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08:15 EDT 29th August 2014 | BioPortfolio

The US National Library of Medicine and National Institutes of Health manage which comprises of more than 21 million records, papers, reports for biomedical literature, including MEDLINE, life science and medical journals, articles, reviews, reports and  books.  BioPortfolio aims to publish relevant information on published papers, clinical trials and news associated with users selected topics.

For example view all recent relevant publications on Epigenetics and associated publications and clincial trials.

Showing PubMed Articles 26–50 of 29,000+


FTIR Studies of Metal Ligands, Networks of Hydrogen Bonds, and Water Molecules near the Active Site Mn4CaO5 Cluster in Photosystem II.

The photosynthetic conversion of water to molecular oxygen is catalyzed by the Mn4CaO5 cluster in Photosystem II and provides nearly our entire supply of atmospheric oxygen. The Mn4CaO5 cluster accumulates oxidizing equivalents in response to light-driven photochemical events within Photosystem II and then oxidizes two molecules of water to oxygen. The Mn4CaO5 cluster converts water to oxygen much more efficiently than any synthetic catalyst because its protein environment carefully controls the cluster's r...


Febrile Young Infants with Altered Urinalysis at Low Risk for Invasive Bacterial Infection. A Spanish Pediatric Emergency Research Network's Study.

Urinary tract infection (UTI) is the most common serious bacterial infection in infants less than 90 days of age. Many physicians admit infants younger than 90 days old because of their greater risk of developing invasive bacterial infections (IBI), secondary to UTI. The primary objective of this study was to design a prediction model to identify febrile infants less than 90 days old with an altered urinalysis who were at low risk for IBI and suitable for outpatient management METHODS:: Prospective multicen...


Fibrin-genipin adhesive hydrogel for annulus fibrosus repair: performance evaluation with large animal organ culture, in situ biomechanics, and in vivo degradation tests.

Annulus fibrosus (AF) defects from annular tears, herniation, and discectomy procedures are associated with painful conditions and accelerated intervertebral disc (IVD) degeneration. Currently, no effective treatments exist to repair AF damage, restore IVD biomechanics and promote tissue regeneration. An injectable fibrin-genipin adhesive hydrogel (Fib-Gen) was evaluated for its performance repairing large AF defects in a bovine caudal IVD model using ex vivo organ culture and biomechanical testing of motio...


Fluid therapy and iatrogenic hyponatraemia risk in children hospitalised with acute gastroenteritis: prospective study.

Objective: The purpose of this study is to analyse whether the use of hypotonic fluids increases the risk of iatrogenic hyponatraemia in children hospitalised with acute gastroenteritis (AGE). Patients and methods: Prospective study carried out on 205 patients with ages ranging from 1 to 28 months and admitted with a diagnosis of mild or moderate dehydration due to AGE and treated with intravenous hypotonic fluids in a paediatric department in Madrid (Spain). The degree of dehydration at presentation was es...


Frameless neuronavigation based only on 3D digital subtraction angiography using surface-based facial registration.

Object Cerebrovascular lesions can have complicated abnormal anatomy that is not completely characterized by CT or MR angiography. Although 3D rotational angiography provides superior spatial and temporal resolution, catheter angiograms are not easily registered to the patient, limiting the use of these images as a source for neuronavigation. However, 3D digital subtraction angiography (DSA) contains not only vascular anatomy but also facial surface anatomy data. The authors report a novel technique to regi...


Fabrication of Nitrogen-Modified Annealed Nanodiamond with Improved Catalytic Activity.

Annealed ultra-dispersed nanodiamond (ADD) with sp2 curved concentric graphitic shells is an interesting material consisting of the remarkable surface properties of graphene-based nanomaterials and the intrinsic properties of a diamond core. In this case, based on its specific properties and surface oxygen functional groups, nitrogen-modified ADD powders have been tunably synthesized via three different preparation methods in a calcination treatment process. The detailed formation and dynamic behaviors of t...


Factors Associated with Four or More Antenatal Care Visits and Its Decline among Pregnant Women in Tanzania between 1999 and 2010.

In Tanzania, the coverage of four or more antenatal care (ANC 4) visits among pregnant women has declined over time. We conducted an exploratory analysis to identify factors associated with utilization of ANC 4 and ANC 4 decline among pregnant women over time. We used data from 8035 women who delivered within two years preceding Tanzania Demographic and Health Surveys conducted in 1999, 2004/05 and 2010. Multivariate logistic regression models were used to examine the association between all potential facto...


Food Fortification and Supplement Use - Are there Health Implications?

Abstract Dietary supplements are a multi-billion dollar industry in the U.S., and their use is increasing exponentially. Additionally, many foods and beverages are increasingly being fortified with single or multiple vitamins and minerals. Consequently, nutrient intakes are exceeding the safe limits established by the Institute of Medicine. In this paper, we examine the benefits and drawbacks of vitamin and mineral supplements and increasing consumption of fortified foods (in addition to dietary intake) in...


