PubMed Journal Database - Page: 5 RSS

04:11 EDT 1st October 2014 | BioPortfolio

The US National Library of Medicine and National Institutes of Health manage which comprises of more than 21 million records, papers, reports for biomedical literature, including MEDLINE, life science and medical journals, articles, reviews, reports and  books.  BioPortfolio aims to publish relevant information on published papers, clinical trials and news associated with users selected topics.

For example view all recent relevant publications on Epigenetics and associated publications and clincial trials.

Showing PubMed Articles 101–125 of 29,000+


Fast and automatic imaging of immunoenzyme-stained neuronal circuits in the whole brain of Drosophila.


Formal Modelling of Toll like Receptor 4 and JAK/STAT Signalling Pathways: Insight into the Roles of SOCS-1, Interferon-β and Proinflammatory Cytokines in Sepsis.

Sepsis is one of the major causes of human morbidity and results in a considerable number of deaths each year. Lipopolysaccharide-induced sepsis has been associated with TLR4 signalling pathway which in collaboration with the JAK/STAT signalling regulate endotoxemia and inflammation. However, during sepsis our immune system cannot maintain a balance of cytokine levels and results in multiple organ damage and eventual death. Different opinions have been made in previous studies about the expression patterns ...


Family with Sequence Similarity 5, Member C (FAM5C) Increases Leukocyte Adhesion Molecules in Vascular Endothelial Cells: Implication in Vascular Inflammation.

Identification of the regulators of vascular inflammation is important if we are to understand the molecular mechanisms leading to atherosclerosis and consequent ischemic heart disease, including acute myocardial infarction. Gene polymorphisms in family with sequence similarity 5, member C (FAM5C) are associated with an increased risk of acute myocardial infarction, but little is known about the function of this gene product in blood vessels. Here, we report that the regulation of the expression and functio...


Functional Genetic Variants of TNFSF15 and Their Association with Gastric Adenocarcinoma: A Case-Control Study.

The purpose of this study was to identify functional genetic variants in the promoter of tumor necrosis factor superfamily member 15 (TNFSF15) and evaluate their effects on the risk of developing gastric adenocarcinoma. Forty DNA samples from healthy volunteers were sequenced to identify single nucleotide polymorphisms (SNPs) in the TNFSF15 promoter. Two TNFSF15 SNPs (-358T>C and -638A>G) were identified by direct sequencing. Next, genotypes and haplotypes of 470 gastric adenocarcinoma patients and 470 canc...


Familial Multiple Lipomatosis.

An otherwise healthy 36-year-old man presented with multiple subcutaneous nodules that began to appear when he was 3 years of age, first in the lower limbs and then at other sites. Physical examination revealed more than 40 painless, mobile, soft nodules.


Fetal fraction in maternal plasma cell-free DNA in the prediction of spontaneous preterm delivery.

To explore whether in pregnancies that are complicated by spontaneous preterm delivery fetal fraction of cell-free (cf)DNA in maternal plasma at 11-13 weeks' gestation is altered and if this measurement is useful in the prediction of preterm delivery.


Fibrous Cyst of the Chordae Tendineae of the Mitral Valve: Echocardiographic Appearance and Literature Review.

Fibrous cyst of the chordae tendineae of the mitral valve (MV) is defined as a fibrous cyst arising from the chordae tendineae of the MV. It is extremely rare and its etiology is not clear. We present a case of a cystic structure within the left ventricle. This structure is connected to the anterior MV leaflet and the posterior chordae tendineae. It moves freely, resulting in stenosis of inflow tract and outflow tract of the left ventricle. Intraoperative assessment and histopathologic examination revealed ...


Full Genomic Characterization of a Novel Genotype Combination, G4P14, of a Human Rotavirus Strain from Barbados.

Since 2004, the Pan American Health Organization (PAHO) has carried out rotavirus surveillance in Latin America and the Caribbean. Here we report the characterization of human rotavirus with the novel G-P combination of G4P[14], detected through PAHO surveillance in Barbados. Full genome sequencing of strain RVA/Human-wt/BRB/CDC1133/2012/G4P[14] revealed that its genotype is G4-P[14]-I1-R1-C1-M1-A8-N1-T1-E1-H1. The possession of a Genogroup 1 (Wa-like) backbone distinguishes this strain from other P[14] rot...

