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PubMed Journals Articles About "World Class Medical Affairs Changes Thought Leaders Want" RSS

03:37 EDT 23rd September 2017 | BioPortfolio

World Class Medical Affairs Changes Thought Leaders Want PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest World Class Medical Affairs Changes Thought Leaders Want articles that have been published worldwide.

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Showing "World Class Medical Affairs Changes Thought Leaders Want" PubMed Articles 1–25 of 18,000+

CsPb0.9Sn0.1IBr2 Based All-Inorganic Perovskite Solar Cells with Exceptional Efficiency and Stability.

The emergence of perovskite solar cells (PSCs) has generated enormous interests in the photovoltaic research community. Recently, cesium metal halides (CsMX3, M = Pb or Sn; X = I, Br, Cl or mixed halides) as a class of inorganic perovskites showed great promise for PSCs and other optoelectronic devices. However, CsMX3-based PSCs usually exhibit lower power conversion efficiencies (PCEs) than organic-inorganic hybrid PSCs, due to the unfavorable bandgaps. Herein, a novel mixed-Pb/Sn mixed-halide inorganic pe...


Design and Structure-Guided Development of Novel Inhibitors of the Xeroderma Pigmentosum Group A (XPA) Protein-DNA Interaction.

XPA is a unique and essential protein required for the nucleotide excision DNA repair pathway and represents a therapeutic target in oncology. Herein, we are the first to develop novel inhibitors of the XPA-DNA interaction through structure-guided drug design efforts. Ester derivatives of the compounds 1 (X80), 22, and 24 displayed excellent inhibitory activity (IC50 of 0.82 ± 0.18 μM and 1.3 ± 0.22 μM, respectively) but poor solubility. We have synthesized novel amide derivatives that retain potency an...

Infant Iron Deficiency, Child Affect, and Maternal Unresponsiveness: Testing the Long-Term Effects of Functional Isolation.

Children who are iron deficient (ID) or iron-deficient anemic (IDA) have been shown to seek and receive less stimulation from their caregivers, contributing to functional isolation. Over time, the reduced interactions between child and caregiver are thought to interfere with the acquisition of normative social competencies and adversely affect the child's development. The current study examined functional isolation in children who were ID or IDA in infancy in relation to social difficulties in middle childh...


Mexican-Origin Youth Substance Use Trajectories: Associations With Cultural and Family Factors.

The current study identified alcohol and cannabis use trajectories among a sample of Mexican-origin youth and examined cultural and familial correlates from childhood to adolescence. Mexican-origin youth (N = 674) from Northern California were assessed annually from ages 10 to 17 (8 waves). Latent class growth modeling examined variability in developmental trajectories for last 3-month alcohol and cannabis use frequency. Analyses also examined between-trajectory differences in youth's cultural practices and...

Ontogeny of Emotional and Behavioral Problems in a Low-Income, Mexican American Sample.

Clinically meaningful behavior problems are thought to be present beginning in the early toddler years, yet few studies have investigated correlates of behavior problems assessed before age 2 years. The current study investigated the direct and interactive contributions of early infant and caregiver characteristics thought to play an important role in the ontogeny of behavior problems. Specifically, the study examined: (a) the links between infant temperamental reactivity and toddler behavioral symptoms, (b...

Identifying Stable Variants of Callous-Unemotional Traits: A Longitudinal Study of At-Risk Girls.

Callous-unemotional (CU) traits have proven important for designating children and adolescents showing a pattern of particularly severe, stable, and aggressive antisocial behaviors (Frick, Ray, Thornton, & Kahn, 2014). Individuals with secondary CU traits represent a subpopulation that are distinguished from those with primary CU traits by their high anxiety levels and marked histories of social/environmental adversity; however, evidence is largely based on cross-sectional male samples and this study is the...

Environmental Sensitivity in Children: Development of the Highly Sensitive Child Scale and Identification of Sensitivity Groups.

A large number of studies document that children differ in the degree they are shaped by their developmental context with some being more sensitive to environmental influences than others. Multiple theories suggest that Environmental Sensitivity is a common trait predicting the response to negative as well as positive exposures. However, most research to date has relied on more or less proximal markers of Environmental Sensitivity. In this paper we introduce a new questionnaire-the Highly Sensitive Child (H...

Erasing and Blurring Memories: The Differential Impact of Interference on Separate Aspects of Forgetting.

Interference disrupts information processing across many timescales, from immediate perception to memory over short and long durations. The widely held similarity assumption states that as similarity between interfering information and memory contents increases, so too does the degree of impairment. However, information is lost from memory in different ways. For instance, studied content might be erased in an all-or-nothing manner. Alternatively, information may be retained but the precision might be degrad...

Ranking Low, Feeling High: How Hierarchical Position and Experienced Power Promote Prosocial Behavior in Response to Procedural Justice.

Research shows that power can lead to prosocial behavior by facilitating the behavioral expression of dispositional prosocial motivation. However, it is not clear how power may facilitate responses to contextual factors that promote prosocial motivation. Integrating fairness heuristic theory and the situated focus theory of power, we argue that in particular, organization members in lower (vs. higher) hierarchical positions who simultaneously experience a high (vs. low) sense of power respond with prosocial...

Alan Gregg, the Diary of a Thoughtful Eye-Witness.

After two years of discussions and delays surrounding his eventual departure, Alan Gregg, the 37-year-old associate director of the Rockefeller Foundation's Division of Medical Education (DME), set out from his Paris, France, office in late November 1927, destined for a 17-day trip to Moscow and Leningrad in the Soviet Union. His mission-the first time a Rockefeller officer had ever set foot on Soviet soil(1)-was to gather first-hand knowledge about the state of public health and medical education in Russia...

A Revolutionary Attack on Tobacco: Bolshevik Antismoking Campaigns in the 1920s.

