PubMed Journal Database

The US National Library of Medicine and National Institutes of Health manage PubMed.gov which comprises of more than 21 million records, papers, reports for biomedical literature, including MEDLINE, life science and medical journals, articles, reviews, reports and  books.  BioPortfolio aims to publish relevant information on published papers, clinical trials and news associated with users selected topics.

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Showing PubMed Articles 1–25 of 322237

Sat 26 May 2012
Melanoma of the sellar region mimicking pituitary adenoma.We report here the case of an 82-year-old woman who presented with visual disturbance. MRI demonstrated a sellar mass. The diagnosis of pituitary adenoma was made. She underwent transnasal surgery. Histologic, immunohistochemical and ultrastructural studies indicated that the tumor was a melanoma. Despite an exhaustive search for a primary lesion elsewhere, none was found. The sellar tumor was considered a primary lesion, although extrasellar primary tumor imaging cannot be excluded with 100% certainty. Rep...
Episodic blindness and ataxia in a horse with cholesterinic granulomas.An 11-year-old Oldenburg mare presented following three episodes of acute, transient blindness, ataxia, and disorientation within the preceding 7 months. Clinical improvement, including return of vision, occurred within 1 week of initiating corticosteroid therapy for each of the three episodes. However, mild right-sided miosis was a consistent finding on ophthalmic examinations. Routine clinicopathologic testing revealed no significant abnormalities, and testing of cerebral spinal fluid for selected inf...
Subsidising patient dispensing fees: The cost of injecting equity into the opioid pharmacotherapy maintenance system.Introduction and Aims. Australian pharmacotherapy maintenance programs incur costs to patients. These dispensing fees represent a financial burden to patients and are inconsistent with Australian health-care principles. No previous work has examined the current costs nor the future predicted costs if government subsidised dispensing fees. Design and Methods. A system dynamics model, which simulated the flow of patients into and out of methadone maintenance treatment, was developed. Costs were imputed from e...
Alterations of platelet function and clot formation kinetics after in vitro exposure to anti-A and -B.BACKGROUND: ABO-mismatched platelets (PLTs) are commonly transfused despite reported complications. We hypothesized that because PLTs possess A and B antigens on their surface, ABO-mismatched transfused or recipient PLTs could become activated and/or dysfunctional after exposure to anti-A or -B in the transfused or recipient plasma. We present here in vitro modeling data on the functional effects of exposure of PLTs to ABO antibodies. STUDY DESIGN AND METHODS: PLT functions of normal PLTs of all ABO types w...
The functional significance of E277K and V295A HFE mutations.Hereditary haemochromatosis (HH) is an autosomal recessive disorder characterized by excessive intestinal iron absorption resulting in increased pathological body iron stores. It is typically associated with homozygosity for the c.845G>A (p.C282Y) mutation in the HFE gene. However, other HFE alterations have been reported in affected individuals but their association with the disease is unclear. This study analysed the functional consequences of two HFE mutations, c.829G>A (p.E277K) and c.884T>C (p.V295A)....
Coagulation and fibrinolysis abnormalities in familial amyloid polyneuropathy.Objective: Familial amyloid polyneuropathy (FAP) is an autosomal dominant form of hereditary amyloidosis. Several studies reported coagulation factor X deficiency and excessive fibrinolysis in immunoglobulin light chain amyloidosis. However, few have investigated coagulation and fibrinolysis in FAP. The objective of this study was to determine abnormalities in plasma biomarkers of coagulation and fibrinolysis in FAP. Methods: We prospectively recruited eight FAP patients with transthyretin mutations and ten...
Relationship between total bilirubin and endothelial function, inflammation and oxidative stress in HIV-infected adults on stable antiretroviral therapy.OBJECTIVES: Enhanced inflammation is evident in HIV infection, even with virological suppression. Outside HIV infection, studies show an independent association between higher total bilirubin and better endothelial function as well as a lower prevalence of coronary heart disease, possibly as a consequence of the anti-inflammatory and antioxidant effect of bilirubin. The aim of this study was to determine whether such an association exists in HIV-infected individuals. METHODS: A cross-sectional study was per...
