PubMed Journal Database | Nature reviews. Molecular cell biology 
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Showing PubMed Articles 1–25 of 346 from Nature reviews. Molecular cell biology
Metabolism: A cold, brite start.
Cell signalling: New G protein family rules.
Cell signalling: Crystallizing active arrestins.
Origins and implications of pluripotent stem cell variability and heterogeneity.
Pluripotent stem cells constitute a platform to model disease and developmental processes and can potentially be used in regenerative medicine. However, not all pluripotent cell lines are equal in their capacity to differentiate into desired cell types in vitro. Genetic and epigenetic variations contribute to functional variability between cell lines and heterogeneity within clones. These genetic and epigenetic variations could 'lock' the pluripotency network resulting in residual pluripotent cells or alter...
Stem cells: A gated exit from pluripotency.
Mechanisms and function of substrate recruitment by F-box proteins.
S phase kinase-associated protein 1 (SKP1)-cullin 1 (CUL1)-F-box protein (SCF) ubiquitin ligase complexes use a family of F-box proteins as substrate adaptors to mediate the degradation of a large number of regulatory proteins involved in diverse processes. The dysregulation of SCF complexes and their substrates contributes to multiple pathologies. In the 14 years since the identification and annotation of the F-box protein family, the continued identification and characterization of novel substrates has gr...
Metabolism: Putting energy into mitophagy.
Protein metabolism: Quality control at the ribosome.
Signalling change: signal transduction through the decades.
The past few years have marked significant anniversaries in signal transduction, including the identification of classic growth factors and morphogens, the notion of protein modification through phosphorylation and the characterization of protein interaction domains. Here, six researchers reflect on the context in which these discoveries were made, and how our concept of cell signalling has evolved during the past three decades.
Cytoskeleton: Formins induce nuclear actin assembly.
Stem cells: TFIID promotes pluripotency.
Cell division: Different daughters.
DNA replication: Quality and quantity.
DNA repair: Repair with a twist.
Diversity in the origins of proteostasis networks - a driver for protein function in evolution.
Although the sequence of a protein largely determines its function, proteins can adopt different folding states in response to changes in the environment, some of which may be deleterious to the organism. All organisms -Bacteria, Archaea and Eukarya - have evolved a protein homeostasis, or proteostasis, network comprising chaperones and folding factors, degradation components, signalling pathways and specialized compartmentalized modules that manage protein folding in response to environmental stimuli and v...
Senescence: back to telomeres.
Development: A good hair day for ROS.
Cell signalling: DDX3 in command of CK1ε
Cell signalling: Where the mTOR action is.
The role of transcription-independent damage signals in the initiation of epithelial wound healing.
Wound healing is an essential biological process that comprises sequential steps aimed at restoring the architecture and function of damaged cells and tissues. This process begins with conserved damage signals, such as Ca(2+), hydrogen peroxide (H(2)O(2)) and ATP, that diffuse through epithelial tissues and initiate immediate gene transcription-independent cellular effects, including cell shape changes, the formation of functional actomyosin structures and the recruitment of immune cells. These events integ...
Cell signalling: A new Hippo pathway component.
Non-coding RNA: RNA stability control by Pol II.
Development: Growing a blood vessel network.
