PubMed Journals Articles About "These Highlights Include Information Needed GEODON Safely Effectively"

Addressing the ethical, policy, and social challenges of preclinical Alzheimer disease.

Research suggests that Alzheimer disease (AD) pathophysiology begins prior to the clinical expression of the disease and that biomarker measures may provide direct evidence of this process. As a result, it may be possible to uncouple the diagnosis of AD from the clinical expression of the disease. The shifting boundaries between normal brain aging and disease present 3 challenges: 1) establishing guidelines for researchers and clinicians to safely and effectively communicate the diagnosis of preclinical AD,...

SonoKnife for ablation of neck tissue: In vivo verification of a computer layered medium model.

Purpose: This study aimed to determine which treatment parameters of the SonoKnife device can be used to safely and effectively perform non-invasive thermal ablation of subcutaneous tissue. Methods: A three-dimensional computational layered medium model was constructed to simulate thermal ablation treatment of the SonoKnife device. The acoustic and thermal fields were calculated with the Fast Object-Oriented C++ Ultrasound-Simulator software and a finite difference code, respectively. Subcutaneous tissue wa...

Botulinum toxin assessment, intervention and after-care for upper limb hypertonicity in adults: international consensus statement.

Upper limb spasticity affecting elbow, wrist, and finger flexors can be safely and effectively reduced with injections of botulinum toxin type-A (BoNT-A). It has been best studied in adults in the context of post-stroke spasticity. The clinical benefits include reduction in pain and deformity, improvement in washing and dressing the upper limb, and a reduction in caregiver burden (Class I evidence, recommendation level A). Some patients show improvement in function performed by active movement of the affect...

Uncovering common bacterial skin infections.

ABSTRACT: The four most common bacterial skin infections are impetigo, erysipelas, cellulitis, and folliculitis. This article summarizes current information about the etiology, clinical presentation, diagnosis, prevention, treatment, and implications for primary care practice needed to effectively diagnose and treat common bacterial skin infections.

Community pharmacists' attitudes relating to patients' use of health products in Japan.

Background There is little information about Japanese pharmacists' perceived facilitators and barriers to communication with patients about orally taken health products, including herbs and dietary supplements. Objective To explore Japanese pharmacists' attitudes relating to patients' use of health products. Method Qualitative study involving focus group interviews with pharmacists was conducted. Data were analyzed using the constant comparative method. Setting Focus group interviews with community pharmaci...

Endoscopic approach to the post liver transplant patient.

Biliary complications occur after liver transplantation. These complications can be effectively and safely managed using endoscopic approaches and can prevent unnecessary and potentially morbid surgery.

Percutaneous Fasciotomy for Dupuytren's Contracture.

Needle aponeurotomy (percutaneous needle fasciotomy) for Dupuytren's contracture can be performed in the office setting with local anesthesia. It is simple and inexpensive and has a low complication rate and rapid recovery compared with open fasciectomy. It can usually be repeated safely and effectively for recurrent disease.

Electronic medical records and personalized medicine.

If the dream of personalized medicine is to be realized, tremendous amounts of data specific to each individual must be captured, synthesized and presented to clinicians at the time this information is needed to make care decisions for the patient. This can only be accomplished through the use of sophisticated electronic medical record (EMR) systems that are designed to support this function. This article will define two important aspects of a fully functional EMR the ability to: present patients or clinici...

Turing, ciphers and quanta.

Alan Turing has certainly contributed to a widespread belief that the quest for a perfect, unbreakable, cipher is a futile pursuit. The ancient art of concealing information has, in the past, been matched by the ingenuity of code-breakers, but no longer! With the advent of quantum cryptography, the hopes of would-be eavesdroppers have been dashed, perhaps for good. Moreover, recent research, building on schemes that were invented decades ago to perform quantum cryptography, shows that secure communication c...

Oncolytic vaccinia virus safely and effectively treats skin tumours in mouse models of xeroderma pigmentosum.

Xeroderma pigmentosum (XP) is an orphan autosomal recessive disorder of DNA repair. When exposed to genotoxic stress, XP patients have reduced capacity to remove bulky adducts by nucleotide excision repair and are thus greatly predisposed to cancer. Unfortunately, given the nature of their underlying genetic defect, tumour-bearing XP patients cannot be treated with conventional DNA damaging therapies. Engineered strains of the poxvirus Vaccinia have been shown to cure cancer in numerous pre-clinical models,...

Research Highlights: Highlights from the latest pharmacogenomic genome-wide association studies.

Patient satisfaction in relation to nipple reconstruction: The importance of information provision.

127 women who had previously undergone surgical nipple reconstruction completed self-report questionnaires to assess body image, anxiety, depression, information preference, and satisfaction with surgical outcome, information provision, and the decision to undergo the procedure. Whilst most women were satisfied with the outcome of surgery and of their decision to have nipple reconstruction, this study highlights the importance of information provision that meets patients' needs at the time of decision-makin...

Evaluation of intracellular trafficking and clearance from HeLa cells of doxorubicin-bound block copolymers.

New technologies are needed to deliver medicines safely and effectively. Polymeric nanoparticulate carriers are one such technology under investigation. We examined the intracellular trafficking of doxorubicin-bound block copolymers quantitatively and by imaging doxorubicin-derived fluorescence using confocal microscopy. The polymers were internalized by endocytosis and distributed in endosomal/lysosomal compartments and the endoplasmic reticulum; unlike free doxorubicin, the polymers were not found in the...

