PubMed Journal Database | Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment RSS

01:49 EDT 27th May 2015 | BioPortfolio

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Showing PubMed Articles 1–25 of 249 from Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment


Determination of potential illegal addition of β-blockers to function foods by QuEChERS sample preparation and UPLC-MS/MS analysis.

A novel method has been established for the determination of 11 β-blockers in sedative functional foods using QuEchERS sample preparation coupled with UPLC-MS/MS. The analytes were extracted twice with acetic acid-acetonitrile- methanol (0.1:3:7,v/v/v), and the extracts were purified with mixed QuEchERS adsorbents. Separation was performed on a C18 column, and detection using electrospray ionisation in positive-ion mode. The linear range for the 11 analytes was from 1 to 500 μg/L, and the correlation coe...


Potentiation of the effect of a commercial animal feed additive mixed with different probiotic yeast strains on the adsorption of aflatoxin B1.

This study potentiates the adsorbent effect for aflatoxin B1 (AFB1) of a commercial additive (CA) of animal feed, containing inactive lysate of three Saccharomyces cerevisiae strains, active enzymes, adsorbents and a selenium-amino acid complex, when the additive was mixed separately with three S. cerevisiae strains. Levels of AFB1 of 20 and 50 ng g(-1) were used to determine the binding capacity of different concentrations of CA alone and in the presence of yeast strains, as well as toxin desorption, und...

Monday 28th November 1222

6-iso chlortetracycline or keto form of chlortetracycline ? Need for clarification for relevant monitoring of chlortetracycline residues in food.

Chlortetracycline is a broad spectrum antibiotic used in veterinary medicine for pulmonary or digestive infections and having a regulatory Maximum Residue Limit (MRL) necessitating an official analytical control method. The purpose of this study was to clarify the identification of different forms of chlortetracycline observed in standard solution, in spiked muscle samples and in naturally incurred muscle samples of pigs analysed by LC-MS/MS and to demonstrate the in vivo formation of 6-iso-chlortetracyclin...

Tuesday 13th September 1222

Bisphenol A contamination in soft drinks as a risk for children's health in Italy.

Bisphenol A (BPA) was determined in sugary carbonated, non-carbonated and milk-based beverages, through HLPC-fluorescence detection and confirmed by LC-MS/MS, in a selection of brands which are mostly consumed by Italian children. The daily intake was determined through the WHO budget method (BM). BPA was found at detectable levels in 57% of carbonated beverages, in 50% of non-carbonated and in 100% of milk based beverages. The median concentrations were 1.24 µg/L (range:

Monday 13th June 1222

Use and impact of usual intake models on dietary exposure estimate and risk assessment of chemical substances: a practical example for cadmium, acrylamide and sulphites.

To estimate of food and nutrient intakes, 24-hour recalls are frequently used in dietary assessment, however intake data collected for a short period are a limited estimator of long-term usual intake. An important limitation of such data is that the within-person variability tends to inflate the intake distribution leading to a biased estimation of extreme percentiles. Statistical models, named usual-intake-models, that separate the within-person variability from the between-persons variability have lately ...


A suitable method to detect a potential fraud of bringing Macaque monkey meat into the food chain.

Being the third-largest primate population has not made Macaque (Macaca fascicularis sp.) monkeys less exposed to threats and dangers. Despite wildlife protection, they have been widely hunted and consumed in several countries because of purported nutritional values. In addition to trading as pure bush meats in several places, monkey meat has been sold in meatball and soup products in Indonesia. Thus the possibility of Macaque meat trafficking under the label of common meats is quite high. This paper report...


A case of human poisoning by grayanotoxins following honey ingestion - elucidation of the toxin profile by mass spectrometry.

High resolution mass spectrometry was applied to the detection of grayanotoxins (GrTx) in a contaminated honey sample. This sample was provided by a hospital due to the suspicion of intoxication after a patient had shown the typical symptoms of GrTx poisoning. The subsequent analysis proved the contamination with high amounts of GrTx and other toxins belonging to grayanane-type diterpenoids. This group of natural toxins is synthesised by the plant family Ericaceae and comprises more than 60 individual toxin...


Do fattening process and biological parameters affect the accumulation of metals in Atlantic bluefin tuna?

The objective of this study was to determine the current levels of heavy metals and trace elements in Atlantic bluefin tuna muscle tissues and how they are influenced by the fattening process and various life history parameters, to ascertain whether the concentrations in muscle tissue exceed the maximum levels defined by the European Commission Decision and to evaluate the health risk posed by fish consumption. A total of 20 bluefin tuna reared in sea cages, ranging from 160 to 295 cm in length and from 80...


The development of an ultra-high performance liquid chromatography coupled to high resolution quadrupole-Orbitrap mass spectrometry method for the rapid detection and confirmation of illegal adulterated sedative-hypnotics in dietary supplements.

