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The US National Library of Medicine and National Institutes of Health manage PubMed.gov which comprises of more than 21 million records, papers, reports for biomedical literature, including MEDLINE, life science and medical journals, articles, reviews, reports and books. BioPortfolio aims to publish relevant information on published papers, clinical trials and news associated with users selected topics.
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Stromal interaction molecule 1 (STIM1) senses depletion of ER-Ca(2+) store and clusters in ER-PM junctions where it associates with and gates Ca(2+) influx channels, Orai1 and TRPC1. Clustering of TRPC1 with STIM1 and Orai1 in these junctions is critical since Orai1-mediated Ca(2+) entry triggers surface expression of TRPC1 while STIM1 gates the channel. Thus, plasma membrane function of TRPC1 depends on the delivery of the channel to the sites where STIM1 puncta are formed. This study examines intracellula...
The differentiation of embryonic mesenchymal cells into chondrocytes and the subsequent formation of a cartilaginous scaffold that enables the formation of long bones are hallmarks of endochondral ossification. During this process, chondrocytes undergo a remarkable sequence of events involving proliferation, differentiation, hypertrophy and eventually apoptosis. Forkhead Box O (FoxO) transcription factors (TFs) are well-known regulators of such cellular processes. Although FoxO3a was previously shown to be ...
In 2009, China launched its new round of health care reform. One of its priorities was to strengthen primary care and establish a family practice system.
The intestinal tract is the main organ involved in host nutritional homeostasis. Intestinal function in both vertebrates and invertebrates is partly controlled by enteric neurons that innervate the gut. Though anatomical and functional aspects of enteric neurons are relatively less characterized in Drosophila than in large insects, analyses of the role of the enteric neurons in flies have remarkably progressed in the last few years. In this review, we first provide a summary of the structure and function of...
To evaluate the feasibility, surgical outcomes and complications of laparoscopic restaging surgery for women with unexpected ovarian malignancy.
Producing flocs with desired properties is significant for contaminants removal in water treatment works. In this study, an inorganic composite coagulant, polyaluminum ferric chloride (PAFC), was prepared and used in surface water treatment, and the influence of Al/Fe molar ratio and basicity (B) on floc properties was investigated. The contribution of metal species analysis showed a competition relationship between Al and Fe in the pre-hydrolysis, while the monomeric contents decreased with the increase of...
We present a rare case of 4 limb amputations due to peripheral gangrene which resulted from the use of inotropes for septic shock.
This article examines the suitability of filled hydrogel particles for use as a delivery system for n-3 long chain PUFAs in low-fat frankfurters. Their effects on product characteristics over chilled storage were compared with those of frankfurters containing all-pork fat (control) or a comparable amount of fish oil (n-3 LCPUFA) incorporated in liquid form or in an oil-in-water emulsion. In modified samples n-3 fatty acids ranged between 801.34 to 996.37mg/100g as opposed to 66mg/100g in all-pork fat produc...
Urea fertilization decreases Pinus taeda L. growth in clay soils of subtropical areas. The negative effect of urea is related to changes in some hydraulic traits, similar to those observed in plants growing under drought. The aims of this work were (i) to determine whether different sources of nitrogen applied as fertilizers produce similar changes in growth and hydraulic traits to those observed by urea fertilization and (ii) to analyze the impact of those changes in plant drought tolerance. Plants fertili...
Food handlers (FHs) may facilitate transmission and dissemination of pathogens. The importance of FHs as a link in the epidemiological chain of transmission of Giardia duodenalis and other intestinal protozoa was assessed.
New clinical symptoms in the context of rheumatic inflammatory system diseases require the exact knowledge of the anamnestic symptom-characteristic. Fever, skin changes and myalgia are frequent and unspecific symptoms that need a particularly broad-based interdisciplinary approach to identify potential causes. The attending physician can thereby avoid unnecessary, expensive and somewhat stressful tests. This article is intended to give important advice for everyday practice in step-wise diagnostics.
Although F11 receptor (F11R), also named junctional adhesion molecular A (JAM-A), participates in leukocyte migration, its role in autoimmune diseases has not been specifically disclosed. In this study, we examined the association of F11R expression with the development and clinical manifestations of rheumatoid arthritis (RA).
The literature on paroxysmal nocturnal hemoglobinuria (PNH) in aplastic anemia (AA) is largely focused on adults with few studies in children. Moreover, large studies are conspicuously absent from developing countries. Knowledge of the prevalence and utility of their detection is required before widespread use of PNH screening in pediatric AA in resource-limited settings.
Longevity is associated with changes in circulating levels of thyroid hormone (TH) and/or thyroid stimulating hormone (TSH) in animals and humans, but underlying mechanisms remain elusive.
The use of cytology specimens for next-generation sequencing (NGS) is particularly challenging because of the unconventional substrate of smears and the often limited sample volume. An analysis of factors affecting NGS testing in cytologic samples may help to increase the frequency of successful testing.
Spatiotemporal activity that emerges spontaneously 'at rest' has been proposed to reflect individual a priori biases in cognitive processing. This research focused on testing neurocognitive models of visual attention by studying the functional connectivity (FC) of the superior parietal lobule (SPL) given its central role in establishing priority maps during visual search tasks. Twenty-three human participants completed a functional MRI session that featured a resting state scan, followed by a visual search ...
Effects of the impact of a mechanical structure on the human body are of great interest in the understanding of body trauma. Experimental tests have led to first conclusions about the dangerousness of an impact observing impact forces or displacement time history with PMHS (Post Mortem human Subjects). They have allowed providing interesting data for the development and the validation of numerical biomechanical models. These models, widely used in the framework of automotive crashworthiness, have led to the...
The bioavailability of organic chemicals in soil and sediment is an important area of scientific investigation by environmental scientists, but it is still poorly understood by regulators and industry working in the environmental sector. Regulators are starting to consider bioavailability within retrospective risk assessment frameworks for organic chemicals: by doing this, realistic decision-making on polluted environments is achievable, rather than relying on the traditional approach of using total extract...
The clinical diagnosis and classification of neurodegenerative diseases based on clinical examination or available biomarkers are currently insufficiently accurate. Although histologic examination is considered the gold standard for diagnosis, brain biopsies have been avoided because of the high risk-benefit ratio. However, brain biopsies have previously been performed with a craniotomy and excision of approximately 1 cm of cerebral cortex tissue, and it is possible that needle core brain biopsies would hav...
It is well established that cuing facilitates behavioral performance and that different aspects of instructional cues evoke specific neural preparatory processes in cued task-switching paradigms. To deduce the functional role of these neural preparatory processes the majority of studies vary aspects of the experimental paradigm and describe how these variations alter markers of neural preparatory processes. Although these studies provide important insights, they also have notable limitations, particularly i...
Trypanosomatid parasites of the genus Leishmania are the causative agents of leishmaniasis, a neglected tropical disease with several clinical manifestations. Leishmania major is the causative agent of cutaneous leishmaniasis (CL), which is largely characterized by ulcerative lesions appearing on the skin. Current treatments of leishmaniasis include pentavalent antimonials and amphotericin B, however, the toxic side effects of these drugs and difficulty with distribution makes these options less than ideal....