Hormonal contraception and HIV acquisition: reanalysis using marginal structural modeling.
Summary of "Hormonal contraception and HIV acquisition: reanalysis using marginal structural modeling."
Hormonal contraceptives are used widely worldwide; their effect on HIV acquisition remains unresolved. We reanalyzed data from the Hormonal Contraception and HIV Study using marginal structural modeling to reduce selection bias due to time-dependent confounding. Replicating our original analysis closely, we found that depo-medroxyprogesterone acetate (DMPA) but not combined oral contraceptive (COC) was associated with increased HIV acquisition. Also, young (18-24 years) but not older women who used DMPA and COCs were at increased HIV risk.
Affiliation
Behavioral and Biomedical Research Division, Family Health International, Research Triangle Park, North Carolina 27709, USA. cmorrison@fhi.org
Journal Details
This article was published in the following journal.
Name: AIDS (London, England)
ISSN: 1473-5571
Pages: 1778-81
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20588106
- DOI: http://dx.doi.org/10.1097/QAD.0b013e32833a2537
Medical and Biotech [MESH] Definitions
Contraception, Barrier
Methods of contraception in which physical, chemical, or biological means are used to prevent the SPERM from reaching the fertilizable OVUM.
Gingival Hemorrhage
The flowing of blood from the marginal gingival area, particularly the sulcus, seen in such conditions as GINGIVITIS, marginal PERIODONTITIS, injury, and ASCORBIC ACID DEFICIENCY.
Contraception Behavior
Behavior patterns of those practicing CONTRACEPTION.
Contraception
Prevention of CONCEPTION by blocking fertility temporarily, or permanently (STERILIZATION, REPRODUCTIVE). Common means of reversible contraception include NATURAL FAMILY PLANNING METHODS; CONTRACEPTIVE AGENTS; or CONTRACEPTIVE DEVICES.
Dental Marginal Adaptation
The degree of approximation or fit of filling material or dental prosthetic to the tooth surface. A close marginal adaptation and seal at the interface is important for successful dental restorations.
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