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PubMed Journal Database | Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment RSS

09:21 EDT 22nd September 2017 | BioPortfolio

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Showing PubMed Articles 1–25 of 386 from Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment

HPLC-DAD METHOD DEVELOPMENT AND VALIDATION FOR THE QUANTIFICATION OF HYDROXYMETHYLFURFURAL IN CORN CHIPS BY MEANS OF RESPONSE SURFACE OPTIMIZATION.

In recent years, there has been an increased concern about the presence of toxic compounds derived from the Maillard reaction produced during food cooking at high temperatures. The main toxic compounds derived from this reaction are acrylamide and hydroxymethylfurfural (HMF). The majority of analytical methods require sample treatments using solvents which are highly polluting for the environment. The difficulty for quantifying HMF in complex fried food matrices encourages the development of new analytical ...

Development of a Quantitative Multi-Compound Method for the Detection of 14 Nitrogen-rich Adulterants by LC-MS/MS in Food Materials.

The increasing number of food frauds using exogenous nitrogen-rich adulterants to artificially raise the protein content for economically motivated adulteration has demonstrated the need of a robust analytical methodology. This method should be applicable for quality control in operations covering a wide range of analyte concentrations to be able to analyze high levels as usually found in adulteration, as well as low levels due to contamination. The paper describes a liquid chromatography tandem mass spectr...

Persistent organic pollutants in farmed European seabass (Dicentrarchus labrax, Linnaeus, 1758) from Sicily (Italy).

Farmed European seabass (Dicentrarchus labrax, Linnaeus, 1758) were collected during 2016 from one Sicilian fish farm which uses two different rearing systems: sea cage and concrete tank, for determination of PCB, OCP and PAH residues, by HRGC-MS/MS. Moreover, commercial feed was analyzed. The aims of this study was to verify if the different rearing systems affect the concentration of these compounds and to verify the safety of cultured fish. PCBs represent the pollutants with the highest concentration and...

Impact of agronomic and climatic factors on the mycotoxin content of harvested oats in the UK.

A survey was conducted to determine the concentration of fusarium mycotoxins in UK oats over three seasons (2006-2008). One hundred oat samples were collected each year at harvest, together with agronomic details, and analysed for ten fusarium mycotoxins. The incidence and concentration of most fusarium mycotoxins, including deoxynivalenol and zearalenone, were relatively low in oats compared to values previously reported for wheat. HT-2 toxin (HT2) and T-2 toxin (T2) levels were relatively high with an ove...

Impact of ion-pairs for the determination of multiclass antimicrobials residues in honey by LC-MS/MS.

This study examines the behavior of volatile perfluorinated carboxylic acids used as ion-pairing reagents for the separation of multiclass antimicrobial residues in honey (tetracyclines, sulfonamides, macrolides and aminoglycosides). Heptafluorobutanoic acid and pentafluoropentanoic acid were compared as mobile phase additives at concentrations between 0-20 mmol.L(-1) using reversed phase chromatography. Our objective was to find optimal conditions that enable the separation of antimicrobials with a minimum...

Spectroscopy applied to feed additives of the European Union Reference Laboratory: a valuable tool for traceability.

Feed additives need to be authorised to be placed on the market according to Regulation (EU) No. 1831/2003. Next to laying down the procedural requirements, the regulation creates the European Union Reference Laboratory for Feed Additives (EURL-FA) and requires that applicants send samples to the EURL-FA. Once authorised, the characteristics of the marketed feed additives should correspond to those deposited in the sample bank of the EURL-FA. For this purpose, the submitted samples were subjected to near-in...

Fate of pyrrolizidine alkaloids during processing of milk of cows treated with ragwort.

To investigate the fate of pyrrolizidine alkaloids (PAs) during milk processing, milk of cows treated via rumen fistula with a mixture of 84% (w/w) ragwort (Jacobaea vulgaris, syn. Senecio jacobaea) and 16% narrow-leaved ragwort (Senecio inaequidens), was processed using laboratory scale heating systems with industrial settings. Pasteurised and sterilised (UHT) milk were produced, as well as set-type yoghurt and cheese. Samples were analysed for 29 PAs using LC-MS/MS, of which eleven PAs were detected above...

Determination of Fusarium toxins in functional vegetable milks applying salting out assisted liquid-liquid extraction combined with ultra-high performance liquid chromatography tandem mass spectrometry.

Vegetable milks are considered as functional foods due to their physiological benefits. Although the consumption of these products has significantly increased, they have received little attention in legislation, as regard to contaminants. However, they may contain mycotoxins resulting from the use of contaminated raw materials. In this work, ultra-high performance liquid chromatography tandem mass spectrometry has been proposed for the determination of the most relevant Fusarium toxins (fumonisin B1 and B2,...

Direct determination of 3-chloropropanol esters in edible vegetable oils using high resolution mass spectrometry (HRMS-Orbitrap).

