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PubMed Journals Articles About "Vantage Consulting Group Joins Healthcare Initiative Improve Supply" RSS

03:38 EDT 23rd September 2017 | BioPortfolio

Vantage Consulting Group Joins Healthcare Initiative Improve Supply PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Vantage Consulting Group Joins Healthcare Initiative Improve Supply articles that have been published worldwide.

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Showing "Vantage Consulting Group Joins Healthcare Initiative Improve Supply" PubMed Articles 1–25 of 21,000+

Synthesis, Crystal Structure, and Magnetic Properties of the Highly Frustrated Orthorhombic Li4MgReO6.

In an effort to understand the structure-property relationship in magnetically frustrated systems, an orthorhombic analog of the S = 1/2 Re-based oxide Li4MgReO6 has been successfully synthesized and its physical properties were investigated. Li4MgReO6 had been previously synthesized in a monoclinic system in an ordered NaCl structure type. That system was shown to exhibit spin glass behavior below ∼12 K. The crystal structure of the latter phase was determined using powder X-ray diffraction data. A struc...


Detoxification of atrazine by low molecular weight thiols in alfalfa (Medicago sativa).

Low molecular weight (LMW) thiols in higher plants are a group of sulfur-rich non-protein compounds and play primary and multiple roles in cellular redox homeostasis, enzyme activities, and xenobiotics detoxification. This study focused on identifying thiols-related protein genes from the legume alfalfa exposed to the herbicide atrazine (ATZ) residues in environment. Using high-throughput RNA-sequencing, a set of ATZ-responsive thiols-related protein genes highly up-regulated and differentially expressed in...

Synthesis of Benzosiloles by Intramolecular anti-Hydroarylation via ortho-C-H Activation of Aryloxyethynyl silanes.

Straightforward synthesis of benzosiloles was achieved by the invention of intramolecular anti-hydroarylation of aryloxyethynyl silanes via ortho-C-H bond activation in the presence of palladium and Brønsted acid catalysis. The aryloxy group bound to the ethynyl carbon is the key factor for this transformation. The proposed hydroarylation mechanism involves the initial formation of a vinylpalladium carboxylate followed by isomerization and ortho-C-H bond activation.


Preparation and characterization of mucoadhesive nanoparticles for enhancing cellular uptake of coenzyme Q10.

The mucoadhesive nanoparticles (NPs) for oral delivery of coenzyme Q10 (CoQ10) were prepared using natural mucoadhesive polysaccharides, chitosan (CS) and dextran sulfate sodium salt (DS) in order to improve the solubility, cellular uptake, thermo- and photo-stability of CoQ10. CoQ10-loaded NPs were prepared in the range of 340-450 nm with an entrapment efficiency of 60-98%. The mucoadhesiveness and cellular uptake of NPs were evaluated by measuring the amount of mucin adsorbed on NPs and CoQ10 absorbed in ...

Design and Structure-Guided Development of Novel Inhibitors of the Xeroderma Pigmentosum Group A (XPA) Protein-DNA Interaction.

XPA is a unique and essential protein required for the nucleotide excision DNA repair pathway and represents a therapeutic target in oncology. Herein, we are the first to develop novel inhibitors of the XPA-DNA interaction through structure-guided drug design efforts. Ester derivatives of the compounds 1 (X80), 22, and 24 displayed excellent inhibitory activity (IC50 of 0.82 ± 0.18 μM and 1.3 ± 0.22 μM, respectively) but poor solubility. We have synthesized novel amide derivatives that retain potency an...

Entangled Two-Photon Absorption Cross Section on the 808 nm Region for the Common Dyes Zinc Tetraphenylporphyrin and Rhodamine B.

We report the measurement of the entangled two photon absorption (ETPA) cross section, σΕ , at 808 nm on organic chromophores in solution in a low photon flux regime. We performed measurements on Zinc tetraphenylporphyrin (ZnTPP) in Toluene and Rhodamine B (RhB) in Methanol. This is, to the best of our knowledge, the first time that σΕ is measured for RhB. Additionally, we report a study of the dependence of σΕ on the molecular concentration for both molecular systems. In contrast to previous experime...

Epigenetic DNA modification N6-methyladenine causes site-specific RNA polymerase II transcriptional pausing.

