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04:35 EDT 28th July 2016 | BioPortfolio

The US National Library of Medicine and National Institutes of Health manage which comprises of more than 21 million records, papers, reports for biomedical literature, including MEDLINE, life science and medical journals, articles, reviews, reports and  books.  BioPortfolio aims to publish relevant information on published papers, clinical trials and news associated with users selected topics.

For example view all recent relevant publications on Epigenetics and associated publications and clincial trials.

Showing PubMed Articles 1–25 of 1,500,000+

Regarding "Airway Management in Pierre Robin Sequence: Patterns of Practice".

The 52nd North American Chemical Residue Workshop.

The eight manuscripts selected for this Symposium issue of Journal of Agricultural and Food Chemistry were presented at the 52nd North American Chemical Residue Workshop (NACRW 2015), held July 19-22, 2015 at the TradeWinds Island Grand Resort in St. Pete Beach, FL. These manuscripts represent the broad range of topics presented at NACRW 2015: the analysis of pesticides, veterinary drugs, toxins, and environmental contaminants in various food, biological and environmental matrices; advanced instrumentation ...

Hydrological Controls on Ecosystem Dynamics in Lake Fryxell, Antarctica.

The McMurdo Dry Valleys constitute the largest ice free area of Antarctica. The area is a polar desert with an annual precipitation of ∼ 3 cm water equivalent, but contains several lakes fed by glacial melt water streams that flow from four to twelve weeks of the year. Over the past ∼20 years, data have been collected on the lakes located in Taylor Valley, Antarctica as part of the McMurdo Dry Valley Long-Term Ecological Research program (MCM-LTER). This work aims to understand the impact of climate var...

Conducting Precision Medicine Research with African Americans.

Precision medicine is an approach to detecting, treating, and managing disease that is based on individual variation in genetic, environmental, and lifestyle factors. Precision medicine is expected to reduce health disparities, but this will be possible only if studies have adequate representation of racial minorities.

A Preliminary Study of the Effects of pH upon Fluorescence in Suspensions of Prevotella intermedia.

The quantification of fluorescence in dental plaque is currently being developed as a diagnostic tool to help inform and improve oral health. The oral anaerobe Prevotella intermedia exhibits red fluorescence due to the accumulation of porphyrins. pH affects the fluorescence of abiotic preparations of porphyrins caused by changes in speciation between monomers, higher aggregates and dimers, but this phenomenon has not been demonstrated in bacteria. Fluorescence spectra were obtained from suspensions of P. in...

The era of active surveillance for low-risk.Prostate cancer is here.

Call for Papers: Special Issue on Big Data in Robotics.

Call for Papers: Special Issue on Social and Technical Trade-Offs.

Visualization for Data Science: Adding Credibility, Legitimacy, and Saliency.

A Framework for Considering Comprehensibility in Modeling.

Comprehensibility in modeling is the ability of stakeholders to understand relevant aspects of the modeling process. In this article, we provide a framework to help guide exploration of the space of comprehensibility challenges. We consider facets organized around key questions: Who is comprehending? Why are they trying to comprehend? Where in the process are they trying to comprehend? How can we help them comprehend? How do we measure their comprehension? With each facet we consider the broad range of opti...

Visual Circular Analysis of 266 Years of Sunspot Counts.

Sunspots, colder areas that are visible as dark spots on the surface of the Sun, have been observed for centuries. Their number varies with a period of ∼11 years, a phenomenon closely related to the solar activity cycle. Recently, observation records dating back to 1749 have been reassessed, resulting in the release of a time series of sunspot numbers covering 266 years of observations. This series is analyzed using circular analysis to determine the periodicity of the occurrence of solar maxima. The circ...

Integration and Visualization of Translational Medicine Data for Better Understanding of Human Diseases.

Translational medicine is a domain turning results of basic life science research into new tools and methods in a clinical environment, for example, as new diagnostics or therapies. Nowadays, the process of translation is supported by large amounts of heterogeneous data ranging from medical data to a whole range of -omics data. It is not only a great opportunity but also a great challenge, as translational medicine big data is difficult to integrate and analyze, and requires the involvement of biomedical ex...

Visualizing Dynamic Bitcoin Transaction Patterns.

This work presents a systemic top-down visualization of Bitcoin transaction activity to explore dynamically generated patterns of algorithmic behavior. Bitcoin dominates the cryptocurrency markets and presents researchers with a rich source of real-time transactional data. The pseudonymous yet public nature of the data presents opportunities for the discovery of human and algorithmic behavioral patterns of interest to many parties such as financial regulators, protocol designers, and security analysts. Howe...

An Exercise in Exploring Big Data for Producing Reliable Statistical Information.

The availability of copious data about many human, social, and economic phenomena is considered an opportunity for the production of official statistics. National statistical organizations and other institutions are more and more involved in new projects for developing what is sometimes seen as a possible change of paradigm in the way statistical figures are produced. Nevertheless, there are hardly any systems in production using Big Data sources. Arguments of confidentiality, data ownership, representative...

