Hormonal contraception and HIV acquisition: reanalysis using marginal structural modeling.

06:00 EDT 1st July 2010 | BioPortfolio

Summary of "Hormonal contraception and HIV acquisition: reanalysis using marginal structural modeling."

Hormonal contraceptives are used widely worldwide; their effect on HIV acquisition remains unresolved. We reanalyzed data from the Hormonal Contraception and HIV Study using marginal structural modeling to reduce selection bias due to time-dependent confounding. Replicating our original analysis closely, we found that depo-medroxyprogesterone acetate (DMPA) but not combined oral contraceptive (COC) was associated with increased HIV acquisition. Also, young (18-24 years) but not older women who used DMPA and COCs were at increased HIV risk.


Behavioral and Biomedical Research Division, Family Health International, Research Triangle Park, North Carolina 27709, USA. cmorrison@fhi.org

Journal Details

This article was published in the following journal.

Name: AIDS (London, England)
ISSN: 1473-5571
Pages: 1778-81


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