N6-methyladenine (N6-mA or 6mA) is an epigenetic DNA modification in eukaryotic genomes. In contrast to the well-established roles of 5-methylcytosine for epigenetic regulation of gene expression, the functional roles of N6-mA remain elusive. In particular, the impact of N6-mA modification at DNA template on RNA polymerase II (pol II) transcription elongation is not known. In this work, using the Saccharomyces cerevisiae pol II transcriptional elongation system as a model, we investigated the molecular mech...

Stereoselective Synthesis of Z-Vinylsilanes via Palladium-Catalyzed Direct Intermolecular Silylation of C(sp(2))-H Bonds.

An efficient and convenient palladium-catalyzed direct intermolecular silylation of C(sp(2))-H bonds by using disilanes as the silicon source with the assistance of a readily removable bidentate directing group is reported. This strategy provided a regio- and stereoselective protocol for exclusive synthesis of Z-vinylsilanes with reasonable to excellent yields and good functional group compatibility. Silylation of the isolated palladacycle intermediate revealed the Z-stereoselective pathway. Moreover, the p...

Is testing a more effective learning strategy than note-taking?

The testing effect is both robust and generalizable. However, most of the underlying studies compare testing to a rather ineffective control condition: massed repeated reading. This article therefore compares testing with note-taking, which has been shown to be more effective than repeated reading. Experiment 1 is based on a 3 × 3 between-participants design with the factors learning condition (repeated reading vs. repeated testing vs. repeated note-taking) and final test delay (5 min vs. 1 week vs. 2 week...

Group Norms, Intergroup Resource Allocation, and Social Reasoning Among Children and Adolescents.

Cooperation is a fundamental drive of moral behavior from infancy, yet competitive intergroup contexts can exert a significant influence on resource allocation behavior in childhood. The present study explored how ingroup and outgroup norms of competition and cooperation influenced the allocation of resources between groups among children and adolescents, along with how they reasoned about these allocations. Ingroup norms combined, for the first time, with outgroup norms were manipulated to examine their ef...

Identifying Stable Variants of Callous-Unemotional Traits: A Longitudinal Study of At-Risk Girls.

Callous-unemotional (CU) traits have proven important for designating children and adolescents showing a pattern of particularly severe, stable, and aggressive antisocial behaviors (Frick, Ray, Thornton, & Kahn, 2014). Individuals with secondary CU traits represent a subpopulation that are distinguished from those with primary CU traits by their high anxiety levels and marked histories of social/environmental adversity; however, evidence is largely based on cross-sectional male samples and this study is the...

The Forward Testing Effect: Interim Testing Enhances Inductive Learning.

Induction refers to the process in which people generalize their previous experience when making uncertain inferences about the environment that go beyond direct experience. Here we show that interim tests strongly enhance inductive learning. Participants studied the painting styles of eight famous artists across four lists, each comprising paintings by one pair of artists. In an interim test group participants' induction was tested after each list. In two control groups participants solved math problems (i...

A Cross-Level Investigation of Informal Field-Based Learning and Performance Improvements.

Organizations often operate in complex and dynamic environments which place a premium on employees' ongoing learning and acquisition of new competencies. Additionally, the majority of learning in organizations does not take place in formal training settings, but we know relatively little about how informal field-based learning (IFBL) behaviors relate to changes in job performance. In this study, we first clarified the construct of IFBL as a subset of informal learning. Second, on the basis of this clarified...

Differential Support for Female Supervisors Among Men and Women.

Two studies evaluated the lay belief that women feel particularly negatively about other women in the workplace and particularly in supervisory roles. The authors tested the general proposition, derived from social identity theory (Tajfel & Turner, 1979, 2004), that women, compared to men, may be more supportive of other women in positions of authority, whereas men would respond more favorably to other men than to women in positions of authority. Consistent with predictions, data from an online experiment (...

Propagandizing the Healthy, Bolshevik Life in the Early USSR.

This essay outlines the problems facing Soviet health authorities at the inception of the People's Commissariat of Public Health in 1918 and the innovative methods employed in sanitary enlightenment propaganda in Russia throughout the 1920s. Beset by funding issues and supply problems, the emissaries of health chose the cheapest means of health improvement (propaganda) with the most cost-effective method (prevention), and crowed of great successes even as large portions of the nation still suffered from lac...

A Smartphone Application to Reduce Time-to-Notification of Sexually Transmitted Infections.

