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18:58 EDT 27th May 2017 | BioPortfolio

The US National Library of Medicine and National Institutes of Health manage which comprises of more than 21 million records, papers, reports for biomedical literature, including MEDLINE, life science and medical journals, articles, reviews, reports and  books.  BioPortfolio aims to publish relevant information on published papers, clinical trials and news associated with users selected topics.

For example view all recent relevant publications on Epigenetics and associated publications and clincial trials.

Showing PubMed Articles 1–25 of 1,700,000+

Response to: "Relationship between parental hypertension and cardiometabolic risk factors in adolescents: Methodological issues".

Outcomes of Trastuzumab Therapy for 6 and 12 Months in Indonesian National Health Insurance System Clients with Operable HER2-Positive Breast Cancer

Objective: The aim of this study is to determine the outcome of trastuzumab therapy for 6 or 12 months in patients with HER2 positive operable breast cancer who followed the national health insurance system in Indonesia. Methods: Data were extracted from medical records of Dr. M Djamil General Hospital Padang and Dharmais Cancer Hospital/ National Cancer Center Jakarta for post-operative breast HER-2 positive cancer patients treated with trastuzumab for 6 or 12 months who had been followed up for at least 5...

Comparison of Direct and Indirect Methods of Teaching Breast Self-Examination – Influence on Knowledge and Attitudes of Iranian Nursing and Midwifery Personnel

Background: Breast cancer is the most common cancer in women. Monthly breast self-examination (BSE) has been presented as one of the best screening methods available. The aim of this study was to compare effects of both direct and indirect methods of teaching of BSE on knowledge and attitudes of nursing and midwifery personnel. Materials and Methods: The present study was performed on 89 nursing and midwifery personnel in Valiasr hospital of Borujen city. Participants were randomly divided into a direct and...

Trends in Breast Cancer Epidemiology in Chelyabinsk Region, 2006-2015

Breast cancer among women occupies a leading position in the profile of cancer incidence in most parts of the world. The present study of the incidence and prevalence of breast cancer was carried out using data from the Chelyabinsk population cancer registry for 2006-2015. A stable growth trend in the incidence over time was noted overall, as well as major differences in the figures for women of different ethnicities (Russian, Tatar, Bashkir), by far the highest incidences being observed for Russian women. ...

Whole-Exome Sequencing of ETV6/RUNX1 in Four Childhood Acute Lymphoblastic Leukaemia Cases

Background: ETV6/RUNX1 gene fusion is the most frequently seen chromosomal abnormality in childhood acute lymphobastic leukamia (ALL). However, additional genetic changes are known to be required for the development of this type of leukaemia. Therefore, we here aimed to assess the somatic mutational profile of four ALL cases carrying the ETV6/RUNX1 fusion gene using whole-exome sequencing. Methods: DNA was isolated from bone marrow samples using a QIAmp DNA Blood Mini kit and subsequently sequenced using th...

Recurrent mitral paravalvular leak: benefits of leak site repair compared to re-replacement.

Mitral paravalvular leak (PVL) recurrence after surgical correction has not yet been well demonstrated. The aims of this study were (1) to evaluate the long-term results of surgical mitral PVL correction, including recurrent PVL, and (2) to elucidate the factors including surgical technique that affect the risk of recurrent PVL.

BeGraft Peripheral PMCF Study: 12-month results.

The Begraft Peripheral PMCF study is a prospective, non-randomized study, conducted at the vascular departments of 4 hospitals in Belgium. This manuscript reports the findings up to 12-month follow-up time for the total cohort. The primary endpoint of the study is primary patency at 12 months. Primary patency is defined as a target lesion without a hemodynamically significant stenosis on duplex ultrasound (>50%, systolic velocity ratio no greater than 2.4) and without Target Lesion Revascularization (TLR) w...

Initial experience with the E-ventus® stentgraft for endovascular treatment of visceral artery aneurysms.

