Effect Of Rilapladib (SB-659032) On Platelet Aggregation

18:56 EDT 30th October 2014 | BioPortfolio

Summary

The purpose of this study is to compare the effects of repeat doses of SB-659032 with placebo on platelet aggregation in subjects.

Study Design

Allocation: Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Diagnostic

Conditions

Healthy Subjects

Intervention

Rilapladib (SB-659032)

Location

GSK Investigational Site
Randwick
New South Wales
Australia
2031

Status

Completed

Source

GlaxoSmithKline

Results (where available)

View Results

Links

Clinical Trials [2 Associated Clinical Trials listed on BioPortfolio]

An Imaging Study in Patients With Atherosclerosis Taking Rilapladib or Placebo for 12 Weeks

A study in patients with atherosclerosis to assess safety, effect and PK of rilapladib vs. placebo over 12 weeks of dosing.

Study to Determine the Effect of Itraconazole on the Pharmacokinetics of Rilapladib (SB659032) in Healthy Volunteers

Rilapladib is a potent and selective inhibitor of lipoprotein associated phospholipase A2 (Lp-PLA2), which was previously under development for the treatment of atherosclerosis and is curr...

PubMed Articles [4406 Associated PubMed Articles listed on BioPortfolio]

CLINICAL EVALUATION OF PAZOPANIB EYE DROPS IN HEALTHY SUBJECTS AND IN SUBJECTS WITH NEOVASCULAR AGE-RELATED MACULAR DEGENERATION.

To evaluate pazopanib 10 mg/mL eye drops (pazopanib) in healthy subjects and in subjects with previously untreated subfoveal choroidal neovascularization secondary to age-related macular degeneration.

Comparison of Hba1c Levels in Non-Diabetic Healthy Subjects and Subjects With Periodontitis Before and After Non-Surgical Periodontal Therapy.

Background: Only a few studies have examined the association between periodontitis and glycosylated hemoglobin (HbA1c) levels in non-diabetics. The aim of this study was to compare HbA1c levels in non...

Macrophage Inflammatory Protein-1α Shows Predictive Value as a Risk Marker for Subjects and Sites Vulnerable to Bone Loss in a Longitudinal Model of Aggressive Periodontitis.

Improved diagnostics remains a fundamental goal of biomedical research. This study was designed to assess cytokine biomarkers that could predict bone loss (BL) in localized aggressive periodontitis. 2...

Fatigue Affects Health Status and Predicts Mortality Among Subjects with COPD: Report from the Population-Based OLIN COPD Study.

Abstract Background: COPD is associated to increased fatigue, decreased health status and mortality. However, these relationships are rarely evaluated in population-based studies. Aims: To describe th...

Decreased aorto-septal angle may contribute to left ventricular diastolic dysfunction in healthy subjects.

Left ventricular (LV) diastolic dysfunction is often observed in healthy older subjects without structural heart disease, although its exact mechanisms have not been established. A decrease in the aor...

Medical and Biotech [MESH] Definitions

Books intended for use in the study of specific subjects, containing systematic presentation of the principles and essential knowledge of the subjects.

A type of analysis in which subjects in a study group and a comparison group are made comparable with respect to extraneous factors by individually pairing study subjects with the comparison group subjects (e.g., age-matched controls).

Studies in which a number of subjects are selected from all subjects in a defined population. Conclusions based on sample results may be attributed only to the population sampled.

Persons who are enrolled in research studies or who are otherwise the subjects of research.

Hospital or other institutional committees established to protect the welfare of research subjects. Federal regulations (the "Common Rule" (45 CFR 46)) mandate the use of these committees to monitor federally-funded biomedical and behavioral research involving human subjects.

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