Outcomes after central grey matter injury in term perinatal hypoxic-ischaemic encephalopathy.
Summary of "Outcomes after central grey matter injury in term perinatal hypoxic-ischaemic encephalopathy."
Central grey matter damage following perinatal hypoxia-ischaemia frequently leads to death or motor abnormality often with deficits in other developmental domains. Predicting these different outcomes is difficult yet very important for early management, planning and providing for needs on discharge and later and not least for parents to know how their children will be affected. The best single predictor of the pattern of outcomes for an individual infant is an early MRI scan. We present a guide for predicting outcome at 2years in different developmental domains based on the severity of injury seen in the basal ganglia and thalami (BGT) on neonatal MRI.
Affiliation
Department of Paediatrics and Imaging Sciences, Imperial College London, Hammersmith Hospital Campus, London, United Kingdom; Department of Neonatology, La Paz University Hospital, Madrid, Spain.
Journal Details
This article was published in the following journal.
Name: Early human development
ISSN: 1872-6232
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20864278
- DOI: http://dx.doi.org/10.1016/j.earlhumdev.2010.08.013
Medical and Biotech [MESH] Definitions
Posterior Leukoencephalopathy Syndrome
A condition that is characterized by HEADACHE; SEIZURES; and visual loss with edema in the posterior aspects of the CEREBRAL HEMISPHERES, such as the BRAIN STEM. Generally, lesions involve the white matter (nerve fibers) but occasionally the grey matter (nerve cell bodies).
Encephalomalacia
Softening or loss of brain tissue following CEREBRAL INFARCTION; cerebral ischemia (see BRAIN ISCHEMIA), infection, CRANIOCEREBRAL TRAUMA, or other injury. The term is often used during gross pathologic inspection to describe blurred cortical margins and decreased consistency of brain tissue following infarction. Multicystic encephalomalacia refers to the formation of multiple cystic cavities of various sizes in the cerebral cortex of neonates and infants following injury, most notably perinatal hypoxia-ischemic events. (From Davis et al., Textbook of Neuropathology, 2nd ed, p665; J Neuropathol Exp Neurol, 1995 Mar;54(2):268-75)
Perinatology
The branch of medicine dealing with the fetus and infant during the perinatal period. The perinatal period begins with the twenty-eighth week of gestation and ends twenty-eight days after birth. (From Dorland, 27th ed)
Tegmentum Mesencephali
The portion of midbrain situated under the dorsal TECTUM MESENCEPHALI. The two ventrolateral cylindrical masses or peduncles are large nerve fiber bundles providing a tract of passage between the forebrain with the hindbrain. Ventral midbrain also contains three colorful structures: the grey matter (PERIAQUEDUCTAL GRAY), the black substance (SUBSTANTIA NIGRA), and the RED NUCLEUS.
Contrecoup Injury
An injury in which the damage is located on the opposite side of the primary impact site. A blow to the back of head which results in contrecoup injury to the frontal lobes of the brain is the most common type.
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