Study of INS115644 Ophthalmic Solution in Subjects With Ocular Hypertension or Glaucoma
Summary
The purpose of this trial is to evaluate the safety and tolerability of INS115644 Ophthalmic Solution in subjects with bilateral ocular hypertension or early primary open angle glaucoma and to investigate the intraocular pressure lowering effects of INS115644 Ophthalmic Solution.
Study Design
Allocation: Randomized, Control: Placebo Control, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Treatment
Conditions
Ocular Hypertension
Intervention
INS115644 Ophthalmic Solution, Placebo, INS115644 Ophthalmic Solution, INS115644 Ophthalmic Solution, INS115644 Ophthalmic Solution
Location
Sall Research Medical Center
Artesia
California
United States
90701
Status
Completed
Source
Inspire Pharmaceuticals
Results (where available)
Links
- Source: http://clinicaltrials.gov/show/NCT00443924
- Information obtained from ClinicalTrials.gov on July 15, 2010
Medical and Biotech [MESH] Definitions
Saline Solution, Hypertonic
Hypertonic sodium chloride solution. A solution having an osmotic pressure greater than that of physiologic salt solution (0.9 g NaCl in 100 ml purified water).
Ophthalmic Nerve
A sensory branch of the trigeminal (5th cranial) nerve. The ophthalmic nerve carries general afferents from the superficial division of the face including the eyeball, conjunctiva, upper eyelid, upper nose, nasal mucosa, and scalp.
Osmotic Pressure
The pressure required to prevent the passage of solvent through a semipermeable membrane that separates a pure solvent from a solution of the solvent and solute or that separates different concentrations of a solution. It is proportional to the osmolality of the solution.
Glucose Solution, Hypertonic
Solution that is usually 10 percent glucose but may be higher. An isotonic solution of glucose is 5 percent.
Vaginal Douching
The washing of the VAGINA cavity or surface with a solution. Agents or drugs can be added to the irrigation solution.
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