A prospective clinical trial evaluating the safety and efficacy of the combination of rituximab and plerixafor as a mobilization regimen for patients with lymphoma.BACKGROUND: Previous reports suggested that rituximab may impair stem cell collection and posttransplant engraftment in lymphoma patients undergoing autologous hematopoietic progenitor cell transplantation. STUDY DESIGN AND METHODS: A prospective biologic allocation study examined the effect of adding rituximab to a mobilization regimen of plerixafor and granulocyte-colony-stimulating factor (G-CSF) for patients with CD20+ lymphoma compared with CD20- lymphoma patients mobilized without rituximab. The prima...
Guidelines on the diagnosis and management of thrombotic thrombocytopenic purpura and other thrombotic microangiopathies.
Serum amyloid A and cholesterol: a pivotal role on inflammation.
When Less Is More: Evidence for a Facilitative Cathodal tDCS Effect in Attentional Abilities.Many previous studies reported that the hyperpolarization of cortical neurons following cathodal stimulation (in transcranial direct current stimulation) has resulted in cognitive performance degradation. Here, we challenge this assumption by showing that cathodal stimulation will not always degrade cognitive performance. We used an attentional load paradigm in which irrelevant stimuli are processed only under low but not under high attentional load. Thirty healthy participants were randomly allocated into...
Response Suppression by Automatic Retrieval of Stimulus-Stop Association: Evidence from Transcranial Magnetic Stimulation.Behavioral studies show that subjects respond more slowly to stimuli to which they previously stopped. This response slowing could be explained by "automatic inhibition" (i.e., the reinstantiation of motor suppression when a stimulus retrieves a stop association). Here we tested this using TMS. In Experiment 1, participants were trained to go or no-go to stimuli. Then, in a test phase, we compared the corticospinal excitability for go stimuli that were previously associated with stopping (no-go_then_go) wit...
Task-relevant and Task-irrelevant Dimensions Are Modulated Independently at a Task-irrelevant Location.Single-cell and fMRI experiments indicate that task-relevant features are enhanced globally across the visual field (VF). Moreover, this global feature-based attention can spread to task-irrelevant features of the attended object. Here we ask whether a task-irrelevant feature, by virtue of being bound to a task-relevant feature, can also be enhanced at a task-irrelevant location. Specifically, we asked whether attending to the color of moving dots in one VF would influence the motion signal to colored movin...
Multiple Cognitive Abilities from a Single Cortical Algorithm.One strong claim made by the representational-hierarchical account of cortical function in the ventral visual stream (VVS) is that the VVS is a functional continuum: The basic computations carried out in service of a given cognitive function, such as recognition memory or visual discrimination, might be the same at all points along the VVS. Here, we use a single-layer computational model with a fixed learning mechanism and set of parameters to simulate a variety of cognitive phenomena from different parts o...
Evaluation of arterial structure and function in pediatric patients with end-stage renal disease on dialysis and after renal transplantation.Tawadrous H, Kamran H, Salciccioli L, Schoeneman MJ, Lazar J. Evaluation of arterial structure and function in pediatric patients with end-stage renal disease on dialysis and after renal transplantation. Abstract:  CVD is a major cause of morbidity and mortality in pediatric patients with CKD. It is unclear whether vascular abnormalities in these patients are reversible, and if transplantation portends salutary effects on arterial function. We compared FMD, PWV, AI75, and CIMT in 15 dialysis (D), 14 trans...
Microparticle detection in platelet products by three different methods.BACKGROUND: Standardization of platelet-derived microparticle (PMP) enumeration by flow cytometry (FCM) is limited due to its intrinsic characteristics. Because of high clinical relevance of microparticle (MP) detection, standardization of MP assays is required. STUDY DESIGN AND METHODS: This prospective paired study analyzed 31 healthy blood donors (18 male, 13 female) and compared pre- and postdonation results of donors with results of plateletpheresis products by three different methods. PMP counts were...