Using archival records of the Commissariat of Public Health, journals, and propaganda materials from the antismoking campaign of the Soviet 1920s, this article argues that the revolutionary state pursued an antitobacco policy unique in the world in its attack on tobacco use at a national scale. The commissar of public health, Nikolai Alexandrovich Semashko, attempted to severely curtail tobacco cultivation and production, limit tobacco sales, and create a public opinion against tobacco with a propaganda cam...

The Changing Pattern of Nutrition Intake by Social Class in Contemporary China, 1991-2011.

To explore the changing pattern of nutrition intake by social class in contemporary China.

Nursing and the Public Health Legacies of the Russian Revolution.

The centenary of the October Revolution in 1917 provides a timely opportunity to assess the legacies of that event. I examine the role of the revolution in public health with a focus on nursing, assessing the Imperial Russian health care system, the development of Soviet nursing, and current plans for nursing and public health care in Putin's Russia. Analyzing nursing shows that there was a great deal of continuity in terms of medical personnel and ideas on how public health care service in Russia should op...

Legacies of 1917 in Contemporary Russian Public Health: Addiction, HIV, and Abortion.

I examine the legacies of Soviet public health policy and the socialist health care system and trace how the Soviet past figures in contemporary Russian policymaking and debates about drug use, HIV, and abortion. Drug policies and mainstream views of HIV reflect continuities with key aspects of Soviet-era policies, although political leaders do not acknowledge these continuities in justifying their policies. In abortion policy, by contrast, which is highly debated in the public realm, advocates represent th...

Emergency Medical Service Personnel's Risk From Violence While Serving the Community.

To determine the risks of violence-related injury among emergency medical services (EMS) personnel in the United States.

Detecting Spatial Patterns of Disease in Large Collections of Electronic Medical Records Using Neighbor-Based Bootstrapping.

We introduce a method called neighbor-based bootstrapping (NB2) that can be used to quantify the geospatial variation of a variable. We applied this method to an analysis of the incidence rates of disease from electronic medical record data (International Classification of Diseases, Ninth Revision codes) for ∼100 million individuals in the United States over a period of 8 years. We considered the incidence rate of disease in each county and its geospatially contiguous neighbors and rank ordered diseases i...

Tool to assess causality of direct and indirect adverse events associated with therapeutic interventions.

To develop and test a tool to assess causality of direct and indirect adverse events associated with therapeutic interventions. The intervention was one or more drugs and/or natural health products, a device, or practice (professional delivering the intervention).

AID Biology: A pathological and clinical perspective.

Activation-induced cytidine deaminase (AID), primarily expressed in activated mature B lymphocytes in germinal centers, is the key factor in adaptive immune response against foreign antigens. AID is responsible for producing high-affinity and high-specificity antibodies against an infectious agent, through the physiological DNA alteration processes of antibody genes by somatic hypermutation (SHM) and class-switch recombination (CSR) and functions by deaminating deoxycytidines (dC) to deoxyuridines (dU), the...

The importance of calprotectin levels in the obstructive sleep apnea syndrome severity.

Obstructive sleep apnea syndrome (OSAS) is mostly seen in adult populations. It is known that increased levels of several inflammatory mediators play roles in OSAS and related comorbidities. Calprotectin is an inflammatory mediator that increases in some diseases such as Bechet's syndrome, bowel diseases and cardiovascular and cerebrovascular diseases.

Impact of Preexisting Mental Illness on All-Cause and Breast Cancer-Specific Mortality in Elderly Patients With Breast Cancer.

Purpose Limited data are available on the survival of patients with breast cancer with preexisting mental illness, and elderly women are of special interest because they experience the highest incidence of breast cancer. Therefore, we compared all-cause and breast cancer-specific mortality for elderly patients with breast cancer with and without mental illness. Methods A retrospective cohort study was conducted by using SEER-Medicare data, including 19,028 women ≥ 68 years of age who were diagnosed with s...

Medical students' reflections of a post-hospital discharge patient visit.

Transfiguring Light and Symphonic Blooming: A Wabi Sabi Story of Humanbecoming and Human Caring.

Transfiguring Light and Symphonic Blooming is word-art to describe the flowering of the humanbecoming and human caring schools of thought over time. A Wabi Sabi story journey was created to turn the tide in a world where the building of a unique body of knowledge for nursing has fallen into disfavor with nursing itself. Using nature-aligned paintings and a Japanese story-art aesthetic with poetry, the beauty of falling away to unitary essentials and holding the value of "both-and" in unitary consciousness w...

A Framework for Latino Nursing Leadership.

There is an urgent need for Latino leaders in nursing, yet little has been written about Latino leaders and leadership. Leadership comes with challenges and opportunities in particular for Latino nurses who contend with specific cultural imperatives and obstacles. In this article, I review the current healthcare environment and propose a framework for Latino nursing leadership within the context of current challenges and opportunities and my personal experience in nursing. This framework is meant to serve a...

Latino Nursing Leadership: A Leading-Following Perspective.

Nurse leaders have many demands that must be attended to in a manner that is focused, so that organizational, professional, and personal visions are moved forward. The focus emerges from the values and beliefs of the nurse leaders. These values and beliefs embrace nursing models and theories that are the foundation from which they lead others.

Delayed Urinary Symptoms Induced by Ketamine.

One of the side-effects of ketamine abuse is genito-urinary damage. This report describes a case of a former ketamine user who presented with urinary symptoms associated with ketamine years after stopping consumption. This was a 26-year-old male with a history of ketamine abuse. He started treatment for alcohol dependence at age 19. He smoked marijuana daily and denied any other drug use. During the follow-up, urinary symptoms were evidenced (dysuria, frequency, urgency, incontinence, nocturia, hematuria, a...


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