Cigarette Smoke and Susceptibility to Influenza Infection
Summary
This study will be a descriptive comparison of the effects of live attenuated influenza virus (FluMist) on nasal inflammation and oxidative stress in healthy young adults who are not exposed to smoke vs smokers. It is hypothesized that passive exposure to second-hand smoke (SHS) results in increased susceptibility to the effects of influenza virus in nasal epithelium in humans and that these effects are mediated by SHS-induced oxidative stress
Description
Epidemiologic evidence supports a significant relationship between passive cigarette smoke exposure and increased risk for viral respiratory illnesses. Published and preliminary data suggest that airborne pollutants including tobacco smoke increase susceptibility of respiratory epithelium to infection with influenza A and that this effect is at least partially mediated by oxidative stress. However, no studies have specifically looked at the interaction between smoking and the effects of influenza virus in human volunteers.
Study Design
Observational Model: Cohort, Time Perspective: Prospective
Conditions
Healthy
Location
UNC Center for Environmental Medicine, Asthma and Lung Biology
Chapel Hill
North Carolina
United States
27599-7310
Status
Recruiting
Source
University of North Carolina, Chapel Hill
Results (where available)
Links
- Source: http://clinicaltrials.gov/show/NCT00448617
- Information obtained from ClinicalTrials.gov on July 15, 2010
Medical and Biotech [MESH] Definitions
Clinical Trials
None
PubMed Articles
None
