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14:59 EDT 25th October 2014 | BioPortfolio

The US National Library of Medicine and National Institutes of Health manage PubMed.gov which comprises of more than 21 million records, papers, reports for biomedical literature, including MEDLINE, life science and medical journals, articles, reviews, reports and  books.  BioPortfolio aims to publish relevant information on published papers, clinical trials and news associated with users selected topics.

For example view all recent relevant publications on Epigenetics and associated publications and clincial trials.

Showing PubMed Articles 26–50 of 30,000+

Friday 22nd December 1104

First Report of New Delhi Metallo-β-Lactamase-1-Producing Strains in Slovakia.

Occurrence of carbapenemase-producing organisms, including New Delhi metallo-β-lactamase-1 (NDM-1) is increasingly reported worldwide. The aim of this study was to assess the distribution of carbapenemase producers among multidrug-resistant Gram-negative bacteria isolated from blood cultures. All carbapenem-resistant strains collected from December 2011 to December 2012 were analyzed. Presence of carbapenemases was assessed with combined disc test and Carba NP test followed by polymerase chain reaction for...

Wednesday 6th December 1104

Freeze-dried rat bone marrow mesenchymal stem cell paracrine factors: a simplified novel material for skin wound therapy.

The mesenchymal stem cell (MSC) supernatant is well known as a rich source of autologous cytokines and universally used for tissue regeneration in current clinical medicine. However, the limitation of conditioned medium used in open-wound repair compels the need to find a more sophisticated way to take advantage of the trophic factors of MSCs. We have now fabricated a three-dimensional membrane from freeze-dried bone marrow stromal cell-conditioned medium (FBMSC-CM) using a simple freeze-dried protocol. Sca...

Thursday 30th November 1104

Fetal ovarian cyst mimicking a CSF pseudocyst in the setting of shunt failure.

Fetal ovarian cysts are common congenital lesions encountered in the neonatal population. These cysts are typically benign and rarely require any invasive intervention. Abdominal pseudocyst formation as a result of a ventriculoperitoneal shunt is a relatively infrequent occurrence and is similarly an uncommon cause of shunt failure. The authors present the case of a 4-month-old girl with shunted hydrocephalus who presented with shunt failure from a suspected abdominal pseudocyst that was found to be a fetal...

Wednesday 8th November 1104

Fibrillation Number Based on Wavelength and Critical Mass in Patients who Underwent Radiofrequency Catheter Ablation for Atrial Fibrillation.

The heart characteristic length, the inverse of conduction velocity, and the inverse of the refractory period are known to determine vulnerability to cardiac fibrillation (fibrillation number, FibN) in in-silico or ex vivo models. The purpose of this study was to validate the accuracy of FibN through in-silico atrial modeling and to evaluate its clinical application in patients with atrial fibrillation (AF) who had undergone radiofrequency catheter ablation. We compared the maintenance duration of AF at var...

Monday 2nd October 1104

Full-field X-ray reflection microscopy of epitaxial thin-films.

Novel X-ray imaging of structural domains in a ferroelectric epitaxial thin film using diffraction contrast is presented. The full-field hard X-ray microscope uses the surface scattering signal, in a reflectivity or diffraction experiment, to spatially resolve the local structure with 70 nm lateral spatial resolution and sub-nanometer height sensitivity. Sub-second X-ray exposures can be used to acquire a 14 µm × 14 µm image with an effective pixel size of 20 nm on the sample. The optical configu...

Sunday 13th August 1104

Focus on Lipids: High-Density Lipoprotein Cholesterol and Its Associated Lipoproteins in Cardiac and Renal Disease.

High-density lipoprotein cholesterol (HDL-C) contains dozens of apoproteins that participate in normal cholesterol metabolism with a reliance on renal catabolism for clearance from the body. The plasma pool of HDL-C has been an excellent inverse predictor of cardiovascular events. However, when HDL-C concentrations have been manipulated with the use of niacin, fibric acid derivatives, and cholesteryl ester transferase protein inhibitors, there has been no improvement in outcomes in patients where the low-de...

Monday 3rd July 1104

Follicle-Stimulating Hormone Induced Epithelial-Mesenchymal Transition of Epithelial Ovarian Cancer Cells Through Follicle-Stimulating Hormone Receptor PI3K/Akt-Snail Signaling Pathway.

