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05:20 EST 29th January 2015 | BioPortfolio

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Showing PubMed Articles 1–25 of 497 from Nature reviews. Molecular cell biology


Morphogenesis: Getting cells moving.


Cytoskeleton: How big cells are organized.


Technique: Capturing translation initiation.


Cell migration: Making contacts while on the move.


Telomeres: Chaperonin' telomerase.


Intrinsically disordered proteins in cellular signalling and regulation.

Intrinsically disordered proteins (IDPs) are important components of the cellular signalling machinery, allowing the same polypeptide to undertake different interactions with different consequences. IDPs are subject to combinatorial post-translational modifications and alternative splicing, adding complexity to regulatory networks and providing a mechanism for tissue-specific signalling. These proteins participate in the assembly of signalling complexes and in the dynamic self-assembly of membrane-less nucl...


Protein neddylation: beyond cullin-RING ligases.

NEDD8 (neural precursor cell expressed developmentally downregulated protein 8) is a ubiquitin-like protein that activates the largest ubiquitin E3 ligase family, the cullin-RING ligases. Many non-cullin neddylation targets have been proposed in recent years. However, overexpression of exogenous NEDD8 can trigger NEDD8 conjugation through the ubiquitylation machinery, which makes validating potential NEDD8 targets challenging. Here, we re-evaluate studies of non-cullin targets of NEDD8 in light of the curre...

Friday 24th March 1092

Chromatin dynamics in the regulation of cell fate allocation during early embryogenesis.

Following fertilization, gametes undergo epigenetic reprogramming in order to revert to a totipotent state. How embryonic cells subsequently acquire their fate and the role of chromatin dynamics in this process are unknown. Genetic and experimental embryology approaches have identified some of the players and morphological changes that are involved in early mammalian development, but the exact events underlying cell fate allocation in single embryonic cells have remained elusive. Experimental and technologi...

Thursday 23rd March 1092

Signalling dynamics in the spindle checkpoint response.

The spindle checkpoint ensures proper chromosome segregation during cell division. Unravelling checkpoint signalling has been a long-standing challenge owing to the complexity of the structures and forces that regulate chromosome segregation. New reports have now substantially advanced our understanding of checkpoint signalling mechanisms at the kinetochore, the structure that connects microtubules and chromatin. In contrast to the traditional view of a binary checkpoint response - either completely on or o...


Cell death: RIPK1 protects epithelial cells.


Capping protein regulators fine-tune actin assembly dynamics.

Capping protein (CP) binds the fast growing barbed end of the actin filament and regulates actin assembly by blocking the addition and loss of actin subunits. Recent studies provide new insights into how CP and barbed-end capping are regulated. Filament elongation factors, such as formins and ENA/VASP (enabled/vasodilator-stimulated phosphoprotein), indirectly regulate CP by competing with CP for binding to the barbed end, whereas other molecules, including V-1 and phospholipids, directly bind to CP and ste...


RNA metabolism: The fates of mRNAs in P bodies.


Plant cell biology: SUMOylation mediates brassinosteroid effects.


Recombination: mRNAs repair double-strand breaks.


The physiological relevance of death receptor-mediated apoptosis.

Thursday 28th June 1026

Endocytosis: Bend it like galectin 3.

Saturday 8th December 1009

Stem cells: Stressed HSCs choose death.

Friday 7th December 1009

Post-translational modifications: Lys33-linked ubiquitin in post-Golgi transport.

Thursday 6th December 1009

RNA interference: Nuclear Dicer makes the cut.

Wednesday 5th December 1009

Autophagy: Structural insight into autophagy initiation.

Tuesday 4th December 1009

Mechanotransduction: Vinculin discrimination at adhesions.

Monday 3rd December 1009

Gene expression: CTD Tyr1 gives direction.

Sunday 2nd December 1009

The amyloid state and its association with protein misfolding diseases.

The phenomenon of protein aggregation and amyloid formation has become the subject of rapidly increasing research activities across a wide range of scientific disciplines. Such activities have been stimulated by the association of amyloid deposition with a range of debilitating medical disorders, from Alzheimer's disease to type II diabetes, many of which are major threats to human health and welfare in the modern world. It has become clear, however, that the ability to form the amyloid state is more genera...

Saturday 1st December 1009

Cellular mechanisms and physiological consequences of redox-dependent signalling.

Reactive oxygen species (ROS), which were originally characterized in terms of their harmful effects on cells and invading microorganisms, are increasingly implicated in various cell fate decisions and signal transduction pathways. The mechanism involved in ROS-dependent signalling involves the reversible oxidation and reduction of specific amino acids, with crucial reactive Cys residues being the most frequent target. In this Review, we discuss the sources of ROS within cells and what is known regarding ho...

Friday 30th November 1009

The faces of Big Science.

Fifty years ago, academic science was a calling with few regulations or financial rewards. Today, it is a huge enterprise confronted by a plethora of bureaucratic and political controls. This change was not triggered by specific events or decisions but reflects the explosive 'knee' in the exponential growth that science has sustained during the past three-and-a-half centuries. Coming to terms with the demands and benefits of 'Big Science' is a major challenge for today's scientific generation. Since its fou...

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