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03:00 EDT 27th October 2016 | BioPortfolio

The US National Library of Medicine and National Institutes of Health manage which comprises of more than 21 million records, papers, reports for biomedical literature, including MEDLINE, life science and medical journals, articles, reviews, reports and  books.  BioPortfolio aims to publish relevant information on published papers, clinical trials and news associated with users selected topics.

For example view all recent relevant publications on Epigenetics and associated publications and clincial trials.

Showing PubMed Articles 51–75 of 1,400+

Youths in the shantytowns (favelas) of Rio de Janeiro/Brazil: from social vulnerability to opportunities for human development.

Based on a review of living conditions in the complex and dynamic reality of the shantytowns ("favelas") of Rio de Janeiro and the main difficulties facing the human development of youths in this context, we analyze the social protection function involved in educational projects that offer new opportunities for life. In this article we analyze the relationship between the variables of social exclusion, poverty and violence, jointly grouped in the social vulnerability category, and the variables related to o...

Yoga for asthma.

Asthma is a common chronic inflammatory disorder affecting about 300 million people worldwide. As a holistic therapy, yoga has the potential to relieve both the physical and psychological suffering of people with asthma, and its popularity has expanded globally. A number of clinical trials have been carried out to evaluate the effects of yoga practice, with inconsistent results.

Yakushinamides, Polyoxygenated Fatty Acid Amides That Inhibit HDACs and SIRTs, from the Marine Sponge Theonella swinhoei.

Yakushinamides A (1) and B (2), prolyl amides of polyoxygenated fatty acids, have been isolated from the marine sponge Theonella swinhoei as inhibitors of HDACs and SIRTs. Their planar structures were determined by interpretation of the NMR data of the intact molecules and tandem FABMS data of the methanolysis products. For the assignment of the relative configurations of the three contiguous oxymethine carbons in 1 and 2, Kishi's universal NMR database was applied to the methanolysis products. During the a...

Y-box-binding protein 1 as a non-canonical factor of base excision repair.

Base excision repair (BER) is a flagship DNA repair system responsible for maintaining genome integrity. Apart from basal enzymes, this system involves several accessory factors essential for coordination and regulation of DNA processing during substrate channeling. Y-box-binding protein 1 (YB-1), a multifunctional factor that can interact with DNA, RNA, poly(ADP-ribose) and plenty of proteins including DNA repair enzymes, is increasingly considered as a non-canonical protein of BER. Here we provide quantit...

Young drivers' engagement with social interactive technology on their smartphone: Critical beliefs to target in public education messages.

The current study forms part of a larger study based on the Step Approach to Message Design and Testing (SatMDT), a new and innovative framework designed to guide the development and evaluation of health communication messages, including road safety messages. This four step framework is based on several theories, including the Theory of Planned Behaviour. The current study followed steps one and two of the SatMDT framework and utilised a quantitative survey to validate salient beliefs (behavioural, normativ...

Your patient has chronic leukemia: Now what?

Although still in their infancy, biologic therapies for hematologic cancers are making rapid strides, diminishing the role of chemotherapy and offering long-term remission. More patients are surviving cancer and therefore are increasingly being seen by primary care physicians, who must be aware of complications of standard and newer treatments and how to manage them.

You Can Teach an Old Drug New Tricks-Aminophylline for Cardiac Surgery-Associated Acute Kidney Injury.

Yeast Biodiversity in Vineyard Environments Is Increased by Human Intervention.

One hundred and five grape samples were collected during two consecutive years from 33 locations on seven oceanic islands of the Azores Archipelago. Grape samples were obtained from vineyards that were either abandoned or under regular cultivation involving common viticultural interventions, to evaluate the impact of regular human intervention on grape yeast biota diversity in vineyards. A total of 3150 yeast isolates were obtained and 23 yeast species were identified. The predominant species were Hansenias...

Young People Smokers' Reactions on Peer Influence Not to Smoke.

Peers exert influence not to smoke but little is yet known on how this affects young people's behavior and cognitions.

Young Women's Contraceptive Decision Making: Do Preferences for Contraceptive Attributes Align with Method Choice?

Understanding how women's preferences for certain attributes of contraceptive methods relate to their method choice can inform the content of contraceptive counseling.

YMO1 suppresses invasion and metastasis by inhibiting RhoC signaling and predicts favorable prognosis in hepatocellular carcinoma.

Previous studies have shown that 4.1 proteins, which are deregulated in many cancers, contribute to cell adhesion and motility. Yurt/Mosaic eyes-like 1 (YMO1) is a member of 4.1 protein family but it is unclear whether YMO1 plays a role in tumor invasion. This study aimed to investigate the effects of YMO1 on hepatocellular carcinoma (HCC) and attempted to elucidate the underlying molecular mechanisms. YMO1 expression in HCC tissues and its correlation with clinicopathological features and postoperative pro...

YBR/EiJ mice: a new model of glaucoma caused by genes on chromosomes 4 and 17.

A variety of inherited animal models with different genetic causes and distinct genetic backgrounds are needed to help dissect the complex genetic etiology of glaucoma. The scarcity of such animal models has hampered progress in glaucoma research. Here, we introduce a new inherited glaucoma model: the inbred mouse strain YBR/EiJ (YBR). YBR mice develop a form of pigmentary glaucoma. They exhibit a progressive age-related pigment dispersing iris disease characterized by iris stromal atrophy. Subsequently, th...

Yellow Fever-More a Policy and Planning Problem than a Biological One.