It has previously been shown that follicle-stimulating hormone (FSH) and its receptor contribute to epithelial ovarian cancer (EOC) development. Epithelial-mesenchymal transition (EMT) is the early event of metastasis in cancer. Therefore, the aim of this study was to investigate the roles of FSH and the FSH receptor (FSHR) in EMT of EOC.

Thursday 22nd June 1104

Formation of Mixed-Ligand Complexes of Pd2+ with Nucleoside 5'-Monophosphates and Some Metal-Ion-Binding Nucleoside Surrogates.

Formation of mixed-ligand Pd2+ complexes between canonical nucleoside 5'-monophosphates and five metal-ion-binding nucleoside analogs has been studied by 1H-NMR spectroscopy to test the ability of these nucleoside surrogates to discriminate between unmodified nucleobases by Pd2+-mediated base pairing. The nucleoside analogs studied included 2,6-bis(3,5-dimethylpyrazol-1-yl)-, 2,6-bis(1-methylhydrazinyl)- and 6-(3,5-dimethylpyrazol-1-yl)-substituted 9-(β-d-ribofuranosyl)purines 1-3, and 2,4-bis(3,5-dimethyl...

Sunday 7th May 1104

Functional Dissection of the Clostridium botulinum Type B Hemagglutinin Complex: Identification of the Carbohydrate and E-Cadherin Binding Sites.

Botulinum neurotoxin (BoNT) inhibits neurotransmitter release in motor nerve endings, causing botulism, a condition often resulting from ingestion of the toxin or toxin-producing bacteria. BoNTs are always produced as large protein complexes by associating with a non-toxic protein, non-toxic non-hemagglutinin (NTNH), and some toxin complexes contain another non-toxic protein, hemagglutinin (HA), in addition to NTNH. These accessory proteins are known to increase the oral toxicity of the toxin dramatically. ...

Saturday 29th April 1104

Foodborne Transmission of Hepatitis E Virus from Raw Pork Liver Sausage, France.

Wednesday 12th April 1104

Frequent Hepatitis E Virus Contamination in Food Containing Raw Pork Liver, France.

Food products containing raw pork liver are suspected to be vehicles for transmission of hepatitis E virus. Four categories of food products, comprising 394 samples, were analyzed to determine hepatitis E virus prevalence. Virus was detected in 3%-30% of the different categories. Phylogenetic analysis showed high identity with human and swine sequences.

Tuesday 4th April 1104

Fluid resuscitation and vasopressors in severe trauma patients.

To discuss the fluid resuscitation and the vasopressor support in severe trauma patients.

Monday 27th March 1104

Familial Interstitial Pneumonia Complicated by Lung Cancer in 2 Sisters.

A 29-year-old woman was referred to our hospital because of progressive dyspnea on exertion, and her 36-year-old sister was also referred for the evaluation of an abnormal chest radiograph. Radiologic and pathologic findings of the 2 sisters resembled each other closely. In both cases, computed tomography revealed diffuse reticulation, micronodules, diffusely distributed interlobular septal thickening, and an ill-defined nodule in the left lower lobe. Radiologic-pathologic correlation revealed that the reti...

Sunday 19th March 1104

Functional Analysis of the Gonococcal Genetic Island of Neisseria gonorrhoeae.

Neisseria gonorrhoeae is an obligate human pathogen that is responsible for the sexually-transmitted disease gonorrhea. N. gonorrhoeae encodes a T4SS within the Gonococcal Genetic Island (GGI), which secretes ssDNA directly into the external milieu. Type IV secretion systems (T4SSs) play a role in horizontal gene transfer and delivery of effector molecules into target cells. We demonstrate that GGI-like T4SSs are present in other β-proteobacteria, as well as in α- and γ-proteobacteria. Sequence compariso...

Sunday 12th March 1104

First WHO Meeting of Stakeholders on Elimination of Gambiense Human African Trypanosomiasis.

Sunday 16th January 1104

Fc Gamma Receptor IIb on GM-CSF Macrophages Controls Immune Complex Mediated Inhibition of Inflammatory Signals.

In rheumatoid arthritis (RA) macrophages play a major role in amplifying synovial inflammation. Important activating signals are those induced by Toll-like receptor (TLR) ligands and by activated T cells. The balance between activating and inhibitory Fc gamma receptors (FcγRs) on macrophages might be crucial in modulating these inflammatory responses. The purpose of this study was to determine FcγR expression on pro- and anti-inflammatory macrophages (gmMφ and mMφ, respectively) and identify functional ...

