Magnetic Resonance Imaging of Brain Development in Autism
Summary
The purpose of this study is to investigate brain development in autism by longitudinally assessing children with autism, as well as typically developing controls, using advanced MR techniques. We will use longitudinal diffusion tensor imaging (DTI) measures to investigate the protracted development of long-range white matter fibers in autism. In addition, we will investigate the effect of autism risk genes on brain development.
Study Design
Observational Model: Case Control, Observational Model: Natural History, Time Perspective: Longitudinal, Time Perspective: Prospective
Conditions
Autism
Location
Dept. of Child and Adolescent Psychiatry, UMC Utrecht
Utrecht
Netherlands
3584CX
Status
Recruiting
Source
UMC Utrecht
Results (where available)
Links
- Source: http://clinicaltrials.gov/show/NCT00449566
- Information obtained from ClinicalTrials.gov on July 15, 2010
Medical and Biotech [MESH] Definitions
Asperger Syndrome
A childhood disorder predominately affecting boys and similar to autism (AUTISTIC DISORDER). It is characterized by severe, sustained, clinically significant impairment of social interaction, and restricted repetitive and stereotyped patterns of behavior. In contrast to autism, there are no clinically significant delays in language or cognitive development. (From DSM-IV)
Clinical Trials
A Trial of CM-AT in Children With Autism
The purpose of this study is to determine whether CM-AT is safe and effective in treating the core symptoms of autism.
Autism in Adult Patients and the Effects on Caregivers
Background: The number of adults with autism is expected to rise significantly in the near future, due to two main reasons: First, a dramatic increase in the estimates of the prevalence of...
Relationship Training for Children With Autism and Their Peers
This study will determine whether peer interaction training interventions are effective in enhancing the social relationships of children with autism.
Early Characteristics of Autism
This study will identify factors that distinguish children with autism from children with developmental delay and those with normal development and study the efficacy of intensive behavior...
Childhood Autism Risks From Genetics and the Environment (The CHARGE Study)
The purpose of this study is to understand how genes, environment, and the interplay between the two, influences the development of autism and other neurodevelopmental disorders.
PubMed Articles
The promise and the pitfalls of autism research: An introductory note for new autism researchers.
The last decade has seen an enormous growth in the quantity of research directed at understanding the biological underpinnings of autism spectrum disorders. This increase has been spurred on, in part,...
Middle School Students' Knowledge of Autism.
Authors examined 1,015 middle school students' knowledge of autism using a single item of prior awareness and a 10-item Knowledge of Autism (KOA) scale. The KOA scale was designed to assess students'...
Knowledge and Attitude of General Practitioners Regarding Autism in Karachi, Pakistan.
General practitioners (GPs) could have an important role in early diagnosis of autism. There have been no studies evaluating the knowledge of GPs regarding autism in Pakistan. We aimed to fill that ga...
Ethics and Autism: Where is the Autistic Voice? Commentary on Post et al.
Genomics, intellectual disability, and autism.
To the Editor: Mefford et al. (Feb. 23 issue)(1) provide an excellent review of the genomic factors in autism but do not mention that the quantitative contribution of the enumerated genetic factors to...
