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00:34 EDT 1st July 2016 | BioPortfolio

The US National Library of Medicine and National Institutes of Health manage which comprises of more than 21 million records, papers, reports for biomedical literature, including MEDLINE, life science and medical journals, articles, reviews, reports and  books.  BioPortfolio aims to publish relevant information on published papers, clinical trials and news associated with users selected topics.

For example view all recent relevant publications on Epigenetics and associated publications and clincial trials.

Showing PubMed Articles 51–75 of 1,300+

Yohimbine hydrochloride ameliorates collagen type-II-induced arthritis targeting oxidative stress and inflammatory cytokines in Wistar rats.

Rheumatoid arthritis (RA) is the most common type of chronic inflammatory disease which is triggered by dysfunction in the immune system which in turn affects synovial joints. Current treatment of RA with NSAIDs and DMRDs is limited by their side effect. As a result, the interest in alternative, well tolerated anti-inflammatory remedies has re-emerged. Our aim was to evaluate the antioxidant and anti-inflammatory activities underlying the anti-RA effect of Yohimbine hydrochloride (YCL) in collagen induced a...

Young Children's Sensitivity to Their Own Ignorance in Informing Others.

Prior research suggests that young children selectively inform others depending on others' knowledge states. Yet, little is known whether children selectively inform others depending on their own knowledge states. To explore this issue, we manipulated 3- to 4-year-old children's knowledge about the content of a box and assessed the impact on their decisions to inform another person. Moreover, we assessed the presence of uncertainty gestures while they inform another person in light of the suggestions that c...

You, Me, and We: Biolabs for the 21st Century.

Twenty-first century biomedical research is advantaged by institutional infrastructures that foster a collaborative, multidisciplinary approach. A few critical elements in the design of labs, research buildings, or campus can make interaction easier while preserving privacy and comfort for the individual researcher.

Young patients with hematologic and lymphatic malignancies have an increased risk of hip and knee arthroplasty.

Background Skeletal complications such as osteonecrosis (ON) are potential adverse events in patients treated for cancer, especially in those treated for hematologic and lymphatic malignancies (HLMs). ON may damage the hip or knee joints and may lead to arthrosis requiring total joint arthroplasty (TJA). The aim of this study was to address the risk of TJA in patients with cancer, especially those treated for HLM, in a nationwide population-based setting. Material and methods All patients who had undergone ...

Young children's referent selection is guided by novelty for both words and actions.

Young children are biased to select novel, name-unknown objects as referents of novel labels and to similarly favor novel, action-unknown objects as referents of novel actions. What process underlies these common behaviors? In the case of word learning, children may be driven by a novelty bias favoring novel objects as referents. Our study investigated this bias further by investigating whether novelty also affects children's selection of novel objects when a new action is given. In a pre-exposure session, ...

Young rats exhibit an age- and sex-dependent bladder response to alpha-antagonists but not beta-agonists.

Previous studies have suggested that the onset of alpha- (α) and beta- (β) adrenergic receptor activity is delayed in young animals. The use of alpha1- (α1-) antagonists for dysfunctional voiding, and beta3- (β3-) agonists for overactive bladder in younger children may not be indicated if maturation is required before bladder and urethral adrenergic receptors are active.

Yttrium-90 Radioembolization for Hepatocellular Carcinoma.

(90)Y radioembolization refers to the selective, transcatheter, and intra-arterial injection of micrometer-sized particles loaded with the radioisotope yttrium-90 for the treatment of primary and metastatic hepatic malignancies. In the treatment of intermediate- and advanced-stage hepatocellular carcinoma, (90)Y radioembolization provides favorable outcomes with minimal side effects, offering an alternative treatment option to other transarterial therapies, such as bland embolization and chemoembolization. ...

Y-90 Radiomicrosphere Therapy for Colorectal Cancer Liver Metastases.

At present, the systemic treatment of unresectable colorectal cancer liver metastases involves oxaliplatin and irinotecan-based chemotherapy regimens combined with targeted therapies such as bevacizumab (Avastin) and cetuximab (Erbitux). Radiation therapy, traditionally, is not considered a viable treatment modality owing to its unacceptably high hepatic toxicity, and still steering traditional wisdom or dogma that chemoradiation cannot be an oncological strategy for a stage IV disease. Selective internal r...

Youth Screen Time and Behavioral Health Problems: The Role of Sleep Duration and Disturbances.

The purpose of this study was to examine the indirect effect of youth screen time (e.g., television, computers, smartphones, video games, and tablets) on behavioral health problems (i.e., internalizing, externalizing, and peer problems) through sleep duration and disturbances.

You can't pay me to quit: the failure of financial incentives for smoking cessation in head and neck cancer patients.

A prospective randomised study was conducted at a tertiary care hospital to evaluate the effects of financial incentives for smoking cessation targeted at a high-risk population.

YihQ is a sulfoquinovosidase that cleaves sulfoquinovosyl diacylglyceride sulfolipids.

Sulfoquinovose is produced by photosynthetic organisms at a rate of 10(10) tons per annum and is degraded by bacteria as a source of carbon and sulfur. We have identified Escherichia coli YihQ as the first dedicated sulfoquinovosidase and the gateway enzyme to sulfoglycolytic pathways. Structural and mutagenesis studies unveiled the sequence signatures for binding the distinguishing sulfonate residue and revealed that sulfoquinovoside degradation is widespread across the tree of life.

Yeast Two-Hybrid and One-Hybrid Screenings Identify Regulators of hsp70 Gene Expression.