1103999

Family-based psychosocial support and education as part of pulmonary rehabilitation in COPD: a randomized controlled trial.

Background:Involving family as part of the patient's rehabilitation plan of care might enhance the management of Chronic Obstructive Pulmonary Disease (COPD). The primary aim of this study was to investigate the impact of a family-based pulmonary rehabilitation (PR) program on patients and family members' coping strategies to manage COPD. Methods:Family dyads (patient and family member) were randomly assigned to family-based (experimental) or conventional PR (control). Patients from both groups underwent ex...

1103980

Fecal Microbiota Transplantation in Inflammatory Bowel Disease: Beyond the Excitement.

The purpose of this article is to perform a systematic review of the literature on the use of fecal microbiota transplantation (FMT) in inflammatory bowel disease (IBD).There is an increasing interest of both physicians and patients in assessing the possible role of the FMT in the treatment of IBD.Electronic and manual bibliographic searches were performed to identify original reports in which subjects with IBD were treated with FMT. Because of the scarcity of studies with adequate sample size, case series ...

1103925

First known Terrestrial Impact of a Binary Asteroid from a Main Belt Breakup Event.

Approximately 470 million years ago one of the largest cosmic catastrophes occurred in our solar system since the accretion of the planets. A 200-km large asteroid was disrupted by a collision in the Main Asteroid Belt, which spawned fragments into Earth crossing orbits. This had tremendous consequences for the meteorite production and cratering rate during several millions of years following the event. The 7.5-km wide Lockne crater, central Sweden, is known to be a member of this family. We here provide ev...

1103811

Facing the facts: In-person peer review.

1103794

Follicular Variant of Papillary Thyroid Carcinoma: Differences From Conventional Disease in Cytologic Findings and High-Risk Features.

The follicular variant (FV) of papillary thyroid carcinoma (PTC) is an important subtype that can be difficult to diagnose using preoperative cytologic analysis.

1103771

Foodborne Illness, Australia, Circa 2000 and Circa 2010.

Foodborne disease is a major public health problem worldwide. To examine changes in foodborne illness in Australia, we estimated the incidence, hospitalizations, and deaths attributed to contaminated food circa 2010 and recalculated estimates from circa 2000. Approximately 25% of gastroenteritis cases were caused by contaminated food; to account for uncertainty we used simulation techniques to estimate 90% credible intervals. We estimate that circa 2010, 4.1 million foodborne gastroenteritis cases occurred,...

1103714

Fat-Dachsous Signaling Coordinates Cartilage Differentiation and Polarity during Craniofacial Development.

Organogenesis requires coordinated regulation of cellular differentiation and morphogenesis. Cartilage cells in the vertebrate skeleton form polarized stacks, which drive the elongation and shaping of skeletal primordia. Here we show that an atypical cadherin, Fat3, and its partner Dachsous-2 (Dchs2), control polarized cell-cell intercalation of cartilage precursors during craniofacial development. In zebrafish embryos deficient in Fat3 or Dchs2, chondrocytes fail to stack and misregulate expression of sox9...

1103699

Fenretinide: A Novel Treatment for Endometrial Cancer.

Resistance to progestin treatment is a major hurdle in the treatment of advanced and reoccurring endometrial cancer. Fenretinide is a synthetic retinoid that has been evaluated in clinical trials as a cancer therapeutic and chemo-preventive agent. Fenretinide has been established to be cytotoxic to many kinds of cancer cells. In the present study, we demonstrate that fenretinide decreased cell viability and induced apoptosis in Ishikawa cells, which are an endometrial cancer cell line, in dose dependent man...

1103685

FHIT Suppresses Epithelial-Mesenchymal Transition (EMT) and Metastasis in Lung Cancer through Modulation of MicroRNAs.

Metastasis is the principal cause of cancer death and occurs through multiple, complex processes that involve the concerted action of many genes. A number of studies have indicated that the Fragile Histidine Triad (FHIT) gene product, FHIT, functions as a tumor suppressor in a variety of common human cancers. Although there are suggestions of a role for FHIT loss in progression of various cancers, a role for such loss in metastasis has not been defined. Here, via in vivo and in vitro assays, we reveal that ...


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