A series of refined edible oils derived from mixed seeds, peanuts, corn, sunflower and palm, obtained from the local supermarket were analyzed for their content of 3-MCPD esters. A direct analytical method for the determination of 3-chloro-1,2-propanediol fatty acid esters (3-MCPD esters) was applied to investigate the major MCPD esters found in common edible oils; in particular seven types of monoesters and eleven types of diesters were detected. The LODs for monoesters and diesters of 3-MCPD were in the r...

Receptor Binding Assay for the Detection of Paralytic Shellfish Poisoning Toxins: Comparison to the Mouse Bioassay and Applicability under Regulatory Use.

The receptor-binding assay (RBA) method for the detection of paralytic shellfish poisoning (PSP) toxins was evaluated for its overall performance in comparison with the mouse bioassay (MBA). An initial study to evaluate the effects of filtering shellfish extracts prior to running the RBA indicated no significant difference between filtered and unfiltered extracts on the determined saxitoxin concentrations. Next, we tested the RBA assay on 295 naturally contaminated mussel tissue samples, ranging in concentr...

A Review of the Current Situation of Aflatoxin M1 in Cow's Milk in Serbia - Risk Assessment and Regulatory Aspects.

The aim of this systematic review is to provide information regarding the incidence and levels of Aflatoxin M1 (AFM1) in raw and heat processed cow's milk in Serbia during 2015-2016 and to compare these with collected data on the occurrence of AFM1 in raw milk and dairy products during last decade in our region. Estimation of Dietary Exposure (EDI) and Hazard Index (HI) calculations for different age groups of the population were also carried out, based on the AFM1 content of the milk samples and on availab...

Longitudinal modelling of the exposure of young UK patients with PKU to Acesulfame K and Sucralose.

Artificial sweeteners are used in protein substitutes intended for the dietary management of inborn errors of metabolism (Phenylketonuria, PKU) to improve the variety of medical foods available to patients and ensure dietary adherence to the prescribed course of dietary management. These patients can be exposed to artificial sweeteners from the combination of free and prescribed foods. Young children have a higher risk of exceeding acceptable daily intakes (ADI) for additives than adults due to higher food ...

Multiclass mycotoxin analysis in edible oils using a simple solvent extraction method and liquid chromatography with tandem mass spectrometry.

A simple and rapid method for the simultaneous determination of eleven mycotoxins-aflatoxins B1, B2, G1, and G2; fumonisins B1, B2, and B3; ochratoxin A; zearalenone; deoxynivalenol; and T-2 toxin-in edible oils was established using liquid chromatography tandem mass spectrometry (LC-MS/MS). In this study, QuEChERS, QuEChERS with dispersive liquid-liquid microextraction, and solvent extraction were examined for sample preparation. Among these methods, solvent extraction with a mixture of formic acid/acetoni...

Non-targeted workflow for identification of antimicrobial compounds in animal feed using bioassay-directed screening in combination with LC-HRMS.

A non-targeted workflow is reported for the isolation and identification of antimicrobial active compounds using bioassay-directed screening and liquid chromatography coupled to high resolution mass spectrometry. Suspect samples are extracted using a generic protocol and fractionated using two different liquid chromatography conditions (A and B). The behavior of the bioactive compound under these different conditions yields information about the physicochemical properties of the compound and introduces vari...

Probabilistic dietary exposure to ethyl carbamate from fermented foods and alcoholic beverages in the Korean population.

The occurrence of ethyl carbamate was investigated in fermented foods and alcoholic beverages of the Korean total diet study. The concentrations of ethyl carbamate ranged from not-detected to 166.5 μg kg(-1). Dietary exposure to ethyl carbamate was estimated by the probabilistic method. Estimated intakes of ethyl carbamate from foods and alcoholic beverages were 4.12 ng kg(-1) body weight (bw) per day for average consumers and 12.37 ng kg(-1) bw per day for 95(th) percentile high consumers. The major foods...

Development of a confirmatory method for detecting recombinant bovine somatotropin in plasma by immunomagnetic precipitation followed by ultra-high performance liquid chromatography coupled to tandem mass spectrometry.

Recombinant bovine somatotropin (rbST), a synthetic growth hormone, is used to stimulate growth and enhance milk production in dairy cows. Both its use and the sale of dairy products from treated animals are prohibited in the European Union, Japan, Australia, New Zealand, and Canada, but authorised in several countries (e.g. the USA, Brazil). Screening methods involve detecting anti-rbST antibodies (biomarkers) in treated cows. Confirmatory methods are required to prove rbST abuse. The major challenges in d...

Risk assessment of patulin intake through apple-based food by infants and preschool children in Serbia.