Facile Deposition of YSZ-Inverse Photonic Glass Films.

An alternative all-colloidal and single-step deposition method of yttrium-stabilized zirconia (YSZ)-infiltrated polymeric photonic glass films is presented. Heterocoagulation of oppositely charged polystyrene (PS) microspheres and YSZ nanocrystals in aqueous dispersions created PS/YSZ core-shell spheres. These composite particles were deposited on glass substrates by a simple drop-coating process. Heterocoagulation impaired self-assembly of the particles, resulting in a disordered structure. Burn-out of the...


Fecal Microbiota Transplantation for Treatment of Clostridium difficile Infection.

Sunday 13th December 1056

Flexibility of PCNA-Protein Interface Accommodates Differential Binding Partners.

The expanding roles of PCNA in functional assembly of DNA replication and repair complexes motivated investigation of the structural and dynamic properties guiding specificity of PCNA-protein interactions. A series of biochemical and computational analyses were combined to evaluate the PIP Box recognition features impacting complex formation. The results indicate subtle differences in topological and molecular descriptors distinguishing both affinity and stoichiometry of binding among PCNA-peptide complexes...

Monday 9th November 1056

Fluctuations of an exposed π-helix involved in lipoxygenase substrate recognition.

ABSTRACT The second helix in lipoxygenases adapts to permit substrate access to the active site, but details of this process are varied and poorly understood. We therefore examined dynamics of helix 2 in solutions of spin-labeled soybean lipoxygenase-1 and spin relaxation at 60K of the spin labels by catalytic iron. Helix 2 in soybean lipoxygenase structures is surface exposed and contains one turn of π-helix, centrally located. A site-directed spin label scan of 18 of the 21 helix 2 residues, and EPR, sho...

Sunday 8th November 1056

Function Preservation After Conservative Resection and Radiotherapy for Soft-tissue Sarcoma of the Distal Extremity: Utility and Application of the Toronto Extremity Salvage Score (TESS).

To evaluate outcomes after conservative resection and radiotherapy (RT) for soft-tissue sarcoma (STS) of the distal extremity, with assessment of functional quality of life using the validated Toronto Extremity Salvage Score (TESS) questionnaire and Common Terminology Criteria for Adverse Events (CTCAE), v4.0.

Monday 26th October 1056

Fusion of an intact secretory protein permits a misfolded protein to exit from the endoplasmic reticulum in yeast.

Upon exit from the endoplasmic reticulum (ER), the nascent polypeptides of secretory proteins undergo sorting events. If properly folded, they are directly or indirectly recognized by the coat proteins of budding vesicles for forward transport, while unfolded or misfolded proteins are retained in the ER by a quality control mechanism. To gain insight into the interplay between ER export and ER quality control, we fused a secretory protein invertase to the C-terminus of mutated carboxypeptidase Y (CPY*), a m...

Saturday 17th October 1056

Formation by yeast of 2-furanmethanethiol and ethyl 2-mercaptopropionate aroma compounds in Japanese soy sauce.

Two aroma compounds of volatile thiols, 2-furanmethanethiol (2FM) and ethyl 2-mercaptopropionate (ET2MP), were formed in five types of Japanese soy sauce during fermentation by yeast. The concentrations of 2FM and ET2MP in the soy sauce samples increased during alcoholic fermentation. The concentrations of 2FM and ET2MP were higher in the soy sauce fermented by Zygosaccharomyces rouxii than in that fermented by Candida versatilis. The enantiomers of ET2MP were separated by gas chromatography in a capillary...

Wednesday 17th June 1056

From Thiol to Sulfonic Acid: Modelling the Oxidation Pathway of Protein Thiols by Hydrogen Peroxide.

Hydrogen peroxide is a natural oxidant that can oxidize protein thiols (\ce{RSH}) via sulfenic acid (\ce{RSOH}) and sulfinic acid (\ce{RSO2H}) to sulfonic acid (\ce{RSO3H}). In this paper, we study the complete anionic and neutral oxidation pathway from thiol to sulfonic acid. Reaction barriers and reaction free energies for all three oxidation steps are computed, both for the isolated substrates and for the substrates in the presence of different model ligands (\ce{CH4}, \ce{H2O}, \ce{NH3}) mimicking the e...

Tuesday 5th May 1056

Familial idiopathic small-bowel and colonic varices in three siblings.

Idiopathic small-bowel and colonic varices are a rare source of bleeding from the gastrointestinal tract. To date there are only eight published case series of familial idiopathic small-bowel and colonic varices. We present a case series detailing three affected siblings who presented with significant lower gastrointestinal bleeding and had multiple varices on endoscopy and imaging. Though not confirmed, consanguinity in the parents suggests an autosomal recessive mode of inheritance. We summarize the liter...

