A Comparison of Mometasone to Advair in Patients With Milder Persistent Asthma
The research hypothesis for the proposed study asks the question, can Asmanex® demonstrate comparable anti-inflammatory therapeutic efficacy to the combination product, Advair® in control of mild persistent asthma?
The purpose is to demonstrate that the anti-inflammatory protection afforded by monotherapy with an inhaled steroid (Asmanex®) is comparable to combination therapy with Advair® 100/50, when measured by this standard methodology (methacholine bronchoprovocation) in subjects with mild persistent asthma.
Allocation: Randomized, Control: Active Control, Intervention Model: Parallel Assignment, Masking: Single Blind, Primary Purpose: Treatment
Mometasone or Advair
Johns Hopkins Asthma and Allergy Center
Johns Hopkins University
Results (where available)
- Source: http://clinicaltrials.gov/show/NCT00461812
- Information obtained from ClinicalTrials.gov on July 15, 2010
Collect PK/PD data for this age group to compare ADVAIR DISKUS with ADVAIR HFA
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Medical and Biotech [MESH] Definitions
Asthma attacks following a period of exercise. Usually the induced attack is short-lived and regresses spontaneously. The magnitude of postexertional airway obstruction is strongly influenced by the environment in which exercise is performed (i.e. inhalation of cold air during physical exertion markedly augments the severity of the airway obstruction; conversely, warm humid air blunts or abolishes it).
Drugs that are used to treat asthma.
A beta-adrenergic agonist used in the treatment of asthma and bronchospasms.
An adrenergic beta-agonist used as a bronchodilator agent in asthma therapy.
Adrenergic beta-2 agonist used as bronchodilator for emphysema, bronchitis and asthma.