Response to metoprolol succinate sustained-release tablets in correlation to pulse pressure, serum vascular endothelial growth factor and C-reactive protein in elderly hypertensive patients with chronic heart failure.
Summary of "Response to metoprolol succinate sustained-release tablets in correlation to pulse pressure, serum vascular endothelial growth factor and C-reactive protein in elderly hypertensive patients with chronic heart failure."
OBJECTIVE:
To investigate the effect of metoprolol succinate sustained-release tablets on cardiac function, serum vascular endothelial growh factor (VEGF) and C-reactive protein (CRP) in elderly hypertensive patients and its relation with pulse pressure (PP).
METHODS:
A total of 330 elderly hypertensive patients with chronic heart failure receiving basic therapy were included. Before initiation and 3 months after the maximal tolerated dose of metoprolol succinate sustained-release tablets, the parameters of blood pressure, clinical features, radionuclide ventriculographic and laboratory findings of the patients were analyzed.
RESULTS:
As the PP was elevated, the serum levels of VEGF, hs-CRP and BNP increased and the cardiac systolic and diastolic functions decreased. In patients with PP of 59-68 mmHg and >68 mmHg, 3 months of treatment with the tablets caused significantly increased LVEF by (3.32∓2.35)% and (4.12∓3.05)% and LVPER by 0.37∓0.26 and 0.53∓0.37, respectively; PP were decreased by 8.2∓3.1 mmHg and 9.4∓4.3 mmHg and VEGF by 18.39∓8.43 pg/ml and 26.79∓14.32 pg/ml, respectively. The treatment also resulted in lowered hs-CRP and BNP in these patients by 0.26∓0.13 mg/L and 0.33∓0.16 mg/L and by 140.36∓68.62 ng/L and 155.39∓73.58 ng/L, respectively.
CONCLUSION:
Obvious elevation of PP is associated with a better response to metoprolol succinate sustained-release tablets in elderly hypertensive patients with chronic heart failure, and 3 months of treatment with the tablets can significantly improve the cardiac function and lower the levels of VEGF, hs-CRP and BNP in these patients.
Affiliation
Department of Cardiology, Sun Yat-sen Cardiovascular Hospital, Shenzhen 518020, China.E-mail:xiaosi1210000@ 163.com.
Journal Details
This article was published in the following journal.
Name: Nan fang yi ke da xue xue bao = Journal of Southern Medical University
ISSN: 1673-4254
Pages: 2171-4
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20855282
- DOI: http://dx.doi.org/
Medical and Biotech [MESH] Definitions
Tablets, Enteric-coated
Tablets coated with material that delays release of the medication until after they leave the stomach. (Dorland, 28th ed)
Succinate-coa Ligases
Enzymes that catalyze the first step leading to the oxidation of succinic acid by the reversible formation of succinyl-CoA from succinate and CoA with the concomitant cleavage of ATP to ADP (EC 6.2.1.5) or GTP to GDP (EC 6.2.1.4) and orthophosphate. Itaconate can act instead of succinate and ITP instead of GTP.EC 6.2.1.-.
Succinate-semialdehyde Dehydrogenase
An enzyme that plays a role in the GLUTAMATE and butanoate metabolism pathways by catalyzing the oxidation of succinate semialdehyde to SUCCINATE using NAD+ as a coenzyme. Deficiency of this enzyme, causes 4-hydroxybutyricaciduria, a rare inborn error in the metabolism of the neurotransmitter 4-aminobutyric acid (GABA).
Pulse Radiolysis
Use of a pulse of X-rays or fast electrons to generate free radicals for spectroscopic examination.
Psychophysics
The science dealing with the correlation of the physical characteristics of a stimulus, e.g., frequency or intensity, with the response to the stimulus, in order to assess the psychologic factors involved in the relationship.
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