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The US National Library of Medicine and National Institutes of Health manage PubMed.gov which comprises of more than 21 million records, papers, reports for biomedical literature, including MEDLINE, life science and medical journals, articles, reviews, reports and books. BioPortfolio aims to publish relevant information on published papers, clinical trials and news associated with users selected topics.
For example view all recent relevant publications on Epigenetics and associated publications and clincial trials.
Cooling rates of molten PbTe-CdTe compositions play a determinant role in defining the nanoscale precipitate size distribution and the corresponding number densities, resulting in distinct trends of lattice thermal conductivity evolution with varying CdTe fractions.
Mixed silver and gold plasmonic nanoparticle architectures are synthesized using DNA-programmable assembly, unveiling exquisitely tunable optical properties that are predicted and explained both by effective thin-film models and explicit electrodynamic simulations. These data demonstrate that the manner and ratio with which multiple metallic components are arranged can greatly alter optical properties, including tunable color and asymmetric reflectivity behavior of relevance for thin-film applications.
An effective approach to deposit a uniform ultrathin polymer film over a large area with molecular level precision is demonstrated by the simple wire-wound bar-coating method. The bar-coated ultrathin films not only exhibit high transparency of up to 90% in the visible wavelength range but also high charge carrier mobility with a high degree of percolation through the uniformly covered polymer nanofibrils. They are capable of realizing highly sensitive multigas sensors and represent the first successful rep...
On page 1129, K. Kusada and H. Kitagawa present a review of recent work on phase-controlled nanoparticles (NPs), including "novel solid-solution alloy" NPs and "crystal structure controlled" NPs, newly discovered by chemical synthesis. These materials exhibit enhanced properties different from conventional materials because of their crystal and electronic structures, which are unobtainable in the bulk state. Phase-controlled synthesis will provide us more undiscovered materials and can be a new strategy to ...
Starting from a powder mixture of ketones/urea, gentle heating results in liquefaction below the melting point of the respective components. The back-cover image shows a polarized optical microscopy image of a liquid-crystalline eutectic mixture in the supercooled liquidus, as discussed on page 1287 by N. Fechler and co-workers. This indicates the coupling of the monomers toward larger, preorganized assemblies. From this precursor system, "C2N" carbon is synthesized.
DNA origami is a DNA-based nanotechnology that utilizes programmed combinations of short complementary oligonucleotides to fold a large single strand of DNA into precise 2D and 3D shapes. The exquisite nanoscale shape control of this inherently biocompatible material is combined with the potential to spatially address the origami structures with diverse cargoes including drugs, antibodies, nucleic acid sequences, small molecules, and inorganic particles. This programmable flexibility enables the fabrication...
As well as acting to fill defects and allow for cell infiltration and proliferation in regenerative medicine, biomaterial scaffolds can also act as carriers for therapeutics, further enhancing their efficacy. Drug and protein delivery on scaffolds have shown potential, however, supraphysiological quantities of therapeutic are often released at the defect site, causing off-target side effects and cytotoxicity. Gene therapy involves the introduction of foreign genes into a cell in order to exert an effect; ei...
A novel photogelling mechanism by the phototriggered-imine-crosslinking (PIC) reaction is demonstrated. Hyaluronic acid grafted with o-nitrobenzene, a photogenerated aldehyde group, can quickly photo-crosslink with amino-bearing polymers or proteins. Once the in situ photogelling on a wound occurs, the PIC gelling process can well integrate a hydrogel with surrounding tissue by covalent bonding, thus making it a powerful tool for tissue engineering and regenerative medicine.
Free-standing serum-albumin mats can transport protons over millimetre length-scales. The results of photoinduced proton transfer and voltage-driven proton conductivity measurements, together with temperature dependent and isotope effect studies, suggest that oxo-amino-acids of the protein serum albumin play a major role in the translocation of protons via an "over-the-barrier" hopping mechanism. The use of proton-conducting protein mats opens new possibilities for bioelectronic interfaces.
