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10:08 EDT 2nd September 2014 | BioPortfolio

The US National Library of Medicine and National Institutes of Health manage which comprises of more than 21 million records, papers, reports for biomedical literature, including MEDLINE, life science and medical journals, articles, reviews, reports and  books.  BioPortfolio aims to publish relevant information on published papers, clinical trials and news associated with users selected topics.

For example view all recent relevant publications on Epigenetics and associated publications and clincial trials.

Showing PubMed Articles 26–50 of 29,000+


Functional Results after Implantation of an Aspheric, Aberration-Neutral Intraocular Lens.

Purpose: The aim of this study was to perform a clinical evaluation of the functional results and quality of vision after implantation of an aspheric, aberration-neutral, monofocal intraocular lens (IOL). Patients and Methods: 47 eyes of 34 patients (median age: 68 years) with cataract were enrolled in this prospective clinical study that had Ethics Committee approval. The C-flex or Superflex aspheric IOL (Rayner, UK) was implanted after phacoemulsification. Follow-up examinations were performed two to four...


Fabrication of Superhydrophobic Three-dimensionally Ordered Macroporous Polytetrafluoroethylene Films and Its Application.

Three-dimensionally ordered macroporous (3DOM) polytetrafluoroethylene (PTFE) has hardly been prepared due to the poor solubility in most of solvents and high melting temperature of PTFE raw material. In this work, monodispersed polystyrene (PS) microspheres and PTFE latex particles were controlled to simultaneously deposit from water. After the deposits were calcinated at 400 oC, a self-supported superhydrophobic 3DOM PTFE film with a static water contact angle of 154° was successfully fabricated. The por...


Fixed Irbesartan/Amlodipine Combination: Efficacy and Safety of the Use of Four Dosing Regimens in Patients With Arterial Hypertension.

Aim: to assess efficacy, safety, and tolerability of 4 fixed irbesartan/amlodipine combinations in hypertensive patients resistant to monotherapy with 150 mg irbesartan or 5 mg amlodipine in a 16 week prospective open uncontrolled randomized multicenter study. Material and methods. We included in this study 158 patients with essential arterial hypertension (AH) (mean age 57.6+/-10.1years, 119 women) receiving monotherapy with 150 mg irbesartan (n=78; 49.4%) or 5 mg amlodipine (n=80; 50.6%). Patients not ach...


Feasibility of second-generation bioresorbable vascular scaffold implantation in complex anatomical and clinical scenarios.

Bioresorbable vascular scaffolds (BVS) have become an emerging tool to treat coronary artery disease. However, the current use of BVS is still widely restricted to stable patients and non-complex lesions. In real-world practice patients are far more complex than those with simple type A lesions and the extended use of BVS to complex lesions and high-risk patients needs to be evaluated. Therefore, we sought to investigate the feasibility and performance of BVS in a broad spectrum of patients.


Factors associated with right ventricular dilatation and dysfunction in patients with chronic pulmonary regurgitation after repair of tetralogy of Fallot: Analysis of magnetic resonance imaging data from 218 patients.

The aim of the present study was to identify the factors associated with right ventricular (RV) dilatation and dysfunction in patients with chronic pulmonary regurgitation (PR) after repair of tetralogy of Fallot.


Fulminant hepatic failure and hepatitis B virus reactivation: case reports and analyses of the pathological mechanism.

To investigate the clinical features and mechanisms of hepatitis B virus (HBV)reactivation induced by chemotherapy or immunosuppressive therapy and subsequent fulminant hepatic failure (FHF) in patients with autoimmune diseases.


Fully automated dual-frequency three-pulse-echo 2DIR spectrometer accessing spectral range from 800 to 4000 wavenumbers.

A novel dual-frequency two-dimensional infrared instrument is designed and built that permits three-pulse heterodyned echo measurements of any cross-peak within a spectral range from 800 to 4000 cm(-1) to be performed in a fully automated fashion. The superior sensitivity of the instrument is achieved by a combination of spectral interferometry, phase cycling, and closed-loop phase stabilization accurate to ∼70 as. The anharmonicity of smaller than 10(-4) cm(-1) was recorded for strong carbonyl stretching...


Femtosecond time-resolved photoemission electron microscopy for spatiotemporal imaging of photogenerated carrier dynamics in semiconductors.

