Intraurethral Instillation of Ketamine for Male Rigid Cystoscopy.
Summary of "Intraurethral Instillation of Ketamine for Male Rigid Cystoscopy."
Abstract Purpose: This study was conducted to examine the efficacy of ketamine along with lidocaine gel for instillation in the male urethra for easiness of outpatient rigid cystoscopy, as compared with only using lidocaine gel. Patients and Methods: A total of 60 consecutive men who were scheduled to undergo rigid cystoscopy were randomly assigned to receive either 10 mL of 2% lidocaine gel combined with 2 mL normal saline, or 10 mL of 2% lidocaine gel combined with 2 mL ketamine (100 mg). Hemodynamic changes and the level of pain perception of patients at the beginning, during, and after every procedure in both groups were recorded by using the visual analogue scale. Results: There were no significant differences in hemodynamic changes between the two groups; however, the perception of pain was significantly decreased when lidocaine was used in conjunction with ketamine, most notably during the first 5 minutes of cystoscopy. Conclusions: Instillation of lidocaine gel in conjunction with ketamine in the urethra could decrease pain perception and make men undergoing outpatient rigid cystoscopy more comfortable during the procedure.
Affiliation
1 Department of Anesthesiology, Sina Hospital, Tehran University of Medical Sciences , Tehran, Iran .
Journal Details
This article was published in the following journal.
Name: Journal of endourology / Endourological Society
ISSN: 1557-900X
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20858034
- DOI: http://dx.doi.org/10.1089/end.2010.0193
Medical and Biotech [MESH] Definitions
Ketamine
A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
Phencyclidine
A hallucinogen formerly used as a veterinary anesthetic, and briefly as a general anesthetic for humans. Phencyclidine is similar to KETAMINE in structure and in many of its effects. Like ketamine, it can produce a dissociative state. It exerts its pharmacological action through inhibition of NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE). As a drug of abuse, it is known as PCP and Angel Dust.
Penile Prosthesis
Rigid, semi-rigid, or inflatable cylindric hydraulic devices, with either combined or separate reservoir and pumping systems, implanted for the surgical treatment of organic ERECTILE DYSFUNCTION.
Cystoscopy
Endoscopic examination, therapy or surgery of the urinary bladder.
Tuberculosis, Male Genital
MYCOBACTERIUM infections of the male reproductive tract (GENITALIA, MALE).
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