The mammalian stress protein Hsp105β, which is specifically expressed during mild heat shock and localizes to the nucleus, induces the major stress protein Hsp70. In the present study, we performed yeast two-hybrid and one-hybrid screenings to identify the regulators of Hsp105β-mediated hsp70 gene expression. Six and two proteins were detected as Hsp105β- and hsp70 promoter-binding proteins, respectively. A luciferase reporter gene assay revealed that hsp70 promoter activation is enhanced by the transcri...

Yoga for Adult Women with Chronic PTSD: A Long-term Follow-up Study.

Yoga-the integrative practice of physical postures and movement, breath exercises, and mindfulness-may serve as a useful adjunctive component of trauma-focused treatment to build skills in tolerating and modulating physiologic and affective states that have become dysregulated by trauma exposure. A previous randomized controlled study was carried out among 60 women with chronic, treatment-resistant post-traumatic stress disorder (PTSD) and associated mental health problems stemming from prolonged or multipl...

Young Females Exhibit Decreased Coronal Plane Postural Stability Compared to Young Males.

Female athletes are at significantly higher risk of noncontact ACL injury than males, particularly in pivoting sports such as soccer and basketball. Sex-based differences in proprioception and core stability may contribute to this elevated risk.

You are not Robinson Crusoe.

Yield of screening for atrial fibrillation in primary care with a hand-held, single-lead electrocardiogram device during influenza vaccination.

To assess the yield of screening for atrial fibrillation (AF) with a hand-held single-lead electrocardiogram (ECG) device during influenza vaccination in primary care in the Netherlands.

Young man with unexplained hair loss.

Topical antifungals had failed to improve the patchy hair loss on this patient's head. The pattern of the alopecia and a closer look at his history provided valuable diagnostic clues.

Youth access to cigarettes in six sub-Saharan African countries.

Tobacco smoking is initiated and established mostly during adolescence. The World Health Organization (WHO) Framework Convention on Tobacco Control (FCTC) Article 16 outlines the obligation of parties to prohibit the sale of tobacco products to minors. This study examined where and how student smokers obtain cigarettes.

Yellow Mealworm Protein for Food Purposes - Extraction and Functional Properties.

A protocol for extraction of yellow mealworm larvae proteins was established, conditions were evaluated and the resulting protein extract was characterised. The freeze-dried yellow mealworm larvae contained around 33% fat, 51% crude protein and 43% true protein on a dry matter basis. The true protein content of the protein extract was about 75%, with an extraction rate of 70% under optimised extraction conditions using 0.25 M NaOH, a NaOH solution:ethanol defatted worm ratio of 15:1 mL/g, 40°C for 1 h and ...

Yolk testosterone affects growth and promotes individual-level consistency in behavioral lateralization of yellow-legged gull chicks.

Behavioral lateralization is common in animals and may be expressed at the individual and at the population level. The ontogenetic processes that control lateralization, however, are largely unknown. Well-established sex-dependence in androgen physiology and sex-dependent variation in lateralization have led to the hypothesis that testosterone (T) has organizational effects on lateralization. The effects of T exposure in early life on lateralization can be efficiently investigated by manipulating T levels i...

YiQi ChuTan Recipe Inhibits Epithelial Mesenchymal Transition of A549 Cells under Hypoxia.

This study aims to investigate mechanism of YiQi ChuTan Recipe (YCR) for inhibiting epithelial mesenchymal transition (EMT) of A549 cells under hypoxia. Flow cytometry was used to optimize YCR dosage by measuring A549 apoptosis, which were subjected to different treatments, including normal condition, hypoxia, hypoxia+YCR. Cell morphology and expression of EMT were measured with differential interference contrast microscopy, real-time PCR and western blot. Optimized condition of 4 mg/ml YCR and 2% O2 for 72...

Youth internalizing symptoms, sleep-related problems, and disordered eating attitudes and behaviors: A moderated mediation analysis.

Internalizing symptoms increase the risk for disordered eating; however, the mechanism through which this relationship occurs remains unclear. Sleep-related problems may be a potential link as they are associated with both emotional functioning and disordered eating. The present study aims to evaluate the mediating roles of two sleep-related problems (sleep disturbance and daytime sleepiness) in the relationship between youth internalizing symptoms and disordered eating, and to explore if age moderates thes...

Years of life lost (Yll) attributable to alcohol consumption in Mexico city.

The aim of this study was to estimate the YLL attributable to alcohol consumption in Mexico City from 2006 - 2012. Vital statistics on mortality attributable to alcohol consumption from the INEGI (Instituto Nacional de Estadística y Geografía) were used to determine YLL as well as the average age of death in relation to different age ranges by sex. A total estimate of 168,607 YLL was obtained, with an average loss of 18.32 years being observed for men and 17.54 years for women. Men accounted for a higher ...

Yoga and mental health services.

Y1-xScxBaZn3GaO7 (0 ≤ x ≤ 1): Structure Evolution by Sc-Doping and the First Example of Photocatalytic Water Reduction in "114" Oxides.

"114" oxides have shown intriguing physical properties while their performance in photocatalysis has not yet been reported probably due to the instability in aqueous solution. YBaZn3GaO7 is an exception, which is stable and indeed shows observable photocatalytic H2 evolution (∼2 μmol/h/g) in methanol aqueous solution under UV light. This activity was enhanced to 23.6 μmol/h/g by a full replacement of Y(3+) by Sc(3+). Optical absorption spectra and theoretical calculations show no significant difference ...

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