To measure whether the implementation of Healthvana-an online patient engagement platform and smartphone application-reduced the number of days between sexually transmitted infection (STI) testing, notification, and treatment at AIDS Healthcare Foundation (AHF) Wellness Centers.

An Assessment of Primary Care and Pulmonary Provider Perspectives on Lung Cancer Screening.

Lung cancer screening (LCS) has a mortality benefit to high-risk smokers, but implementation remains suboptimal. Providers represent the key entry point to screening, and an understanding of provider perspectives on lung cancer screening is necessary to improve referral and overall implementation.

A Developmentally Relevant Approach to Classifying Nonconsensual Sexual Experiences in the Study of Women's Sexual Well-Being.

In this article we propose a sexual developmental approach to classifying the onset of nonconsensual sexual experiences (NSEs) that differs from the traditional age cutoff approach. Online measures of sexual self-schemas, sexual response, and sexual functioning were administered to 797 women with and without NSE histories. Women were grouped based on when their NSEs first occurred in reference to their age of menarche and age of their first consensual sexual experience (i.e., premenarche onset, postmenarche...

Identification of novel SPG11 mutations in a cohort of Chinese families with hereditary spastic paraplegia.

Hereditary spastic paraplegia (HSP) is a group of clinically and genetically heterogeneous neurological diseases. To date, studies about Chinese ARHSP have been small and limited to single case. To fill this gap, we have scanned the whole exons of KIAA1840, ZFYVE26, SPG7 and CYP7B1 genes in a group of 36 unrelated ARHSP families, which is the first study conducted to investigate the mutation frequency of these ARHSP types in China. Finally, SPG11 mutations are found in 33.33% (12/36) of ARHSP patients in ou...

Magnetic resonance imaging in the early detection of prostate cancer and review of the literature on magnetic resonance imaging-stratified clinical pathways.

With level 1 evidence now available on the diagnostic accuracy of multiparametric magnetic resonance imaging (MRI) we must now utilise this data in developing an MRI-stratified diagnostic pathway for the early detection of prostate cancer. Areas covered: A literature review was conducted and identified seven randomised control trials (RCT's) assessing the diagnostic accuracy of such a pathway against the previously accepted systematic/random trans-rectal ultrasound guided (TRUS) biopsy pathway. The studies ...

Foot problems in older women.

Between 20 and 45% of women aged over 65 years of age will develop one or more foot problems, which, although not specific to older women, are more common in that age group than in younger women. These include structural defects of the toes including hallux valgus, hammer, mallet or claw toes, skin disorders, fungal infection of the toes and toe nails, thickened toe nails, ulcers, fissures or cracks between the toes, corns and calluses, flat or high-arched feet. Foot pain is common and may be associated wit...

Use of virtual reality intervention to improve reaction time in children with cerebral palsy: A randomized controlled trial.

The purpose of this study was to investigate the training effects of Virtual Reality (VR) intervention program on reaction time in children with cerebral palsy.

Geographic Access to Cancer Care and Mortality Among Adolescents.

Adolescents with cancer have had less improvement in survival than other populations in the United States. This may be due, in part, to adolescents not receiving treatment at Children's Oncology Group (COG) institutions, which have been shown to increase survival for some cancers. The objective of this ecologic study was to examine geographic distance to COG institutions and adolescent cancer mortality.

Solid Phase Extraction of Large Volume of Water and Beverage Samples to Improve Detection Limits for GC-MS Analysis of Bisphenol A and Four Other Bisphenols.

Solid phase extraction (SPE) of large volumes of water and beverage products was investigated for the GC-MS analysis of bisphenol A (BPA), bisphenol AF (BPAF), bisphenol F (BPF), bisphenol E (BPE), and bisphenol B (BPB). While absolute recoveries of the method were improved for water and some beverage products (e.g., diet cola, iced tea), breakthrough may also have occurred during SPE of 200 mL of other beverages (e.g., BPF in cola). Improvements in method detection limits were observed with the analysis of...

Biomarker Enrichment Considerations in Oncology Early Development Single Arm Studies.

Oncology drug development has been increasingly shaped by molecularly targeted agents (MTAs), which often demonstrate differential effectiveness driven by the biomarker expression levels on tumors. Innovative statistical designs have been proposed to tackle this challenge, e.g., Freidlin et al (2005), Jiang et al (2007) and Freidlin et al (2010). All of these are essentially adaptive confirmatory Phase 3 designs that combine the testing of treatment effectiveness in the overall population with an alternativ...


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