PubMed Journal Database - Page: 5 RSS

07:07 EDT 27th August 2014 | BioPortfolio

The US National Library of Medicine and National Institutes of Health manage which comprises of more than 21 million records, papers, reports for biomedical literature, including MEDLINE, life science and medical journals, articles, reviews, reports and  books.  BioPortfolio aims to publish relevant information on published papers, clinical trials and news associated with users selected topics.

For example view all recent relevant publications on Epigenetics and associated publications and clincial trials.

Showing PubMed Articles 101–125 of 29,000+

Tuesday 9th January 1054

Fruits, vegetables and their polyphenols protect dietary lipids from oxidation during gastric digestion.

Previous studies indicate that the ingestion of oxidized vegetable oils leads to the incorporation of chemically reactive molecules issued from the decomposition of the initial lipid hydroperoxides into lipoproteins. The aim of the present study is to investigate the oxidation of dietary lipids in the gastric compartment and their inhibition by plant polyphenols provided either as fruit and vegetables (F&V) or an extract. Six minipigs received a standard Western diet containing primarily sunflower oil, grou...


FBXO7 Y52C Polymorphism as a Potential Protective Factor in Parkinson's Disease.

Mutations in the F-box only protein 7 gene (FBXO7), the substrate-specifying subunit of SCF E3 ubiquitin ligase complex, cause Parkinson's disease (PD)-15 (PARK15). To identify new variants, we sequenced FBXO7 cDNA in 80 Taiwanese early onset PD patients (age at onset ≤50) and only two known variants, Y52C (c.155A>G) and M115I (c.345G>A), were found. To assess the association of Y52C and M115I with the risk of PD, we conducted a case-control study in a cohort of PD and ethnically matched controls. There w...


FAS-Based Cell Depletion Facilitates the Selective Isolation of Mouse Induced Pluripotent Stem Cells.

Cellular reprogramming of somatic cells into induced pluripotent stem cells (iPSC) opens up new avenues for basic research and regenerative medicine. However, the low efficiency of the procedure remains a major limitation. To identify iPSC, many studies to date relied on the activation of pluripotency-associated transcription factors. Such strategies are either retrospective or depend on genetically modified reporter cells. We aimed at identifying naturally occurring surface proteins in a systematic approac...


Facile Access to Functionalized Spiroindoline-3,2'-pyrrole-2,5'-diones via Post-Ugi Domino Buchwald-Hartwig/Michael Reaction.

A novel access to spiro[indoline-3,2'-pyrrole]-2,5'-diones is presented via a palladium-catalyzed post-Ugi cascade cyclization approach involving a Buchwald-Hartwig/Michael reaction sequence. The method allows the easy construction of a library of spirooxindoles in moderate to good yields starting from readily available precursors. In addition, alkynoic acids are replaced with α,β-unsaturated acids leading to variably substituted spirooxindoles.


Fever management in intensive care patients with infections.


Front cover.


Flexible and Transparent Polyimide Films Containing Two-Dimensional Alumina Nanosheets Templated by Graphene Oxide for Improved Barrier Property.

Unique two-dimensional alumina nanosheets (Alns) using graphene oxide (GO) as templates are fabricated and successfully incorporated with organo-soluble polyimide (PI) to obtain highly transparent PI nanocomposite films with improved moisture barrier property. The effects of filler types and contents on water vapor transmission rate (WVTR) and transparency of PI are systematically studied. The hydroxyl groups on GO react with aluminum isopropoxide via sol-gel process to obtain alumina coverd-GO (Al-GO), and...


Fighting respiratory diseases: divided efforts lead to weakness.


Fate and degradation kinetics of nonylphenol compounds in aerobic batch digesters.

Nonylphenol (NP) compounds are toxic and persistent chemicals that are not fully degraded either in natural or engineered systems. Current knowledge indicates that these compounds concentrate in sewage sludge. Therefore, investigating the degradation patterns and types of metabolites formed during sludge treatment are important for land application of sewage sludge. Unfortunately, the information on the fate of nonylphenol compounds in sludge treatment is very limited. This study aims to investigate the bio...


Fibrovascular Ingrowth Into Porous Polyethylene Orbital Implants (Medpor) After Modified Evisceration.

To evaluate, using MRI, the extent and pattern of fibrovascular ingrowth into Medpor implants after modified evisceration.