You'll Never Guess Who Wrote That: 78 Surprising Authors of Psychological Publications.

One can find psychological authors in the most unexpected places. We present a capsule summary of scholarly publications of psychological interest authored or coauthored by 78 surprising individuals, most of whom are celebrities or relatives of celebrities, historical figures, or people who have otherwise achieved visibility in academic circles, politics, religion, art, and diverse realms of popular culture. Still other publications are authored by individuals who are far better known for their contribution...

Your word is my command: Oxytocin facilitates the understanding of appeal in verbal communication.

The hormone oxytocin is known to facilitate positive communication behaviors. In the current study, we aimed to examine how it affects the interpretation of verbal information during communication. We predicted oxytocin to promote the understanding of the socially most effortful dimension of appeal. After intranasal administration of oxytocin or a placebo, participants responded to a "four-ear communication" questionnaire. Results revealed that participants under oxytocin not only chose the dimension of app...

Yet another pattern recognition receptor involved in the chemotherapy-induced anticancer immune response: Formyl peptide receptor-1.

Several pattern recognition receptors including toll-like receptors and purinergic receptors are implicated in the anticancer immune response elicited by anthracyclines or oxaliplatin. Recently, formyl peptide receptor-1 (FPR1) has been involved in this response as well. FPR1 is required for the correct positioning of dendritic cells (DC) close to dying cancer cells. A genetic defect in FPR1 abrogates cross-presentation of tumor antigens by DC, thereby compromising therapy-elicited immunosurveillance.

Yb9+xCuMg4-x (x = 0.034): A κ-Phase Formed by Lanthanoids.

Atom order in the crystal structures of Yb2Cu2-xMg (x = 0.17; Mo2FeB2-type; P4/mbm; a = 0.75592(2) nm; c = 0.40282(1) nm) and Yb9+xCuMg4-x (x = 0.034; Hf9Mo4B-type; P63/mmc; a = 1.0169(5) nm; c = 1.0290(5) nm) was determined from powder and X-ray single-crystal counter data analyses supported by electron probe microanalyses. Among the group of the so-called κ-phases, Yb9+xCuMg4-x is the first representative formed by a lanthanoid element. The structure of this κ-phase can be viewed as a typical network of...

Yoga as Coping: A Conceptual Framework for Meaningful Participation in Yoga.

Yoga facilitates relaxation and connection of mind, body, and spirit through the use of breathing, meditation, and physical postures. Participation in yoga has been extensively linked to decreased stress, and as a result, is considered a therapeutic intervention by many. However, few theories exist that explain the link between yoga participation and improved psychosocial wellbeing. The leisure-stress coping conceptual framework suggests that through participation in leisure, an individual can decrease stre...

Y-27632, a Rho-Associated Protein Kinase Inhibitor, Inhibits Voltage-Dependent K+ Channels in Rabbit Coronary Arterial Smooth Muscle Cells.

We examined the effects of the Rho-associated protein kinase (ROCK) inhibitor Y-27632 on voltage-dependent K+ (Kv) channels in rabbit coronary arterial smooth muscle cells using the whole-cell patch clamp technique. Y-27632 reduced the amplitude of the Kv current in a concentration-dependent manner, with an IC50 of 0.87 ± 0.06 μmol/l and a Hill coefficient of 1.48 ± 0.06. Y-27632 did not affect the steady-state activation or inactivation curves, suggesting that the drug does not affect the voltage sensit...

Young Adult With Abdominal Lump.

Yoga and positive body image: A test of the Embodiment Model.

The study aimed to test the Embodiment Model of Positive Body Image (Menzel & Levine, 2011) within the context of yoga. Participants were 193 yoga practitioners (124 Iyengar, 69 Bikram) and 127 university students (non-yoga participants) from Adelaide, South Australia. Participants completed questionnaire measures of positive body image, embodiment, self-objectification, and desire for thinness. Results showed yoga practitioners scored higher on positive body image and embodiment, and lower on self-objectif...

Years of Life Lost due to Premature Mortality in a Province with the Shortest Life Expectancy in Poland.

The aim of the study was to evaluate years of life lost for citizens of the Lodz Province, which is characterized by the lowest life expectancy in Poland, and to identify current trends in this area according to the most common causes of death.

Young children's ability to report on past, future and hypothetical pain states: a cognitive developmental perspective.

Children are at times asked by clinicians or researchers to rate their pain associated with past, future or hypothetical experiences. However, little consideration is typically given to the cognitive-developmental requirements of such pain reports. Consequently, these pain assessment tasks may exceed the abilities of some children, potentially resulting in biased or random responses. This could lead to the over- or under-treatment of children's pain. This review provides an overview of factors, and specific...

Young children's behavioral and emotional responses to different social norm violations.

From an early age, children can talk meaningfully about differences between moral and conventional norms. But does their understanding of these differences manifest itself in their actual behavioral and emotional reactions to norm violations? And do children discriminate between norm violations that affect either themselves or a third party? Two studies (N=224) were conducted in which children observed conventional game rule violations and moral transgressions that either disadvantaged themselves directly o...

You can lead a horse to water … what Self-Determination Theory can contribute to our understanding of clinical policy implementation.

There has been increasing reliance on policy directives as instruments for shaping clinical practice in health care, despite it being widely recognized that there is a significant translation gap between clinical policy and its implementation. Self-Determination Theory, a widely researched and empirically validated theory of human needs' fulfilment and motivation, offers a potentially valuable theoretical framework for understanding not only why the current policy environment has not led to the anticipated ...

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