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07:14 EST 19th December 2014 | BioPortfolio

The US National Library of Medicine and National Institutes of Health manage which comprises of more than 21 million records, papers, reports for biomedical literature, including MEDLINE, life science and medical journals, articles, reviews, reports and  books.  BioPortfolio aims to publish relevant information on published papers, clinical trials and news associated with users selected topics.

For example view all recent relevant publications on Epigenetics and associated publications and clincial trials.

Showing PubMed Articles 26–50 of 31,000+


Fertility: The Role of mTOR Signaling and KIT Ligand.

Activation of a limited pool of diminishing ovarian follicles determines women's reproductive lifespan. A recent rodent study describes the role of mTOR signaling and KIT ligand in granulosa cells of primordial follicles for follicle activation and for reproductive lifespan regulation.


Fish Vision: Size Selectivity in the Zebrafish Retinotectal Pathway.

A recent study has shown that the zebrafish tectum processes inputs from the retina tuned to ethologically relevant size classes, suggesting a role for the tectum in selecting approach or avoidance behaviours based on size-based categorization of visual targets.


Food for thought.


Front cover.


Functional normalization of 450k methylation array data improves replication in large cancer studies.

We propose an extension to quantile normalization that removes unwanted technical variation using control probes. We adapt our algorithm, functional normalization, to the Illumina 450k methylation array and address the open problem of normalizing methylation data with global epigenetic changes, such as human cancers. Using data sets from The Cancer Genome Atlas and a large case-control study, we show that our algorithm outperforms all existing normalization methods with respect to replication of results bet...


Formation of Hydrogen Sulfide from Cysteine in Saccharomyces cerevisiae BY4742: Genome Wide Screen Reveals a Central Role of the Vacuole.

Discoveries on the toxic effects of cysteine accumulation and, particularly, recent findings on the many physiological roles of one of the products of cysteine catabolism, hydrogen sulfide (H2S), are highlighting the importance of this amino acid and sulfur metabolism in a range of cellular activities. It is also highlighting how little we know about this critical part of cellular metabolism. In the work described here, a genome-wide screen using a deletion collection of Saccharomyces cerevisiae revealed a ...


Facile synthesis and enhanced ultraviolet emission of ZnO nanorods prepared by vapor-confined face-to-face annealing.

In this study, we report a novel regrowth method of sol-gel prepared ZnO films using a vapor-confined face-to-face annealing (VC-FTFA) technique, in which mica was inserted between two films, followed by annealing with the FTFA method. The ZnO nanorods are regrown when zinc acetate dihydrate and zinc chloride (ZnCl2) are used as the solvent, because these generate ZnCl2 vapor. The near-band-edge emission intensity of the ZnO nanorods was enhanced through the VC-FTFA method, increasing significantly by a fac...


Frequency of antibodies against Sarcocystis neurona and Neospora caninum in domestic cats in the state of Bahia, Brazil.

Sarcocystis neurona is the major agent of equine protozoal myeloencephalitis. It infects several mammalian species in the Americas, where the definitive hosts, marsupials of the genus Didelphis (D. virginiana and D. albiventris) are found. Domestic cats are one of the confirmed intermediate hosts of the parasite; however, antibodies against S. neurona had never before been demonstrated in Brazilian cats. The aim of this study was to determine whether cats in Bahia, Brazil, are exposed to the parasite. A tot...


Fluence-to-effective dose conversion coefficients from a Saudi population based phantom for monoenergetic photon beams from 10 keV to 20 MeV.

Fluence-to-dose conversion coefficients are important quantities for radiation protection, derived from Monte Carlo simulations of the radiation particles through a stylised phantom or voxel based phantoms. The voxel phantoms have been developed for many ethnic groups for their accurate reflection of the anatomy. In this study, we used the Monte Carlo code MCNPX to calculate the photon fluence-to-effective dose conversion coefficients with a voxel phantom based on the Saudi Arabian male population. Six irra...


Foreseeable Risks? Informed Consent for Studies within the Standard of Care.

More than 1400 babies were born prematurely in the United States every day in 2005, according to the Centers for Disease Control and Prevention, and neonatologists still weren't sure how much oxygen to give them. More than 50 years of research had offered some answers, but critical questions remained: too high an oxygen level was known to carry an increased risk of retinopathy, but what was the ideal target saturation? American Academy of Pediatrics guidelines recommended maintaining oxygen saturations betw...


Factors Associated with Durable Response to Infliximab in Crohn's Disease 5 Years and Beyond: A Multicenter International Cohort.

Infliximab (IFX) has been used for over a decade worldwide. Less is known about the natural history of IFX use beyond a few years and which patients are more likely to sustain benefits.

Wednesday 27th November 1128

Ferrets exclusively synthesize Neu5Ac and express naturally humanized influenza A virus receptors.

Mammals express the sialic acids N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc) on cell surfaces, where they act as receptors for pathogens, including influenza A virus (IAV). Neu5Gc is synthesized from Neu5Ac by the enzyme cytidine monophosphate-N-acetylneuraminic acid hydroxylase (CMAH). In humans, this enzyme is inactive and only Neu5Ac is produced. Ferrets are susceptible to human-adapted IAV strains and have been the dominant animal model for IAV studies. Here we show that ferr...

