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Monoclonal Antibodies in the Treatment of Asthma.

Summary of "Monoclonal Antibodies in the Treatment of Asthma."

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Affiliation

Division of Pediatric Allergy and Clinical Immunology, Department of Pediatrics, McGill University Health Center, Montreal, Quebec, Canada. daliamoshebs@gmail.com‬

Journal Details

This article was published in the following journal.

Name: Recent patents on inflammation & allergy drug discovery
ISSN: 1872-213X
Pages:

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Treatment with anti-cytokine monoclonal antibodies can potentiate the target cytokine rather than neutralize its activity.

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Medical and Biotech [MESH] Definitions

Loss of detectable antigen from the surface of a cell after incubation with antibodies. This is one method in which some tumors escape detection by the immune system. Antigenic modulation of target antigens also reduces the therapeutic effectiveness of treatment by monoclonal antibodies.

Antibodies obtained from a single clone of cells grown in mice or rats.

Antibodies produced by clones of cells such as those isolated after hybridization of activated B LYMPHOCYTES with neoplastic cells. These hybrids are often referred to as HYBRIDOMAS.

Antibodies, often monoclonal, in which the two antigen-binding sites are specific for separate ANTIGENIC DETERMINANTS. They are artificial antibodies produced by chemical crosslinking, fusion of HYBRIDOMA cells, or by molecular genetic techniques. They function as the main mediators of targeted cellular cytotoxicity and have been shown to be efficient in the targeting of drugs, toxins, radiolabeled haptens, and effector cells to diseased tissue, primarily tumors.

A vasodilator that also has bronchodilatory action. It has been employed in the treatment of angina pectoris, in the treatment of asthma, and in conjunction with ultraviolet light A, has been tried in the treatment of vitiligo. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1024)

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