PubMed Journal Database | Nature reviews. Molecular cell biology RSS

21:17 EST 19th December 2014 | BioPortfolio

The US National Library of Medicine and National Institutes of Health manage PubMed.gov which comprises of more than 21 million records, papers, reports for biomedical literature, including MEDLINE, life science and medical journals, articles, reviews, reports and  books.  BioPortfolio aims to publish relevant information on published papers, clinical trials and news associated with users selected topics.

For example view all recent relevant publications on Epigenetics and associated publications and clincial trials.

Showing PubMed Articles 1–25 of 490 from Nature reviews. Molecular cell biology

Friday 24th March 1092

Chromatin dynamics in the regulation of cell fate allocation during early embryogenesis.

Following fertilization, gametes undergo epigenetic reprogramming in order to revert to a totipotent state. How embryonic cells subsequently acquire their fate and the role of chromatin dynamics in this process are unknown. Genetic and experimental embryology approaches have identified some of the players and morphological changes that are involved in early mammalian development, but the exact events underlying cell fate allocation in single embryonic cells have remained elusive. Experimental and technologi...

Thursday 23rd March 1092

Signalling dynamics in the spindle checkpoint response.

The spindle checkpoint ensures proper chromosome segregation during cell division. Unravelling checkpoint signalling has been a long-standing challenge owing to the complexity of the structures and forces that regulate chromosome segregation. New reports have now substantially advanced our understanding of checkpoint signalling mechanisms at the kinetochore, the structure that connects microtubules and chromatin. In contrast to the traditional view of a binary checkpoint response - either completely on or o...

1066642

Cell death: RIPK1 protects epithelial cells.

1066641

Capping protein regulators fine-tune actin assembly dynamics.

Capping protein (CP) binds the fast growing barbed end of the actin filament and regulates actin assembly by blocking the addition and loss of actin subunits. Recent studies provide new insights into how CP and barbed-end capping are regulated. Filament elongation factors, such as formins and ENA/VASP (enabled/vasodilator-stimulated phosphoprotein), indirectly regulate CP by competing with CP for binding to the barbed end, whereas other molecules, including V-1 and phospholipids, directly bind to CP and ste...

1066640

RNA metabolism: The fates of mRNAs in P bodies.

1066639

Plant cell biology: SUMOylation mediates brassinosteroid effects.

1066638

Recombination: mRNAs repair double-strand breaks.

1066637

The physiological relevance of death receptor-mediated apoptosis.

Thursday 28th June 1026

Endocytosis: Bend it like galectin 3.

Saturday 8th December 1009

Stem cells: Stressed HSCs choose death.

Friday 7th December 1009

Post-translational modifications: Lys33-linked ubiquitin in post-Golgi transport.

Thursday 6th December 1009

RNA interference: Nuclear Dicer makes the cut.

Wednesday 5th December 1009

Autophagy: Structural insight into autophagy initiation.

Tuesday 4th December 1009

Mechanotransduction: Vinculin discrimination at adhesions.

Monday 3rd December 1009

Gene expression: CTD Tyr1 gives direction.

Sunday 2nd December 1009

The amyloid state and its association with protein misfolding diseases.

The phenomenon of protein aggregation and amyloid formation has become the subject of rapidly increasing research activities across a wide range of scientific disciplines. Such activities have been stimulated by the association of amyloid deposition with a range of debilitating medical disorders, from Alzheimer's disease to type II diabetes, many of which are major threats to human health and welfare in the modern world. It has become clear, however, that the ability to form the amyloid state is more genera...

Saturday 1st December 1009

Cellular mechanisms and physiological consequences of redox-dependent signalling.

Reactive oxygen species (ROS), which were originally characterized in terms of their harmful effects on cells and invading microorganisms, are increasingly implicated in various cell fate decisions and signal transduction pathways. The mechanism involved in ROS-dependent signalling involves the reversible oxidation and reduction of specific amino acids, with crucial reactive Cys residues being the most frequent target. In this Review, we discuss the sources of ROS within cells and what is known regarding ho...

Friday 30th November 1009

The faces of Big Science.

Fifty years ago, academic science was a calling with few regulations or financial rewards. Today, it is a huge enterprise confronted by a plethora of bureaucratic and political controls. This change was not triggered by specific events or decisions but reflects the explosive 'knee' in the exponential growth that science has sustained during the past three-and-a-half centuries. Coming to terms with the demands and benefits of 'Big Science' is a major challenge for today's scientific generation. Since its fou...

927017

Development: Morphogen gradients revisited.

927016

DNA damage response: A ligase makes sense of DNA damage.

927015

Synthetic biology in mammalian cells: next generation research tools and therapeutics.

Recent progress in DNA manipulation and gene circuit engineering has greatly improved our ability to programme and probe mammalian cell behaviour. These advances have led to a new generation of synthetic biology research tools and potential therapeutic applications. Programmable DNA-binding domains and RNA regulators are leading to unprecedented control of gene expression and elucidation of gene function. Rebuilding complex biological circuits such as T cell receptor signalling in isolation from their natur...

927014

The lipid trade.

906153

Size and position matter.

The 2013 Nobel Prize in Physiology or Medicine emphasizes the progress made in understanding the molecular mechanisms that underpin the vesicular movement of cargo through the exocytic and endocytic pathways. Attention now focuses on those mechanisms that govern the relative size and position of the many different membrane-bound compartments. These homeostatic mechanisms are discussed in this issue of Nature Reviews Molecular Cell Biology and must be integrated so as to satisfy the needs of the cell and the...

904480

Self-consumption: the interplay of autophagy and apoptosis.

Autophagy and apoptosis control the turnover of organelles and proteins within cells, and of cells within organisms, respectively, and many stress pathways sequentially elicit autophagy, and apoptosis within the same cell. Generally autophagy blocks the induction of apoptosis, and apoptosis-associated caspase activation shuts off the autophagic process. However, in special cases, autophagy or autophagy-relevant proteins may help to induce apoptosis or necrosis, and autophagy has been shown to degrade the cy...

876096

Calcium: An ion channel for cilia.


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