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09:24 EDT 25th September 2017 | BioPortfolio

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Showing "Lose Rights Nursing Homes Obama Rule Overturned" PubMed Articles 1–25 of 9,300+

N1366S mutation of human skeletal muscle sodium channel causes paramyotonia congenita.

Paramyotonia congenita is an autosomal dominant skeletal muscle channelopathy caused by missense mutations in SCN4A, the gene encoding the α subunit of the human skeletal muscle voltage-gated sodium channel NaV1.4. Here, we report a three-generation family in which six members present clinical symptoms of paramyotonia congenita characterized by a marked worsening of myotonia by cold and by the presence of clear episodes of paralysis. We identified a novel mutation in SCN4A (Asn-1366-Ser, N1366S) in all pat...


In Reply.

We appreciate the comments and concerns raised by members of SAEM's Academy of Diversity and Inclusion in Emergency Medicine(1) regarding the findings of our article, "A Systematic Review of the Impact of Physician Implicit Racial Bias on Clinical Decision Making."(2) We agree with Samuels et al.(1) that there are notable methodological limitations of earlier studies examining the influence of physician implicit bias on clinical decision making that must be considered when interpreting the findings of our ...

Detection of ABCB5-tumour-antigen-specific CD8(+) T cells in Melanoma Patients and Implications for Immunotherapy.

ABCB5 has been identified as a tumour initiating cell marker and is expressed in various malignancies, including melanoma. Moreover, treatment with anti-ABCB5 monoclonal antibodies has been shown to inhibit tumour growth in xenotransplantation models. Therefore, ABCB5 represents a potential target for cancer immunotherapy. However, cellular immune responses against ABCB5 in humans have not been described so far. Here, we investigated whether ABCB5-reactive T cells are present in human melanoma patients and ...


Template for using biological trait groupings when exploring large-scale variation in seafloor multifunctionality.

Understanding large-scale spatial variation in ecosystem properties and associated functionality is key for successful conservation of ecosystems. This study provides a template for how to estimate differences in ecosystem functionality over large spatial scales by using groupings of biological traits. We focus on trait groupings that describe three important benthic ecosystem properties, namely bioturbation, community stability and juvenile dispersal. Recognizing that groups of traits interact and are cons...

A Closer Look at Dark Toxicity of the Photosensitizer TMPyP in Bacteria.

Photodynamic inactivation of bacteria (PIB) is based on photosensitizers which absorb light and generate reactive oxygen species (ROS), killing cells via oxidation. PIB is evaluated by comparing viability with and without irradiation, where reduction of viability in the presence of the photosensitizer without irradiation is considered as dark toxicity. This effect is controversially discussed for photosensitizers like TMPyP (5,10,15,20-Tetrakis(1-methyl-4-pyridinio)porphyrin tetra(p-toluensulfonate). TMPyP ...

EAACI Guidelines on Allergen Immunotherapy: Allergic Rhinoconjunctivitis.

Allergic rhinoconjunctivitis (AR) is an allergic disorder of the nose and eyes affecting about a fifth of the general population. Symptoms of AR can be controlled with allergen avoidance measures and pharmacotherapy. However, many patients continue to have ongoing symptoms and an impaired quality of life; pharmacotherapy may also induce some side-effects. Allergen immunotherapy (AIT) represents the only currently available treatment that targets the underlying pathophysiology and it may have a disease modif...

The catalytic mechanism of cyclic gmp-amp synthase (cGAS) and implications for innate immunity and inhibition.

Cyclic GMP-AMP synthase (cGAS) is activated by ds-DNA binding to produce the secondary messenger 2',3'-cGAMP. cGAS is an important control point in the innate immune response; dysregulation of the cGAS pathway is linked to autoimmune diseases while targeted stimulation may be of benefit in immunoncology. We report here the structure of cGAS with dinucleotides and small molecule inhibitors, and kinetic studies of the cGAS mechanism. Our structural work supports the understanding of how ds-DNA activates cGAS,...

cAMP levels in lymphocytes and CD4+ regulatory T cell functions are affected by dopamine receptor gene polymorphisms.