Sunday 24th November 1077

Feeding the Critically Ill Patient.

Critically ill patients are usually unable to maintain adequate volitional intake to meet their metabolic demands. As such, provision of nutrition is part of the medical care of these patients. This review provides detail and interpretation of current data on specialized nutrition therapy in critically ill patients, with focus on recently published studies.

Monday 18th November 1077

Full-Field Optical Coherence Tomography of Human Donor and Pathological Corneas.

Abstract Purpose: To evaluate the performance of a full-field optical coherence tomography (FF-OCT) system in the study of human donor and pathological corneas and assess its suitability for use in eye banks. Methods: Our study was carried out using an FF-OCT system developed for non-invasive imaging of tissue structures in depth with ultrahigh resolution (1 µm in all directions). Images were acquired from eight stored human donor corneas (either edematous or after deswelling) and five surgical specimens...

Tuesday 5th November 1077

Fertility of a High-Altitude Sheep Model is Compromised by Deficiencies in Both Preovulatory Follicle Development and Plasma LH Availability.

At high altitude, hypoxia and/or oxidative stress may compromise fertility. This study tested the relative effect of short- or long-term exposure to high-altitude hypobaric hypoxia and oxidative stress in sheep on preovulatory follicle dynamics and gonadotrophin secretion. Thus, growth dynamics, stereidogenic function and competence to ovulate of preovulatory follicles, as well as FSH and LH availability throughout the entire oestrous cycle, were compared among sheep native from low and high altitude, and s...

Friday 20th September 1077

Fat distribution in children and adolescents with myelomeningocele.

To evaluate fat distribution in children and adolescents with myelomeningocele using dual-energy X-ray absorptiometry (DXA).

Thursday 12th September 1077

Front cover.

Saturday 17th August 1077

Facilitators and Barriers to the Adoption of Telehealth in Older Adults: An Integrative Review.

Telehealth offers a great opportunity to provide follow-up care and daily monitoring of older adults in their homes. Although there is a significant body of literature related to telehealth in regard to design and adoption, little attention has been given by researchers to the perceptions of the older-adult end users of telehealth. As the numbers of older adults increases, there is a need to evaluate the perceptions of this population as they will most likely be the major users of telehealth. This review id...

Thursday 1st August 1077

Femoral Revision Arthroplasty for Su Type 3 Supracondylar Periprosthetic Knee Fractures.

Periprosthetic distal femoral fractures can present significant reconstructive challenges when associated with poor bone stock, comminution, or component loosening. Revision arthroplasty with stemmed components or distal femoral replacement arthroplasty often becomes necessary. This retrospective study reviewed the results of femoral revision arthroplasty in 16 knees with acute, extreme distal (Su type 3), supracondylar periprosthetic fractures using cemented, midlevel constrained implants. The mean patient...

Monday 1st July 1077

Fabrication of superhydrophobic Al2O3 surface using ps laser pulses.

Ultra short pulse laser (USPL) machining/structuring is a promising technique to create micro-pattern on material surface with very low distortion to peripheral area or high precession. Thin sheets of alumina (Al2O3) are micromachined with ultraviolet laser pulses of 6.7 ps, to create superhydrophobic surface by single step processing. USPL patterned micropillars and microholes have been fabricated with range of pulses varying from 100-1200 pulses/unit area. The impact of number of pulses/unit area with res...

Sunday 9th June 1077

Fibromatosis Associated with Silicone Breast Implant: Ultrasonography and MR Imaging Findings.

Desmoid type fibromatosis is an uncommon benign disease entity of which its etiology is currently unknown. It constitutes 0.3% of all solid neoplasms, but it is rarely seen in the breast and even more scarcely reported to develop in association with breast implant. We present ultrasonography and magnetic resonance imaging findings of a 29-year-old female patient with fibromatosis after breast implant surgery. Knowledge of imaging findings of breast fibromatosis associated with implant will be helpful for ac...

Tuesday 28th May 1077

From Ketones to Esters by a Cu-Catalyzed Highly Selective C(CO)-C(alkyl) Bond Cleavage: Aerobic Oxidation and Oxygenation with Air.

