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18:21 EDT 1st September 2015 | BioPortfolio

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Showing PubMed Articles 1–25 of 534 from Nature reviews. Molecular cell biology

Sunday 26th September 1322

Transcription: PAF1 regulates promoter-proximal pausing.

Saturday 25th September 1322

Gene expression: PolyQ repeats regulate transcription.

Friday 24th September 1322

Metabolism: Human bone marrow can make fat.

Thursday 23rd September 1322

DNA methylation pathways and their crosstalk with histone methylation.

Methylation of DNA and of histone 3 at Lys 9 (H3K9) are highly correlated with gene silencing in eukaryotes from fungi to humans. Both of these epigenetic marks need to be established at specific regions of the genome and then maintained at these sites through cell division. Protein structural domains that specifically recognize methylated DNA and methylated histones are key for targeting enzymes that catalyse these marks to appropriate genome sites. Genetic, genomic, structural and biochemical data reveal ...

Wednesday 22nd September 1322

Microfluidics: reframing biological enquiry.

The underlying physical properties of microfluidic tools have led to new biological insights through the development of microsystems that can manipulate, mimic and measure biology at a resolution that has not been possible with macroscale tools. Microsystems readily handle sub-microlitre volumes, precisely route predictable laminar fluid flows and match both perturbations and measurements to the length scales and timescales of biological systems. The advent of fabrication techniques that do not require high...

Wednesday 2nd April 1298

Cell signalling: One kinase targets many secreted proteins.

Tuesday 1st April 1298

Exosomes: Apoptotic beads on a string.

Monday 31st March 1298

Cytoskeleton: Degrading proteins at the primary cilium.

Sunday 30th March 1298

Chromosomes: Transgenerational remodelling of sperm DNA.

Saturday 29th March 1298

Cytoskeleton: Controlling microtubules with light.

Friday 28th March 1298

Post-translational modifications: Resisting heat stress with SUMO.

Thursday 27th March 1298

Short- and long-term effects of chromosome mis-segregation and aneuploidy.

Dividing cells that experience chromosome mis-segregation generate aneuploid daughter cells, which contain an incorrect number of chromosomes. Although aneuploidy interferes with the proliferation of untransformed cells, it is also, paradoxically, a hallmark of cancer, a disease defined by increased proliferative potential. These contradictory effects are also observed in mouse models of chromosome instability (CIN). CIN can inhibit and promote tumorigenesis. Recent work has provided insights into the cellu...

Wednesday 26th March 1298

Sound of silence: the properties and functions of repressive Lys methyltransferases.

The methylation of histone Lys residues by Lys methyltransferases (KMTs) regulates chromatin organization and either activates or represses gene expression, depending on the residue that is targeted. KMTs are emerging as key components in several cellular processes, and their deregulation is often associated with pathogenesis. Here, we review the current knowledge on the main KMTs that are associated with gene silencing: namely, those responsible for methylating histone H3 Lys 9 (H3K9), H3K27 and H4K20. We ...

Friday 17th August 1291

Cell signalling: Limiting the side effects of senescence.

Thursday 16th August 1291

Autophagy at the crossroads of catabolism and anabolism.

Autophagy is a conserved catabolic process that degrades cytoplasmic constituents and organelles in the lysosome. Starvation-induced protein degradation is a salient feature of autophagy but recent progress has illuminated how autophagy, during both starvation and nutrient-replete conditions, can mobilize diverse cellular energy and nutrient stores such as lipids, carbohydrates and iron. Processes such as lipophagy, glycophagy and ferritinophagy enable cells to salvage key metabolites to sustain and facilit...

Wednesday 15th August 1291

Chromatin: Histone influences on chromosomal translocations.

Tuesday 17th October 1194

Lipid metabolism: Fatty acids on the move.

Monday 16th October 1194

Signalling scaffolds and local organization of cellular behaviour.

Cellular responses to environmental cues involve the mobilization of GTPases, protein kinases and phosphoprotein phosphatases. The spatial organization of these signalling enzymes by scaffold proteins helps to guide the flow of molecular information. Allosteric modulation of scaffolded enzymes can alter their catalytic activity or sensitivity to second messengers in a manner that augments, insulates or terminates local cellular events. This Review examines the features of scaffold proteins and highlights ex...

Sunday 15th October 1194

Development: Switching off WNT with precision.


Non-coding RNA: Circular RNAs promote transcription.


Replication fork reversal in eukaryotes: from dead end to dynamic response.

The remodelling of replication forks into four-way junctions following replication perturbation, known as fork reversal, was hypothesized to promote DNA damage tolerance and repair during replication. Albeit conceptually attractive, for a long time fork reversal in vivo was found only in prokaryotes and specific yeast mutants, calling its evolutionary conservation and physiological relevance into question. Based on the recent visualization of replication forks in metazoans, fork reversal has emerged as a gl...


Orchestrating transcription with the pol II CTD.


Cell signalling: Orphan receptor finds ligand.


Transcription: A mitochondrial switch between transcription and replication.


Structural basis of transcription initiation by RNA polymerase II.

Transcription of eukaryotic protein-coding genes commences with the assembly of a conserved initiation complex, which consists of RNA polymerase II (Pol II) and the general transcription factors, at promoter DNA. After two decades of research, the structural basis of transcription initiation is emerging. Crystal structures of many components of the initiation complex have been resolved, and structural information on Pol II complexes with general transcription factors has recently been obtained. Although mec...