Improving the Efficiency and Ease of Healthcare Analysis Through Use of Data Visualization Dashboards.

The digitization of a patient's health record has profoundly impacted medicine and healthcare. The compilation and accessibility of medical history has provided clinicians an unprecedented, holistic account of a patient's conditions, procedures, medications, family history, and social situation. In addition to the bedside benefits, this level of information has opened the door for population-level monitoring and research, the results of which can be used to guide initiatives that are aimed at improving qual...

Correction to: Big Data 2016;4:60-66.

Machine Learning Techniques for the Detection of Shockable Rhythms in Automated External Defibrillators.

Early recognition of ventricular fibrillation (VF) and electrical therapy are key for the survival of out-of-hospital cardiac arrest (OHCA) patients treated with automated external defibrillators (AED). AED algorithms for VF-detection are customarily assessed using Holter recordings from public electrocardiogram (ECG) databases, which may be different from the ECG seen during OHCA events. This study evaluates VF-detection using data from both OHCA patients and public Holter recordings. ECG-segments of 4-s a...

Correction: Induction of MiR-21 by Stereotactic Body Radiotherapy Contributes to the Pulmonary Fibrotic Response.

[This corrects the article DOI: 10.1371/journal.pone.0154942.].

Contrasting Potato Foliage and Tuber Defense Mechanisms against the Late Blight Pathogen Phytophthora infestans.

The late blight pathogen Phytophthora infestans can attack both potato foliage and tubers. When inoculated with P. infestans, foliage of nontransformed 'Russet Burbank' (WT) develops late blight disease while that of transgenic 'Russet Burbank' line SP2211 (+RB) does not. We compared the foliar transcriptome responses of these two lines to P. infestans inoculation using an RNA-seq approach. A total of 515 million paired end RNA-seq reads were generated, representing the transcription of 29,970 genes. We als...

Performance of the Finnish Diabetes Risk Score and a Simplified Finnish Diabetes Risk Score in a Community-Based, Cross-Sectional Programme for Screening of Undiagnosed Type 2 Diabetes Mellitus and Dysglycaemia in Madrid, Spain: The SPREDIA-2 Study.

To evaluate the performance of the Finnish Diabetes Risk Score (FINDRISC) and a simplified FINDRISC score (MADRISC) in screening for undiagnosed type 2 diabetes mellitus (UT2DM) and dysglycaemia.

Colloidal CdSe Quantum Rings.

Semiconductor quantum rings are of great fundamental interest because their non-trivial topology creates novel physical properties. At the same time, toroidal topology is difficult to achieve for colloidal nanocrystals and epitaxially grown semiconductor nanostructures. In this work, we introduce the synthesis of luminescent colloidal CdSe nanorings and nanostructures with double and triple toroidal topology. The nanorings form during controlled etching and rearrangement of two-dimensional nanoplatelets. We...

A closer look on the coordination of soft nitrogen-donor ligands to Cm(iii): SO3-Ph-BTBP.

We present a combined theoretical and experimental study on the recently developed hydrophilic SO3-Ph-BTBP ligand. Vibronic side band spectroscopy and time-resolved laser fluorescence spectroscopy (TRLFS) were employed to prove the theoretical prediction of the ligand's coordination mode.

Plasma membrane TLR activation increases bacterial uptake but abrogates endosomal Lactobacillus acidophilus induction of Interferon-B.

Lactobacillus acidophilus induces a potent IFN-β response in dendritic cells (DCs) by a TLR2 dependent mechanism in turn leading to a strong IL-12 production. In the present study, we investigated the involvement of different types of endocytosis in the L. acidophilus induced IFN-β and IL-12 response and how TLR2 or TLR4 ligation by LPS and Pam3/4CSK4 influenced endocytosis of L .acidophilus and the induced IFN-β and IL-12 production. L. acidophilus was endocytosed by constitutive macropinocytosis taking...

Selective Synthesis of Isoquinolines by Rhodium(III)-Catalyzed C-H/N-H Functionalization with α-Substituted Ketones.

A rhodium(III)-catalyzed C-H/N-H bond functionalization for the synthesis of 1-aminoisoquinolines from aryl amidines and α-MsO/TsO/Cl ketones was achieved under mild reaction conditions. Thus, this approach provides a practical method for the site-selective synthesis of various synthetically valuable isoquinolines with wide functional group tolerance.

The auxin response factor MONOPTEROS controls meristem function and organogenesis in both the shoot and root through the direct regulation of PIN genes.

The regulatory effect auxin has on its own transport is critical in numerous self-organizing plant patterning processes. However, our understanding of the molecular mechanisms linking auxin signal transduction and auxin transport is still fragmentary, and important regulatory genes remain to be identified. To track a key link between auxin signaling and auxin transport in development, we established an Arabidopsis thaliana genetic background in which fundamental patterning processes in both shoot and root w...

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