Hormonal contraception and HIV acquisition: reanalysis using marginal structural modeling.

06:00 EDT 1st July 2010 | BioPortfolio

Summary of "Hormonal contraception and HIV acquisition: reanalysis using marginal structural modeling."

Hormonal contraceptives are used widely worldwide; their effect on HIV acquisition remains unresolved. We reanalyzed data from the Hormonal Contraception and HIV Study using marginal structural modeling to reduce selection bias due to time-dependent confounding. Replicating our original analysis closely, we found that depo-medroxyprogesterone acetate (DMPA) but not combined oral contraceptive (COC) was associated with increased HIV acquisition. Also, young (18-24 years) but not older women who used DMPA and COCs were at increased HIV risk.


Behavioral and Biomedical Research Division, Family Health International, Research Triangle Park, North Carolina 27709, USA.

Journal Details

This article was published in the following journal.

Name: AIDS (London, England)
ISSN: 1473-5571
Pages: 1778-81


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