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11:32 EDT 31st October 2014 | BioPortfolio

The US National Library of Medicine and National Institutes of Health manage PubMed.gov which comprises of more than 21 million records, papers, reports for biomedical literature, including MEDLINE, life science and medical journals, articles, reviews, reports and  books.  BioPortfolio aims to publish relevant information on published papers, clinical trials and news associated with users selected topics.

For example view all recent relevant publications on Epigenetics and associated publications and clincial trials.

Showing PubMed Articles 1–25 of 1,100,000+

Thursday 30th November 1110

Involvement of Class II Phosphoinositide 3-Kinase α-Isoform in Antigen-Induced Degranulation in RBL-2H3 Cells.

In this study, we present findings that suggest that PI3K-C2α, a member of the class II phosphoinositide 3-kinase (PI3K) subfamily, regulates the process of FcεRI-triggered degranulation. RBL-2H3 cells were transfected with shRNA targeting PI3K-C2α. The knockdown impaired the FcεRI-induced release of a lysosome enzyme, β-hexosaminidase, without affecting the intracellular Ca2+ mobilization. The release of mRFP-tagged neuropeptide-Y, a reporter for the regulated exocytosis, was also decreased in the PI3...

Wednesday 29th November 1110

Substrate Selection for Fundamental Studies of Electrocatalysts and Photoelectrodes: Inert Potential Windows in Acidic, Neutral, and Basic Electrolyte.

The selection of an appropriate substrate is an important initial step for many studies of electrochemically active materials. In order to help researchers with the substrate selection process, we employ a consistent experimental methodology to evaluate the electrochemical reactivity and stability of seven potential substrate materials for electrocatalyst and photoelectrode evaluation. Using cyclic voltammetry with a progressively increased scan range, we characterize three transparent conducting oxides (in...

Tuesday 28th November 1110

Quality Assurance Test of Delivered Dose Uniformity of Multiple-Dose Inhaler and Dry Powder Inhaler Drug Products*

Abstract The delivered dose uniformity is one of the most critical requirements for dry powder inhaler and metered dose inhaler products. In 1999, Food and Drug Administration (FDA) issued a Draft Guidance entitled Nasal Spray and Inhalation Solution, Suspension, and Spray Drug Products-Chemistry, Manufacturing and Controls Documentation and recommended a two-tier acceptance sampling plan that is a modification of the United States Pharmacopeia (USP) sampling plan of dose content uniformity (USP34). This sa...

Monday 27th November 1110

Performance of Protein-Ligand Docking with Simulated Chemical Shift Perturbations.

Protein chemical shift perturbations (CSPs) that result from the binding of a ligand to the protein contain structural information about the complex. Therefore, the CSP data, typically obtained during library screening from two-dimensional (2D) nuclear magnetic resonance (NMR) spectra, are often available before attempts to solve the experimental structure of the complex are started, and can be used to solve the complex structure with CSP-based docking. Here, we compare the performance of the post-docking f...

Sunday 26th November 1110

Upper limb aerobic training improves aerobic fitness and all-out performance of America's Cup grinders.

This research on "America's Cup" grinders investigated the effects of a specific eight-week long-arm cranking ergometer (ACE) training on upper body (UB) aerobic fitness (ventilatory threshold - Tvent, respiratory compensation point- RCP, -oxygen uptake peak - [Formula: see text]O2peak) and high intensity working capacity. The training consisted of sessions carried out for 20-30 mins, three times per week, at an intensity between the UB-Tvent and UB-RCP, and replaced part of a typical lower limb aerobic tra...

Saturday 25th November 1110

Programming Supramolecular Biohybrids as Precision Therapeutics.

Conspectus Chemical programming of macromolecular structures to instill a set of defined chemical properties designed to behave in a sequential and precise manner is a characteristic vision for creating next generation nanomaterials. In this context, biopolymers such as proteins and nucleic acids provide an attractive platform for the integration of complex chemical design due to their sequence specificity and geometric definition, which allows accurate translation of chemical functionalities to biological ...

Friday 24th November 1110

Rectus Muscle Plication Procedure.

Thursday 23rd November 1110

Visible-light photodecomposition of acetaldehyde by TiO2-coated gold nanocages: plasmon-mediated hot electron transport via defect states.