The neurotransmitter dopamine (DA) has prominent effects in the immune system and between the immune cells, CD4+ regulatory T lymphocytes (Treg), a specialized T cell subsets crucial for the control of immune homeostasis, are especially sensitive to DA. Dopaminergic receptors (DR) are grouped into two families according to their pharmacological profile and main second messenger coupling: the D1 -like (D1 and D5 ) which activate adenylate cyclase and the D2 -like (D2 , D3 and D4 ) which inhibit adenylate cyc...

Activation of the NLRP3 inflammasome in microglia: The role of ceramide.

Inflammation within the CNS is a major component of many neurodegenerative diseases. A characteristic feature is the generation of microglia-derived factors that play an essential role in the immune response. IL-1β is a pro-inflammatory cytokine released by activated microglia, able to exacerbate injury at elevated levels. In the presence of caspase-1, pro-IL-1β is cleaved to the mature cytokine following NLRP3 inflammasome activation. Growing evidence suggests that ceramide plays a critical role in NLRP3...

Substrate stiffness regulated migration and angiogenesis potential of A549 cells and HUVECs.

Tumor tissue tends to stiffen during solid tumor progression. Substrate stiffness is known to alter cell behaviors, such as proliferation and migration, during which angiogenesis is requisite. Mono-culture and co-culture systems of lung cancer cell line A549 and human umbilical vein endothelial cells (HUVECs), on polydimethylsiloxane substrates (PDMS) with varying stiffness, were used for investigating the effects of substrate stiffness on the migration and angiogenesis of lung cancer. The expressions of ma...

The need for spatially explicit quantification of benefits in invasive-species management.

Worldwide, invasive species are a leading driver of environmental change across terrestrial, marine, and freshwater environments and cost billions of dollars annually in ecological damages and economic losses. Resources limit invasive-species control, and planning processes are needed to identify cost-effective solutions. Thus, studies are increasingly considering spatially variable natural and socioeconomic assets (e.g., species persistence, recreational fishing) when planning the allocation of actions for...

Molecular and clinical spectra of FBXL4 deficiency.

F-box and leucine-rich repeat protein 4 (FBXL4) is a mitochondrial protein whose exact function is not yet known. However, cellular studies have suggested that it plays significant roles in mitochondrial bioenergetics, mitochondrial DNA (mtDNA) maintenance, and mitochondrial dynamics. Biallelic pathogenic variants in FBXL4 are associated with an encephalopathic mtDNA maintenance defect syndrome that is a multisystem disease characterized by lactic acidemia, developmental delay, and hypotonia. Other features...

Number needed to suffer?

I was surprised to read in the "different view" article that Dr Lönnqvist believes that "disability-free survival" is a new concept (1). "Disability-free survival" is unfortunately a widespread concept in neonatology, with literally hundreds of publications addressing the combined outcome of "death or NDI". It is a concept which I and others have severely criticised for several years (2), and which is criticised also by parents (3). This article is protected by copyright. All rights reserved.

Migration from Mexico to the United States: A High-Speed Cancer Transition.

Differences and similarities in cancer patterns between the country of Mexico and the United States' Mexican population, 11% of the entire US population, have not been studied. Mortality data from 2008-2012 in Mexico and California were analyzed and compared for causes of cancer death among adult and pediatric populations, using standard techniques and negative binomial regression. A total of 380,227 cancer deaths from Mexico and California were included. Mexican Americans had 49% and 13% higher mortality t...

Reactive Oxygen Species (ROS) are a key determinant of cancer's metabolic phenotype.

Cancer cells exhibit a wide range of metabolic phenotypes, ranging from strict aerobic glycolysis to increased mitochondrial respiration. The cause and utility of this metabolic variation is poorly understood. Given that cancer cells experience heavy selection within their microenviorment, survival requires metabolic adaptation to both extracellular and intracellular conditions. Herein, we suggest that reactive oxygen species (ROS) are a key determinant of cancer's metabolic phenotype. Intracellular ROS lev...

Aggression supersedes individual oxygen demand to drive group air-breathing in a social catfish.

Group-living is widespread among animals and comes with numerous costs and benefits. To date, research examining group-living has focused on trade-offs surrounding foraging, while other forms of resource acquisition have been largely overlooked. Air breathing has evolved in many fish lineages, allowing animals to obtain oxygen in hypoxic aquatic environments. Breathing air increases the threat of predation, so some species perform group air breathing, to reduce individual risk. Within species, air breathing...

Prioritizing forest fuels treatments based on the probability of high-severity fire restores adaptive capacity in Sierran forests.