Sunday 29th March 1056

Felbamate as an add-on therapy for refractory epilepsy.

This review is an update of a previously published review in The Cochrane Database of Systematic Reviews (Issue 1, 2011) on 'Felbamate as an add-on therapy for refractory epilepsy'. Epilepsy is a chronic and disabling neurologic disorder, affecting approximately 1% of the population. Up to 30% of people with epilepsy have seizures that are resistant to currently available drugs. Felbamate is one of the second-generation antiepileptic drugs and its effects as an add-on therapy to standard drugs are assessed...

Monday 24th February 1056

Factors Underlying the Psychological and Behavioral Characteristics of Office of Strategic Services Candidates: The Assessment of Men Data Revisited.

During World War II, the Office of Strategic Services (OSS), the forerunner of the Central Intelligence Agency, sought the assistance of clinical psychologists and psychiatrists to establish an assessment program for evaluating candidates for the OSS. The assessment team developed a novel and rigorous program to evaluate OSS candidates. It is described in Assessment of Men: Selection of Personnel for the Office of Strategic Services (OSS Assessment Staff, 1948). This study examines the sole remaining multiv...

Sunday 23rd February 1056

Fat-Tailed Fluctuations in the Size of Organizations: The Role of Social Influence.

Organizational growth processes have consistently been shown to exhibit a fatter-than-Gaussian growth-rate distribution in a variety of settings. Long periods of relatively small changes are interrupted by sudden changes in all size scales. This kind of extreme events can have important consequences for the development of biological and socio-economic systems. Existing models do not derive this aggregated pattern from agent actions at the micro level. We develop an agent-based simulation model on a social n...

Monday 27th January 1056

Fusion imaging of real-time ultrasonography with CT or MRI for hepatic intervention.

With the technical development of ultrasonography (US), electromagnetic tracking-based fusion imaging of real-time US and computed tomography/magnetic resonance (CT/MR) images has been used for percutaneous hepatic intervention such as biopsy and radiofrequency ablation (RFA). Because of the fusion imaging technique, the fused CT or MR images show the same plane and move synchronously while performing real-time US. With this information, fusion imaging can enhance lesion detectability and reduce the false p...


Field analyses of (238)U and (226)Ra in two uranium mill tailings piles from Niger using portable HPGe detector.

The radioactivities of (238)U and (226)Ra in mill tailings from the U mines of COMINAK and SOMAÏR in Niger were measured and quantified using a portable High-Purity Germanium (HPGe) detector. The (238)U and (226)Ra activities were measured under field conditions on drilling cores with 600s measurements and without any sample preparation. Field results were compared with those obtained by Inductive Coupled Plasma Atomic Emission Spectroscopy (ICP-AES) and emanometry techniques. This comparison indicates tha...


Forced expression of FLO11 confers pellicle-forming ability and furfural tolerance on Saccharomyces cerevisiae in ethanol production.

We constructed a plasmid that expresses FLO11 encoding a cell surface glycoprotein of Saccharomyces cerevisiae under the control of a constitutive promoter. This plasmid conferred pellicle-forming ability on the non-pellicle-forming industrial strain of S. cerevisiae at the air-liquid interface of the glucose-containing liquid medium. The induced pellicle-forming cells exhibited tolerance to furfural, which is a key toxin in lignocellulosic hydrolysates, in ethanol production.


Full-dimensional Quantum Dynamics of Vibrationally Mediated Photodissociation of NH3 and ND3 on Coupled Ab Initio Potential Energy Surfaces: Absorption Spectra and NH2(A(2)A1 )/NH2(X(2)B1) Branching Ratios.

Vibrationally mediated photodissociation of NH3 and ND3 in the A band allows the exploration of the excited state potential energy surface in regions that are not accessible from the ground vibrational state of these polyatomic systems. Using our recently developed coupled ab initio potential energy surfaces in a quasi-diabatic representation, we report here a full-dimensional quantum characterization of the absorption spectra for vibrationally excited NH3 and ND3 and the corresponding non-adiabatic dissoci...


Fabrication of magnetic porous Fe-Mn binary oxide nanowires with superior capability for removal of As(III) from water.

Magnetic porous Fe-Mn binary oxide nanowires were successfully fabricated to efficient removal of As(III) from water. The adsorption capacity of the porous nanowires for As(III) obviously increased with increasing of manganese oxide in the composite, accompanying decrease of the saturation magnetization of the adsorbents. Magnetic porous Fe-Mn binary oxide nanowires with an initial Fe:Mn molar ratio of 1:3 exhibited the highest absorption capacity for As(III) and enable magnetic separation from water. The m...

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