Skeletal gold nanocages (Au NCs) are synthesized and coated with TiO2 layers (TiO2-Au NCs). The TiO2-Au NCs exhibit enhanced photodecomposition activity toward acetaldehyde under visible light (>400 nm) illumination because hot electrons are generated over the Au NCs by local surface plasmon resonance (LSPR) and efficiently transported across the metal/semiconductor interface via the defect states of TiO2.

Wednesday 22nd November 1110

Suicides and suicide attempts among active component members of the U.S. Armed Forces, 2010-2012; methods of self-harm vary by major geographic region of assignment.

This report analyzed data from the Department of Defense Suicide Event Report program about suicide events (suicide attempts and suicides) among active component service members during 2010-2012. Most attempts (85.2%) and suicides (83.5%) occurred among service members stationed in the U.S. Drugs were identified as the method of self-harm in 54.8% of attempts but in only 3.6% of suicides. Firearms were the leading method of suicide in both the U.S. and combat zones (61.1% and 97.2%, respectively) but accoun...

Tuesday 21st November 1110

Risk of type II diabetes and hypertension associated with chronic insomnia among active component, U.S. Armed Forces, 1998-2013.

Chronic insomnia is a common clinical complaint and its incidence in both U.S. military and civilian populations has increased. Several studies have evaluated the association between chronic insomnia and the development of other chronic diseases. This study estimates the incidence of chronic insomnia. In addition, this report examines the association between both hypertension and type II diabetes and chronic insomnia in active component military members. The Defense Medical Surveillance System was used to i...

Monday 20th November 1110

Update: cold weather injuries, active and reserve components, U.S. Armed Forces, July 2009-June 2014.

From July 2013 through June 2014, the number of active and reserve component service members treated for cold injuries (n=719) was the highest of the past five cold seasons (2009-2014). The rate of cold injury among active component personnel was also the highest of the 5-year period. Army personnel accounted for the majority (62%) of cold injuries. Frostbite was the most common type of cold injury in each of the services. Consistent with trends from previous cold seasons, service members who were female, y...

Sunday 19th November 1110

Surveillance snaphsot: influenza immunization among U.S. Armed Forces healthcare workers, August 2008-April 2014.

Saturday 18th November 1110

Surveillance snapshot: manner and cause of death, active component, U.S. Armed Forces, 1998-2013.

Friday 17th November 1110

Impact of new guidelines and educational programme on awareness of medical fitness to drive among general practitioners in ireland.

ABSTRACT Objective: To investigate changes in attitudes, resources and practices of GPs towards evaluating medical fitness to drive (MFTD) following the publication of national guidelines and an extensive educational programme in traffic medicine. Method: Postal questionnaire-survey to GPs (n = 1,000) in November 2013. Results: The final response rate was 46%. GPs are confident (57%) or very confident (14%) in assessing MFTD. There is a high awareness of the new Irish guidelines with 86% of GPs using them f...

Thursday 16th November 1110

Genome-Wide Distribution of RNA-DNA Hybrids Identifies RNase H Targets in tRNA Genes, Retrotransposons and Mitochondria.

During transcription, the nascent RNA can invade the DNA template, forming extended RNA-DNA duplexes (R-loops). Here we employ ChIP-seq in strains expressing or lacking RNase H to map targets of RNase H activity throughout the budding yeast genome. In wild-type strains, R-loops were readily detected over the 35S rDNA region, transcribed by Pol I, and over the 5S rDNA, transcribed by Pol III. In strains lacking RNase H activity, R-loops were elevated over other Pol III genes, notably tRNAs, SCR1 and U6 snRNA...

Wednesday 15th November 1110

Autologous Proliferative Therapies in Recalcitrant Lateral Epicondylitis.

This study investigates the clinical effects of autologous conditioned plasma (ACP) injections and low-level laser application as therapy options for chronic lateral epicondylitis.

Tuesday 14th November 1110

Relationship Between Cognition and Functional Outcomes After Dysvascular Lower Extremity Amputation: A Prospective Study.

The aim of this study was to examine associations between a cognitive screen and four neuropsychologic tests administered at both 6 wks and 4 mos after amputation and five functional outcomes measured 12 mos after lower extremity amputation.