We constructed an instrument for time-resolved photoemission electron microscopy (TR-PEEM) utilizing femtosecond (fs) laser pulses to visualize the dynamics of photogenerated electrons in semiconductors on ultrasmall and ultrafast scales. The spatial distribution of the excited electrons and their relaxation and/or recombination processes were imaged by the proposed TR-PEEM method with a spatial resolution about 100 nm and an ultrafast temporal resolution defined by the cross-correlation of the fs laser pul...


Focusing electrode and coaxial reflector used for reducing the guiding magnetic field of the Ku-band foilless transit-time oscillator.

Based on the theoretical analysis of the intense relativistic electron beam propagation in the coaxial drift-tube, a focusing electrode and a coaxial reflector is proposed to lessen the demand of the coaxial Ku-band foilless transit-time oscillator (TTO) for the guiding magnetic field. Moreover, a Ku-band TTO with the focusing electrode and the coaxial reflector is designed and studied by particle in cell simulation. When the diode voltage is 390 kV, the beam current 7.8 kA, and the guiding magnetic field i...


Fiber-optic thermometer application of thermal radiation from rare-earth end-doped SiO2 fiber.

Visible light thermal radiation from SiO2 glass doped with Y, La, Ce, Pr, Nd, Eu, Tb, Dy, Ho, Er, Tm, Yb, and Lu were studied for the fiber-optic thermometer application based on the temperature dependence of thermal radiation. Thermal radiations according to Planck's law of radiation are observed from the SiO2 fibers doped with Y, La, Ce, Pr, Eu, Tb, and Lu at the temperature above 1100 K. Thermal radiations due to f-f transitions of rare-earth ions are observed from the SiO2 fibers doped with Nd, Dy, Ho, ...


Fluorescence imaging of viscous materials in the ultraviolet-visible wavelength range.

This paper presents an approach of an innovative measurement principle for the quality control of viscous materials during a manufacturing process based on fluorescence imaging. The main contribution to the state of the art provided by this measurement system is that three equal fluorescence images of a static or moving viscous object are available in different optical paths. The independent images are obtained by two beam splitters which are connected in series. Based on these images, it is possible to eva...


Fibronectin predicts the outcome of acute-on-chronic hepatitis B liver failure.

Acute-on-chronic hepatitis B liver failure (ACHBLF) is a serious condition with varied etiologies and manifestations, and is associated with a high mortality rate. Fibronectin is involved in a number of biological processes, including cellular adhesion, motility, differentiation, apoptosis, hemostasis, wound healing and ischemic injury. Serum fibronectin concentrations may provide prognostic information in ACHBLF; however, as a prognostic marker of mortality in patients with ACHBLF, it needs further validat...


Foetal radiography for suspected skeletal dysplasia: technique, normal appearances, diagnostic approach.

Despite advances in antenatal imaging and genetic techniques, post-delivery post-mortem foetal radiography remains the key investigation in accurate diagnosis of skeletal dysplasia manifesting in the foetus. Foetal radiography is best performed using pathology-specimen radiography equipment and is often carried out in the pathology department without involvement of the radiology unit. However, paediatric radiologists may be asked to interpret post-mortem foetal radiographs when an abnormality is suspected. ...


Functional Magnetic Resonance Imaging of Sensorimotor Transformations in Saccades and Antisaccades.

Saccades to peripheral targets require a direct visuomotor transformation. In contrast, antisaccades, saccades in opposite direction of a peripheral target, require more complex transformation processes due to the inversion of the spatial vector. Here, the differential neural mechanisms underlying sensorimotor control in saccades and antisaccades were investigated using functional magnetic resonance imaging (fMRI) at 3T field strength in 22 human volunteers. We combined a task factor (prosaccades: look towa...

Thursday 15th December 1058

From plants to pharmacy shelf.

Thursday 15th September 1058

Fatty acid synthase/oxidized low-density lipoprotein as metabolic oncogenes linking obesity to colon cancer via NF-kappa B in Egyptians.

Obesity is a major health problem which heightens the risk of several chronic illnesses including cancer development particularly colon cancer. The underlying pathophysiology of obesity associated colon cancer remains to be elucidated. The purpose of this current study was to determine fatty acid synthase (FASN) activity/expression, oxidized low-density lipoprotein (ox-LDL) level and redox status under the context of anthropometric measurements and lipid profile to find their potential role as interacting b...

Sunday 3rd July 1058

Field emission scanning electron microscopy (FE-SEM) as an approach for nanoparticle detection inside cells.

