PubMed Journal Database - Page: 5 
The US National Library of Medicine and National Institutes of Health manage PubMed.gov which comprises of more than 21 million records, papers, reports for biomedical literature, including MEDLINE, life science and medical journals, articles, reviews, reports and books. BioPortfolio aims to publish relevant information on published papers, clinical trials and news associated with users selected topics.
For example view all recent relevant publications on Epigenetics and associated publications and clincial trials.
Showing PubMed Articles 101–125 of 13,000+
Nonylphenol (NP), a representative endocrine disruptor, interferes with reproductive function in aquatic organisms and animals. Although many previous studies have focused on apoptotic cell death by NP, the fundamental mechanism of NP on apoptosis remains poorly understood. Here, we investigated the molecular mechanism on NP-induced apoptotic cell death in mouse TM4 Sertoli cells. To evaluate NP treatment on cell viability, formazan and lactate dehydrogenase (LDH) assays were performed. Results indicate tha...
Nitrogen Deposition in and near an Urban Ecosystem.
Excess nitrogen (N) is a serious water-quality problem in most of the estuaries in the United States, especially those downstream of developed coastal basins. Understanding sources of N is a key first step in managing and mitigating N pollution. While the major sources of this N, atmospheric deposition, wastewater, fertilizer, and other agricultural sources are well-known, their relative importance as N sources to particular estuaries is not. Much of this uncertainty is due to difficulties associated with e...
Navigating the Genome's "Dark Matter"
Nikola Tesla: flashes of inspiration.
GS-9219, a novel prodrug of the nucleotide analogue 9-(2-phosphonylmethoxyethyl) guanine (PMEG) has significant activity as monotherapy in dogs with non-Hodgkin's lymphoma. Phase I trials have been initiated in humans based on the encouraging activity observed in canine lymphoma. Two new analogues of GS-9219 (GS-343074 and GS-424044) were recently produced for evaluation as potential novel antineoplastic agents against solid tumours. As a preclinical step, effect of GS-343074 and GS-424044 were evaluated ag...
This study examined the neuropsychological performance of 125 outpatient Operation Enduring Freedom/Operation Iraqi Freedom combat veterans with posttraumatic stress disorder (PTSD) and nonacute mild traumatic brain injury (TBI) (n = 66) and PTSD (n = 59) across multiple cognitive domains to determine whether mild TBI results in greater impairment among those with PTSD. Profile analyses revealed that veterans with PTSD and mild TBI did not differ significantly from those with just PTSD across domain...
Novel word retention in sequential bilingual children.
ABSTRACT Children's ability to learn and retain new words is fundamental to their vocabulary development. This study examined word retention in children learning a home language (L1) from birth and a second language (L2) in preschool settings. Participants were presented with sixteen novel words in L1 and in L2 and were tested for retention after either a 2-month or a 4-month delay. Results showed that children retained more words in L1 than in L2 for both of the retention interval conditions. In addition,...
How plants tailor their defense responses to attack from different insects remains largely unknown. Here, we studied the role of a mitogen-activated protein kinase (MAPK), MPK4, in the resistance of a wild tobacco Nicotiana attenuata to two herbivores, the specialist Manduca sexta and the generalist Spodoptera littoralis. Stably transformed N. attenuata plants silenced in MPK4 (irMPK4) were generated and characterized for traits important for defense against herbivores. Only the oral secretions (OS) from M...
New avenues in the medical treatment of Cushing's disease: corticotroph tumor targeted therapy.
Cushing's disease (CD) is a condition of chronic hypercortisolism caused by an adrenocorticotropic hormone-secreting pituitary adenoma. First-line transsphenoidal surgery is not always curative and disease sometimes recurs. Radiotherapy often requires months or years to be effective, and is also not curative in many cases. Consequently, effective medical therapies for patients with CD are needed. Corticotroph adenomas frequently express both dopamine (D2) and somatostatin receptors (predominantly sstr5). Pa...
Three species of Kiluluma Skrjabin, 1916 were identified in Ceratotherium simium (Burchell) from a captive population in New South Wales, Australia, based on analysis of the second internal transcribed spacer (ITS-2) of ribosomal DNA. One species was identified as K. solitaria Thapar, 1924 and is redescribed. A second species is new and is described here as K. ceratotherii n. sp. The third species is new but was represented by two individuals only and is described but is not named.
