Synthesis of a series of caffeic acid phenethyl amide (CAPA) fluorinated derivatives: comparison of cytoprotective effects to caffeic acid phenethyl ester (CAPE).
Summary of "Synthesis of a series of caffeic acid phenethyl amide (CAPA) fluorinated derivatives: comparison of cytoprotective effects to caffeic acid phenethyl ester (CAPE)."
A series of catechol ring-fluorinated derivatives of caffeic acid phenethyl amide (CAPA) were synthesized and screened for cytoprotective activity against H2O2 induced oxidative stress in human umbilical vein endothelial cells (HUVEC). CAPA and three fluorinated analogs were found to be significantly cytoprotective when compared to control, with no significant difference in cytoprotection between caffeic acid phenethyl ester (CAPE) and CAPA.
Division of Pharmaceutics, College of Pharmacy, The University of Texas, Austin, TX 78712, USA.
This article was published in the following journal.
Name: Bioorganic & medicinal chemistry
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20598894
- DOI: http://dx.doi.org/10.1016/j.bmc.2010.05.080
Medical and Biotech [MESH] Definitions
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