Facile synthesis of Ag-ZnO hybrid nanospindles for highly efficient photocatalytic degradation of methyl orange.

Highly photocatalytically active Ag nanoparticle decorated ZnO nanospindles were synthesized by a facile wet chemical method. The structural and optical properties of the as-synthesized materials were characterized by X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM) and high resolution TEM (HRTEM) with energy dispersive X-ray spectroscopy, UV-visible absorption spectroscopy and Raman spectroscopy. The photocatalytic activity of these nanost...


Fabrication of Segmented Au/Co/Au Nanowires: Insights in the Quality of Co/Au Junctions.

Electrodeposition is a versatile method, which enables the fabrication of a variety of wire-like nanoarchitectures such as nanowires, nanorods and nanotubes. By means of template-assisted electrodeposition, segmented Au/Co/Au nanowires are grown in anodic aluminium oxide templates from two different electrolytes. In order to tailor the properties of the cobalt segments, several electrochemical conditions are studied as a function of current density, pulse deposition and pH. The morphology, the crystal struc...

Tuesday 26th December 1053

Frictional resistance of self-ligating versus conventional brackets in different bracket-archwire-angle combinations.

Objective: To compare the influence of archwire material (NiTi, beta-Ti and stainless steel) and brackets design (self-ligating and conventional) on the frictional force resistance. Material and Methods: Two types of brackets (self-ligating brackets - Smartclip, 3M/Unitek - and conventional brackets - Gemini, 3M/Unitek) with three (0, 5, and 10 degrees) slot angulation attached with elastomeric ligatures (TP Orthodontics) were tested. All brackets were tested with archwire 0.019"x0.025" nickel-titanium, bet...

Wednesday 6th December 1053

First Photoswitchable Neurotransmitter Transporter Inhibitor: Light-induced Control of γ-Aminobutyric Acid Transporter 1 (GAT1) Activity in Mouse Brain.

Inhibition of mGAT1, the most abundant GABA transporter in the brain, enhances GABA signaling and alleviates symptoms of CNS disorders such as epilepsy assumed to be associated with low GABA levels. We have now developed a potent and subtype selective photoswitchable inhibitor of this transporter which for the first time extends the photoswitch concept for the light-induced control of ligand affinity to active membrane transporters. The new inhibitor exhibited reduced activity upon irradiation with light as...

Wednesday 8th November 1053

Food for thought; dietary changes in essential fatty acid ratios and the increase in Autism Spectrum Disorders.

K. van Elst, H. Bruining, B. Birtoli, C. Terreaux, J.K. Buitelaar and M.J. Kas. Food for thought; dietary changes in essential fatty acid ratios and the increase in Autism Spectrum Disorders. NEUROSCI BIOBEHAV REV 37 (9) XXX-XXX, 2014 The last decades have shown a spectacular and partially unexplained rise in the prevalence of autism spectrum disorders (ASD). This rise in ASD seems to parallel changes in the dietary composition of fatty acids. This change is marked by the replacement of cholesterol by omega...

Friday 8th September 1053

Fuzzy Logic for Personalized Healthcare and Diagnostics: FuzzyApp-A Fuzzy Logic Based Allergen-Protein Predictor.

Abstract The path to personalized medicine demands the use of new and customized biopharmaceutical products containing modified proteins. Hence, assessment of these products for allergenicity becomes mandatory before they are introduced as therapeutics. Despite the availability of different tools to predict the allergenicity of proteins, it remains challenging to predict the allergens and nonallergens, when they share significant sequence similarity with known nonallergens and allergens, respectively. Hence...

Thursday 7th September 1053

Facile Estimation of Catalytic Activity and Selectivities in Copolymerization of Propylene Oxide with Carbon Dioxide Mediated by Metal Complexes with Planar Tetradentate Ligand.

Mechanistic studies were conducted to estimate (1) catalytic activity for PPC, (2) PPC/CPC selectivity, and (3) PPC/PPO selectivity for the metal-catalyzed copolymerization of propylene oxide with carbon dioxide [PPC: poly(propylene carbonate); CPC = cyclic propylene carbonate; PPO: poly(propylene oxide)]. Density functional theory (DFT) studies demonstrated that the ΔGcrb - ΔGepx value should be an effective indicator for the catalytic activities [ΔGepx: dissociation energy of ethylene oxide from the ep...