Longidorus aetnaeus Roca, Lamberti, Agostinelli & Vinciguerra, 1986 is reported for the first time from Iran and Ajaria (Georgia). Morphological and morphometric data are provided for two Iranian and one Ajarian populations. The D2-D3 region of 28S rDNA for both Iranian populations was sequenced for the first time and the data reported. A detailed study of juveniles of L. aetnaeus from Iran, Georgia and Bulgaria demonstrated that this species develops through three juvenile stages. Furthermore, phylogenetic...
Non-Cigarette Tobacco and the Lung.
Cigarette smoking is known to cause a wide range of damaging health outcomes; however, the effects of non-cigarette tobacco products are either unknown or perceived as less harmful than cigarettes. Smokeless tobacco, cigar smoking, and waterpipe smoking have increased in usage over the past few decades. Some experts believe that their use is reaching epidemic proportions. Factors such as a perception of harm reduction, targeted advertising, and unrecognized addiction may drive the increased consumption of n...
Na/K pump regulation of cardiac repolarization: insights from a systems biology approach.
The sodium-potassium pump is widely recognized as the principal mechanism for active ion transport across the cellular membrane of cardiac tissue, being responsible for the creation and maintenance of the transarcolemmal sodium and potassium gradients, crucial for cardiac cell electrophysiology. Importantly, sodium-potassium pump activity is impaired in a number of major diseased conditions, including ischemia and heart failure. However, its subtle ways of action on cardiac electrophysiology, both directly...
New evidence for the symbiosis between Tuber aestivum and Picea abies.
The Burgundy truffle (Tuber aestivum Vittad.), an ectomycorrhizal fungus living in association with host plants, is one of the most exclusive delicacies. The symbiosis with deciduous oak, beech, and hazel dominates our concept of truffle ecophysiology, whereas potential conifer hosts have rarely been reported. Here, we present morphological and molecular evidence of a wildlife T. aestivum symbiosis with Norway spruce (Picea abies Karst.) and an independent greenhouse inoculation experiment, to confirm our f...
Nontarget Embolisation or Local Effect of Infarction?
Nocturnal Temazepam in the Treatment of Narcolepsy.
Narcolepsy is characterized by fragmented nighttime sleep and frequent arousals. One treatment approach to improve daytime symptoms is to consolidate nighttime sleep through decreasing arousals. Sodium oxybate is the first FDA-approved medication that follows this approach. Benzodiazepines are known to also decrease arousals at night and have been proposed to help with sleep fragmentation. In one report, clonazepam was shown to improve cataplexy in 10 of 14 patients with narcolepsy although no improvement i...
Normal Ferritin in a Patient with Iron Deficiency and RLS.
Hyperspectral imaging was exploited for its potential in direct and fast determination of Pseudomonas loads in raw chicken breast fillets. A line-scan hyperspectral imaging system (900-1700nm) was employed to obtain sample images, which were then further corrected, modified and processed. The prepared images were correlated with the true Pseudomonas counts of these samples using partial least squares (PLS) regression. To enhance model performance, different spectral extraction approaches, spectral preproces...
New treatment options for castration-resistant prostate cancer.
Published efficacy and safety data from clinical trials of three recently approved agents for the management of metastatic castration-resistant prostate cancer (CRPC) are reviewed.
Nicholas Lechmere Tilney, M.D. (1935-2013): Surgeon, Scientist, Writer, and Gentleman.
New approaches to reversing oral anticoagulant therapy Introduction.
New approaches to reversing oral anticoagulant therapy.
Natural variation in heading-date genes enables rice, a short-day (SD) plant, to flower early under long-day (LD) conditions at high latitudes. Through analysis of heading-date quantitative trait loci (QTL) with F7 recombinant inbred lines from the cross of early heading 'H143' and late heading 'Milyang23 (M23)', we found a minor-effect Early Heading3 (EH3) QTL in the Hd16 region on chromosome 3. We found that Early flowering1 (EL1), encoding casein kinase I (CKI), is likely to be responsible for the EH3/Hd...