This study reports for the first time in Serbia the occurrence of patulin in apple-based food and the risk assessment associated with patulin intake by infants and preschool children. In total, 214 samples of infant fruit juices (48), infant purée (66) and juices for children (small package with straw, 100) were collected over three years (2013-2015) and analysed using high performance liquid chromatography with ultraviolet detection. Patulin was found in 43.8% of infant juices and 16.7% of infant purée w...

Dispersed synthesis of uniform Fe3O4 magnetic nanoparticles via in situ decomposition of iron precursor along cotton fiber for Sudan dyes analysis in food samples.

Fe3O4 magnetic nanoparticles, with a negative charge surface, are known to have efficient adsorbent properties, but they tend to be agglomerated into larger aggregates or flocs, which can cause loss of specific area. The addition of cotton fiber, as a stabilizer in preparation of the Fe3O4 nanoparticles, is able to efficiently reduce particle aggregation, and thus, effective particle size, resulting in much greater specific surface area and adsorption sites. Fe3O4 nanoparticles synthesis was accomplished by...

Quantitative analysis of veterinary drugs in bovine muscle and milk by liquid chromatography quadrupole time-of-flight mass spectrometry.

A simple and reliable multiresidue method for quantitative determination of veterinary drugs in bovine muscle and milk using liquid chromatography quadrupole time-of-flight mass spectrometry (LC-QTOF-MS) was developed. Critical MS parameters such as capillary voltage, cone voltage, collision energy, desolvation gas temperature, and extraction mass window were carefully optimised to obtain the best possible sensitivity. Analytical samples were prepared using extraction with acetonitrile and hexane in the pre...

Quantification of Mycotoxins in Vegetable Oil by UPLC-MS/MS after Magnetic Solid Phase Extraction.

Detection of mycotoxin contamination in foodstuffs is highly significant for public health. Herein we report an analytical method based on magnetic solid phase extraction (MSPE) and UPLC-MS/MS for simultaneous determination of mycotoxins, including fumonisins B1 (FB1), zearalenone (ZON) and ochratoxin A (OTA) in vegetable oil. Magnetic nanoparticles coated with double layers of silicon dioxide were synthesized and found to be an effective MSPE adsorbent for mycotoxins. The proposed MSPE procedure serves not...

Analytical determination of bisphenol A (BPA) and bisphenol analogues in paper products by GC-MS/MS.

Bisphenol A (BPA; 4-[2-(4-Hydroxyphenyl)propan-2-yl]phenol), a suspected endocrine disruptor with a weak estrogenic activity is used in a variety of consumer products, including food contact materials made of paper and cardboard products. Due to restrictions for the use of BPA because of its potential health risks, BPA is gradually being replaced by other bisphenols, as no limitations exist for these substances. The present study presents a method for the simultaneous analysis of bisphenol A (BPA), bispheno...

Chemical composition of rosehips from different Rosa species: an alternative source of antioxidants for food industry.

It is important to explore new sources of natural additives because the demand for these compounds by consumers is increasing. These products also provide health benefits and help in food preservation. An unexplored source of nutrients and antioxidant compounds is rosehip, the fleshy fruit of roses. This work compares antioxidant compounds (vitamin C, neutral phenols and acidic phenols) content of four Rosa species rosehips: R. pouzinii, R. corymbifera, R. glauca and R. canina coming from different geograph...

Elimination of dioxins in milk by dairy cows after the long-term intake of contaminated sugar beet pellets.

Dried feed materials, such as sugar beet pellets, may be a source of high levels of PCDD/Fs. The studies followed up dioxin congener elimination from contaminated milk (5.02 ± 1.39 pg WHO PCDD/F-PCBs-TEQ g(-1) fat) up to 338 days after withdrawal of polluted feed ingredient (4.37 ± 0.25 ng PCDD/F/DL-PCBs-TEQ kg(-1) feed). The main objectives of the study were to estimate the length of the time needed to achieve an acceptable PCDD/F milk level as set by European Union law, to track the fate of the PCD...

Understanding the Contamination of Food with Mineral Oil : the need for a Confirmatory Analytical and Procedural Approach.

The contamination of food by mineral oil hydrocarbons (MOH) found in packaging is a long running concern. A main source of MOH in foods is the migration of mineral oil from recycled board into the packed food products. Consequently, the majority of food manufacturers have taken protective measures, for example by using virgin board instead of recycled fibers, and where feasible, introducing functional barriers to mitigate migration. Despite these protective measures, MOH may still be observed at low amounts...

Dietary exposures for the safety assessment of seven emulsifiers commonly added to foods in the United States and implications for safety.

Dietary exposure assessment using food consumption data and ingredient use level is essential for assessing safety of food ingredients. Dietary exposure estimates are compared to safe intake levels, such as Acceptable Daily Intake (ADI). ADI is estimated by applying a safety factor to an experimentally determined no-observed-adverse-effect-level of a test substance. Two food ingredients classified as emulsifiers, sodium carboxymethylcellulose (CMC) and polysorbate 80 (P80), received attention recently due t...


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