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Mechanisms of Tubulointerstitial Fibrosis.

06:00 EDT 25th September 2010 | BioPortfolio

Summary of "Mechanisms of Tubulointerstitial Fibrosis."

The pathologic paradigm for renal progression is advancing tubulointerstitial fibrosis. Whereas mechanisms underlying fibrogenesis have grown in scope and understanding in recent decades, effective human treatment to directly halt or even reverse fibrosis remains elusive. Here, we examine key features mediating the molecular and cellular basis of tubulointerstitial fibrosis and highlight new insights that may lead to novel therapies. How to prevent chronic kidney disease from progressing to renal failure awaits even deeper biochemical understanding.

Affiliation

*Division of Matrix Biology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts; and.

Journal Details

This article was published in the following journal.

Name: Journal of the American Society of Nephrology : JASN
ISSN: 1533-3450
Pages:

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