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04:14 EDT 2nd May 2016 | BioPortfolio

The US National Library of Medicine and National Institutes of Health manage which comprises of more than 21 million records, papers, reports for biomedical literature, including MEDLINE, life science and medical journals, articles, reviews, reports and  books.  BioPortfolio aims to publish relevant information on published papers, clinical trials and news associated with users selected topics.

For example view all recent relevant publications on Epigenetics and associated publications and clincial trials.

Showing PubMed Articles 1–25 of 1,400,000+

Multiple somatic symptoms and frailty: cross-sectional study in Japanese community-dwelling elderly people.

Physical frailty is relevant to adverse outcomes, but appropriate procedures for screening populations are lacking. We hypothesized that frailty is associated with multiple somatic symptoms because frail elderly people might have several somatic symptoms attributed to deterioration of multiple organs.

Differential bioaccumulation of potentially toxic elements in benthic and pelagic food chains in Lake Baikal.

Lake Baikal is located in eastern Siberia in the center of a vast mountain region. Even though the lake is regarded as a unique and pristine ecosystem, there are existing sources of anthropogenic pollution to the lake. In this study, the concentrations of the potentially toxic trace elements As, Cd, Pb, Hg, and Se were analyzed in water, plankton, invertebrates, and fish from riverine and pelagic influenced sites in Lake Baikal. Concentrations of Cd, Hg, Pb and Se in Lake Baikal water and biota were low, wh...

Characterization of the variation of carbonyl compounds concentrations before, during, and after the renovation of an apartment at Niterói, Brazil.

The present work reports the variation of 31 carbonyl compounds (CC) in an apartment located at Niterói City, Rio de Janeiro State, Brazil. Eight sampling campaigns were conducted through a 1-year period, and three areas (living room, kitchen, and bedroom) were evaluated before, during, and after the renovation activities and reoccupation of the apartment. Samples were collected using SEP-PAK cartridges impregnated with 2,4-dinitrophenylhydrazine, and the hydrazones were analyzed using rapid resolution liq...

The relationships of meteorological factors and nutrient levels with phytoplankton biomass in a shallow eutrophic lake dominated by cyanobacteria, Lake Dianchi from 1991 to 2013.

Long-term interannual (1991-2013) and monthly (1999-2013) data were analyzed to elucidate the effects of meteorological factors and nutrient levels on phytoplankton biomass in the cyanobacteria-dominated Waihai basin of Lake Dianchi. The interannual ln(chl. a) exhibited positive correlations with the mean air temperature, mean minimum air temperature, and mean maximum air temperature; in addition, a positive relationship between Δln(chl. a) and ΔTP was observed throughout the period. Additionally, ln(chl....

Comparative developmental toxicity of eight typical organic pollutants to red sea bream (Pagrosomus major) embryos and larvae.

The red sea bream (Pagrosomus major) 48-h embryo-larval bioassay was used to assess and compare the developmental toxicities of eight typical organic pollutants, including polycyclic aromatic hydrocarbons (PAHs), organophosphorus pesticides, polychlorinated biphenyls (PCBs) and alkylphenol. Toxicological endpoints such as survival rates of P. major embryos or larvae and the rates of hatching and of malformation (oedema, condensed blood, spinal curvatures or eye abnormalities) were noted and described within...

Physiological mechanisms to cope with Cr(VI) toxicity in lettuce: can lettuce be used in Cr phytoremediation?

This research aims at identifying the main deleterious effects of Cr(VI) on the photosynthetic apparatus and at selecting the most sensitive endpoints related to photosynthesis. To achieve this goal, we used lettuce (Lactuca sativa), a sensible ecotoxicological crop model. Three-week-old plants were exposed to 0, 50, 150 and 200 mg L(-1) of Cr(VI). These concentrations ranged from levels admitted in irrigation waters to values found in several Cr industry effluents and heavily contaminated environments. A...

