%) diabetic and 47 (94%) non-diabetic patients (P = 0.002). Abdominal pain or discomfort during and an hour after the procedure was similar in both groups (P >0.05). The changes in Na, K, Ca, P and creatinine levels after NaP use did not reach statistical significance between the groups (P >0.05). In the diabetic patients, there was a significant correlation between the quality of bowel cleansing and mean age, duration of diabetes mellitus, level of hemoglobin A1c (HbA1c), fasting blood glucose level, and diabetic late complications (P <0.05).
CONCLUSION:
: These data suggest that NaP is safe and tolerable in diabetic patients, but the quality of bowel cleansing is worse than in non-diabetic patients. These observations support the concept that the quality of bowel cleansing in those with type 2 diabetes is closely related to the duration and regulation of the disease and the presence of late complications.
Affiliation
From the Department of Gastroenterology, Faculty of Medicine, Baskent University, Konya, Turkey; and Department of Gastroenterology, Faculty of Medicine, Baskent University, Ankara, Turkey.
Journal Details
This article was published in the following journal.
Name: Southern medical journal
ISSN: 1541-8243
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20856180
- DOI: http://dx.doi.org/10.1097/SMJ.0b013e3181f20b13
Medical and Biotech [MESH] Definitions
Sodium-phosphate Cotransporter Proteins, Type Iii
A family of highly conserved and widely expressed sodium-phosphate cotransporter proteins. They are electrogenic sodium-dependent transporters of phosphate that were originally identified as retroviral receptors in HUMANS and have been described in yeast and many other organisms.
Sodium-phosphate Cotransporter Proteins, Type Iic
A non-electrogenic sodium-dependent phosphate transporter. It is found primarily in apical membranes of PROXIMAL RENAL TUBULES.
Sodium-phosphate Cotransporter Proteins, Type Iib
A sodium-dependent phosphate transporter present primarily at apical sites of EPITHELIAL CELLS in the SMALL INTESTINE.
Sodium-phosphate Cotransporter Proteins, Type Iia
An electrogenic sodium-dependent phosphate transporter. It is present primarily in BRUSH BORDER membranes of PROXIMAL RENAL TUBULES.
Sodium-phosphate Cotransporter Proteins, Type I
A family of sodium-phosphate cotransporter proteins that also transport organic ANIONS. They are low affinity phosphate transporters.
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