Can we safely administer the recommended dose of phenobarbital in very low birth weight infants?

AIM: We investigated whether the recommended phenobarbital loading dose of 15-20 mg/kg with maintenance of 3-4 mg/kg/day can safely be administered to very low birth weight preterm newborns with seizures. METHODS: Twenty-four convulsive preterms of

The combination of four different clinical decision rules and an age-adjusted D-dimer cut-off increases the number of patients in whom acute pulmonary embolism can safely be excluded.

Four clinical decision rules (CDRs) (Wells score, Revised Geneva Score (RGS), simplified Wells score and simplified RGS) safely exclude pulmonary embolism (PE), when combined with a normal D-dimer test. Recently, an age-adjusted cut-off of the D-dimer (patient's age x 10 μg/l) safely increased the number of patients above 50 years in whom PE could safely be excluded. We validated the age-adjusted D-dimer test and assessed its performance in combination with the four CDRs in patients with suspected PE. A to...

Recurrence of thymoma in the right atrium arising from the coronary sinus.

Invasive thymoma is a malignant tumor of the anterior mediastinum that could have intravenous affinity associated with a high recurrence rate. This report highlights the need of coronary sinus exploration when intraatrial thymoma recurrence is diagnosed. Surgical resection of invaded coronary sinus can be achieved safely with a good result.

Three cases of laparoscopic myomectomy performed during pregnancy for pedunculated uterine myomas.

PURPOSE: Laparoscopic myomectomy during pregnancy is indicated when symptoms related to uterine myomas persist despite pharmacologic therapy; however, currently there is very little information concerning its safety. METHODS: We report three cases of antepartum laparoscopic myomectomy performed to manage complicated myomas requiring surgical intervention. RESULTS: In particular, we report for the first time in literature the laparoscopic removal of two myomas in a patient during a single surgery performed i...

The Prognostic Significance of Coronary CT Angiography.

Coronary computed tomography angiography (CTA) is an increasingly utilized, highly accurate noninvasive test for the diagnosis of coronary artery disease. Accumulating data have convincingly demonstrated that the presence, extent, and location of both obstructive and nonobstructive coronary atherosclerosis visualized on coronary CTA conveys powerful prognostic information, incremental to that provided by clinical variables and coronary calcium scoring. Proposed markers of future plaque instability and coron...

Renal vitamin D receptor expression and vitamin D renoprotection.

Therapy to enhance the renoprotective actions of vitamin D receptor (VDR) activation should safely overcome the distinct VDR content along the nephron to effectively control renal calcium reabsorption, control renal klotho levels for the phosphaturic actions of FGF23, and inhibit proteinuria and the activation of the renin-angiotensin system.

Keeping practice knowledge current: Part 1.

ABSTRACT: Today's fast-paced healthcare environment can make it challenging for nurse practitioners (NPs) to keep abreast of information they need to practice effectively. To make the task easier, NPs should set up a system to capture relevant information and evaluate it for applicability to clinical practice.

The Art of MicroRNA Research.

Originally identified as moderate biological modifiers, microRNAs have recently emerged as powerful regulators of diverse cellular processes with especially important roles in disease and tissue remodeling. The rapid pace of studies on microRNA regulation and function necessitates the development of suitable techniques for measuring and modulating microRNAs in different model systems. This review summarizes experimental strategies for microRNA research and highlights the strengths and weaknesses of differen...

Prenatal Evaluation and Management of Fetuses Exposed to Anti-SSA/Ro Antibodies.

Maternal anti-SSA antibodies are common, existing in up to 2 % of the general population. Fetuses exposed to these antibodies are at risk for both cardiac and noncardiac complications. The cardiac complications include arrhythmias, structural disease, and cardiomyopathy. Although rare, the cardiac disease associated with these antibodies is permanent and severe. Current fetal echocardiographic screening tools are nonspecific. The type and frequency of screening needed is controversial. Although promising t...

Summary of the ISPD Preconference Day, June 3, 2012, Miami Beach.

Preceding the 16th International International Society for Prenatal Diagnosis (ISPD) Conference in Miami Beach, a day of educational courses was organized on Sunday, 3 June 2012. There were eight courses, each lasting half a day. Some of the courses, but not all, were organized by the Special Interest Groups (SIGs) of the ISPD. For more information about these SIGs and their activities, please go to the ISPD website (www.ispdhome.org). Most of the courses were basic courses, designed to give the participant...

Information on blinding in registered records of clinical trials.

ABSTRACT: Information on blinding is part of the data that should be provided upon registration of a trial at a clinical trials registry. Reporting of blinding is often absent or of low quality in published articles of clinical trials. This study researched the presence and quality of information on blinding in registered records of clinical trials and highlights the important role of data-recording formats at clinical trial registries in ensuring high-quality registration.

A study of the health food information for cancer patients on Japanese websites.

The aim of this paper is to evaluate the reliability of websites providing health food information for cancer patients and, to assess the status to get this information online. We used four common Japanese search engines (Yahoo!, Google, goo, and MSN) to look up websites on Dec. 2, 2008. The search keywords were "health food" and "cancer". The websites for the first 100 hits generated by each search engine were screened and extracted by three conditions. We extracted 64 unique websites by the result of retr...