Microbial-based evaluation of foaming events in full-scale wastewater treatment plants by microscopy survey and quantitative image analysis.

Activated sludge systems are prone to be affected by foaming occurrences causing the sludge to rise in the reactor and affecting the wastewater treatment plant (WWTP) performance. Nonetheless, there is currently a knowledge gap hindering the development of foaming events prediction tools that may be fulfilled by the quantitative monitoring of AS systems biota and sludge characteristics. As such, the present study focuses on the assessment of foaming events in full-scale WWTPs, by quantitative protozoa, meta...

Methylene blue removal by submerged plasma irradiation system in the presence of persulfate.

The submerged plasma irradiation (SPI) system is utilized in applications and implications of many environmental fields as an advanced oxidation technology (AOT). However, ramifications of the SPI-based technologies for water treatment are constrained by the different inadequacies. To overcome this matter, in this study, the influence of added persulfate such as peroxydisulfate (PDS) or peroxymonosulfate (PMS) on the removal efficiency of methylene blue (MB) in the SPI system was investigated. The SPI-PMS s...

Carbamazepine and oxcarbazepine: reflections after an oxcarbazepine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis overlap.

Management of Diabetes in Indigenous Communities: Lessons from the Australian Aboriginal Population.

Type 2 diabetes mellitus and other chronic cardio-metabolic conditions are significant contributors to the large disparities in life expectancy between Indigenous and non-Indigenous Australians. Type 2 diabetes is more prevalent from a young age among Indigenous Australians, and often preceded by a cluster of risk factors including central obesity, dyslipidaemia, albuminuria and socio-economic disadvantage. Management of type 2 diabetes in the Australian Indigenous population can be challenging in the setti...

Repolarization Heterogeneity: Beyond the QT Interval.

Remnant Lipoprotein Cholesterol and Incident Coronary Heart Disease: The Jackson Heart and Framingham Offspring Cohort Studies.

Remnant lipoproteins (RLPs), the triglyceride-enriched precursors to low-density lipoprotein, are an emerging risk factor for coronary heart disease (CHD). We sought to determine the association of RLP cholesterol (RLP-C) levels with incident CHD in 2 diverse, prospective, longitudinal observational US cohorts.

HIV and Hepatitis C-Coinfected Patients Have Lower Low-Density Lipoprotein Cholesterol Despite Higher Proprotein Convertase Subtilisin Kexin 9 (PCSK9): An Apparent "PCSK9-Lipid Paradox".

Proprotein convertase subtilisin kexin 9 (PCSK9) inhibitors reduce low-density lipoprotein cholesterol (LDL-C) and improve outcomes in the general population. HIV-infected individuals are at increased risk for cardiovascular events and have high rates of dyslipidemia and hepatitis C virus (HCV) coinfection, making PCSK9 inhibition a potentially attractive therapy.

An abnormal post-procedure chest radiograph.

Transcriptional Regulation of SULT1C2 by Vitamin D Receptor in LS180 Human Colorectal Adenocarcinoma Cells.

The factors that regulate expression of genes in the 1C family of human cytosolic sulfotransferases (SULT1C) are not well understood. In a recent study evaluating the effects of a panel of transcription factor activators on SULT1C family member expression in LS180 human colorectal adenocarcinoma cells, we found that SULT1C2 expression was significantly increased by 1α,25-dihydroxyvitamin D3 (VitD3) treatment. The objective of the current study was to identify the mechanism responsible for VitD3-mediated ac...

Biotransformation capacity of carboxylesterase in skin and keratinocytes for the penta-ethyl ester prodrug of DTPA.

The penta-ethyl ester prodrug of the chelating agent diethylene triamine pentaacetic acid (DTPA), referred to as C2E5, effectively accelerated clearance of americium after transdermal delivery. Carboxylesterases (CESs) play important roles in facilitating C2E5 hydrolysis. However, whether CESs in human skin hydrolyze C2E5 remains unknown. We evaluated the gene and protein expression of CESs in distinctive human epidermal cell lines: HEKa, HEKn, HaCaT and A431. The substrates, p-nitrophenyl acetate (pNPA) an...

