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08:21 EST 28th November 2014 | BioPortfolio

The US National Library of Medicine and National Institutes of Health manage which comprises of more than 21 million records, papers, reports for biomedical literature, including MEDLINE, life science and medical journals, articles, reviews, reports and  books.  BioPortfolio aims to publish relevant information on published papers, clinical trials and news associated with users selected topics.

For example view all recent relevant publications on Epigenetics and associated publications and clincial trials.

Showing PubMed Articles 51–75 of 947

Saturday 1st November 1050

YAP activation is an early event and a potential therapeutic target in liver cancer development.

Although the growth suppressor Hippo pathway has been implicated in hepatocellular carcinoma (HCC) pathogenesis, it is unknown at which stage of hepatocarcinogenesis its dysregulation occurs. We investigated in early rat and human preneoplastic lesions whether overexpression of the transcriptional co-activator Yes-associated protein (YAP) is an early event.


Young Physicians' Thoughts about Leaving Patient Care - Results of a Survey in Saxony, Germany.

Background: The fear of a shortage of physicians in some regions of Germany is growing. A drain of physicians into non-clinical activities is being discussed as a possible reason. To counteract this drain the extent of physicians' thinking about leaving patient care and the corresponding reasons need to be elucidated. Methods: All physicians upto 40 years of age and registered with the State Chamber of Physicians of Saxony (n=5 956) received a paper-pencil questionnaire inquiring about socio-demographics,...


Youth Mental Health Interventions via Mobile Phones: A Scoping Review.

Abstract Mobile phone technologies have been hailed as a promising means for delivering mental health interventions to youth and adolescents, the age group with high cell phone penetration and with the onset of 75% of all lifetime mental disorders. Despite the growing evidence in physical health and adult mental health, however, little information is available about how mobile phones are implemented to deliver mental health services to the younger population. The purpose of this scoping study was to map the...


You spoke, and we listened: we're growing!


Yoga as an adjunctive treatment for posttraumatic stress disorder: a randomized controlled trial.

More than a third of the approximately 10 million women with histories of interpersonal violence in the United States develop posttraumatic stress disorder (PTSD). Currently available treatments for this population have a high rate of incomplete response, in part because problems in affect and impulse regulation are major obstacles to resolving PTSD. This study explored the efficacy of yoga to increase affect tolerance and to decrease PTSD symptomatology.

Friday 11th December 1045

YASARA View - molecular graphics for all devices - from smartphones to workstations.

Today's graphics processing units (GPUs) compose the scene from individual triangles. Since about 320 triangles are needed to approximate a single sphere - an atom - in a convincing way, visualizing larger proteins with atomic details requires tens of millions of triangles, far too many for smooth interactive frame rates. We describe a new approach to solve this 'molecular graphics problem', which shares the work between GPU and multiple CPU cores, generates high quality results with perfectly round spheres...


Years of life lost as a measure of cancer burden on a national level.

Background:The severity of cancers is often measured in number of deaths. However, number of years of life lost (YLL) may be a more appropriate indicator of impact on society. Here we have calculated the YLL of adult cancers in Norway for the year 2012, as well as for the previous 15-year period.Methods:Data on age composition, expected remaining years of life, total numbers of deaths and deaths due to cancer were retrieved from the National Census Agency Statistics Norway. YLL were calculated for both sexe...

Wednesday 22nd October 1044

Y-stent-assisted coil embolization of cerebral aneurysms.

Y-stent-assisted coiling is a technique used by neuroendovascular surgeons to treat complex, wide-necked, bifurcation aneurysms in locations such as basilar tip and middle cerebral artery bifurcation. Several recent studies have demonstrated low complication rate and favorable clinical and angiographic outcomes. The Y-stent technique is illustrated here in detail and the intraoperative nuances are also discussed to minimize potential complications associated with technique. The video can be found here: http...

Monday 23rd April 1043

Young Children Create Iconic Gestures to Inform Others.

Much is known about young children's use of deictic gestures such as pointing. Much less is known about their use of other types of communicative gestures, especially iconic or symbolic gestures. In particular, it is unknown whether children can create iconic gestures on the spot to inform others. Study 1 provided 27-month-olds with the opportunity to inform a novice how to perform a task. The majority of children created appropriate iconic gestures, and they did so significantly more than in a control cond...


Youth Mixed Martial Arts: Time to Regulate.


Young Children Bet on Their Numerical Skills: Metacognition in the Numerical Domain.

Metacognition, the ability to assess one's own knowledge, has been targeted as a critical learning mechanism in mathematics education. Yet the early childhood origins of metacognition have proven difficult to study. Using a novel nonverbal task and a comprehensive set of metacognitive measures, we provided the strongest evidence to date that young children are metacognitive. We showed that children as young as 5 years made metacognitive "bets" on their numerical discriminations in a wagering task. However, ...


YouTube as an educational resource for learning ECGs.


Yes-Associated Protein (YAP) Modulates Oncogenic Features and Radiation Sensitivity in Endometrial Cancer.

Yes-associated protein (YAP) is a transcriptional co-activator and regulates cell proliferation and apoptosis. We investigated the clinical and biological significance of YAP in endometrial cancer (EMCA).