Heart failure is a significant clinical issue. It is the cause of enormous healthcare costs worldwide and results in significant morbidity and mortality. Cardiac regenerative therapy has progressed considerably from clinical and preclinical studies delivering simple suspensions of cells, macromolecule, and small molecules to more advanced delivery methods utilizing biomaterial scaffolds as depots for localized targeted delivery to the damaged and ischemic myocardium. Here, regenerative strategies for cardia...
A magnetic-assisted noncontact triboelectric nanogenerator (TENG) is developed by combining a magnetic responsive layer with a TENG. The novel TENG device is applied to harvest mechanical energy which can be converted into electricity and light emissions. This work has potential for energy harvesting, magnetic sensor, self-powered electronics and optoelectronics applications.
Single-crystal perovskite solar cells with a lateral structure yield an efficiency enhancement 44-fold that of polycrystalline thin films, due to the much longer carrier diffusion length. A piezoelectric effect observed in perovskite single-crystal and the strain-generated grain-boundaries enable ion migration to form a p-i-n structure.
Extensive research suggests a bright future for the graphene market. However, for a long time there has been a huge gap between laboratory-scale research and commercial application due to the challenging task of reproducible bulk production of high-quality graphene at low cost. Electrochemical exfoliation of graphite has emerged as a promising wet chemical method with advantages such as upscalability, solution processability and eco-friendliness. Recent progress in the electrochemical exfoliation of graphit...
Electronically conducting polymers constitute an emerging class of materials for novel electronics, such as printed electronics and flexible electronics. Their properties have been further diversified to introduce elasticity, which has opened new possibility for "stretchable" electronics. Recent discoveries demonstrate that conducting polymers have thermoelectric properties with a low thermal conductivity, as well as tunable Seebeck coefficients - which is achieved by modulating their electrical conductivit...
As described on page 857, synergic combination of a soluble redox mediator and a protected lithium (Li) metal electrode is successfully demonstrated by J.-K- Park, H.-T. Kim, and co-workers by exploiting a redox mediator of 2,2,6,6-tetramethylpiperidinyl 1-oxyl (TEMPO) and a composite protective layer (CPL). Self-discharge, resulting from extensive migration and chemical reduction of the oxidized TEMPO can be suppressed by a simple coating of a CPL on the Li metal surface. Building a selective barrier to re...
Defect-free mismatched heterostructures on Si substrates are produced by an innovative strategy. The strain relaxation is engineered to occur elastically rather than plastically by combining suitable substrate patterning and vertical crystal growth with compositional grading. Its validity is proven both experimentally and theoretically for the pivotal case of SiGe/Si(001).
DNA-driven hierarchical core-satellite nanostructures with plasmonic gold nanorods and upconversion nanoparticles are fabricated by L. Xu, H. Kuang, and co-workers, as described on page 898. Combined photothermal therapy and photodynamic therapy under the guidance of multimodal imaging techniques are carried out and the photothermal efficiency of the designed architecture reaches 42.3%. The developed proposal exhibits the multifunctional biological applications of the DNA-based self-assemblies.
The effects of graphene n-doping on metal-graphene (M-G) contacts in combination with 1D edge contacts is discussed by J.-H. Park and co-workers, as described on page 864, presenting a record contact resistance of 23 Ω μm at room temperature (19 Ω μm at 100 K). This is lower than the value required for the latest Si CMOS technology. This contact scheme is applied to graphene-perovskite hybrid photo-detectors, significantly improvement of its performance (0.6 → 1.8 A W(-1) in photoresponsivity and 3.3 ...
Ordered arrays of metal nanowires are employed as transparent electrodes by E. C. Garnett and co-workers, as described on page 905. The subwavelength dimensions enable high transmittance, while the metal allows for low sheet resistance. The growth of crystalline silver in solution leads to a larger grain size than in evaporated films, which reduces electron scattering and increases the conductivity by a factor of 2-3, approaching that of bulk silver.
A honeycomb-like carbon-based network is obtained by in situ nucleation and directed growth of MOFs arrays on the surface of LDHs nanoplatelets, followed by a subsequent pyrolysis process, which exhibits largely enhanced electrocatalytic ORR performances. A successful paradigm for the directed growth of highly-oriented MOFs arrays is demonstrated, with potential applications for energy storage and conversion.