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Showing "Developmental biology brainy background" PubMed Articles 1–25 of 15,000+

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The Renaissance of Developmental Biology.

Since its heyday in the 1980s and 90s, the field of developmental biology has gone into decline; in part because it has been eclipsed by the rise of genomics and stem cell biology, and in part because it has seemed less pertinent in an era with so much focus on translational impact. In this essay, I argue that recent progress in genome-wide analyses and stem cell research, coupled with technological advances in imaging and genome editing, have created the conditions for the renaissance of a new wave of deve...


Modelling from the experimental developmental biologists viewpoint.

In this review we consider Reaction-Diffusion as the archetype of a model in developmental biology. We consider its history in relation to experimental work since it was first proposed in 1952 by Turing and revived in the 1970s by Meinhardt. We then discuss the most recent examples of experiments that address this model, including the challenges that remain in capturing the physico-chemical manifestation of the model mechanism in a real developmental system. Finally we discuss the model's current status and...

The childhood solid tumor network: A new resource for the developmental biology and oncology research Communities.

Significant advances have been made over the past 25 years in our understanding of the most common adult solid tumors such as breast, colon, lung and prostate cancer. Much less is known about childhood solid tumors because they are rare and because they originate in developing organs during fetal development, childhood and adolescence. It can be very difficult to study the cellular origins of pediatric solid tumors in developing organs characterized by rapid proliferative expansion, growth factor signaling,...

Decoding the jargon of bottom-up metabolic systems biology.

Bottom-up metabolic systems biology is of particular relevance to biochemists. The jargon of bottom-up metabolic systems biology however represents a major obstacle that needs to be overcome by a prospective practitioner in this emerging field. Herein, we diminish this early hurdle by providing a lexicon of the most important terms.

Cell death in development: Signaling pathways and core mechanisms.

Programmed cell death eliminates unneeded and dangerous cells in a timely and effective manner during development. In this review, we examine the role cell death plays during development in worms, flies and mammals. We discuss signaling pathways that regulate developmental cell death, and describe how they communicate with the core cell death pathways. In most organisms the majority of developmental cell death is seen in the nervous system. Therefore we focus on what is known about the regulation of develop...

"Surprised by Joy"*: Four Decades of Contributions to Developmental Physiology.

Presented at the 40th Anniversary Celebration of the Center for Perinatal Biology of Loma Linda University School of Medicine, honoring Dr. Longo for his 40 years of extraordinary leadership and service, February 11, 2013.

Impact of Next-Generation Technologies on Exploring Socioeconomically Important Parasites and Developing New Interventions.

High-throughput molecular and computer technologies have become instrumental for systems biological explorations of pathogens, including parasites. For instance, investigations of the transcriptomes of different developmental stages of parasitic nematodes give insights into gene expression, regulation and function in a parasite, which is a significant step to understanding their biology, as well as interactions with their host(s) and disease. This chapter (1) gives a background on some key parasitic nematod...

Best practices in developmental screening and referral for young children.

: Developmental screening is recommended by the American Academy of Pediatrics as best practice to identify children with developmental delays. Nurse practitioners play a critical role in developmental screening and referral. This article describes best practices in developmental screening and referral resources available to NPs performing developmental screening.


Basic and Applied Problems in Developmental Biology and Immunobiology of Cestode Infections: Hymenolepis, Taenia and Echinococcus.

Differentiation and development of parasites, including longevity in host animals, are thought to be governed by host-parasite interactions. In this review, several topics on the developmental biology of cestode infections are discussed from immunobiological perspective with a focus on Hymenolepis, Taenia and Echinococcus infections. The basic premise of this review is that "differentiation and development of cestodes" are somehow affected by host immune responses with an evolutionary history. This article ...

Developmental biology: Cells unite by trapping a signal.

Developmental biology: Stem cells for bone growth.

Mechanisms involved in developmental programming of hypertension and renal diseases. Gender differences.

Abstract Background: A substantial body of epidemiological and experimental evidence suggests that a poor fetal and neonatal environment may "program" susceptibility in the offspring to later development of cardiovascular, renal and metabolic diseases. Materials and methods: This review focuses on current knowledge from the available literature regarding the mechanisms linking an adverse developmental environment with an increased risk for cardiovascular, renal and metabolic diseases in adult life. Moreover...

SIRT7 and hepatic lipid metabolism.

Blood-brain barrier in health and disease.

Characterisation of the Small RNAs in the Biomedically Important Green-Bottle Blowfly Lucilia sericata.

The green bottle fly maggot, Lucilia sericata, is a species with importance in medicine, agriculture and forensics. Improved understanding of this species' biology is of great potential benefit to many research communities. MicroRNAs (miRNA) are a short non-protein coding regulatory RNA, which directly regulate a host of protein coding genes at the translational level. They have been shown to have developmental and tissue specific distributions where they impact directly on gene regulation. In order to impr...

The world after print: Mind how you write, like never before…

Inside the cell: One of a series, but something special …

The 2001 uses of GFP: A review of "Illuminating Disease"

When am I dead? Another case for some applied philosophy….

Big questions and skepsis: Review of "In Search of Cell History.

New developmental data for Cynomya mortuorum (L., 1761) in Belgium (Diptera: Calliphoridae).

The calliphorid Cynomya mortuorum (L., 1761) is a forensically important species mainly found in the Palearctic region. Knowledge about its biology and ecology is scarce. Thermal constants as well as developmental time were studied at constant and variable regimes of 5 average temperatures: 14, 16, 18, 20 and 22°C, respectively. Total developmental time varied between 15.82±0.40 days at 22°C and 28.67±2.38 days at 14°C, for the constant regime, and between 16.05±0.67 days at 22°C and 32.79±1.77 days...

Comparative developmental psychology: How is human cognitive development unique?

The fields of developmental and comparative psychology both seek to illuminate the roots of adult cognitive systems. Developmental studies target the emergence of adult cognitive systems over ontogenetic time, whereas comparative studies investigate the origins of human cognition in our evolutionary history. Despite the long tradition of research in both of these areas, little work has examined the intersection of the two: the study of cognitive development in a comparative perspective. In the current artic...

A century of phage research: Bacteriophages and the shaping of modern biology.

2015 marks the centennial of the discovery of bacteriophages, viruses that infect bacteria. Phages have been central to some of biology's most meaningful advances over the past hundred years (shown here); they greatly influence the workings of the biosphere, and are poised to play expanded roles in biomedicine, biotechnology, and ecology.

CDC Kerala 15: Developmental Evaluation Clinic (2-10 y) - Developmental Diagnosis and Use of Home Intervention Package.

To describe the last 5 years' experience of Child Development Centre (CDC), Kerala Developmental Evaluation Clinic II for children between 2 and 10 y, referred for suspicion of developmental lag in the preschool years and scholastic difficulty in the primary classes with specific focus on developmental profile and the experience of the home based intervention package taught to the mothers.

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