When developing new nanoparticles for bio-applications, it is important to fully characterize the nanoparticle's behavior in biological systems. The most common techniques employed for mapping nanoparticles inside cells include transmission electron microscopy (TEM) and scanning transmission electron microscopy (STEM). These techniques entail passing an electron beam through a thin specimen. STEM or TEM imaging is often used for the detection of nanoparticles inside cellular organelles. However, lengthy sam...

Monday 27th June 1058

Fluorescent sensors reveal subcellular thermal changes.

In mammals and birds, thermoregulation to conserve body temperature is vital to life. Multiple mechanisms of thermogeneration have been proposed, localized in different subcellular organelles. However, studying thermogenesis directly in intact organelles has been challenging. Visualizing patterns of thermal changes at subcellular resolution would reveal physiologically relevant spatio-temporal information, especially if this could be done in the native cellular configuration of the cell. Here we review and ...

Saturday 9th April 1058

Famines in the Last 100 Years: Implications for Diabetes.

Overnutrition is a major cause of diabetes. The contrary situation of undernutrition has also been suggested to increase the risk of the disease. Especially undernutrition during prenatal life has been hypothesized to program the structure and physiology of the fetus in such a way that it is more prone to develop diabetes in later life. Famines over the last 100 years have provided historical opportunities to study later-life health consequences of poor nutritional circumstances in early life. The majority...

Wednesday 16th March 1058

Feasibility of electrokinetic oxygen supply for soil bioremediation purposes.

This paper studies the possibility of providing oxygen to a soil by an electrokinetic technique, so that the method could be used in future aerobic polluted soil bioremediation treatments. The oxygen was generated from the anodic reaction of water electrolysis and transported to the soil in a laboratory-scale electrokinetic cell. Two variables were tested: the soil texture and the voltage gradient. The technique was tested in two artificial soils (clay and sand) and later in a real silty soil, and three vol...

Friday 18th February 1058

Functional lysophosphatidic acid receptors expressed in Oryzias latipes.

Lysophosphatidic acid (LPA) signaling is known to play biological and pathophysiological roles in many types of animals. Medaka (Oryzias latipes) is an experimental fish that can be easily maintained, propagated, and analyzed, and whose genome has been completely sequenced. However, there is limited information available regarding medaka LPA receptors. Here, using information from the medaka genome database, we examine the genomic structures, expression, and functions of six LPA receptor genes, Lpar1-Lpar6....

Thursday 17th February 1058

Fungi associated with drug recalls and rare disease outbreaks.

Fungi rarely cause disease outbreaks associated with use of microbe-contaminated drugs. These rare episodes typically involve a restricted spectrum of common environmental species with relatively low virulence, rather than classical pathogens. Review of data involving over-the-counter contact lens solutions and prescription drug-related recalls revealed six episodes during the past decade with significant adverse health and financial impact (including loss of vision and death). Contaminations involved fungi...

Saturday 12th February 1058

Fluoranthene, a polycyclic aromatic hydrocarbon, inhibits light as well as dark reactions of photosynthesis in wheat (Triticum aestivum).

The toxic effect of fluoranthene (FLT) on seed germination, growth of seedling and photosynthesis processes of wheat (Triticum aestivum) was investigated. Wheat seeds were exposed to 5µM and 25µM FLT concentrations for 25 days and it was observed that FLT had inhibiting effect on rate of seed germination. The germination rate of wheat seeds decreased by 11% at 25µM FLT concentration. Root/shoot growth and biomass production declined significantly even at low concentrations of FLT. Chlorophyll a fluoresce...

Saturday 29th January 1058

Faster recovery of a diatom from UV damage under ocean acidification.

Diatoms are the most important group of primary producers in marine ecosystems. As oceanic pH declines and increased stratification leads to the upper mixing layer becoming shallower, diatoms are interactively affected by both lower pH and higher average exposures to solar ultraviolet radiation. The photochemical yields of a model diatom, Phaeodactylum tricornutum, were inhibited by ultraviolet radiation under both growth and excess light levels, while the functional absorbance cross sections of the remaini...


Feasibility of three-dimensional virtual surgical planning in living liver donors.

The aim of the study was to determine the accuracy, reproducibility, and improvement in the clinical workflow of a semiautomatic computed tomography (CT) virtual surgical planning program in estimating graft volume using actual graft weight as a standard of reference in living liver donors.

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