A novel method using ultra-high performance liquid chromatography coupled to hybrid quadrupole-Orbitrap high resolution mass spectrometry (UHPLC-Q-Orbitrap) has been developed and validated for the simultaneous screening, identification and quantification of sedative-hypnotics in dietary supplements. Chromatographic conditions were optimised and Full data-dependent MS(2) scan (MS/dd-MS(2)) in positive and negative ion mode was used. A single injection was sufficient to perform the simultaneous screening and...


Occurrence of pesticide residues and transformation products in different types of dietary supplements.

The purpose of this study was to evaluate the presence of pesticide residues and transformation products in dietary supplement products. 32 samples were analysed to determine 177 pesticides by GC-MS/MS and 333 pesticides by liquid LC-high resolution mass spectrometry (LC-HRMS). Pesticides were extracted from different kinds of dietary supplements by the use of a modified QuEChERS extraction method. Six samples contained pesticide residues at concentration up to 92.7 µg kg(-1), but only butralin exceeded ...


Perchlorate: water and infant formulae contamination in France and risk assessment in infants.

Perchlorate ions ClO4-, known to competitively inhibit the uptake of iodine by the thyroid, have been detected in drinking water in France as well as in infant formulae. A Tolerable Daily Intake (TDI) has been established at 0.7 µg/kg bw/d based on the inhibition of iodine uptake. Due to this mechanism of action, the iodine status could strongly influence the biological effect of perchlorate. Perchlorate concentrations in water and infant formulae have been measured and the exposure of children under 6 m...


Tissue distribution and residue depletion of metronidazole in rainbow trout (Oncorhynchus mykiss).

Tissue distribution and residue depletion of metronidazole (MNZ) was studied in rainbow trout (Oncorhynchus mykiss) following oral administration of metronidazole in feed at the average dose of 25 mg kg(-1) body weight day(-1) for 7 days at 11 ± 2°C. The MNZ concentration in feed was 0.25% while daily feed intake was 1% of body weight. The concentrations of metronidazole and its main metabolite, hydroxymetronidazole (MNZOH), in fish tissues were determined by LC-MS/MS. The drug was well distributed i...

Monday 13th October 1203

Characterization and potential migration of silver nanoparticles from commercially available polymeric food contact materials.

The potential for consumer exposure to nano-components in food contact materials (FCMs) is dependent on the migration of nanomaterials into food. Therefore, characterizing the physico-chemical properties and potential for migration of constituents is an important step in assessing the safety of FCMs. A number of commercially available food storage products, purchased domestically within the US and internationally, which claim to contain nanosilver were evaluated. The products were made of polyethylene, poly...

Sunday 15th April 1201

Rapid detection of copper chlorophyll in vegetable oils based on surface-enhanced Raman spectroscopy.

The addition of copper chlorophyll and its derivatives (Cu-Chl) to vegetable oils to disguise them as more expensive oils, such as virgin olive oils, would not only create public confusion, but also disturb the olive oil market. Given that existing detection methods of Ch-Chl in oils, such as LC-MS are costly and time consuming, it is imperative to develop economical and fast analytical techniques to provide information quickly. This paper demonstrates a rapid analytical method based on surface-enhanced Ram...

Saturday 14th April 1201

Ultra-HPLC method for quality and adulterant assessment of steviol glycosides sweeteners - Stevia rebaudiana and stevia products.

Stevia products are advertised as a zero-calorie sweetener. Glucose should not be an intrinsic component of this product, but it has been identified from some of stevia products in a preliminary study. An UHPLC-UV method was developed for the quantitative determination of glucose from stevia products. After stevia products reacted with 1-phenyl-3-methyl-5-pyrazolone (PMP), PMP derivatives were analysed and glucose was found in seven out of 35 products in the range 0.3-91.5% (w/w). Two products, SPR-12 and S...

Friday 13th April 1201

A quantum dot-based immunoassay for screening of tylosin and tilmicosin in edible animal tissues.

A rapid, indirect competitive fluorescence-linked immunosorbent assay (ic-FLISA) based on quantum dots (QDs) as the fluorescent marker was developed for the detection of tylosin and tilmicosin in edible animal tissues. The end point fluorescent detection system was carried out using QDs conjugated with goat anti-mouse secondary antibody. The limits of detection (LODs) for the determination of tylosin and tilmicosin were 0.02 and 0.04 μg kg(-1), respectively. This detection method was used to analyse spik...


Other factors to consider in formation of chloropropandiol fatty esters in oil processes.

