Late Effects of Radiation Therapy and Natural History of Disease in Patients Previously Treated for Cancer at the National Institutes of Health
RATIONALE: Radiation therapy may cause side effects that appear months or years after treatment has ended. A study that evaluates patients for several years after they have undergone radiation therapy may help doctors provide the best follow-up care.
PURPOSE: This clinical trial is studying the late effects of radiation therapy and the natural history of disease over time in patients previously treated for cancer at the National Institutes of Health (NIH).
- Continue follow-up care for long-term survivors and other patients who received radiotherapy at the National Cancer Institute's (NCI) Radiation Oncology Branch at the National Institutes of Health (NIH) in the past and for whom continued follow-up at NIH is considered beneficial to both the patient and the Radiation Oncology Branch.
- Assess the natural history of the disease in these patients.
- Assess late effects of treatment in these patients.
OUTLINE: Patients are evaluated by Radiation Oncology Branch staff at appropriate intervals (based on good medical practices) to determine the natural history of the disease, long-term effects of previous therapies, and potential eligibility for enrollment on future protocols. Diagnostic tests, evaluations, and subsequent treatments (if needed) vary according to the individual patient's circumstances. Data is collected to assist researchers in studying long-term effects of radiotherapy and outcomes of the disease.
PROJECTED ACCRUAL: A maximum of 300 patients will be accrued for this study.
Unspecified Adult Solid Tumor, Protocol Specific
Warren Grant Magnuson Clinical Center - NCI Clinical Trials Referral Office
National Cancer Institute (NCI)
Results (where available)
- Source: http://clinicaltrials.gov/show/NCT00436813
- Information obtained from ClinicalTrials.gov on July 15, 2010
Medical and Biotech [MESH] Definitions
Testing or screening required by federal, state, or local law or other agencies for the diagnosis of specified conditions. It is usually limited to specific populations such as categories of health care providers, members of the military, and prisoners or to specific situations such as premarital examinations or donor screening.
A solid, unencapsulated tumor of the KIDNEY composed of spindle mesenchymal cells that resemble FIBROBLASTS or muscle cells. The homogeneous mass typically extends into the renal parenchyma and replaces most of the kidney. In most cases, mesoblastic nephroma is benign and occurs in the fetus or newborn, and rarely in the older child or the adult.
Tumor Stem Cell Assay
A cytologic technique for measuring the functional capacity of tumor stem cells by assaying their activity. It is used primarily for the in vitro testing of antineoplastic agents.
Carcinoma, Ehrlich Tumor
A transplantable, poorly differentiated malignant tumor which appeared originally as a spontaneous breast carcinoma in a mouse. It grows in both solid and ascitic forms.
Detection of or testing for certain ALLELES, mutations, genotypes, or karyotypes that are associated with genetic traits, heritable diseases, or with a predisposition to a disease, or that may lead to the disease in descendants. It includes prenatal genetic testing.
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