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02:16 EDT 1st May 2017 | BioPortfolio

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Showing "Developmental biology brainy background" PubMed Articles 1–25 of 12,000+

The Maturation of Development.

An updated, broader definition of developmental biology is needed to capture the full range of exciting research directions of the field, as current studies of adult homeostasis and physiology are extending developmental biology's "Golden Age."

Biasing Opioid Receptors and Cholesterol as a Player in Developmental Biology.

Every month the editors of Cell Chemical Biology bring you highlights of the most recent chemical biology literature. Our September 2016 selection includes the discovery of PZM21, a μOR biased agonist with minimal side effects, and the role of cholesterol in Hedgehog signaling pathway.

The honeybee as a model insect for developmental genetics.

Honeybees are an important component of modern agricultural systems, and a fascinating and scientifically engrossing insect. Honeybees are not commonly used as model systems for understanding development in insects despite their importance in agriculture. Honeybee embryogenesis, while being superficially similar to Drosophila, is molecularly very different, especially in axis formation and sex determination. In later development, much of honeybee biology is modified by caste development, an as yet poorly un...

Single-Cell Approaches: Pandora's Box of Developmental Mechanisms.

Single-cell approaches are providing a new lexicon of developmental cell biology by revealing heterogeneities in seemingly uniform cellular populations. By bridging scales, single-cell approaches should, in principle, galvanize our understanding of how individual cells adopt distinct fates as they build complex tissues.

John Saunders' ZPA, Sonic hedgehog and digit identity - how does it really all work?

Among John Saunders' many seminal contributions to developmental biology, his discovery of the limb 'zone of polarizing activity' (ZPA) is arguably one of the most memorable and ground-breaking. This discovery introduced the limb as a premier model for understanding developmental patterning and promoted the concept of patterning by a morphogen gradient. In the 50 years since the discovery of the ZPA, Sonic hedgehog (Shh) has been identified as the ZPA factor and the basic components of the signaling pathway...

Genotypes, Networks, Phenotypes: Moving Toward Plant Systems Genetics.

One of the central goals in biology is to understand how and how much of the phenotype of an organism is encoded in its genome. Although many genes that are crucial for organismal processes have been identified, much less is known about the genetic bases underlying quantitative phenotypic differences in natural populations. We discuss the fundamental gap between the large body of knowledge generated over the past decades by experimental genetics in the laboratory and what is needed to understand the genotyp...

An Intervention Supporting the Mental Health of Children with a Refugee Background.

This contribution proposes an intervention methodology that provides improved access to and effectiveness of mental health care facilities in Brussels, Belgium, for children and their families with a refugee and migration background. Migration is a complex process that involves several potential risk factors, and referral to mental health facilities is often ineffective. Consequently, optimal developmental opportunities for refugee children are hampered. The intervention is underpinned by a broad-based cont...

A Nucleoporin at the Meiotic Kinetochore.

In this issue of Developmental Cell, Hattersley et al. (2016) use the unique biology of meiosis I, in which the cell can exit the division without reforming the nuclear envelope, to uncover an intriguing role of the nucleoporin MEL-28 in mediating chromosome segregation via its interaction with PP1 at the kinetochore.

Developmental Biology: When Less Damage Causes More Harm.

Circadian clocks are important timekeepers of physiological processes. A new report shows that silencing the circadian clock specifically in steroid-producing cells of Drosophila disrupts development and causes lethality, and is more detrimental than having no clock at all.


A statistical background noise correction sensitive to the steadiness of background noise.

A statistical background noise correction is developed for removing background noise contributions from measured source levels, producing a background noise-corrected source level. Like the standard background noise corrections of ISO 3741, ISO 3744, ISO 3745, and ISO 11201, the statistical background correction increases as the background level approaches the measured source level, decreasing the background noise-corrected source level. Unlike the standard corrections, the statistical background correction...

The enteric nervous system: From embryology to therapy.

Regulation of development by SOX proteins.

Determinants of developmental progress in pre-schoolers referred for neuro-developmental diagnosis.

To determine factors associated with change in developmental progress in pre-schoolers referred to a developmental clinic.

Robo-Enabled Tumor Cell Extrusion.

How aberrant cells are removed from a tissue to prevent tumor formation is a key question in cancer biology. Reporting in this issue of Developmental Cell, Vaughen and Igaki (2016) show that a pathway with an important role in neural guidance also directs extrusion of tumor cells from epithelial tissues.

Cell Division in the Light of Modeling.

Theoretical modeling is central to elucidating underlying principles of emergent properties of complex systems. In cell and developmental biology, the last 15 years have witnessed a convergence of empirical and modeling approaches for fresh perspectives. The role of cell division in coordinating size, shape, and fate in particular illustrates the ever-growing impact of modeling.

Bottom-Up Biology: Harnessing Engineering to Understand Nature.

Engineering as a field has fundamentally different goals than biology, but the perspective that engineers take-that systems can be designed and built-is helping to advance biological sciences by motivating and equipping efforts to construct biological systems from the bottom up.

A purely predatory relationship… Really?

Poly (ADP-ribose) polymerase in growth, death, multicellularity.

Charting developmental dissolution of pluripotency.

The formation of tissues and organs during metazoan development begs fundamental questions of cellular plasticity: How can the very same genome program diverse cell types? How do cell identity programs unfold during development in space and time? How can defects in these mechanisms cause disease and also provide opportunities for therapeutic intervention? And ultimately, can developmental programs be exploited for bioengineering tissues and organs? Understanding principle designs of cellular identity and de...

Sensory Biology: How Female Treefrogs Pick Mates at a Noisy Party.

A recent study has found that, despite strong acoustic masking from background noise, female treefrogs are able to select among individual males advertising for mates by taking advantage of small, periodic decreases in the overall noise structure.

Cellular aspects of gonadal atrophy in Drosophila P-M hybrid dysgenesis.

Gonadal atrophy is the most typical and dramatic manifestation of intraspecific hybrid dysgenesis syndrome leading to sterility in Drosophila melanogaster dysgenic progeny. The P-M system of hybrid dysgenesis is primarily associated with germ cell degeneration during the early stages of Drosophila embryonic development at elevated temperatures. In the present study, we have defined the phase of germ cell death as beginning at the end of embryogenesis immediately following gonad formation. However, the tempe...

Mitochondrial genome erosion and the evolution of sex.

Plagiocephaly and Developmental Delay: A Systematic Review.

Deformational plagiocephaly (includes plagiocephaly and brachycephaly) is a common pediatric condition. Infants who present with altered head shape often experience developmental delay. It is uncertain how common developmental delay is in infants with plagiocephaly and how sustained this is, when present. This review explores the association between plagiocephaly and developmental delay to guide clinical practice.

Organoids: Modeling Development and the Stem Cell Niche in a Dish.

Organoids are three-dimensional in-vitro-grown cell clusters with near-native microanatomy that arise from self-organizing mammalian pluripotent or adult stem cells. Although monolayer stem cell cultures were established more than 40 years ago, organoid technology has recently emerged as an essential tool for both fundamental and biomedical research. For developmental biologists, organoids provide powerful means for ex vivo modeling of tissue morphogenesis and organogenesis. Here we discuss how organoid cu...

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