PubMed Journal Database | Age and ageing 
The US National Library of Medicine and National Institutes of Health manage PubMed.gov which comprises of more than 21 million records, papers, reports for biomedical literature, including MEDLINE, life science and medical journals, articles, reviews, reports and books. BioPortfolio aims to publish relevant information on published papers, clinical trials and news associated with users selected topics.
For example view all recent relevant publications on Epigenetics and associated publications and clincial trials.
Showing PubMed Articles 1–25 of 42 from Age and ageing
BACKGROUND: delirium is likely to be particularly common in care homes, given the clustering of known risk factors in these settings. Preventing delirium should result in significant benefits, including better quality of care and improved outcomes for residents. OBJECTIVE: to test the feasibility of 'Stop Delirium!', an intervention to prevent delirium in care homes for older people, and to optimise parameters to inform the design of a future trial evaluation. Method: we delivered Stop Delirium! to six care...
BACKGROUND: sip feeds are oral nutritional supplements (ONSs) that are commonly prescribed to malnourished patients to improve their nutritional and clinical status. However, ONSs are poorly consumed and frequently wasted, with sweetness being identified as one of the factors leading to patients' dislike of ONSs. OBJECTIVES: to investigate if age affects sweetness thresholds and if this impacts upon perceived sweetness intensity, hedonic (sweetness and overall) and ranked preference of ONS products. DESIGN:...
Despite anticoagulation for atrial fibrillation, some patients still suffer an ischaemic stroke. The issue of whether to stop or continue warfarin, or possibly to reverse the anticoagulation is an area of uncertainty. Continued anticoagulation may, however, increase haemorrhagic transformation of the infarct. In this article we review the published evidence in an attempt to quantify the risks and benefits of each treatment strategy and identify areas for further research.
BACKGROUND: participation in centre-based cardiac rehabilitation (CR) is known to reduce morbidity and mortality but participation rates among the elderly are low. Establishing alternative programmes is important, and home-based CR is the predominant alternative. However, no studies have investigated the effect of home-based CR among a group of elderly patients with coronary heart disease with a long-term follow-up. METHODS: randomised clinical trial comparing home-based CR with comprehensive centre-based C...
The future of orthogeriatrics.
Age and outcome in acute emergency medical admissions.
BACKGROUND: there is a lack of outcome information with respect to older health service users. The purpose of this study was to examine 30-day in-hospital mortality and its predictors in all elderly patients admitted as a medical emergency to our hospital. METHODS: all patients admitted between 2002 and 2008 were studied, linking anonymised clinical, administrative, laboratory and mortality data. Significant univariate predictors of outcome, including co-morbidity and illness severity score, were entered in...
BACKGROUND: several studies suggest that a decreased thyroid activity might be favourable in oldest-old subjects and that subclinical thyroid hyperfunction may be detrimental. OBJECTIVES: to verify whether declining levels of circulating thyroid hormones may contribute to longevity. DESIGN: cross-sectional observational study. SETTING: all subjects were born in Calabria (southern Italy) and their ancestry in the region was ascertained up to the grandparents. SUBJECTS: six hundred and four home-dwelling subj...
Objective measures of physical capability and subsequent health: a systematic review.
BACKGROUND: measures of physical capability may be predictive of subsequent health, but existing published studies have not been systematically reviewed. We hypothesised that weaker grip strength, slower walking speed and chair rising and shorter standing balance time, in community-dwelling populations, would be associated with higher subsequent risk of fracture, cognitive outcomes, cardiovascular disease, hospitalisation and institutionalisation. METHODS: studies were identified through systematic searches...
An unusual cause for cough in an octogenarian.
BACKGROUND: multifactorial falls prevention programmes for older people have been proved to reduce falls. However, evidence of their cost-effectiveness is mixed. DESIGN: economic evaluation alongside pragmatic randomised controlled trial. Intervention: randomised trial of 364 people aged ≥70, living in the community, recruited via GP and identified as high risk of falling. Both arms received a falls prevention information leaflet. The intervention arm were also offered a (day hospital) multidisciplinary f...
OBJECTIVE: the present study investigated the effects of walking under different challenges and kinematics and kinetics generated during these activities and how these vary with age. We hypothesised that age-associated changes in gait speed and kinetics are more pronounced during fast-speed walking and post-activity walking, compared with usual-speed walking. METHODS: investigated walking under three conditions: (i) usual speed, (ii) fast speed and (iii) post-activity in 183 Baltimore Longitudinal Study of...
Telestroke: a concept in practice.
Predictors of long-term survival in nonagenarians: the NonaSantfeliu study.
BACKGROUND: few studies have prospectively evaluated long-term predictors of mortality in nonagenarians. OBJECTIVE: to determine predictors of death in a nonagenarian cohort after 5 years of follow-up. DESIGN: a prospective community-based study. SETTING: a community-based study. SUBJECTS: one hundred and eighty-six nonagenarians both living in the community and institutionalised. METHODS: functional status was determined by the Lawton-Brody and Barthel Indexes (BI) and cognition by the Spanish version of t...
OBJECTIVE: to determine the clinical effectiveness of a day hospital-delivered multifactorial falls prevention programme, for community-dwelling older people at high risk of future falls identified through a screening process. DESIGN: multicentre randomised controlled trial. SETTING: eight general practices and three day hospitals based in the East Midlands, UK. Participants: three hundred and sixty-four participants, mean age 79 years, with a median of three falls risk factors per person at baseline. Inter...
BACKGROUND: drug intake is associated with the risk of drug-related problems (DRPs), e.g. the intake of PIM. OBJECTIVE: the proportion of potentially inappropriate medication (PIM) taken by elderly people was analysed. DESIGN: community-based, prospective cohort study. SETTING: ambulatory health-care sector in a German rural area. SUBJECTS: seven hundred and forty-four patients with age >65 years and regular intake of drugs. METHODS: comprehensive home medication review (HMR) provided by specially qualified...
Renal function in a narrow-age cohort of adults at 79 and 87 years.
Walking and night-time restlessness in mild-to-moderate dementia: a randomized controlled trial.
The oldest old and GP end-of-life care in the Dutch community: a nationwide study.
BACKGROUND: Provision of adequate care for the oldest old is increasingly crucial, given the current ageing trends. This study explores differences in end-of-life care of the oldest (>/=85 years) versus the younger (65-84 years) old; testing the hypothesis that age could be an independent correlate of receiving specialised palliative care services (SPCS), having palliative-centred treatment and dying in a preferred place. METHODS: general practitioners (GPs) participating in the nation-wide representative n...
Myoclonus and delirium associated with ciprofloxacin.
BACKGROUND: height loss beginning in mid-life and post-menopausal period was associated with adverse health outcomes. However, height loss occurring after old age has been little studied. We examined how height loss was related to bone mineral density (BMD) change, fracture incidence and cause-specific mortality in older adults. METHODS: the stature and BMD of 3145 community-dwelling men and women aged >/=65 were measured at baseline and after 4 years. All fracture and cause-specific mortality events were s...
Leukocyte telomere length and marital status among middle-aged adults.
BACKGROUND: being unmarried is associated with worse health and increased mortality risk. Telomere length has emerged as a marker for biological ageing but it is unclear how telomere length relates to marital status. OBJECTIVE: to examine the relationship between telomere length and marital status in a sample of middle-aged adults. Design and subjects: cross-sectional analysis among 321 adults aged 40-64 years. METHODS: telomere length was measured by PCR (T/S ratio). Participants provided information on he...