To evaluate the safety and efficacy of a novel balloon-expandable stentgraft for endovascular treatment of visceral artery aneurysms (VAA).

Aortic aneurysm endovascular treatment with the parallel graft technique from the aortic arch to the iliac axis.

The chimney technique has been developed for the treatment of complex aortic aneurysms. We analyzed the midterm to long-term outcomes of this approach from a single- centre experience.

Patterns of use and durability for the Mitroflow aortic valve: a systematic review of the literature.

To evaluate durability of Mitroflow and patterns of use compared with other aortic valves we performed a systematic review of the literature.

Is cold blood cardioplegia absolutely superior to cold crystalloid cardioplegia in aortic valve surgery?

Experimental evidence suggests that blood cardioplegia (BCP) may be superior to cold crystalloid cardioplegia (CCP) for myocardial protection. However, robust clinical data are lacking. We compared post-operative outcome of patients undergoing aortic valve replacement (AVR) using cold anterograde-retrograde intermittent BCP versus anterograde (CCP).

The 100 most-cited articles focused on thyroid research: a bibliometric analysis.

The number of citations that an article has received reflects its impact on a particular research area.

Influencing of antioxidants' gene variants on risk of diabetes mellitus and its complications: a systematic review.

Oxidative stress has a key role in pathophysiology of type 2 diabetes mellitus (T2DM) and its complications as a most common health problem. Due to controversial evidence regarding the association between antioxidants' gene varients and T2DM, our aim was a systematic review of the current meta-analyses.

Insular gliomas: a surgical reappraisal based on a systematic review of the literature.

Insular gliomas are heterogeneous lesions whose management presents multiple challenges for their tendency to affect young patients in good neurological and cognitive conditions, their deep anatomic location and proximity with critical functional and vascular structures. The appropriate management of insular gliomas requires a multidisciplinary evidence-centred teamwork grounded on the best anatomic, neurophysiological and oncological knowledge. The present study provides a reappraisal of the management of ...

D-retro-enantiomer of Quorum Sensing Peptides-Modified Polymeric Micelles for Brain Tumor Targeted Drug Delivery.

In comparison to other tumors, various barriers such as the blood-brain barrier (BBB), enzymatic barriers and the blood-brain tumor barrier (BBTB) severely impede the successful treatment of glioma. Peptide ligands were frequently used as targeting moieties to mediate brain tumor targeted drug delivery. LWSW (SYPGWSW) is a recently reported quorum sensing peptide which is able to efficiently cross the BBB. Even though the linear LWSW traverses the BBB in vitro, its' in vivo targeting ability has been greatl...

Isolation of Phenotypically-Distinct Cancer Cells Using Nanoparticle-Mediated Sorting.

Isolating subpopulations of heterogeneous cancer cells is an important capability for the meaningful characterization of circulating tumor cells at different stages of tumor progression and during epithelial to mesenchymal transition (EMT). Here, we describe a two-dimensional separation approach that yields phenotypically-distinct subpopulations of cancer cells. Magnetic nanoparticles coated with antibodies against the epithelial cell adhesion molecule (EpCAM) are used to enrich cancer cells in a microfluid...

Simultaneous separation and washing of non-magnetic particles in an inertial ferrofluid/water co-flow.

Magnetic fluids (e.g., paramagnetic solutions and ferrofluids) have been increasingly used for label-free separation of non-magnetic particles in microfluidic devices. Their biocompatibility, however, becomes a concern in high-throughput or large-volume applications. One way to potentially resolve this issue is re-suspending the particles that are separated in a magnetic fluid immediately into a biocompatible buffer. We demonstrate herein the proof-of-principle of the first integration of negative magnetoph...

Nanoscale Junction Formation by Gas-Phase Monolayer Doping.