Yeast Mating and Image-Based Quantification of Spatial Pattern Formation.

Communication between cells is a ubiquitous feature of cell populations and is frequently realized by secretion and detection of signaling molecules. Direct visualization of the resulting complex gradients between secreting and receiving cells is often impossible due to the small size of diffusing molecules and because such visualization requires experimental perturbations such as attachment of fluorescent markers, which can change diffusion properties. We designed a method to estimate such extracellular co...


Yu Ping Feng San, an Ancient Chinese Herbal Decoction, Regulates the Expression of Inducible Nitric Oxide Synthase and Cyclooxygenase-2 and the Activity of Intestinal Alkaline Phosphatase in Cultures.

Yu Ping Feng San (YPFS), a Chinese herbal decoction comprising Astragali Radix (AR; Huangqi), Atractylodis Macrocephalae Rhizoma (AMR; Baizhu), and Saposhnikoviae Radix (SR; Fangfeng), has been used clinically to treat inflammatory bowel diseases (IBD). Previously, we demonstrated a dual role of YPFS in regulating cytokine release in cultured macrophages. In this study, we elucidated the anti-inflammatory effect of YPFS that is mediated through modulating the expression of three key enzymes involved in IBD:...


Yvette Bordelon, MD, PhD, and Carlos Portera-Cailliau, MD, PhD.


You won't regret reading this.

Thursday 22nd March 1037

Young adult social development as a mediator of alcohol use disorder symptoms from age 21 to 30.

Little research has examined social development in the young adult years relative to childhood and adolescence. This study tested the hypothesized pathways of the social development model (SDM) in young adulthood for predicting symptoms of alcohol use disorder (AUD) and positive functioning at age 30. A longitudinal panel study originally drawn from Seattle, Washington, elementary schools was examined. The sample included 808 participants with high retention and was gender balanced and ethnically diverse. A...


You can't always give what you want: The challenge of providing social support to low self-esteem individuals.

It can be challenging for support providers to facilitate effective social support interactions even when they have the best intentions. In the current article, we examine some reasons for this difficulty, with a focus on support recipients' self-esteem as a crucial variable. We predicted that recipients' receptiveness to support would be influenced by both support strategy and recipient self-esteem and that receptiveness in turn would impact providers' perceived caregiving efficacy and relationship quality...

Tuesday 18th May 1035

YAC128 Huntington'S disease transgenic mice show enhanced short-term hippocampal synaptic plasticity early in the course of the disease.

Huntington's disease (HD) is a progressive and fatal neurodegenerative disorder caused by a polyglutamine expansion in the gene encoding the protein huntingtin. The disease progresses over decades, but often patients develop cognitive impairments that precede the onset of the classical motor symptoms. Similar to the disease progression in humans, the yeast artificial chromosome (YAC) 128 HD mouse model also exhibits cognitive dysfunction that precedes the onset of the neuropathological and motor impairments...


Yield-Enhancing Heterotic QTL Transferred from Wild Species to Cultivated Rice Oryza sativa L.

Utilization of "hidden genes" from wild species has emerged as a novel option for enrichment of genetic diversity for productivity traits. In rice we have generated more than 2000 lines having introgression from 'A' genome-donor wild species of rice in the genetic background of popular varieties PR114 and Pusa44 were developed. Out of these, based on agronomic acceptability, 318 lines were used for developing rice hybrids to assess the effect of introgressions in heterozygous state. These introgression line...

Wednesday 11th March 1034

Young Adults, Social Networks, and Addiction Recovery: Post Treatment Changes in Social Ties and Their Role as a Mediator of 12-Step Participation.

Social factors play a key role in addiction recovery. Research with adults indicates individuals with substance use disorder (SUD) benefit from mutual-help organizations (MHOs), such as Alcoholics Anonymous, via their ability to facilitate adaptive network changes. Given the lower prevalence of sobriety-conducive, and sobriety-supportive, social contexts in the general population during the life-stage of young adulthood, however, 12-step MHOs may play an even more crucial recovery-supportive social role for...


Yanagihara Facial Nerve Grading System as a Prognostic Tool in Bell's Palsy.

The aim of this study was to evaluate the accuracy of the Yanagihara facial nerve grading system in assessing the course of recovery and in determining the probability of a complete recovery of Bell's palsy within 1 week after onset.


Yellowing and bleaching of grey hair caused by photo and thermal degradation.

Yellowing is an undesirable phenomenon that is common in people with white and grey hair. Because white hair has no melanin, the pigment responsible for hair colour, the effects of photodegradation are more visible in this type of hair. The origin of yellowing and its relation to photodegradation processes are not properly established, and many questions remain open in this field. In this work, the photodegradation of grey hair was investigated as a function of the wavelength of incident radiation, and its ...


Yeast cell lysis enhances dimethyl trisulfide formation in sake.

The present study showed that the lysis of yeast cells and subsequent release of cell contents in sake mash accelerated dimethyl trisulfide (DMTS) formation. Among these, heat unstable and relatively high molecular weight compounds were assumed to be enzymes; thus, enzymatic reactions probably contribute to DMTS formation.

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