This paper examines the processing steps of extracting palm oil from fresh fruit bunches in a way that may impact on the formation of chloropropandiol fatty esters (3-MCPD esters), particularly during refining. Diacylglycerols (DAGs) do not appear to be a critical factor when crude palm oils are extracted from various qualities of fruit bunches. Highly hydrolysed oils, in spite of the high free fatty acid (FFA) contents, did not show exceptionally high DAGs, and the oils did not display a higher formation o...


Aerobic and anaerobic in vitro testing of feed additives claiming to detoxify deoxynivalenol and zearalenone.

Deoxynivalenol (DON) and zearalenone (ZEN) are mycotoxins produced by fungi of the genus Fusarium which frequently contaminate maize and grain cereals. Mycotoxin-contaminated feed endangers animal health and leads to economic losses in animal production. Several mycotoxin elimination strategies, including the use of commercially available DON and ZEN detoxifying agents, have been developed. However, frequently there is no scientific proof of the efficacy of such adsorbents and degrading products. We therefo...


Simultaneous determination of sweeteners in beverages by LC-MS/MS.

A new method was established for the simultaneous determination of 10 sweeteners and a degradation product in beverages by using LC-MS/MS. An ACQUITY UPLC BEH C18 (2.1 × 100 mm, 1.7 μm) was used as the LC column and 0.1% each of aqueous formic acid and formic acid in acetonitrile were used as the mobile phase. A simple and rapid determination of sweeteners was possible by diluting with a solvent, and in the case of some samples containing a large amount of foreign matter, after pre-treatment by diluti...


Determination and quantification of the emetic toxin cereulide from Bacillus cereus in pasta, rice and cream with liquid chromatography-tandem mass spectrometry.

A rapid and sensitive method has been developed for determination and quantification of cereulide in cream, rice and pasta. Samples are homogenised after addition of amylase to cooked rice and pasta, and cereulide is extracted with methanol. After the removal of water with methyl-tert butyl ether/hexane and evaporation until dryness, no further purification was required before analysis with liquid chromatography-tandem mass spectrometry (LC-MS/MS). Recently, both cereulide and (13)C6-cereulide has become co...

Wednesday 17th October 1195

Non-destructive detection of pesticide residues in cucumber using visible/near-infrared spectroscopy.

The feasibility of using visible/near-infrared (Vis/NIR) spectroscopy was assessed for non-destructive detection of diazinon residues in intact cucumbers. Vis/NIR spectra of diazinon solution and cucumber samples without and with different concentrations of diazinon residue were analysed at the range of 450-1000 nm. Partial least squares-discriminant analysis (PLS-DA) models were developed based on different spectral pre-processing techniques to classify cucumbers with contents of diazinon below and above ...


Analysis of veterinary drug and pesticide residues in animal feed by high-resolution mass spectrometry: comparison between time-of-flight and Orbitrap.

The use of medium-high-resolution mass spectrometers (M-HRMS) provides many advantages in multi-residue analysis. A comparison between two mass spectrometers, medium-resolution (MRMS) time-of-flight (TOF) and high-resolution (HRMS) Orbitrap, has been carried out for the analysis of toxic compounds in animal feed. More than 300 compounds belonging to several classes of veterinary drugs (VDs) and pesticides have been determined in different animal feed samples using a generic extraction method. The use of a c...


Effectiveness of hand sorting, flotation/washing, dehulling and combinations thereof on the decontamination of mycotoxin contaminated white maize.

Maize is one of the major staple foods of sub-Saharan Africa and is consumed as whole or dehulled grain. In this region, where the environmental conditions favour fungal growth and mycotoxin production, the majority of the population are subsistence consumers who, unfortunately, have little or no access to mycotoxin testing of their food. In an attempt to develop feasible reduction strategies in dietary mycotoxin exposure of the population, a three-factorial design experiment was conducted to examine and co...


Rapid screening for the adulterants of Berberis aristata using direct analysis in real time mass spectrometry and principal component analysis for discrimination.

Adulteration or substitution of commercial Berberis aristata and its herbal products with inferior quality substituents is very common. Metabolic profiling of Berberis aristata, along with its common adulterants/contaminants/substituents like Berberis asiatica, Mahonia borealis and Coscinium fenestratum was rapidly carried out using direct analysis in real time mass spectrometry to generate the chemical fingerprints for the differentiation of these species. Phytochemical analysis showed the presence of main...


Set-up of a multivariate approach based on serum biomarkers as an alternative strategy for the screening evaluation of the potential abuse of growth promoters in veal calves.

A chemometric class modelling strategy (unequal dispersed classes - UNEQ) was applied for the first time as a possible screening method to monitor the abuse of growth promoters in veal calves. Five serum biomarkers, known to reflect the exposure to classes of compounds illegally used as growth promoters, were determined from 50 untreated animals in order to design a model of controls, representing veal calves reared under good, safe and highly standardised breeding conditions. The class modelling was applie...

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