In frequent fire forests of the western US a legacy of fire suppression coupled with increases in fire weather severity have altered fire regimes and vegetation dynamics. When coupled with projected climate change, these conditions have the potential to lead to vegetation type change and altered carbon (C) dynamics. In the Sierra Nevada, fuels reduction approaches that include mechanical thinning followed by regular prescribed fire are one approach to restore the ability of the ecosystem to tolerate episodi...

LLLT Effects on Oral Keratinocytes in an Organotypic 3D Model.

Several in vitro studies evaluated the cellular and molecular events related to interactions between phototherapy and target tissues, including oral keratinocytes and fibroblasts, providing elucidative data about phototherapy-induced healing. However, these interactions were limited to the application of a bidimensional cell culture model of oral mucosal cells. Thus, the present study evaluated the use of an organotypic oral epithelium model to elucidate the morphological and phenotypic responses of cells s...

VRAC: unravelling the complexity of LRRC8 subunits regulation by oxidation.

To maintain ion homeostasis, cells must regulate their volume. Water flux is controlled through the exchange of ions and osmolytes between the cytosol and the extracellular compartment. This article is protected by copyright. All rights reserved.

Protease-Activated Receptor-2 blockade inhibits changes seen in a chronic murine asthma model.

Proteinase-Activated Receptor-2 (PAR2 ) is a G protein-coupled receptor activated by serine proteinases. We have shown that PAR2 activation in the airways is involved in the development of allergic inflammation and airway hyperresponsiveness (AHR) in acute murine models. We hypothesize that functional inhibition of PAR2 prevents allergic inflammation, AHR and airway remodeling in chronic allergic airway inflammation models. We developed a 12 week model of cockroach extract (CE)-mediated AHR, airway inflamma...

Anti-freezing, conductive self-healing organohydrogels with stable strain-sensitivity at subzero temperatures.

Conductive hydrogels emerge as a fascinating class of stretchable conductive materials that are important for various applications. However, water-based conductive hydrogels inevitably lose elasticity and conductivity at subzero temperatures, which severely limits their practical applications at low temperatures. Here we report anti-freezing conductive organohydrogels by using an H2O/ethylene glycol binary solvent as dispersion medium. Owing to the freezing tolerance of the binary solvent, our organohydroge...

Amine oxidase from Euphorbia characias: kinetic and structural characterization.

This minireview focuses on a plant copper/TPQ amine oxidase isolated from the latex of the shrub Euphorbia characias (ELAO). This enzyme has been investigated in terms of both molecular structure and kinetic mechanism. The characterization of this enzyme allowed us to identify specific amino acids and domains that play a key role in modulating substrate access into the active site of not only for ELAO but also for other plant and mammalian amine oxidases. As mammalian amine oxidases are implicated in severa...

Genetic interaction with temperature is an important determinant of nematode longevity.

As in other poikilotherms, longevity in C. elegans varies inversely with temperature; worms are longer-lived at lower temperatures. While this observation may seem intuitive based on thermodynamics, the molecular and genetic basis for this phenomenon is not well understood. Several recent reports have argued that lifespan changes across temperatures are genetically controlled by temperature-specific gene regulation. Here, we provide data that both corroborate those studies and suggest that temperature-spec...

Using the Sophia Observational Withdrawal Scale improved the assessment of paediatric iatrogenic withdrawal symptoms.

Analgesia and sedation are standard practice when paediatric intensive care patients receive mechanical ventilation. Prolonged exposure to opioid and benzodiazepine leads to an increased risk of withdrawal symptoms when medication ceases or patients are weaned off them (1). When we were updating our local clinical guidelines for managing withdrawal symptoms, we identified the need to improve the assessment of withdrawal symptoms. This article is protected by copyright. All rights reserved.

Porokeratosis ptychotropica: a diagnostic and therapeutic challenge.

The porokeratoses are characterized by the formation of cornoid lamellae. Porokeratosis ptychotropica (PP), is a rare form first described by Lucker, where the dyskeratotic skin changes are mainly located around the gluteal cleft or genital area (1, 2). A 56-year-old man presented with mildly pruritic symmetrical hyperkeratotic brown plaques with subtle fine scaling, and smaller satellite plaques, affecting both buttocks, and partially the intergluteal cleft. (Figure 1 a) The plaque began a year before on t...


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