Incidence of severe congenital neutropenia in Sweden and risk of evolution to myelodysplastic syndrome/leukaemia.Severe congenital neutropenia (SCN) is characterized by low blood neutrophil counts, early bacterial infections, and risk of leukaemia development. As yet, no population-based incidence estimates of SCN have been reported. Children less than 16 years of age with SCN were sought in Sweden during the 20-year period 1987-2006 by a questionnaire to all Swedish Departments of Paediatrics and by reviewing the Swedish Health and Welfare Statistical Databases. Thirty-two patients were diagnosed with congenital neu...
P450 monooxygenases (P450ome) of the model white rot fungus Phanerochaete chrysosporium.Phanerochaete chrysosporium, the model white rot fungus, has been the focus of research for the past about four decades for understanding the mechanisms and processes of biodegradation of the natural aromatic polymer lignin and a broad range of environmental toxic chemicals. The ability to degrade this vast array of xenobiotic compounds was originally attributed to its lignin-degrading enzyme system, mainly the extracellular peroxidases. However, subsequent physiological, biochemical, and/or genetic studies...
Insect repellents and associated personal protection for a reduction in human disease.Personal protection measures against biting arthropods include topical insect repellents, area repellents, insecticide-treated bednets and treated clothing. The literature on the effectiveness of personal protection products against arthropods is mainly limited to studies of prevention of bites, rather than prevention of disease. Tungiasis was successfully controlled by application of topical repellents and scrub typhus was reduced through the use of treated clothing. Successful reduction of leishmaniasis w...
Anxiety and depression among AL amyloidosis patients: the role of cardiac symptoms.Light-chain (AL) amyloidosis has the worst prognosis out of the different forms of cardiac amyloidosis, However, data are not available about the incidence of the disease-related psychological impact of AL amyloidosis in this population. In particular, no data are available about the impact of diagnosis communication or about the impact of cardiac symptom onset and severity on anxiety and depression levels among AL patients. Aim: To evaluate the role of time that has passed since the diagnosis was communica...
Bacillus cereus septicemia attributed to a matched unrelated bone marrow transplant.BACKGROUND: Hematopoietic cell transplantation (HCT) is performed in more than 25,000 patients annually. Clinically significant bacterial transmission from HCT products is rare. CASE REPORT: A 36-year-old male of Asian descent with chronic myelogenous leukemia developed sepsis leading to acute renal failure and disseminated intravascular coagulation during infusion of matched unrelated donor bone marrow. This product later tested positive for Bacillus cereus. DISCUSSION: This HCT product traveled 31 hours a...
Exotic venomous snakebite drill.Background. There were 900 exotic venomous snakebites reported from 2000 to 2009. The Association of Zoos and Aquariums' recommends institutions housing venomous reptiles have protocols for appropriate and timely transport of envenomed individuals to hospitals. The study objective was to evaluate functional aspects and potential problems of our emergency operation procedure designed for handling the response to an exotic venomous snakebite during implementation via a simulated drill. The emergency operation...
Factors associated with the decline in suicide by pesticide poisoning in Taiwan: A time trend analysis, 1987-2010.Objective. Pesticide self-poisoning accounts for one-third of suicides worldwide, but few studies have investigated the national epidemiology of pesticide suicide in countries where it is a commonly used method. We investigated trends in pesticide suicide, and factors associated with such trends, in Taiwan, a rapidly developing East Asian country. Methods. We conducted an ecological study using graphical approaches and Spearman's correlation coefficients to examine trends in pesticide suicide (1987-2010) in...
The impact of liver transplantation on family functioning in pediatric recipients: Can "healthy" families contribute to improved long-term survival?
Is it useful to calculate sum scores of the quality of life questionnaire EORTC QLQ-C30?HINZ A., EINENKEL J., BRIEST S., STOLZENBURG J.-U., PAPSDORF K. & SINGER S. (2012) European Journal of Cancer Care Is it useful to calculate sum scores of the quality of life questionnaire EORTC QLQ-C30? The aim of this paper is to test the psychometric properties of sum scores of the quality of life questionnaire EORTC QLQ-C30. A sample of cancer patients (n= 1529) and a sample of the general population (n= 1185) were tested with the EORTC QLQ-C30, the Hospital Anxiety and Depression Scale and the Multidim...