Tuesday 1st October 1128

Front cover.

Tuesday 17th September 1128

First Occurrence of Platycladus from the Upper Miocene of Southwest China and Its Phytogeographic Implications.

Platycladus Spach is native to Central China, but its natural occurrences are very difficult to establish. According to molecular phylogenetic data, this genus might have originated since the Oligocene, but no fossil record has been reported. Here, we describe eight foliage branches from the upper Miocene in western Yunnan, Southwest China as a new species, P. yunnanensis sp. nov., which is characterized by foliage branches spread in flattened sprays, and leaves decussate, imbricate, scale-like and dimorphi...

Tuesday 30th July 1128

Factors correlated with tuberculosis reported after death.


Sunday 21st July 1128

Failure of the MGIT(TM) 960 culture system in the detection of Mycobacterium tuberculosis.

Wednesday 15th May 1128

Fatigue affects peak joint torque angle in hamstrings but not in quadriceps.

Abstract Primary aim of this study was to investigate peak joint torque angle (i.e. the angle of peak torque) changes recorded during an isokinetic test before and after a fatiguing soccer match simulation. Secondarily we want to investigate functional Hecc:Qconc and conventional Hconc:Qconc ratio changes due to fatigue. Before and after a standardised soccer match simulation, twenty-two healthy male amateur soccer players performed maximal isokinetic strength tests both for hamstrings and for quadriceps mu...

Wednesday 8th May 1128

Filamentous hemagglutinin of Bordetella pertussis: a key adhesin with immunomodulatory properties?

ABSTRACT  The filamentous hemagglutinin of pathogenic Bordetellae is a prototype of a large two-partner-system-secreted and β-structure-rich bacterial adhesin. It exhibits several binding activities that may facilitate bacterial adherence to airway mucosa and host phagocytes in the initial phases of infection. Despite three decades of research on filamentous hemagglutinin, there remain many questions on its structure-function relationships, integrin interactions and possible immunomodulatory signaling ca...

Monday 8th April 1128

Factors associated with satisfaction at work in Psychosocial Care Centers.

to analyze the prevalence of satisfaction at work and identify associated factors in Psychosocial Care Centers.

Wednesday 20th March 1128

Fibrosing Cholestatic Hepatitis C After Hematopoietic Cell Transplantation: Report of 3 Fatal Cases.

Development of liver disease after hematopoietic cell transplantation is common and the causes diverse. Infection by hepatitis C virus (HCV) can be seen in patients who are chronically infected before transplant or from passage of virus from an infected donor; the normal 10-year course of hepatitis C after transplant is one of waxing and waning of serum aminotransferase enzymes, with little morbidity. In the series of 3 patients reported here, the course of hepatitis C was rapidly fatal, with the onset of j...

Sunday 7th January 1128

Fetuin-A is related to syndesmophytes in patients with ankylosing spondylitis: a case control study.

New bone formation is one of the hallmark characteristics of ankylosing spondylitis, which is thereby associated with syndesmophytes. Fetuin-A is a molecule that is abundantly found in calcified tissues and it shows high affinity for calcium phosphate minerals and related compounds. Considering the role of fetuin-A in the regulation of calcified matrix metabolism, we compared the fetuin-A levels in ankylosing spondylitis patients with syndesmophytes with those in patients without syndesmophytes and in healt...


Foxc1 dependent mesenchymal signalling drives embryonic cerebellar growth.

Loss of Foxc1 is associated with Dandy-Walker malformation, the most common human cerebellar malformation characterized by cerebellar hypoplasia and an enlarged posterior fossa and fourth ventricle. Although expressed in the mouse posterior fossa mesenchyme, loss of Foxc1 non-autonomously induces a rapid and devastating decrease in embryonic cerebellar ventricular zone radial glial proliferation and concurrent increase in cerebellar neuronal differentiation. Subsequent migration of cerebellar neurons is dis...


Freshness-Preserving Non-Interactive Hierarchical Key Agreement Protocol over WHMS.

The digitization of patient health information (PHI) for wireless health monitoring systems (WHMSs) has brought many benefits and challenges for both patients and physicians. However, security, privacy and robustness have remained important challenges for WHMSs. Since the patient's PHI is sensitive and the communication channel, i.e., the Internet, is insecure, it is important to protect them against unauthorized entities, i.e., attackers. Otherwise, failure to do so will not only lead to the compromise of ...


Foreign body aspiration: an urgent airway condition.

This study aims to investigate demographic features, type and localization of foreign bodies, mean hospitalization duration, and peri- and postoperative complication ratios of patients with foreign body aspiration.


Fracture of the glenoid fossa without mandibular condylar dislocation or fracture: two case reports.

The mandibular condyle region which protects the middle cranial fossa from facial and jaw traumas has an excellent osteomuscular structure. Condylar structures reduce or limit the force of trauma. Most importantly, the condylar neck is the weakest part of the mandible and is easily fractured without dislocation. Generally, this mechanism prevents condylar penetration into the middle cranial fossa; however, there are condylar penetration into the middle cranial fossa can be rarely. Glenoid fossa fractures wi...

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