Saturday 2nd September 1053

First study of vitellogenesis of the broad fish tapeworm Diphyllobothrium latum (Cestoda, Diphyllobothriidea), a human parasite with extreme fecundity.

In the present study, the process of vitellogenesis of one of the most prolific organisms, the broad tapeworm, Diphyllobothrium latum, the causative agent of human diphyllobothriosis, was studied for the first time using transmission electron microscopy. Cytochemical staining with periodic acid-thiosemicarbazide-silver proteinate for detection of glycogen was applied. Starting from the periphery towards the centre of the vitelline follicle four stages of vitellocytes are differentiated: immature vitellocyte...

Thursday 10th August 1053

Follow-up of endometrial cancer.

Available data on appropriate follow-up in endometrial cancer highlight the need of well-conducted studies. Most recurrences tend to occur within three years and involve symptoms. Routine tests are not advocated without symptoms. In case of suspicious recurrence, TEP/CT seems to be the most sensitive and specific method. There is limited evidence to decide whether follow-up schedules with multiple visits result in survival benefits. An appropriate follow-up should be discussed based upon the risk of recurre...

Thursday 30th March 1053

Finding a Common Path: Predicting Gene Function using Inferred Evolutionary Trees.

Reporting in Cell, Li and colleagues (2014) describe an innovative method to functionally classify genes using evolutionary information. This approach demonstrates broad utility for eukaryotic gene annotation and suggests an intriguing new decomposition of pathways and complexes into evolutionarily conserved modules.

Friday 20th January 1053

Ficus carica Polysaccharides Promote the Maturation and Function of Dendritic Cells.

Various polysaccharides purified from plants are considered to be biological response modifiers and have been shown to enhance immune responses. Ficus carica L. is a Chinese traditional plant and has been widely used in Asian countries for its anti-tumor properties. Ficus carica polysaccharides (FCPS), one of the most essential and effective components in Ficus carica L., have been considered to be a beneficial immunomodulator and may be used in immunotherapy. However, the immunologic mechanism of FCPS is s...


Facilitation between extensor carpi radialis and pronator teres in humans: A study using a post-stimulus time histogram method.

Abstract Group I muscle afferents modulate the excitability of motor neurons through excitatory and inhibitory spinal reflexes. Spinal reflex relationships between various muscle pairs are well described in experimental animals but not in the human upper limb, which exhibits a fine control of movement. In the present study, spinal reflexes between the extensor carpi radialis (ECR) and pronator teres (PT) muscles were examined in healthy human subjects using a post-stimulus time histogram method. Electrical...


Further development of sample preparation and detection methods for O157 and the top 6 non-O157 stec serogroups in cattle feces.

Shiga toxin-producing Escherichia coli (STEC) are food-borne pathogens responsible for outbreaks of human infections worldwide. Ruminant livestock harbor STEC in their intestinal tract, and through fecal contamination possess the potential to compromise the safety of food and water. As a human health safety risk, STEC detection methods on beef carcasses and trim are needed as mandated by the USDA-FSIS. In order to monitor STEC prior to harvest and human consumption, our goal was to evaluate and/or improve d...


Frequency of Use, Awareness, and Attitudes Toward Side Effects of Anabolic-Androgenic Steroids Consumption Among Male Medical Students in Iran.

This study was conducted to determine the frequency of anabolic-androgenic steroids consumption in male students studying at the university and their awareness, attitude, and role of sports activities; the present descriptive study was conducted on 271 volunteers in 2008. The data collected by self-report questionnaires was analyzed by descriptive inferential statistics. The prevalence of consumption was 3.3%, and it was significantly higher in those with a history of bodybuilding or athletic performance. T...


FTO-free counter electrodes for dye-sensitized solar cells using carbon nanosheets synthesised from a polymeric carbon source.

Highly conductive carbon nanosheets (CNSs) are fabricated using a polymeric carbon source and subsequently applied as the counter electrodes (CNS-CEs) for dye-sensitized solar cells (DSSCs). The CNSs have a similar structure to multilayered graphene, and their high electrical conductivity and electrocatalytic activity enable them to have a dual-function as both CEs and charge supporting electrodes. CNSs form a unique CE material that functions successfully while being metal- and fluorine doped tin oxide (FT...

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