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Comparison of Side Effects of Morphine and Hydromorphone PCA

2014-08-26 22:42:08 | BioPortfolio

Summary

Both morphine and hydromorphone are pain medications commonly used after surgery. It is thought at our institution that hydromorphone causes less side effects but this has not been studied. We propose to treat our patients with either morphine or hydromorphone and determine how much nausea, vomiting, and itching they have with each drug

Study Design

Allocation: Randomized, Control: Active Control, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Conditions

Post Operative Pain

Intervention

Morphine PCA, Hydromorphone PCA

Location

Columbia Presbyterian Hospital
New York
New York
United States
10032

Status

Completed

Source

Columbia University

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-26T22:42:08-0400

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A Study of OROS Hydromorphone HCL vs Morphine in Cancer Pain Patients.

The purpose of this study was to demonstrate the clinical equivalence of hydromorphone and morphine (immediate-release [IR] and sustained-release [SR] formulations) using the "worst pain i...

Intrathecal Hydromorphone for Cesarean Section

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Safety and Efficacy Study of Hydromorphone and Morphine

To compare a standard weight-based dose of intravenous (IV) hydromorphone (Dilaudid) to a standard weight-based dose of IV morphine in adults presenting to the ED with acute severe pain...

Post-operative Oral Morphine Versus Ibuprofen

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PubMed Articles [9963 Associated PubMed Articles listed on BioPortfolio]

Morphine versus Hydromorphone: Does Choice of Opioid Influence Outcomes?

Morphine has traditionally been considered the first line agent for analgesia in hospitals; however, in the last few years there has been a shift towards the use of hydromorphone as a first line agent...

Post-operative Analgesia in Opioid Dependent Patients: Comparison of Intravenous Morphine and Sublingual Buprenorphine.

Acute and chronic pain is prevalent in patients with opioid dependence. Lack of knowledge concerning the complex relationship between pain, opioid use, and withdrawal syndrome can account for the barr...

Analgesic efficacy of three different dosages of intra-articular morphine in arthroscopic knee surgeries: Randomised double-blind trial.

Arthroscopic knee surgery is a common procedure and may cause enough pain to delay rehabilitation. Intra-articular (IA) morphine is a known modality for post-operative pain relief. However, the optima...

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Despite the development of multimodal analgesia for postoperative pain management, opioids are still required for effective pain relief after knee arthroplasty. We aimed to identify the determinants o...

Spontaneous Chronic Pain After Experimental Thoractomy Revealed by Conditioned Place Preference: morphine differentiates tactile evoked pain from spontaneous pain.

Chronic pain following surgery limits social activity, interferes with work and causes emotional suffering. A major component of such pain is is reported as "resting" or spontaneous pain with no appar...

Medical and Biotech [MESH] Definitions

An opioid analgesic made from MORPHINE and used mainly as an analgesic. It has a shorter duration of action than morphine.

A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor. Prolonged use may lead to dependence of the morphine type; withdrawal symptoms appear more rapidly than with morphine and are of shorter duration.

An opioid analgesic with actions and uses similar to those of MORPHINE, apart from an absence of cough suppressant activity. It is used in the treatment of moderate to severe pain, including pain in obstetrics. It may also be used as an adjunct to anesthesia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1092)

A benzyl-indazole having analgesic, antipyretic, and anti-inflammatory effects. It is used to reduce post-surgical and post-traumatic pain and edema and to promote healing. It is also used topically in treatment of RHEUMATIC DISEASES and INFLAMMATION of the mouth and throat.

An opioid analgesic used similarly to MORPHINE in the control of moderate to severe pain. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1097)

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