Development and evaluation of probe based real time loop mediated isothermal amplification for Salmonella: A new tool for DNA quantification.

A one step, single tube, accelerated probe based real time loop mediated isothermal amplification (RT LAMP) assay was developed for detecting the invasion gene (InvA) of Salmonella. The probe based RT LAMP is a novel method of gene amplification that amplifies nucleic acid with high specificity and rapidity under isothermal conditions with a set of six primers. The whole procedure is very simple and rapid, and amplification can be obtained in 20min. Detection of gene amplification was accomplished by amplif...

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ASE Scientific Sessions 2016: Sleepless In Seattle.

Top 3 Reasons You MUST Learn About Vascular Imaging at ASE's Annual Scientific Sessions, Seattle, June 10-14, 2016.

Synthesis of novel triazole/isoxazole functionalized 7-(trifluoromethyl)pyrido2,3-dpyrimidine derivatives as promising anticancer and antibacterial agents.

A series of novel 1,2,3-triazole/isoxazole functionalized pyrido[2,3-d]pyrimidine derivatives 6a-c, 7a-h and 8a-e were prepared in series of synthetic steps. All the compounds screened for the anticancer activity against four human cancer cell lines using Nocodazole as standard. Compounds 7d and 7h showed highest activity against PANC-1 (pancreatic cancer) and A549 (lung cancer) cell lines respectively and more than standard. All the compounds also screened for antibacterial activity using Rifampicin and Ci...

Piperidinyl thiazole isoxazolines: A new series of highly potent, slowly reversible FAAH inhibitors with analgesic properties.

Fatty acid amide hydrolase (FAAH) is a membrane anchored serine hydrolase that has a principle role in the metabolism of the endogenous cannabinoid anandamide. Docking studies using representative FAAH crystal structures revealed that compounds containing a novel piperidinyl thiazole isoxazoline core fit within the ligand binding domains. New potential FAAH inhibitors were designed and synthesized incorporating urea, carbamate, alkyldione and thiourea reactive centers as potential pharmacophores. A small li...

Design, synthesis and evaluation of pyrrolo2,3-dpyrimidine-phenylamide hybrids as potent Janus kinase 2 inhibitors.

Janus kinase 2 (JAK2) plays an essential role in the signaling of hormone-like cytokines and growth factors, which has been convinced as an important target of myeloproliferative neoplasms (MPNs) therapy. In this study, a series of novel pyrrolo[2,3-d]pyrimidine-phenylamide hybrids were designed and synthesized as potential JAK2 inhibitors through hybridization strategy. In vitro biological studies showed that most of these compounds exhibited potent activity against JAK2. Especially, compound 16c was ident...

Alcohol and Marijuana Use Trajectories in a Diverse Longitudinal Sample of Adolescents: Examining Use Patterns from Age 11 to 17.

We tested race/ethnic differences in alcohol and marijuana (AM) trajectories (comprising an intercept term; reflecting overall probability of use, and a slope term; reflecting change in probability of use) during adolescence, whether AM use trajectories predicted high school outcomes, and whether outcomes differed by race/ethnicity after controlling for trajectory of AM use.

"Filarial dance sign" real-time ultrasound diagnosis of filarial oophoritis.

Filariasis is a parasitic disease caused by Filarial nematodes (Wuchereria bancrofti, Brugia malayi, and Brugia timori) that commonly causes lymphatic obstruction resulting in edema and increase in the size of the affected organ. Filariasis is diagnosed by identifying microfilariae on Giemsa stain. The immunochromatographic card test is diagnostic. Ultrasound is the imaging modality of choice for detecting adult filarial worms/microfilaria in the lymphatic system, which are responsible for the classic "fila...

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