Monday 13th November 1110

Spontaneous Resolution of Quadrilateral Space Syndrome: A Case Report.

A case of quadrilateral space syndrome is presented, where a large near-circumferential glenoid labrum tear led to a paralabral cyst that dissected into the quadrilateral space and caused a compressive neuropathy of the axillary nerve. This led to a 6-mo history of left shoulder pain, parasthesias, marked weakness to abduction, and marked denervation in both the deltoid and teres minor on electro-diagnostics. This is a presentation of interest as it is the only case report in the literature, to the authors'...

Sunday 12th November 1110

Effects of Treadmill Inclination on Hemiparetic Gait: Controlled and Randomized Clinical Trial.

The aim of this study was to analyze the effects of inclined treadmill training on the kinematic characteristics of gait in subjects with hemiparesis.

Saturday 11th November 1110

Effects of Combined Aerobic and Resistance Exercise on Central Arterial Stiffness and Gait Velocity in Patients with Chronic Poststroke Hemiparesis.

The effects of combined aerobic and resistance exercise training on central arterial stiffness and gait velocity in patients with chronic poststroke hemiparesis were investigated.

Friday 10th November 1110

Vigna nakashimae Extract Prevents Hepatic Steatosis in Obese Mice Fed High-Fat Diets.

Abstract Vigna species are important food resources and are traditionally used for the treatment of various diseases. In this study, we examined the inhibitory effects of Vigna nakashimae (VN) extract on high-fat diet (HFD)-induced hepatic steatosis and elucidated the molecular mechanisms. C57BL/6J mice were fed an HFD with or without VN extract for 16 weeks. VN extract decreased HFD-induced body weight, liver weight, hepatic lipid accumulation, and plasma alanine aminotransferase, and suppressed oxidative ...

Thursday 9th November 1110

Herpes Simplex Virus Clearance During Purification of a Recombinant Adeno-Associated Virus Serotype 1 Vector.

Abstract Gene delivery vectors based on adeno-associated virus (AAV) have potential utility for treatment of many genetic disorders. Current AAV vector manufacturing methods employ helper viruses to deliver functions needed to produce replication-defective recombinant AAV (rAAV) vectors, and clearance of infectious helper virus from the drug substance is essential for ensuring the safety of rAAV-based therapies. We have developed a manufacturing method for the production of rAAV vectors using a recombinant ...

Wednesday 8th November 1110

Assembly of Supramolecular Nanotubes from Molecular Triangles and 1,2-Dihalohydrocarbons.

Precise control of molecular assembly is a challenging goal facing supramolecular chemists. Herein, we report the highly specific assembly of a range of supramolecular nanotubes from the enantiomeric triangular naphthalenediimide-based macrocycles (RRRRRR)- and (SSSSSS)-NDI-Δ and a class of similar solvents-namely, the 1,2-dihalo-ethanes and -ethenes (DXEs). Three kinds of supramolecular nanotubes are formed from the columnar stacking of NDI-Δ units with a 60° mutual rotation angle as a result of coopera...

Tuesday 7th November 1110

Deterministic and Robust Generation of Single Photons from a Single Quantum Dot with 99.5% Indistinguishability Using Adiabatic Rapid Passage.

Single photons are attractive candidates of quantum bits (qubits) for quantum computation and are the best messengers in quantum networks. Future scalable, fault-tolerant photonic quantum technologies demand both stringently high levels of photon indistinguishability and generation efficiency. Here, we demonstrate deterministic and robust generation of pulsed resonance fluorescence single photons from a single semiconductor quantum dot using adiabatic rapid passage, a method robust against fluctuation of dr...

Monday 6th November 1110

Low-lying Electronic States in Bismuth Trimer Bi3 as Revealed by Laser Induced NIR Emission Spectroscopy in Solid Ne.

Laser induced near-infrared (NIR) emission spectra of neutral bismuth timer, Bi3, embedded in solid neon matrices at 3 K were recorded in a range of 870-1670 nm. Using photoexcitation with low energy photons at 1064 nm, two emission band systems were newly identified by their origin bands at T_0 = 6600 and 8470 cm-1. Accordingly, spectral assignment for three NIR emission band systems reported recently was partly revised for the one with its origin band at T_0 = 7755 cm-1 and reconfirmed for the others at T...


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