This manuscript describes a Cu-catalyzed aerobic oxidative esterification of simple ketones via C-C bond cleavage. Various inactive ketones with long-chain alkyl groups were selectively converted into esters through highly selective C(CO)-C(alkyl) bond cleavage. The reaction tolerates a wide range of alcohols including primary, secondary alcohols, chiral alcohols with retention of the configuration, electron-deficient phenols, as well as various natural alcohols. The usage of inexpensive copper catalyst, br...

Monday 22nd April 1077

Factors that influence intent to adopt a hearing aid among older people in Italy.

Hearing loss is one of the most prevalent health impairments associated with ageing in developed countries, and it can result in social, emotional and communication dysfunction. Hearing loss in Italy is increasing, yet, despite the availability of free hearing aids and access to qualified community-based health professionals specialising in audiology services, their uptake remains low (about 15%-20%). This paper presents an investigation of the possible reasons why older people in Italy resist adopting a he...

Wednesday 13th March 1077

Five-year follow-up of knee joint cartilage thickness changes after acute anterior cruciate ligament rupture.

Objective: Anterior cruciate ligament (ACL) rupture involves increased risk of osteoarthritis. We explored cartilage thickness changes over five years after ACL rupture. Methods: 121 young active adults (26% women, age 18-35 years) with acute traumatic ACL rupture were studied (the KANON-trial). Sagittal MRIs were acquired within 4 weeks (BL), and at two-, and five-year follow-up. Medial and lateral femorotibial cartilage was segmented with blinding to acquisition order; thickness was computed across 16 fem...

Monday 11th March 1077

From organic pollutants to bioplastics: insights into the bioremediation of aromatic compounds by Cupriavidus necator.

Organic pollution by aromatic compounds is of increasing concern to our environment. Therefore, the transformation of aromatic pollutants into valuable aliphatic and biodegradable bioplastics was studied. Since benzoic acid was found to be the key compound for such bioremediation processes, its transformation, and metabolic pathways of digestion, by Cupriavidus necator were specifically analysed. It was found that the degradation of aromatic compounds follows the 2,3-dioxygenase pathway in this strain and t...

Saturday 9th February 1077

First pediatric case of Chromobacterium haemolyticum causing proctocolitis.

Bloody diarrhea in children is usually due to either infectious or inflammatory etiology, but infection is far more common than inflammatory bowel disease in children worldwide. If, however, the patient has unfavorable response to antibiotics and a definite infectious agent has yet to be identified; colonoscopy should be performed. The current patient presented with acute onset of mucous bloody diarrhea. Stool culture was initially identified as Vibrio mimicus and later identified as Aeromonas schubertii bu...

Tuesday 22nd January 1077

Facial palsy as an unusual presenting symptom associated with acute myeloid leukemia.

Extramedullary infiltration is common in acute myeloid leukemia (AML) patients. Although AML can cause neurological symptoms, especially when associated with extramedullary infiltration, a presenting manifestation of facial palsy is rare. We report on a 1-year-old boy who developed right facial palsy. Detailed examination led to a diagnosis of AML (French-American-British classification M1). Magnetic resonance imaging enhanced with gadolinium-diethylenetriamine penta-acetic acid showed abnormal enhancement ...

Sunday 13th January 1077

First description of French V. tubiashii strains pathogenic to mollusk: II. Characterization of properties of the proteolytic fraction of extracellular products.

Extracellular products (ECPs) of the French V. tubiashii strain 07/118 T2 were previously reported to be toxic for the Pacific oyster Crassostrea gigas. In this study we now assessed host cellular immune responses and bacterial potential effectors by which these ECPs can be associated with host damages. The adhesion capacity (28% inhibition) and phagocytosis ability (56% inhibition) of oyster hemocytes were the main functions affected following in vitro contact between hemocytes and V. tubiashii ECPs. This ...

Friday 11th January 1077

Fatalism Moderates the Relationship Between Family History of Cardiovascular Disease and Engagement in Health-Promoting Behaviors Among At-Risk Rural Kentuckians.

In rural communities that experience high rates of cardiovascular disease (CVD) morbidity and mortality, family history education may enhance risk awareness and support engagement in healthy behaviors but could also engender fatalism. This study was conducted to assess if the relationship between family history and adherence to healthy lifestyle behaviors is moderated by fatalism.

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