A major challenge in transistor technology scaling is the formation of controlled ultra-shallow junctions with nanometer-scale thickness and high spatial uniformity. Monolayer doping (MLD) is an efficient method to form such nanoscale junctions, where the self-limiting nature of semiconductor surfaces is utilized to form adsorbed monolayers of dopant-containing molecules followed by rapid thermal annealing (RTA) to diffuse the dopants to a desired depth. Unlike ion implantation, the process does not induce ...

Controlled Release of Naringin in Metal-Organic Frameworks (MOFs) Loaded Mineralized Collagen Coating to Simultaneously Enhance Osseointegration and Antibacterial Activity.

Two important goals in orthopedic implants research are to promote osseointegration and prevent infection. However, much of previous efforts have been paid on the design of coatings either to enhance osseointegration while ignoring antibacterial activity or vice versa, to prevent infection while ignoring bone integration. Here, we designed a multifunctional mineralized collagen coating on titanium with the aid of metal-organic frameworks (MOFs) nanocrystals to control the release of naringin, a Chinese herb...

Clinically Relevant Detection Of Streptococcus Pneumoniae With DNA-Antibody Nanostructures.

Streptococcus pneumoniae (SP) is a pathogenic bacterium and a major cause of community-acquired pneumonia that could be fatal if left untreated. Therefore, rapid and sensitive detection of SP is crucial to enable targeted treatment during SP infections. In this study, DNA tetrahedron (DNA TH) with a hollow structure is anchored on gold electrodes to construct an electrochemical immunosensor for rapid detection of pneumococcal surface protein A (PspA) peptide and SP lysate from synthetic and actual human sam...

Elucidation of the Oxygen Surface Kinetics in a Coated Dual-Phase Membrane for Enhancing Oxygen Permeation Flux.

The dual-phase membrane has received much attention as the solution to the instability of the oxygen permeation membrane. It has been reported that the oxygen flux of the dual-phase membrane is greatly enhanced by the active coating layer. However, there has been little discussion about the enhancement mechanism by surface coating in the dual-phase membrane. This study investigates the oxygen flux of Ce0.9Gd0.1O2-δ-La0.7Sr0.3MnO3±δ (GDC 80 vol.%/LSM 20 vol.%) composite membrane depending on the oxygen pa...

The Challenge of Overcoming Antibiotic Resistance: An Adjuvant Approach?

Antibiotic resistance is one of the greatest current threats to human health, and without significant action we face the chilling prospect of a world without effective antibiotics. Although continued effort toward the development of new antibiotics, particularly those with novel mechanisms of action, remains crucial, this alone probably will not be enough to prevail, and it is imperative that additional approaches are also explored. One such approach is the identification of adjuvants that augment the activ...

A Fluorescent Split Aptamer for Visualizing RNA-RNA Assembly In Vivo.

RNA-RNA assembly governs key biological processes and is a powerful tool for engineering synthetic genetic circuits. Characterizing RNA assembly in living cells often involves monitoring fluorescent reporter proteins, which are at best indirect measures of underlying RNA-RNA hybridization events and are subject to additional temporal and load constraints associated with translation and activation of reporter proteins. In contrast, RNA aptamers that sequester small molecule dyes and activate their fluorescen...

Glycosaminoglycans-Specific Cell Targeting and Imaging Using Fluorescent Nanodiamonds Coated with Viral Envelope Proteins.

Understanding virus-host interactions is crucial for vaccine development. This study investigates such interactions using fluorescent nanodiamonds (FNDs) coated with vaccinia envelope proteins as the model system. To achieve this goal, we noncovalently conjugated 100-nm FND with A27(aa 21-84), a recombinant envelope protein of vaccinia virus, for glycosaminoglycans (GAGs)-specific targeting and imaging of living cells. Another recombinant protein A27(aa 33-84) that removes the GAGs-binding sequences was als...

Correction to Microbial Electrosynthesis and Anaerobic Fermentation: An Economic Evaluation for Acetic Acid Production from CO2 and CO.

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